LOCUS       NM_053158               3449 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus mitochondrial ribosomal protein L1 (Mrpl1), transcript
            variant 1, mRNA.
ACCESSION   NM_053158
VERSION     NM_053158.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3449)
  AUTHORS   Cheong,A., Lingutla,R. and Mager,J.
  TITLE     Expression analysis of mammalian mitochondrial ribosomal protein
            genes
  JOURNAL   Gene Expr Patterns 38, 119147 (2020)
   PUBMED   32987154
REFERENCE   2  (bases 1 to 3449)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   3  (bases 1 to 3449)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   4  (bases 1 to 3449)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Structural compensation for the deficit of rRNA with proteins in
            the mammalian mitochondrial ribosome. Systematic analysis of
            protein components of the large ribosomal subunit from mammalian
            mitochondria
  JOURNAL   J Biol Chem 276 (24), 21724-21736 (2001)
   PUBMED   11279069
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132243.3, AK142249.1 and AI462572.1.
            
            On Nov 5, 2013 this sequence version replaced NM_053158.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142249.1, AK083978.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC132243.3         95133-95158         c
            27-3431             AK142249.1         2-3406
            3432-3449           AI462572.1         4-21                c
FEATURES             Location/Qualifiers
     source          1..3449
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 47.29 cM"
     gene            1..3449
                     /gene="Mrpl1"
                     /gene_synonym="2410002L03Rik; 5830418D04Rik; L1mt"
                     /note="mitochondrial ribosomal protein L1"
                     /db_xref="GeneID:94061"
                     /db_xref="MGI:MGI:2137202"
     exon            1..79
                     /gene="Mrpl1"
                     /gene_synonym="2410002L03Rik; 5830418D04Rik; L1mt"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1059
                     /gene="Mrpl1"
                     /gene_synonym="2410002L03Rik; 5830418D04Rik; L1mt"
                     /note="isoform 1 is encoded by transcript variant 1; 39S
                     ribosomal protein L1, mitochondrial; large ribosomal
                     subunit protein uL1m"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL1m isoform 1"
                     /protein_id="NP_444388.2"
                     /db_xref="CCDS:CCDS19449.1"
                     /db_xref="GeneID:94061"
                     /db_xref="MGI:MGI:2137202"
                     /translation="MAAAVRCLRRVLIHHQRHCLCKMASQASLYPCSVNSLLHNRHFA
                     AAAAAATKPARKIKKGAKEKTSDEKPVDDIEKIKSYTYMESDPEDDVYLKRLYPRRIY
                     EVEKAIHLLKKFQVLDFTNPKQGVYLDLTLDMALGKKKTVEPFASVIALPHLFSSEVN
                     KVAVFTANASEIKIAEENGAAFAGGTDLVKKIMDDEVVVDFYVAVPEIMGELNPLRKK
                     LKKRFPKATRNSIGRDIPKMLELFKTAHEIMVDEERQNFLSTKIATLDMPSDQIAANL
                     QAVINEVCKHRPLNLGPFVVRAFLRSSTSEGLLLKTDSLLPKEAKTTEAETEETQTAE
                     AA"
     exon            80..203
                     /gene="Mrpl1"
                     /gene_synonym="2410002L03Rik; 5830418D04Rik; L1mt"
                     /inference="alignment:Splign:2.1.0"
     exon            204..465
                     /gene="Mrpl1"
                     /gene_synonym="2410002L03Rik; 5830418D04Rik; L1mt"
