LOCUS       NM_001177437            3549 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus maestro heat-like repeat family member 4 (Mroh4),
            mRNA.
ACCESSION   NM_001177437 XM_128161
VERSION     NM_001177437.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3549)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3549)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3549)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
COMMENT     PREDICTED REFSEQ: This record has not been reviewed and the
            function is unknown. The reference sequence was derived from
            AC118022.12.
            
            On Apr 9, 2010 this sequence version replaced XM_128161.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK006048.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               AC118022.12        66037-66139         c
            104-193             AC118022.12        65339-65428         c
            194-455             AC118022.12        64463-64724         c
            456-604             AC118022.12        59175-59323         c
            605-697             AC118022.12        58096-58188         c
            698-814             AC118022.12        57774-57890         c
            815-934             AC118022.12        57432-57551         c
            935-1057            AC118022.12        56099-56221         c
            1058-1134           AC118022.12        55931-56007         c
            1135-1270           AC118022.12        55243-55378         c
            1271-1366           AC118022.12        54506-54601         c
            1367-1471           AC118022.12        50922-51026         c
            1472-1607           AC118022.12        46084-46219         c
            1608-1702           AC118022.12        45912-46006         c
            1703-1852           AC118022.12        44731-44880         c
            1853-2007           AC118022.12        44124-44278         c
            2008-2152           AC118022.12        43045-43189         c
            2153-2337           AC118022.12        41692-41876         c
            2338-2475           AC118022.12        41347-41484         c
            2476-2587           AC118022.12        41065-41176         c
            2588-2731           AC118022.12        40718-40861         c
            2732-2908           AC118022.12        40034-40210         c
            2909-3064           AC118022.12        39463-39618         c
            3065-3187           AC118022.12        37932-38054         c
            3188-3290           AC118022.12        36490-36592         c
            3291-3365           AC118022.12        36222-36296         c
            3366-3549           AC118022.12        35849-36032         c
FEATURES             Location/Qualifiers
     source          1..3549
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 34.24 cM"
     gene            1..3549
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /note="maestro heat-like repeat family member 4"
                     /db_xref="GeneID:69439"
                     /db_xref="MGI:MGI:1916689"
     exon            1..103
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            104..193
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            194..455
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            456..604
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             515..3466
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /codon_start=1
                     /product="uncharacterized protein LOC69439"
                     /protein_id="NP_001170908.1"
                     /db_xref="CCDS:CCDS49636.1"
                     /db_xref="GeneID:69439"
