LOCUS       NM_026543               1168 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus MRN complex interacting protein (Mrnip), mRNA.
ACCESSION   NM_026543
VERSION     NM_026543.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1168)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1168)
  AUTHORS   Yao,X., Wang,C., Yu,W., Sun,L., Lv,Z., Xie,X., Tian,S., Yan,L.,
            Li,L. and Liu,J.
  TITLE     BCAS2 regulates oocyte meiotic prophase I by participating in mRNA
            alternative splicing
  JOURNAL   FASEB J 38 (1), e23361 (2024)
   PUBMED   38085152
REFERENCE   3  (bases 1 to 1168)
  AUTHORS   Kazi,S., Castaneda,J.M., Savolainen,A., Xu,Y., Liu,N., Qiao,H.,
            Ramirez-Solis,R., Nozawa,K., Yu,Z., Matzuk,M.M. and
            Prunskaite-Hyyrylainen,R.
  TITLE     MRNIP interacts with sex body chromatin to support meiotic
            progression, spermatogenesis, and male fertility in mice
  JOURNAL   FASEB J 36 (9), e22479 (2022)
   PUBMED   35920200
REFERENCE   4  (bases 1 to 1168)
  AUTHORS   Lin,M., Lv,J., Zhao,D., Liu,S., Xu,J., Wu,Y., Wang,F., Zhang,J.,
            Zheng,B., Shen,C., Guan,X., Yu,J. and Huang,X.
  TITLE     MRNIP is essential for meiotic progression and spermatogenesis in
            mice
  JOURNAL   Biochem Biophys Res Commun 550, 127-133 (2021)
   PUBMED   33689881
REFERENCE   5  (bases 1 to 1168)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1168)
  AUTHORS   Staples,C.J., Barone,G., Myers,K.N., Ganesh,A., Gibbs-Seymour,I.,
            Patil,A.A., Beveridge,R.D., Daye,C., Beniston,R., Maslen,S.,
            Ahel,I., Skehel,J.M. and Collis,S.J.
  TITLE     MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the
            DNA Damage Response
  JOURNAL   Cell Rep 16 (10), 2565-2575 (2016)
   PUBMED   27568553
REFERENCE   7  (bases 1 to 1168)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK019392.1 and BC028428.1.
            
            On May 28, 2009 this sequence version replaced NM_026543.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028428.1, AK019392.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-915               AK019392.1         2-916
            916-1168            BC028428.1         901-1153
FEATURES             Location/Qualifiers
     source          1..1168
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 30.33 cM"
     gene            1..1168
                     /gene="Mrnip"
                     /gene_synonym="2900016G09Rik; 3010026O09Rik"
                     /note="MRN complex interacting protein"
                     /db_xref="GeneID:68067"
                     /db_xref="MGI:MGI:1915317"
     exon            1..101
                     /gene="Mrnip"
                     /gene_synonym="2900016G09Rik; 3010026O09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1043
                     /gene="Mrnip"
                     /gene_synonym="2900016G09Rik; 3010026O09Rik"
                     /note="UPF0544 protein C5orf45 homolog; MRN-interacting
                     protein"
                     /codon_start=1
                     /product="MRN complex-interacting protein"
                     /protein_id="NP_080819.2"
                     /db_xref="CCDS:CCDS48784.1"
                     /db_xref="GeneID:68067"
                     /db_xref="MGI:MGI:1915317"
                     /translation="MAPAQQSRVLRCCSCHIFQAHQVKKSLKWTCKACGEKQSFVRAY
                     GEGSGADCRRHVQKLNLLQGQVSELSLRSVEEAVNGSEEENAGPLQAEAGSQQAPSKP
                     LESRWLKYLDKGCEDQELDRGRPALKTQLSTSAERPSSPAQPRKRKWNQRTGQPAHSL
                     HGQGVDSVEDNFEHQDSTGLFGTEQQGTSPALSTANHTRELGFPRWKLPSPVTQVNAP
                     SSKWARFLLAPGNSPQVDEKPSPLQEATMLADLAQGTVENKTPVEGHFSRAPAIRPPQ
                     AIHTTTPQLDRPDRKTREQPRDMGTPRADGRPLAQGTQKAPPLQLHNLFTTGEDFDDD
                     L"
     exon            102..161
                     /gene="Mrnip"
                     /gene_synonym="2900016G09Rik; 3010026O09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            162..250
                     /gene="Mrnip"
                     /gene_synonym="2900016G09Rik; 3010026O09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            251..326
                     /gene="Mrnip"
                     /gene_synonym="2900016G09Rik; 3010026O09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            327..475
                     /gene="Mrnip"
                     /gene_synonym="2900016G09Rik; 3010026O09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            476..560
                     /gene="Mrnip"
                     /gene_synonym="2900016G09Rik; 3010026O09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            561..1140
                     /gene="Mrnip"
                     /gene_synonym="2900016G09Rik; 3010026O09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1119..1124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrnip"
                     /gene_synonym="2900016G09Rik; 3010026O09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1140
                     /gene="Mrnip"
                     /gene_synonym="2900016G09Rik; 3010026O09Rik"
                     /note="major polyA site"
ORIGIN      
        1 agagcccgag ctcacggcgg gagagtgagt cctgaatggc gccggctcag cagtctcggg
       61 ttctacggtg ctgcagctgc cacatctttc aggcgcatca ggtgaagaag agtctcaaat
      121 ggacatgcaa ggcttgtgga gagaagcagt catttgttcg ggcttacggt gaaggctctg
      181 gtgctgactg cagacgccat gtccaaaagc taaatctgct gcaaggacaa gtgtcagagc
      241 tgtcactcag gtctgtggag gaagctgtaa atggcagtga agaagaaaat gcaggccctc
      301 tgcaggccga ggctgggagt cagcaggcac cgtctaagcc cctcgagtcc cgttggttga
      361 agtatctgga caagggctgc gaggaccagg agctggacag agggagacca gctcttaaga
      421 cacagctttc aaccagtgct gagcggccaa gcagtccagc ccaacccagg aagaggaaat
      481 ggaatcagcg cacagggcag cctgcacaca gcctgcatgg ccagggtgtg gacagtgttg
      541 aagacaactt tgaacaccag gactccactg gcctgtttgg aacagagcag caaggcacca
      601 gccctgccct cagtactgcg aaccacacca gagagctcgg ttttcctagg tggaaactac
      661 caagtcctgt tacacaagtt aatgccccat cttctaaatg ggcacggttt ctcctggcac
      721 ctggaaatag tcctcaagtg gatgagaaac caagtcctct gcaggaggcc accatgctag
      781 ctgacctggc acaagggact gttgagaaca agactccagt ggaaggccac ttcagcagag
      841 cccctgccat taggcctcct caagccattc acactaccac cccacaactg gacagacctg
      901 acaggaagac ccgagagcag ccaagggaca tggggactcc tcgagcagat ggtaggcctt
      961 tggctcaagg gacccagaag gctccaccct tgcaactgca caacctcttt acaaccggag
     1021 aggactttga tgatgacctg tagccttcac tgttctgtgt ccctcaatgc cagtcctcct
     1081 tgtcacagac tggggtgctc tggaacaaat aacccaacaa taaacgtgcc tgtcaacaga
     1141 aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
