LOCUS       NM_001039557            3462 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus maestro heat-like repeat family member 8 (Mroh8),
            mRNA.
ACCESSION   NM_001039557 XM_894391
VERSION     NM_001039557.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3462)
  AUTHORS   Gaudet P, Livstone MS, Lewis SE and Thomas PD.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 3462)
  AUTHORS   Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J,
            BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta
            A, Hansen G, Hu Y, Huang W, Jaing C, Key BW Jr, Kipp P, Kohlhauff
            B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick
            J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N,
            Zhu Q, Person C and Sands AT.
  TITLE     Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap
            screen to identify potential targets for therapeutic intervention
  JOURNAL   Proc Natl Acad Sci U S A 100 (24), 14109-14114 (2003)
   PUBMED   14610273
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029507.1, AK132763.1 and AV273162.1.
            
            On Jun 25, 2013 this sequence version replaced NM_001039557.3.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is more supported by the available
            transcript and conservation data. The transcript is predicted to be
            a candidate for nonsense-mediated mRNA decay (NMD), but the protein
            is represented because the gene is believed to be protein-coding
            based on good conservation of the CDS, and because all currently
            available mouse transcripts (AK029507.1, AK132763.1 and BC150937.1)
            are NMD candidates. Furthermore, the stop codon is only 56 nts from
            the last splice site, which suggests that the transcript is only
            marginally an NMD candidate and may escape NMD at least some of the
            time.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132763.1, BC150937.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               AK029507.1         2-245
            245-2527            AK132763.1         2-2284
            2528-3457           AK029507.1         2500-3429
            3458-3462           AV273162.1         208-212
FEATURES             Location/Qualifiers
     source          1..3462
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 78.12 cM"
     gene            1..3462
                     /gene="Mroh8"
                     /gene_synonym="4922505G16Rik"
                     /note="maestro heat-like repeat family member 8"
                     /db_xref="GeneID:629499"
                     /db_xref="MGI:MGI:3603828"
     exon            1..358
                     /gene="Mroh8"
                     /gene_synonym="4922505G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            359..480
                     /gene="Mroh8"
                     /gene_synonym="4922505G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            481..626
                     /gene="Mroh8"
                     /gene_synonym="4922505G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            627..749
                     /gene="Mroh8"
                     /gene_synonym="4922505G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            750..829
                     /gene="Mroh8"
                     /gene_synonym="4922505G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            830..974
                     /gene="Mroh8"
                     /gene_synonym="4922505G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1070
                     /gene="Mroh8"
                     /gene_synonym="4922505G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1175
                     /gene="Mroh8"
                     /gene_synonym="4922505G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1311
                     /gene="Mroh8"
                     /gene_synonym="4922505G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1433
                     /gene="Mroh8"
                     /gene_synonym="4922505G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1586
                     /gene="Mroh8"
                     /gene_synonym="4922505G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1747
                     /gene="Mroh8"
                     /gene_synonym="4922505G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1883
                     /gene="Mroh8"
                     /gene_synonym="4922505G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2074
                     /gene="Mroh8"
                     /gene_synonym="4922505G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2209
                     /gene="Mroh8"
                     /gene_synonym="4922505G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2324
                     /gene="Mroh8"
                     /gene_synonym="4922505G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2465
                     /gene="Mroh8"
                     /gene_synonym="4922505G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2630
                     /gene="Mroh8"
                     /gene_synonym="4922505G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2786
                     /gene="Mroh8"
