LOCUS       NM_001126487            4346 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus maestro heat-like repeat family member 7 (Mroh7),
            mRNA.
ACCESSION   NM_001126487 XM_978122 XM_993861
VERSION     NM_001126487.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4346)
  AUTHORS   Suzuki,A., Yabuta,N., Shimada,K., Mashiko,D., Tokuhiro,K.,
            Oyama,Y., Miyata,H., Garcia,T.X., Matzuk,M.M. and Ikawa,M.
  TITLE     Individual disruption of 12 testis-enriched genes via the
            CRISPR/Cas9 system does not affect the fertility of male mice
  JOURNAL   J Reprod Immunol 163, 104252 (2024)
   PUBMED   38697008
REFERENCE   2  (bases 1 to 4346)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4346)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4346)
  AUTHORS   Lin,Q., Donahue,S.L., Moore-Jarrett,T., Cao,S., Osipovich,A.B. and
            Ruley,H.E.
  TITLE     Mutagenesis of diploid mammalian genes by gene entrapment
  JOURNAL   Nucleic Acids Res 34 (20), e139 (2006)
   PUBMED   17062627
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929585.11.
            
            On or before May 9, 2008 this sequence version replaced
            XM_993861.1, XM_978122.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               AL929585.11        167247-167422       c
            177-211             AL929585.11        161999-162033       c
            212-1390            AL929585.11        159867-161045       c
            1391-1455           AL929585.11        153572-153636       c
            1456-1539           AL929585.11        150745-150828       c
            1540-1619           AL929585.11        149450-149529       c
            1620-1749           AL929585.11        149079-149208       c
            1750-1845           AL929585.11        147963-148058       c
            1846-1950           AL929585.11        147243-147347       c
            1951-2086           AL929585.11        146951-147086       c
            2087-2199           AL929585.11        143623-143735       c
            2200-2376           AL929585.11        142507-142683       c
            2377-2531           AL929585.11        141975-142129       c
            2532-2670           AL929585.11        139619-139757       c
            2671-2861           AL929585.11        139214-139404       c
            2862-2999           AL929585.11        134483-134620       c
            3000-3114           AL929585.11        133807-133921       c
            3115-3255           AL929585.11        131769-131909       c
            3256-3435           AL929585.11        131007-131186       c
            3436-3591           AL929585.11        130466-130621       c
            3592-3714           AL929585.11        129707-129829       c
            3715-3817           AL929585.11        123401-123503       c
            3818-3880           AL929585.11        121352-121414       c
            3881-4346           AL929585.11        119909-120374       c
FEATURES             Location/Qualifiers
     source          1..4346
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 49.69 cM"
     gene            1..4346
                     /gene="Mroh7"
                     /gene_synonym="Gm1027; Heatr8"
                     /note="maestro heat-like repeat family member 7"
                     /db_xref="GeneID:381538"
                     /db_xref="MGI:MGI:2685873"
     exon            1..176
                     /gene="Mroh7"
                     /gene_synonym="Gm1027; Heatr8"
                     /inference="alignment:Splign:2.1.0"
     exon            177..211
                     /gene="Mroh7"
                     /gene_synonym="Gm1027; Heatr8"
                     /inference="alignment:Splign:2.1.0"
     exon            212..1390