                     /db_xref="MGI:MGI:1916689"
                     /translation="MVVNKIKNMMVMEQGQVLDTICHFLEKENQLWEKPEVSFWNPSV
                     EKLLEFLNLDPRKATDKAFFFHLYGMILRECPSVEKVQCHLASLLDLSHQHSRQREGI
                     ALAVGLASTKHLEEVWALLEHLGRTKFLQSVAATEDSQDEILKSSFLSATILLTRSLQ
                     AEYSSQRYKFTQTPELIQCLLGILQKEPNSLTNFLRQKIILVIIGLSNLRPRFKPLLK
                     SQILKTCLQTVYMLPPAKDSRNDLFSVEQASDTTVLYKKTVRALDLLLQNFISENPSM
                     DEVCFLLQHIEYWLMSDKIHERSRAVQSIYLLLQYVVDSLKLAKEAVPSLLGHQIGIL
                     ILLWRDKDKITQQHSHFCVYLLMELVFQQKGKLVESAQWSKMKHFESNVFREWEMKLY
                     HLVKVFKEDLTVAQHTQLILTLVHSLGSYNHLHSDLAAKLLLLICVEPGFRKEQIAEL
                     LQGLFQELPNIQSKSVQQAISQATLALGTQHIQEVVEVILSLCQPSERWILPLWKALA
                     ANYQVARDVITLLYIKLKLRPPRRLLQSTYRARLVSLMALGTIYELLYTKEYRNTVCW
                     AFSGILLGLLTELYYLLEVGLVQGLFDYQEDDLGSKPLGPCRICLEALKGLFWTTEYW
                     EVFADVKLIQGWELFGQLETFPKGVTLLARAMAHYNCEIKAVLGQALISLKSSEERDN
                     IVGICIITEFLNSPDVSQHMSWKTMYNSLNLGLSSRNQMVRAMSLKGLGSTLMHPKKA
                     TLLRSKLMELLDNFLQPEFKDPAGLMKIMGHLLHCLSAQGIGIVSLKIAQHLLSLFTD
                     ERAAVREGAIFLFGDVIHYGGKKLRQSLKDVASQATVPLLFNMADPCQEVAMKARFTF
                     LRCAILLKWEFRKELFGKLAWGQGLGAANDIFIYMLESNVGNYQQFLSQALTYLDSSH
                     MTVKLAAMKFIGALLQDYFNDLCIYLRKKDVIFLKNCLEALRHDTDSRTRRFYLNYWN
                     DAVELSYYVQD"
     exon            605..697
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            698..814
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            815..934
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1057
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1134
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1270
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1366
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1471
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1607
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1702
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1852
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..2007
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2152
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2337
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2475
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2587
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2731
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2908
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2909..3064
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..3187
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3188..3290
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3291..3365
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3366..3549
                     /gene="Mroh4"
                     /gene_synonym="1700016M24Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggctgtt gggaacttgt cactcaagcc tttgggggct tctggttgga tttcttgggg
       61 gcacaatccc cactgagcct tggggatagt aactcaaaga caggctgccc aaggccacca
      121 ggctcaagac ttcaggtgct agcagagccc tggaccagat cctgtctctc agtttccagc
      181 cccaaagcca gagcctggag gtcacctctg cactgccttt cagcacacag aagtctttct
      241 tcatctacca aagactgctt cgctgcagca gctgcagagt gcactgatat cctggtggcc
      301 ctcagaagtt cactgcgtgc ccagcactaa cccagagcca gagagtaaag agaaagctgg
      361 agagctcagg tgggagaggc cgcagcacca agggatggaa aggtgacaac gaaggatcga
      421 ggggcgtgta ggcagtcaag acagaaacat tccagataac ttggatgtgg ggctcttggg
      481 ggagtacttg aatatcaacc catcctggga ggacatggtg gtcaataaga tcaagaacat
      541 gatggtcatg gagcagggcc aagtactaga caccatctgc cacttcctag agaaggaaaa