                     /gene_synonym="4922505G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2787..2909
                     /gene="Mroh8"
                     /gene_synonym="4922505G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..3009
                     /gene="Mroh8"
                     /gene_synonym="4922505G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..3075
                     /gene="Mroh8"
                     /gene_synonym="4922505G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3076..3246
                     /gene="Mroh8"
                     /gene_synonym="4922505G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3247..3280
                     /gene="Mroh8"
                     /gene_synonym="4922505G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3281..3462
                     /gene="Mroh8"
                     /gene_synonym="4922505G16Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacccttcgg gtccccagca cttcaccagc tcgcagcctc cgccacacgc tcgaccccga
       61 aagcgcccgt gcccatgccc ctgccccgta ggggagggga accgcgccta gccggcgccc
      121 gtgtggtccg cactagcctc ccgcgggcga cgccccgctc cccaaagcgt gtcggccgcg
      181 gggccccact attgagccat gcgcaacgcc tcacccggcg gcgccattcc tccgagcagg
      241 tcccaccgga gcccgagcag gcagacttcc gctccgggaa gtggctccaa gagcgcgccg
      301 gaggggacgc cagggacccg cggcacacgc cacttgccag aatgggctcc cggcaaaggg
      361 ccagcggtac agaagaagta gtgatcccct gtgcttctga cagtgactca gggagtgtag
      421 acctgcagct gagcaactta gacgacgttc aaaagggtgg agctagtgtt gaattcacag
      481 attcggacat cgctgacatc cctacactgc ctcaggagtc cctgccagat aacctcaggt
      541 tacttactct ccaggagccc ctcagtgaga ccagcattga gagactggtc cagtccatcc
      601 aggaagtttt acatggtgag ctaaaggggg aaactcaaaa gttgaagttc ctaagatctt
      661 tgtcttcttt gagccaaact ataccttatg acgaaaacac ggaatcattt attcaccgcc
      721 acacagcaga aatagtgcat gttctaagtg tgttggtaca ggaggagcct ctgcactctc
      781 taaccagcat ggtgcgccag gagatctttg tcaccatcac tgacctcagt ttccaaaatg
      841 tgtacctgtt gtttggctct gaagaccgag aggacttgct tgggcttatc accaaaagta
      901 taatctctct gcccgccaca agcaccccta tccagctgct gaagatagtg tccaaccagg
      961 ccatcgagca agagtgtctc tacagggaga cgttcgaggc cttttctgtg atgctgcaga
     1021 gtctggtaat aaaagatcca catctggaat tttttgacag catttttaag cacatagacc
     1081 cctggttaca gtccgacaga gaccatgagc gggaacgggc taccactgtc atggcccaag
     1141 ttctcaaatg cttatccagt tatctcagcc tgaagcttcc actgcagttc cagaggctcg
     1201 ggaatctcgt ggctgtgatg gcgctgctgt gtggggaccc acagaaagag gtggctgagg
     1261 aggctgcaga ggggacacac tacctgcttc atatcactct gagactgaaa tatatcatgc
     1321 aggacagaga caacaatagc aagaacttga gagaaacttt gaaaaaatgc aggttgctgc
     1381 tggagcaata tagcctcaaa cggttctact gctgtcccta caagattgtt caggtctttg
     1441 aagttttcct cgactctcgg gagctcggcc agtttatcat gacgatattg gacagcctga
     1501 aaaatctgcc gcatccctgt atccagcaga cagcaggaga gttgctgata accttggtga
     1561 agagtgcaga ggctcggttt gagagggtgc cagaaatagt aggtgtgatc tgtgctcggc
     1621 tgtcgataat caccctgact agtgtccggc aacagatcat aaatactgtg agtctgtttg
     1681 tctccagacc taagtacaca gatgtagtgc tcagccacct tttatgccat ccagtaccgt
     1741 atgacaggca tctggctgaa ttgtggagat ccctggaggt agagctgtcc aacacgacct
     1801 gggtcctatg gaggctcctg cggaagctgc agaagtgcca cgaggggccc agccaggaga
     1861 agatggccta cgtggctgtt gctgtgaccg atgcccttta tgaggtgctc atggggaaca
     1921 aactccgagc agccgcattc cgactctttc ctcagctttt gatgaccctg ctcatccaga
     1981 ttcaccacag catcggcctc accatgtctg acgtcagcat cccaagtggc ctgtatgcag
     2041 agcaggaagt accaatggag gttacgcctt tgtgcttcgc catacaagct acaaagactc
     2101 tcctcctcag aaccctgtgc tggcaggagt tcagcatcat ggaaaagagc ggcggatgga
     2161 cccttctgaa gggagaaggc catcttcagg gagtgttcct ccttgccaat gccttgatgg
     2221 aaagaagtca cctctttgca tataagatct tgtacttgct ggtccctttg attaaccgag
     2281 ggaatgacaa gcataaactc acatctgcag gcttttttgt ggagctcctg aagagtccga
     2341 tggccaggag actgcccaag gtatactcta ctatccgcct gaaagcctgg ctgaatgaag
     2401 agagtaagct cttcaggatc cttgcactga ggggactgcg aaatcttgtc agacaccagg
     2461 agatgagaga agacatcaaa agcctgctgc catgcatctt aagtagccta catgagaccg
     2521 atgagaggat cattttgttg gctatccaga ttctcctgca gcttgtcagg atgctagact
     2581 ccaccacctt ggctaccatg atgaagaccc tgctttcctt atttggtgat gtgagacagg
     2641 acgttcactg tttctccatg actctttttg gagcatccat aaaggctgtg aaacacacag
     2701 agaagaagag cgtggaagat caagtgctgg agagcttagt cccactactt ctgttttctc
     2761 aggatgaaaa tgatgaaata gctaaggaga gtagacgagt cctaactctt tgtgcccggt
     2821 tcctgaattg gaagctgccc cgagaagtat actgcaaaga tcccttatac atcaaaccaa
     2881 atgaagttag aagggtctgc aaattctttg gagaaaaaag caaggggaag atagacatcc
     2941 tcgaccaaac actgccgtat tccaaggatc caaaacttcc catcagaaga acagctgtct
     3001 tgtttgtagg gctcttatca cattatgtgg atacaagtga actcaagagg aaaggtactg
     3061 actggataga gaaagatctg agagaactgt tacaagaccc cgagccctct ttgcgcatcc
     3121 ttgcctccca ggctctgttc cgaatccaga gggtggggag tacatcagaa gcagagacaa
     3181 gcgtttcctg gttgaggaag ctcttgtgct gtcttcatac ttagtctgca aagcacatga
     3241 cagcaggctt aaaatccagt ctgaatctac ttccatgcag atggagaagc taaagtaaca
     3301 aacatgaaag tgatttgctc tgggtcacac aactagtaaa tggcaaagcc agaactatgc
     3361 aagtattctg gcgcctacat ccacatcctt gactagtctg ctgtattctt ctccaatctg
     3421 cttgttcttg gaaatgggaa taaacacaga tctgctctac aa
//