                     /gene="Mroh7"
                     /gene_synonym="Gm1027; Heatr8"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..4125
                     /gene="Mroh7"
                     /gene_synonym="Gm1027; Heatr8"
                     /note="HEAT repeat-containing protein 8"
                     /codon_start=1
                     /product="maestro heat-like repeat-containing protein
                     family member 7"
                     /protein_id="NP_001119959.1"
                     /db_xref="CCDS:CCDS51253.1"
                     /db_xref="GeneID:381538"
                     /db_xref="MGI:MGI:2685873"
                     /translation="MALSRGTSLILHEDPEKIPSPNSCEVPGIMSNTTPRPTPDLALA
                     PPPEHALALTPALHPALSPDPEGVSGPVSNDIPSHNASGATTPSSTQINTVDTADQGL
                     NHTSGPDAAGTLCPDSQPARIPSSTQANVLSPENSSRPCSEDVSKSFSSKVFGLGQSN
                     SNPSRPEPNLYIKALSREALVRSHNISRQGSQVPLLLPSNTSLDRLHSGNISKVNLGI
                     APNSNEAITLTSHTIFASISKEALSAPWNTGSKGSINGTSTIQPRSGLNVTVTHASHV
                     SMIPGSSEGLSLQSSARVPNSTLSPSSCMTLIMDSESPSMDSSFLVTDTSTLTLSSHR
                     DYSEDNSIRTMPLEENLGKWDSLQGVTALQSPPEGTSEDVKVNEAEKRNHDNKAALVA
                     NIITYQKNQEMVEMKEEKEATVKMMMRQIQEEPLDSLLSPARRQAMEILAQLSHTKPI
                     LSVRERVELVNTCVRSVFSLPSVQAMQEKDESKAEVIQILYYQTLDSLQKLLNALFIE
                     DPTPTGLKSILEPLGPWMNSGKAHERARAVNSNVSVLNHTLVTLPFLISSGFPTLGLL
                     LGRLLLRIGDPDEEIGREALDGITILYTILDLQKRTKNKEDTNKKELYENNKRFLGPY
                     NPVSPCQNILRVIAEFGDFLGPQQVRDLLLAALEGLKGISETQGKDSGEMMQLASEVM
                     LSSVLEWYRHRALEVIPEIMQGIYMQLTHIQEPRAREVALLPISFLASSFMTEVVVAL
                     LMCPLPLDSNGAEMWRQLILRKPSCDVRDLLDLLLTSLKEKPVTKKGRASIVPLAAAS
                     GLCELLSVNSCVGRVRRIYPQLLLALLIQVHYHIGLNLPSRMAPRKDSKDDTQPPLFI
                     PVRWMVKVVKTLLLKMGCSYESAFLEEQGGWELMGQAESHYRGVSLLARAMVHYSCQE
                     LCRILYLLIPLLERGDERHKITATAFFVELFRMEQVRRIPEEYSLGRMVEGLSHRDPI
                     MNVLSIRGLVILACKSEKMAKVQSLLPSMVKSLKNMDGMLVVEAVHDLKRIFKGQGKK
                     LTDSAVYVEMLQILLPHFTDAREMVRASCINVYGKVVKKLQTPRTQAMEEQLTSTLMP
                     LLFIIQEGNAKVSQKCVKTLVCCSSFMNWELPKKAYSQKPWDNQQLTVTKICKYLVSS
                     HRDNVFTFLNQSLEYAKNSRASLRKSSVIFIGSLVPCMENMMTEERLNEVKATLEILR
                     HDPEASVCICAAQAQDQIMATCWRNSWPLLYGDSWVCDPSSMHRWSPSCENLPTSHQR
                     RSWIMQALASWKMSLKQ"
     exon            1391..1455
                     /gene="Mroh7"
                     /gene_synonym="Gm1027; Heatr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1539
                     /gene="Mroh7"
                     /gene_synonym="Gm1027; Heatr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1619
                     /gene="Mroh7"
                     /gene_synonym="Gm1027; Heatr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1749
                     /gene="Mroh7"
                     /gene_synonym="Gm1027; Heatr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1845
                     /gene="Mroh7"
                     /gene_synonym="Gm1027; Heatr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1950
                     /gene="Mroh7"
                     /gene_synonym="Gm1027; Heatr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2086
                     /gene="Mroh7"
                     /gene_synonym="Gm1027; Heatr8"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2199
                     /gene="Mroh7"
                     /gene_synonym="Gm1027; Heatr8"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2376
                     /gene="Mroh7"
                     /gene_synonym="Gm1027; Heatr8"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2531
                     /gene="Mroh7"
