LOCUS       NM_001360973            4614 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus maestro (Mro), transcript variant 3, mRNA.
ACCESSION   NM_001360973
VERSION     NM_001360973.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4614)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4614)
  AUTHORS   Smith,L., Willan,J., Warr,N., Brook,F.A., Cheeseman,M., Sharpe,R.,
            Siggers,P. and Greenfield,A.
  TITLE     The Maestro (Mro) gene is dispensable for normal sexual development
            and fertility in mice
  JOURNAL   PLoS One 3 (12), e4091 (2008)
   PUBMED   19116663
  REMARK    GeneRIF: Maestro is dispensable for normal male sexual development
            and fertility in laboratory mice
REFERENCE   3  (bases 1 to 4614)
  AUTHORS   Bouma,G.J., Hart,G.T., Washburn,L.L., Recknagel,A.K. and
            Eicher,E.M.
  TITLE     Using real time RT-PCR analysis to determine multiple gene
            expression patterns during XX and XY mouse fetal gonad development
  JOURNAL   Gene Expr Patterns 5 (1), 141-149 (2004)
   PUBMED   15533830
REFERENCE   4  (bases 1 to 4614)
  AUTHORS   Quwailid,M.M., Hugill,A., Dear,N., Vizor,L., Wells,S., Horner,E.,
            Fuller,S., Weedon,J., McMath,H., Woodman,P., Edwards,D.,
            Campbell,D., Rodger,S., Carey,J., Roberts,A., Glenister,P.,
            Lalanne,Z., Parkinson,N., Coghill,E.L., McKeone,R., Cox,S.,
            Willan,J., Greenfield,A., Keays,D., Brady,S., Spurr,N., Gray,I.,
            Hunter,J., Brown,S.D. and Cox,R.D.
  TITLE     A gene-driven ENU-based approach to generating an allelic series in
            any gene
  JOURNAL   Mamm Genome 15 (8), 585-591 (2004)
   PUBMED   15457338
REFERENCE   5  (bases 1 to 4614)
  AUTHORS   Smith,L., Van Hateren,N., Willan,J., Romero,R., Blanco,G.,
            Siggers,P., Walsh,J., Banerjee,R., Denny,P., Ponting,C. and
            Greenfield,A.
  TITLE     Candidate testis-determining gene, Maestro (Mro), encodes a novel
            HEAT repeat protein
  JOURNAL   Dev Dyn 227 (4), 600-607 (2003)
   PUBMED   12889070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124367.4.
            
            On Apr 5, 2022 this sequence version replaced NM_001360973.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1319538.1,
                                           SRR1660815.33754.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-438               AC124367.4         116500-116937       c
            439-532             AC124367.4         110515-110608       c
            533-679             AC124367.4         108498-108644       c
            680-865             AC124367.4         107156-107341       c
            866-1021            AC124367.4         103724-103879       c
            1022-1129           AC124367.4         103025-103132       c
            1130-4614           AC124367.4         99233-102717        c
FEATURES             Location/Qualifiers
     source          1..4614
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 50.21 cM"
     gene            1..4614
                     /gene="Mro"
                     /gene_synonym="4930507C04Rik; 4933435E20Rik"
                     /note="maestro"
                     /db_xref="GeneID:71263"
                     /db_xref="MGI:MGI:2152817"
     exon            1..438
                     /gene="Mro"
                     /gene_synonym="4930507C04Rik; 4933435E20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1183
                     /gene="Mro"
                     /gene_synonym="4930507C04Rik; 4933435E20Rik"
                     /note="isoform 3 is encoded by transcript variant 3;
                     protein maestro; male-specific transcription in the
                     developing reproductive organs"
                     /codon_start=1
                     /product="protein maestro isoform 3"
                     /protein_id="NP_001347902.1"
                     /db_xref="GeneID:71263"
                     /db_xref="MGI:MGI:2152817"
                     /translation="MRPDRRNKLRGRNSKQQAGGTSAVWCTKAQHLGWANDNLVGVVG
                     GQFPPPPHHLVLADPIFFCPTFLFSAVSKFREDLLVSPFFFVCKETRAGKISLIHHIW
                     RPIPNSWRNSVPPEGPRTSPITAVPHVTVTPGASFMEQKISNQPLPTPTSQSKKRRTP