                     /inference="alignment:Splign:2.1.0"
     exon            466..549
                     /gene="Mrpl1"
                     /gene_synonym="2410002L03Rik; 5830418D04Rik; L1mt"
                     /inference="alignment:Splign:2.1.0"
     exon            550..621
                     /gene="Mrpl1"
                     /gene_synonym="2410002L03Rik; 5830418D04Rik; L1mt"
                     /inference="alignment:Splign:2.1.0"
     exon            622..733
                     /gene="Mrpl1"
                     /gene_synonym="2410002L03Rik; 5830418D04Rik; L1mt"
                     /inference="alignment:Splign:2.1.0"
     exon            734..840
                     /gene="Mrpl1"
                     /gene_synonym="2410002L03Rik; 5830418D04Rik; L1mt"
                     /inference="alignment:Splign:2.1.0"
     exon            841..922
                     /gene="Mrpl1"
                     /gene_synonym="2410002L03Rik; 5830418D04Rik; L1mt"
                     /inference="alignment:Splign:2.1.0"
     exon            923..3449
                     /gene="Mrpl1"
                     /gene_synonym="2410002L03Rik; 5830418D04Rik; L1mt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1118..1123
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl1"
                     /gene_synonym="2410002L03Rik; 5830418D04Rik; L1mt"
                     /note="hexamer: TATAAA"
     polyA_site      1138
                     /gene="Mrpl1"
                     /gene_synonym="2410002L03Rik; 5830418D04Rik; L1mt"
                     /note="major polyA site"
     regulatory      2629..2634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl1"
                     /gene_synonym="2410002L03Rik; 5830418D04Rik; L1mt"
                     /note="hexamer: AATAAA"
     polyA_site      2649
                     /gene="Mrpl1"
                     /gene_synonym="2410002L03Rik; 5830418D04Rik; L1mt"
     regulatory      3210..3215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl1"
                     /gene_synonym="2410002L03Rik; 5830418D04Rik; L1mt"
                     /note="hexamer: AATAAA"
     polyA_site      3232
                     /gene="Mrpl1"
                     /gene_synonym="2410002L03Rik; 5830418D04Rik; L1mt"
     regulatory      3412..3417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl1"
                     /gene_synonym="2410002L03Rik; 5830418D04Rik; L1mt"
                     /note="hexamer: ATTAAA"
     polyA_site      3438
                     /gene="Mrpl1"
                     /gene_synonym="2410002L03Rik; 5830418D04Rik; L1mt"
ORIGIN      
        1 agttgaaacc cgggacccac ttcgtcagca caatccggaa cagtcaacat ggcggcggcc
       61 gtaaggtgcc tccgtagagt cttgatacat catcaaaggc attgtctttg caagatggct
      121 tcccaggcat ctctttaccc ttgttctgtg aacagtctct tgcacaacag acattttgct
      181 gctgctgctg ctgctgctac aaagcctgca agaaaaatta aaaaaggtgc caaggaaaag
      241 acatcagatg aaaaaccagt agatgatata gagaaaataa agtcatatac gtacatggaa
      301 agtgatcctg aagatgatgt ctacttaaaa cgcttatacc cacggcggat ctatgaagta
      361 gagaaagcta ttcacttact taagaagttt caagttctgg actttaccaa tccaaagcaa
      421 ggtgtttatc ttgacttaac attagatatg gcattgggga aaaagaaaac agtggagcca
      481 tttgccagtg ttattgcttt accacacctc ttctcctcag aagtcaacaa ggttgctgtg
      541 tttacagcga acgcatcaga aattaaaata gcagaagaaa atggagctgc gtttgcagga
      601 ggaacagatc tggttaagaa gatcatggat gacgaggttg ttgtggactt ttatgtagct