                     /gene_synonym="Gm1027; Heatr8"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2670
                     /gene="Mroh7"
                     /gene_synonym="Gm1027; Heatr8"
                     /inference="alignment:Splign:2.1.0"
     exon            2671..2861
                     /gene="Mroh7"
                     /gene_synonym="Gm1027; Heatr8"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..2999
                     /gene="Mroh7"
                     /gene_synonym="Gm1027; Heatr8"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..3114
                     /gene="Mroh7"
                     /gene_synonym="Gm1027; Heatr8"
                     /inference="alignment:Splign:2.1.0"
     exon            3115..3255
                     /gene="Mroh7"
                     /gene_synonym="Gm1027; Heatr8"
                     /inference="alignment:Splign:2.1.0"
     exon            3256..3435
                     /gene="Mroh7"
                     /gene_synonym="Gm1027; Heatr8"
                     /inference="alignment:Splign:2.1.0"
     exon            3436..3591
                     /gene="Mroh7"
                     /gene_synonym="Gm1027; Heatr8"
                     /inference="alignment:Splign:2.1.0"
     exon            3592..3714
                     /gene="Mroh7"
                     /gene_synonym="Gm1027; Heatr8"
                     /inference="alignment:Splign:2.1.0"
     exon            3715..3817
                     /gene="Mroh7"
                     /gene_synonym="Gm1027; Heatr8"
                     /inference="alignment:Splign:2.1.0"
     exon            3818..3880
                     /gene="Mroh7"
                     /gene_synonym="Gm1027; Heatr8"
                     /inference="alignment:Splign:2.1.0"
     exon            3881..4346
                     /gene="Mroh7"
                     /gene_synonym="Gm1027; Heatr8"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4346
                     /gene="Mroh7"
                     /gene_synonym="Gm1027; Heatr8"
                     /note="major polyA site"
ORIGIN      
        1 ggacagtatc aagggtaggg tcagccttta cggcctccac aaggcagtta ctacctagac
       61 ccccaacccc cccactaggt aaaaatctcc tgtctggctc taagtccaca gttcttactt
      121 catacctttg gattaaagtt gaattttctg ttgccatgtg gatgccccgg gtggaggaga
      181 cccctcctgc ttaagaacac catgttgtca ggagtgctgc agggagcccc acattcagca
      241 gctggagaaa agggacagtg gccttgagag acctccagag ggaacatggc cctgagtcgg
      301 ggaactagtc tcattctcca tgaagacccc gagaagatac caagtcctaa ctcctgtgag
      361 gttccaggaa ttatgtccaa caccacacct aggcccaccc cagacctggc cctcgctcct
      421 cccccagaac atgccttggc tctcactcca gcccttcatc cagctctgag tcctgaccca
      481 gagggggtct ctggcccagt gtctaatgac atccccagcc acaatgccag tggggccacg
      541 actccatcct ccacccagat caacactgtg gacactgctg accagggttt gaaccacacc
      601 tccgggcccg acgctgcagg gactctctgc ccagactcac aaccagctcg aatccccagc
      661 tctacccagg ccaatgtttt gagtccagag aattcttcta ggccatgctc tgaggatgtc
      721 tccaagtcct tctcaagcaa ggtttttggt ttgggtcaga gtaactctaa tccttccagg
      781 cctgagccaa acctatatat aaaggctctt tccagagaag ccttggtccg gagtcataac
      841 atctccaggc agggctcaca ggtacctctt cttcttccct ctaatacttc tttggaccgt
      901 ctgcactctg ggaacatctc caaggtgaac ctgggcatag ctccaaactc aaacgaggcc
      961 atcacgttga cttcacacac tatttttgca tccatttcta aagaagcctt gagtgcaccc
     1021 tggaacacag gctccaaggg gtccatcaat gggacttcca ccatccaacc caggtctggt
     1081 ttaaatgtga cagtcactca tgcttcacat gtcagcatga ttcctggttc cagtgaaggc
     1141 ctcagtctac agtcaagtgc ccgagtaccc aactccactc tctctccatc ttcctgcatg
     1201 acgctgatca tggactctga gtcaccgagc atggactcca gcttcctggt gaccgacacc
     1261 tccaccctga ccctgagcag ccatcgagat tattctgaag acaacagcat ccgcaccatg
     1321 cccctggagg agaatctggg aaagtgggac agcctgcagg gtgttacagc tctccaaagc