                     LLSFLSKVSWKLRLQKRELLKNALFVLAERARDPNAKKRHLAMRGLGALAREAPDKQV
                     RKYKKVMLDLLVRGLYDPVSSEVIHESVKTLTIMLGKIQGHGLGSFFIDITLQARTLL
                     DDEDDSVRYSAFVLFGQLASFAGWRWKKFFTQQVNQTQDSLLGHLQDESPKVAKACKM
                     TVRACVPYLKPRKVPSFQSEEDQKNHRLSRQLSHCHPEILLFFYANKIL"
     exon            439..532
                     /gene="Mro"
                     /gene_synonym="4930507C04Rik; 4933435E20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            533..679
                     /gene="Mro"
                     /gene_synonym="4930507C04Rik; 4933435E20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            680..865
                     /gene="Mro"
                     /gene_synonym="4930507C04Rik; 4933435E20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1021
                     /gene="Mro"
                     /gene_synonym="4930507C04Rik; 4933435E20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1129
                     /gene="Mro"
                     /gene_synonym="4930507C04Rik; 4933435E20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..4614
                     /gene="Mro"
                     /gene_synonym="4930507C04Rik; 4933435E20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1996..2001
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mro"
                     /gene_synonym="4930507C04Rik; 4933435E20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2015
                     /gene="Mro"
                     /gene_synonym="4930507C04Rik; 4933435E20Rik"
                     /note="major polyA site"
     regulatory      2401..2406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mro"
                     /gene_synonym="4930507C04Rik; 4933435E20Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2423
                     /gene="Mro"
                     /gene_synonym="4930507C04Rik; 4933435E20Rik"
     regulatory      2859..2864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mro"
                     /gene_synonym="4930507C04Rik; 4933435E20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2877
                     /gene="Mro"
                     /gene_synonym="4930507C04Rik; 4933435E20Rik"
     regulatory      4590..4595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mro"
                     /gene_synonym="4930507C04Rik; 4933435E20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4614
                     /gene="Mro"
                     /gene_synonym="4930507C04Rik; 4933435E20Rik"
ORIGIN      
        1 agaattgcag ttctttctga agaaagtgtg catgagaccg gacaggagga ataagttaag
       61 gggcaggaac agcaagcagc aggcaggcgg cacctcggca gtgtggtgca caaaggcgca
      121 gcatcttggg tgggcgaacg acaaccttgt gggtgtcgtt ggaggacagt tccctccccc
      181 acctcaccac ctcgtactcg cggatcctat cttcttttgt cccacttttc tgttctctgc
      241 tgtctccaaa ttccgagagg accttctggt ttctcctttt ttttttgtat gtaaggaaac
      301 cagggccggg aaaatctcgc tgattcacca catttggagg ccaatcccga acagctggag
      361 gaacagcgtg cctcccgagg gacccaggac cagccccata acagctgttc ctcacgtgac
      421 agtcacccca ggagccagtt tcatggaaca gaaaatctcg aaccagcccc tccccacccc
      481 tacttcccag tccaagaaga gaagaacacc actgctatcc ttcctttcca aggtctcttg
      541 gaaactgagg ttgcagaagc gggagctttt gaagaatgca cttttcgtct tggcagaaag
      601 agcccgggat cctaatgcta aaaagcgcca tctagcaatg agaggcctgg gtgccctggc
      661 ccgtgaagct cctgacaagc aggtgagaaa gtataagaaa gttatgcttg acctcctggt
      721 tcgtgggctg tatgatcctg tgagttctga agttatccat gagagtgtga agactctgac
      781 catcatgctg ggcaagatcc agggccatgg gctggggtcc ttcttcatag acatcaccct
      841 tcaggcccgg accttactgg atgatgagga cgacagcgtg cggtattcag cttttgtcct
      901 ctttgggcag ttggcctcgt ttgctgggtg gaggtggaag aaatttttca ctcagcaagt
      961 taaccagacc caagattcgc tcttaggcca tttgcaggat gaaagtccta aggttgccaa
     1021 ggcttgcaaa atgactgttc gagcctgtgt cccgtatctg aaacccagaa aggtgccgag
     1081 tttccaaagt gaagaagatc agaagaacca caggctttcc cggcagctga gccactgcca
     1141 tccagagatc ctgctgttct tctatgcgaa taaaatcctg taaagtccgg agcagcagag
     1201 aaagtggccc atgtgagtgc cctgtccagg catggtgctt cctctgtttg gtctcatagg
     1261 ataccttttt gactctcaag tgattgttat ggaaaagagg atgtcagaga gcaactgagg