      601 ccagctctgg gaaaagccag aggtctcatt ctggaatcct tctgttgaaa agctcctaga
      661 gtttctcaac ctggacccca ggaaggctac tgataaggct ttcttcttcc acctctatgg
      721 catgatcctg cgtgagtgcc ccagcgtgga gaaggtgcag tgccacctgg ccagcctcct
      781 ggatttgtcc catcagcact ccagacagcg ggagggcatt gcactggctg tgggcctggc
      841 ctccaccaag cacttggagg aggtgtgggc cctgttggag cacctgggcc gtaccaagtt
      901 tctgcaatca gttgctgcaa cagaggacag ccaggatgag atcctgaagt ccagcttcct
      961 ctctgcgacc atcctgctca ccagatcgct ccaggcagag tacagctccc agaggtacaa
     1021 gttcacacag acaccagagc tcatccagtg cctcttgggc atcctccaga aagagcccaa
     1081 ctccctgacc aatttcttac ggcagaagat catactggtc atcataggcc tgagtaacct
     1141 gcggcccaga ttcaaacccc ttctcaagtc ccagatcctg aagacctgtc tgcagactgt
     1201 gtatatgctt cctcctgcca aggactcgag gaatgactta ttttcagtgg agcaagcctc
     1261 agataccacg gtgctgtaca agaagacagt acgtgccctc gaccttcttc tccagaactt
     1321 catttccgag aacccgagca tggacgaggt ctgcttcctc ctgcagcaca tagaatactg
     1381 gctgatgtct gacaagatcc atgagcgcag tcgggctgtc cagtccatct acctgcttct
     1441 gcaatatgtg gtggactctt tgaagcttgc taaagaggcc gtgccgtcct tgctgggtca
     1501 ccaaataggc atcctgattc tgctgtggcg ggacaaagac aagatcacac agcagcattc
     1561 tcacttctgt gtttacctgc tcatggagct tgttttccag cagaagggga aattggtgga
     1621 gtctgcgcag tggagtaaga tgaagcactt tgaaagcaac gtgtttagag agtgggagat
     1681 gaagctctac cacctggtga aggtcttcaa ggaagacctg acagtggcac agcacacaca
     1741 actgatcctc acgctggtac acagtctagg cagttataat catctccact ctgaccttgc
     1801 tgctaagctc ctgctgctga tctgtgtgga gcctggcttc aggaaggagc agatagctga
     1861 gctcttgcaa ggcctgttcc aggaactgcc gaacatccag tccaagagtg tccagcaggc
     1921 cataagtcag gccaccttgg ctctggggac ccagcatatt caggaggtgg tggaggtgat
     1981 cttatcccta tgtcagccct cagagaggtg gatcctacct ctgtggaagg ctctggctgc
     2041 caattaccaa gtggctcgtg atgttataac tctactctac ataaagctga aactgcgccc
     2101 accaagaagg ctcctccagt ccacatatcg agcccggctg gtctcgctga tggctctggg
     2161 caccatttat gagctcctct ataccaagga gtaccggaac acagtctgct gggccttctc
     2221 gggcatcctt ctgggcctcc tcacagagct ctactacctg ctggaggtgg gcctagtgca
     2281 aggcctgttt gactaccagg aagacgatct gggctctaag cccctcgggc cctgcaggat
     2341 ctgcttggaa gcactcaagg gcctcttctg gaccaccgaa tactgggaag tgtttgctga
     2401 tgtgaagcta atccagggct gggagctctt cgggcagttg gaaactttcc ccaagggagt
     2461 gacccttttg gccagggcca tggctcacta taactgcgag atcaaggctg tcttggggca
     2521 ggctctcatc tccctgaaga gcagcgaaga gcgagacaac attgtgggca tctgcatcat
     2581 cactgagttt ctcaacagcc cagatgtctc ccagcacatg tcttggaaga ccatgtacaa
     2641 ctccctgaac ctgggccttt ctagtcgcaa ccagatggtg cgggctatga gcttgaaggg
     2701 actgggcagc accctgatgc accctaaaaa ggcaactctg ctaagaagta agttgatgga
     2761 gctgttggac aactttctac aacctgagtt caaggaccct gctggcttga tgaagatcat
     2821 gggccacctc ctgcactgtc taagtgccca gggcattgga attgtcagcc tcaagatcgc
     2881 ccagcacctt ctcagcctgt tcacagatga aagggcagcg gttcgggaag gtgccatctt
     2941 cctgtttgga gatgtcatcc actatggtgg caagaagctt aggcagagcc tcaaggatgt
     3001 ggcttctcag gctacagtac ccctcctctt caatatggct gatccctgcc aagaagtagc
     3061 tatgaaggcc aggttcacct tcctgcgctg tgccatcttg ttaaagtggg agttccggaa
     3121 ggagctgttt ggcaagctgg catggggcca agggctgggc gctgcaaatg acatttttat
     3181 ctacatgcta gaaagcaatg tcggcaacta ccagcagttc ctcagtcagg ccttgacgta
     3241 tctggacagt tcccacatga cagtgaagct ggcagccatg aagttcatcg gggcattgct
     3301 tcaggactat ttcaatgacc tatgcatata cttgagaaag aaagatgtga tcttccttaa
     3361 gaactgtttg gaggccctcc gccatgacac ggactccagg acccgaaggt tctacctgaa
     3421 ctactggaat gatgccgtgg agctatctta ctatgttcaa gactagctgc acctgcgatt
     3481 gttcttattt ttgtctttgt tgagtcctat ctttattaaa tgcctcagag tatctctggc
     3541 ctctcacca
//