     1381 ccccctgagg gaacctcaga agatgtgaag gtcaatgagg cagagaagag aaaccatgac
     1441 aacaaagcag ctttggtagc gaacatcatt acttaccaga agaatcagga aatggtggaa
     1501 atgaaagaag aaaaggaggc aaccgtgaag atgatgatga gacagattca ggaggagccg
     1561 ctggattccc ttttgagtcc tgctcgacgg caggctatgg agatcctggc acagctgagt
     1621 cacaccaagc ctatcctgag cgtgcgggag agggtggagc tggtgaacac ctgtgtgcgg
     1681 agcgtgttct cactgccctc cgtgcaggcc atgcaggaga aggacgagtc caaggccgaa
     1741 gtcatccaga tcctttacta ccagaccttg gattccttgc agaaacttct gaatgccctc
     1801 tttattgaag accccactcc tactgggctg aagagcatcc tggagcccct agggccctgg
     1861 atgaactctg ggaaggccca cgagcgggct cgggctgtga acagcaacgt ctctgtgttg
     1921 aaccacacac ttgtgaccct gccattctta atatcctcgg gcttcccaac actgggtctt
     1981 ctgctgggga ggctccttct tcgaatcggg gatcctgatg aggagatcgg acgggaggct
     2041 ctggacggca tcaccatcct ctacaccatc ctggatctcc agaaacggac caagaacaag
     2101 gaagacacca acaagaagga gctgtatgag aacaacaagc gcttcctggg gccttacaac
     2161 cctgtcagcc cgtgccagaa cattctgcgt gtcattgcgg aatttggaga cttcctgggt
     2221 cctcagcagg taagggacct gctgctggca gccttggaag gcctgaaagg tatctctgag
     2281 acccagggca aggactccgg cgagatgatg cagctggctt ccgaggtcat gctcagctca
     2341 gtgctggagt ggtaccgcca cagggcgctg gaggtgatcc cagaaatcat gcagggcatc
     2401 tacatgcaac tgacccacat ccaggagcct cgagcacgtg aagtggctct gctgcccatt
     2461 tcctttctgg ccagctcctt catgactgag gttgtggtgg ctctgctcat gtgtcccctc
     2521 cccctggaca gcaatggggc agagatgtgg aggcagctga tacttcgaaa gcccagctgt
     2581 gacgtcagag acctgctgga tctgctcctg actagcctga aggagaagcc tgtaaccaag
     2641 aagggtcgag cctccattgt gcccctagcg gcagccagtg gtctgtgtga gctcctgtcc
     2701 gtcaacagct gtgtgggccg ggtgaggcgc atctaccctc agctgctcct ggccctgctc
     2761 attcaggtcc attatcacat tggcctcaac ctacccagcc gtatggctcc tcgaaaggat
     2821 tccaaggatg acacgcagcc tcctctcttc atacctgtac gctggatggt gaaggtggtg
     2881 aagaccctgc tgctgaaaat gggctgttct tacgagtccg catttctgga ggagcagggc
     2941 ggttgggaac tcatgggcca ggcagagagc cactaccggg gagtgtccct gctggcaagg
     3001 gccatggttc actactcctg ccaggagctg tgtcgcatcc tctacctgct catcccgctc
     3061 ttggagagag gtgacgagag acacaagatc acagccaccg ccttctttgt ggagctgttc
     3121 cgcatggagc aggtacgtcg catccctgag gaatactccc tggggcggat ggtggaaggc
     3181 ctgagccacc gtgaccccat catgaatgtg ctgtccattc ggggcctggt catcctggca
     3241 tgcaagtctg agaagatggc caaggtgcag agcctgctgc catccatggt gaagagcctg
     3301 aagaacatgg atggaatgct agtggtggag gctgtccatg acctcaagag aatcttcaag
     3361 gggcagggca agaagctaac ggacagtgca gtctatgtgg agatgctgca gatcctgctg
     3421 ccccacttca ctgacgcaag agaaatggtg cgggcttcct gcatcaatgt atacggaaaa
     3481 gtggtgaaga agctccagac accccgcacc caagccatgg aggagcagct gaccagcacg
     3541 ctgatgccct tgctcttcat catacaggag ggcaatgcca aagtgagcca gaaatgtgtg
     3601 aagaccctgg tctgctgctc ttccttcatg aactgggagt tgccaaaaaa ggcttacagc
     3661 cagaagccct gggacaacca gcaactgaca gtgaccaaaa tttgcaagta tcttgtgagc
     3721 tctcaccgag acaacgtctt cactttcctc aaccagagcc tggagtatgc caagaattca
     3781 cgggcttccc tccggaagtc ctctgtcatc ttcatagggt ccctggtccc ctgcatggag
     3841 aacatgatga cagaagagcg gctgaatgaa gtgaaagcta ctctggagat cttgagacac
     3901 gacccagaag cctccgtgtg tatctgcgct gcccaggccc aggatcaaat tatggccact
     3961 tgctggcgga actcttggcc actgctgtat ggggattcat gggtgtgtga cccatccagt
     4021 atgcaccgct ggagccccag ctgtgagaac ctgcccacct cccaccaacg gcgctcctgg
     4081 atcatgcagg cattggcctc ctggaagatg tctctgaagc agtgacataa gccccagcca
     4141 ggtccctgta aacgctatgt ggtcaacctt tccatccaga tggcttcctc acgagagttc
     4201 ccccagtccc tgtggagccc ccgtggagcc cccctggagc ccccgtggaa cccccgtgga
     4261 gcccccgtag agcccctgcg gagccctcac tctgacaagt ctgagaaaag agcatggccc
     4321 ccttgtgctg attcacttca cattta
//