     1321 gcagaaaagt caccccggaa gtatatctct gcccctgaag taaaactcta tgcactcgcg
     1381 tgcacacata tatgcacatg gttgtggagg tcacatactg tccttcagtc accatccacc
     1441 tttccattga aacaggatct ttaactggct tggagcttgc tgattagact aggtgtggtg
     1501 gctggcgagc cagcactggg attataacta tactccagtg aaccagcttt ggtttatttt
     1561 tttatttttt atttttttaa tatgggttct gagagccgaa ttcaggcccc tccacctact
     1621 tgtactgact aggccatctc cccagcccaa taaatgcaca cgtccttaaa acattcaaca
     1681 tgtttgatgt tccaaaagct cctttctcag ttcctctctg tcaggtgaca cacatttcta
     1741 atacgtaatt tctgaggctt gggaaaatca ttgttacctt aagcatttaa aaaatgtatt
     1801 tgtttttttg gggttttttt ttttttgata ctttgctatt tgctaccaac caagatacca
     1861 agaagctggc ttacaacatt gtcttttaat atctgatgat cttaaaatgt cgttgtctga
     1921 aaatcatctt taaaaagaat gagaagaaat gttgctgaag ctctacaccg tctacaggat
     1981 gatgataact tacagaataa aaactctaac atttactgag agtgcttaca actcatgggg
     2041 tactgtggtg gttcgaatga gcatggccct ctaggctcac atatttgaat gcttggtccc
     2101 tagttagtgg aactgtttga gaaggattag agggtgtgtc tttgttggag aaggtatttc
     2161 agtagagttg gaattagaga cttcaaaagc ccaagcaagg cccagtctct ctctctccct
     2221 ctccctctcc ctccctctct ctctctctct ctctctctct ctctttctct ctctctctct
     2281 ccctgcctat tgcctgcaga tcaagatgta aagctctcaa ttagtgcttt agcaccatgc
     2341 ctgcctactc ctgccatgat gataatgaat taaccttcta aaactgtaag ccaaccccca
     2401 attaaatgtt tccttttata agagttgcct aggtcatggt gtctctttgg agcaatagtg
     2461 taagattggc actaataact ttttgaagat aacattaatg caacaactgt atgcaacagg
     2521 tgctattatt tatttattgg gagtgaacat gtgtcatgat gtgtgtggag attgggtgac
     2581 aacttgagag ggtcaattct ctctttccac catgtgggtt ccagggatcc aactcacgtg
     2641 gtcaaacctg gcagcaagca cctttatgtg ctgagccatc ttgctgaccc cagtgataga
     2701 tgctattcta gttttctctt catggaggag aacgcagagg aaaccaagta actcgcccaa
     2761 gatgaatagt agaacttaaa tccacacgat ctgagttctg gaactgaagc tcaatagttc
     2821 taatggtaga ataattctcc gtggttaaat acgtgaaaaa taaaactatg gacaccacca
     2881 cctgcttctg tttttccact caaccaaggt aacttttact ctcgtctgca cacactaatg
     2941 ccatatattt agggttcatt tctaaaattc actatgcatc cattccaaat ctacactgaa
     3001 ttactcgaac tcaatatata ctcttattaa caatttcttg acaaatgcac ccatgttttg
     3061 atggcccatc ttcgctcatc tgaagggtct catcactcat aagcagtttc atccatgtgc
     3121 agtacatgcc atgtacagca gtgtaatgtg cgtccttcta gttctagcta ttgggagaat
     3181 aaagtggaaa agtcacttga aggcatgagt tcaagactag cctgggtatt aatattgagt
     3241 ctcgggctgg agagatggct cagcggttaa gagcattgac tgctcttcca gaggtcctga
     3301 gttcaaatcc tagcaaccac atggtggctc acaaccatct ctaatgagat tggatgccct
     3361 cttctgatgt gtctgaagac agctacagta tacttacata taataataaa taaatctttt
     3421 aaaaattttt ttcaagaata aatttcttag tccttccttc ccacccacaa gcctgtcccc
     3481 caggcttttc ctcagaacca cagctctgaa gccctcactg tgctcagtca cccctggaac
     3541 actgtgttca gtttgggaac tggaaaaatc aacaagaacg gagaacacaa gaggttgtca
     3601 aaacactgag ggatctgaag agctcttctg agaactgaga gactctgtca ccaagaaatg
     3661 aggagatgag cctgtttaac agtgtcctga gagagaaaga atgcagtcag agatggtaga
     3721 agtgatagca ggaggggctt cctcctccct ccaatcccat agctggtgac agcaggccct
     3781 ccaaacagtg accgacacga acagcaggtg ccaagggtct gaaatcatga gctctttcct
     3841 tccccagatg ctggcttgct aaaagctaga ttgccagata ggtttacagt ctggttcaga
     3901 tctgttcagt ggccagcaag tggcatgaga aactgaattt ggatgacatt cagagacagt
     3961 ggagataggc tagggcccgt ggggtcgcac aatctgcagt agagaagaca tacattgtgg
     4021 gtaatgcctt taagttgcta tttgatgttg cttttctatg tgttgctttt ctatgaaacc
     4081 ccctcctcat agccatgcct tgtgtgcact ctgctgctct ctaatctagg ttcctattgc
     4141 gacatggaca tgctttgccc atcaggatgt ggtgacagtg cactgggccc actctacaat
     4201 ccctgacagc ctccttttcc attctggcaa gagaccagcc tctgcataag tcaaaacacc
     4261 acaaccaaag cagcacgcct gggatcacct tgggggagag gtgggaaccc agcccacagc
     4321 agtgtctgaa gcccagactc aggactcaag cctaggtgga ccacacagac cccagttctt
     4381 tgagctctcc tgactgaccc ccacagggag acaaggagct gtctctacca ggctcgtgca
     4441 tgttgtagaa cttagaagga ggaatggaat ggccgacagg tccagtcttt cactttgggg
     4501 atagtttgtc tcagagcaag aaagtcttct tgttgttcat tttgccattt ggtttgttct
     4561 gtaaccctca acgtcagagg tgctcagaga ataaatgctg accagggaag aaaa
//