      661 gtcccagaaa taatgggtga acttaaccct ttaaggaaga aactgaaaaa aagatttcca
      721 aaggctacta gaaattccat tggtcgtgac atccccaaaa tgcttgaatt atttaaaacg
      781 gcacatgaaa ttatggtaga tgaagaaaga cagaacttcc tcagcaccaa aatagcaaca
      841 ttggatatgc caagtgacca gatagctgcc aatcttcaag cagttataaa tgaggtctgt
      901 aagcacagac cactgaatct gggtccgttt gtggtccgtg ccttccttcg tagttcaacc
      961 agtgaaggtt tactactgaa gactgactca ttgctaccca aagaagctaa aactacagaa
     1021 gctgaaacgg aagaaactca aacggcagaa gctgcctaga agtgttatat tgtgaaatta
     1081 ttgggggatg tgtgtgtcaa gaaacaacag aggcatctat aaaactgtat aatttttagt
     1141 ttggctcctc atgttttctt aatcagtgca tttagaagta aattttaaca ctttttcttt
     1201 taacagtttc aaaaatgagg aaaaatgtca gtttctaaaa atcccgttac atttcctttt
     1261 tttaaatttt gtattattct ttatattttt ctggatttgg atcctgtcac gttttctttt
     1321 ttcccctctc atcccctctt tttttttatt atgttttcct ttatttcttt attcactttc
     1381 catcccgatc acagcccttc ttcctcctct tctccatgtc ccaccctcac actcttccat
     1441 tgccccctcc cctttccttc tgagaagggg aggcctcccc atgggtacca acccgccctg
     1501 gcaagtcaag tcgaagcagg actgggtaca tcctctccca cggaggccag ataaggcagc
     1561 cagttatggg aaggggatcc aaagggaggc aacagagtca gagtcagccc ctgctccact
     1621 gttaggaccc gcacggaggc catgctgcac atctgcacaa atgtgtaggc tgtgtaggtc
     1681 cagcccgtgc gtgttcttta gttggtggtt cagcctctgc atctgtagat gcaggttagt
     1741 tgatcctata ggtcttgtgg tgtccttgac tcctccagct ccctcagtcc ttccttagca
     1801 tcagtgttct gtattttggt agaatcccaa gtctagaagc agtttctcgt tttgtgacat
     1861 tccttgagga gacatggcca tctgaaggaa cagcagcatc ctccctcgtt cccccaggct
     1921 gtatcaccag cagggctgtt tgcttctgtg tgtgtggtgc tcggccattg cagatgtgaa
     1981 agctaaacga aagatgaaga agggttgtgg ggatagtgta tgctggagac gtcatttccc
     2041 acagttgcca gattctggaa ccggattcat ccgtgttgga aatatcaatt tacaaagagg
     2101 acaggatttt gattgttgtt gttgttgttt tttttttttt ttgatttttt aattatgtgt
     2161 ctgtgtttgg gtctgggggt caacacagga tgtcttcatc agttgctttc taccttattt
     2221 tttgagacag gctctcaact tggagtttat agactcatca aactggctgg ccagccagcc
     2281 ccgggaccct tctgtctacc ttctctgtag gtgctgggga tgaagcctgt gtccttgtgt
     2341 ttctgcaaca ggcactttac catggagcca ttcccagtcc acttttacat tttaattatg
     2401 cgtagaattg gatgcaaggc catgtgcatg ctaggcaagg gcccaaagct attgctttat
     2461 ttgccaattt ttctcctgac taatggagtg ttaactttag aatggaaata ttcgggacac
     2521 taataaacag gaaaaggaat cactcacaat cctgatactc agacataatc agaaaaaaat
     2581 tgtttagtgg atattccttt tacattttca tttgaaagag acagggcaaa taaaaagagc
     2641 atacatgcat gcatgctggt gggttttgtt ttgtttttaa gatttatttt atgtgtatta
     2701 gtattcggtc tacatatatg taagtatacc atggacccgt ggtggtcaga ggcgggctcc
     2761 tgatgcccta gagctggagt tacagatggt taagggccac catttgggtg ctaggaactg
     2821 aacccaggtc ttttaccaag tgctcttcac ggctaagcca tctctagccc tgcatgtgtg
     2881 ctgtttgaac gtactcattt cttttattca atcctcatgg aaaatgagta acacttcatc
     2941 gctttattgt ggcagtccct caattgctag ccatttaaat tgtttcagga tcgccctccc
     3001 attgacttaa gtaagggttt aaagttttac agtaagtact gatgaatccc aaacgttagt
     3061 ttccatacag attacttaga aggtttgcgt agaacaaata gctggtcttc acctagtaat
     3121 aggagattga ccttggaatt ctgcagtttt tatcaggtag tgggacaatg gggactctag
     3181 tggataccag tgctgtcaac cctgattcta ataaaaagaa atctgatttt cagaccagca
     3241 tcagtttatt ctaaaattcc acaagtgatc taaagtacca gagtgaaagt cactgttgta
     3301 cttcactacc caatttataa aaggttgcaa aatttgtaat attttaaata ttacaaatta
     3361 caatattgta attttgttaa tttgtaatta caaatattaa attttttaac tattaaaaat
     3421 ttaaatattt taaaattatc tttattcta
//
