LOCUS       NM_183263               1492 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus mitochondrial rRNA methyltransferase 3 (Mrm3), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_183263
VERSION     NM_183263.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1492)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1492)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 1492)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 1492)
  AUTHORS   Lee,K.W., Okot-Kotber,C., LaComb,J.F. and Bogenhagen,D.F.
  TITLE     Mitochondrial ribosomal RNA (rRNA) methyltransferase family members
            are positioned to modify nascent rRNA in foci near the
            mitochondrial DNA nucleoid
  JOURNAL   J Biol Chem 288 (43), 31386-31399 (2013)
   PUBMED   24036117
  REMARK    GeneRIF: RNMTL1, MRM1, and MRM2 (FtsJ2) as members of the RNA
            methyltransferase family that may be responsible for the three
            known 2'-O-ribose modifications of the 16 S rRNA core of the large
            mitochondrial ribosome subunit.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132643.1, BC090975.1 and AK014739.1.
            
            On Jan 29, 2008 this sequence version replaced NM_183263.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014739.1, SRR1660813.95675.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AK132643.1         2-29
            29-1432             BC090975.1         1-1404
            1433-1492           AK014739.1         1399-1458
FEATURES             Location/Qualifiers
     source          1..1492
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.92 cM"
     gene            1..1492
                     /gene="Mrm3"
                     /gene_synonym="4833420N02Rik; HC90; Rnmtl1"
                     /note="mitochondrial rRNA methyltransferase 3"
                     /db_xref="GeneID:67390"
                     /db_xref="MGI:MGI:1914640"
     exon            1..351
                     /gene="Mrm3"
                     /gene_synonym="4833420N02Rik; HC90; Rnmtl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1294
                     /gene="Mrm3"
                     /gene_synonym="4833420N02Rik; HC90; Rnmtl1"
                     /EC_number="2.1.1.-"
                     /note="RNA methyltransferase-like protein 1; 16S rRNA
                     [Gm1370] 2'-O-methyltransferase; 16S rRNA
                     (guanosine(1370)-2'-O)-methyltransferase; RNA
                     methyltransferase like 1"
                     /codon_start=1
                     /product="rRNA methyltransferase 3, mitochondrial"
                     /protein_id="NP_899086.2"
                     /db_xref="CCDS:CCDS48852.1"
                     /db_xref="GeneID:67390"
                     /db_xref="MGI:MGI:1914640"
                     /translation="MAAPAKGMWCSLGSLLRVVQTRDLNARRWVRALRRSPVRVLSPS
                     GQVEERKRAPDQQPRKAVPKASSQGQRQKQPLETSPSQTPHTWEEAGLRYDKAFPGDR
                     RLSSVMTIVKSRPFREKQGKILLEGRRLIADALKAGAVPKAFFFSRLEYVKELPVDKL
                     KDVSLIKVKFEDIKDWSDLVTPQGIMGIFAKPDPVKMTYPETPLHHTLPLVLICDNLR
                     DPGNLGTILRSAAGAGCSKVLLTKGCVDAWEPKVLRAGMGAHFQVPIVNNVEWETVPN
                     HLPPDTRVYVADNCGHYAQVQMSDKTGDRDWACDRRFLKFHKYEEDLDTKTRKDWLPK
                     LEVQSYDLDWTGAPAAVVIGGETHGVSLESLQLAESTGGKRLLIPVVPGVDSLNSAMA
                     ASILLFEGKRQLRIKVEDLSRDRSYH"
     exon            352..596
                     /gene="Mrm3"
                     /gene_synonym="4833420N02Rik; HC90; Rnmtl1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..764
                     /gene="Mrm3"
                     /gene_synonym="4833420N02Rik; HC90; Rnmtl1"
                     /inference="alignment:Splign:2.1.0"
     exon            765..1492
                     /gene="Mrm3"
                     /gene_synonym="4833420N02Rik; HC90; Rnmtl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1454..1459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrm3"
                     /gene_synonym="4833420N02Rik; HC90; Rnmtl1"
                     /note="hexamer: ATTAAA"
     polyA_site      1474
                     /gene="Mrm3"
                     /gene_synonym="4833420N02Rik; HC90; Rnmtl1"
                     /note="major polyA site"
ORIGIN      
        1 cgcgcgctcg ggtgaggtag cgcgcgccag gggaaagatg gcagcgccgg cgaagggcat
       61 gtggtgctcc ctgggatcat tgctgcgggt ggtccagact cgggacctca acgctcggcg
      121 ctgggtccgg gcgctgcggc gtagcccggt gagagtgttg tctccctcgg gacaggtgga
      181 ggaacggaag cgcgctcctg accagcagcc tcgcaaggcg gtccctaagg ccagttccca
      241 gggacagcga cagaaacagc ctcttgagac atccccatcc cagacccctc acacctggga
      301 agaggcaggg cttcgctacg ataaggcctt tcccggggac aggaggctaa gcagtgtgat
      361 gacaatagtt aagtccaggc cttttcggga aaagcaaggg aagatcctac tggaaggtcg
      421 caggctgatt gcagatgctc tcaaggctgg agctgtgccc aaagcgttct tttttagccg
      481 tctggagtac gtcaaggagt tgccggtaga caagctgaaa gacgtcagcc tcattaaggt
      541 gaaatttgag gacatcaagg attggtcaga cctagtaacg ccacaaggaa taatggggat
      601 ttttgccaaa cctgaccctg ttaagatgac atatccagag actccgcttc accatacact
      661 gcccctagtg ttgatttgtg acaatctccg tgaccctggg aacctgggga caatcctgag
      721 atctgcagct ggagcaggct gcagtaaagt cttactcacc aaaggctgtg tggatgcctg
      781 ggagcctaaa gtgctccggg caggcatggg ggcacatttc caggtaccca ttgtgaacaa
      841 tgtggaatgg gaaacagtgc ccaatcactt gcctcctgac actcgagtct atgtggcaga
      901 caactgtggt cactatgccc aggttcagat gtctgataaa accggtgacc gtgactgggc
      961 atgtgatcgc cgattcttaa agtttcacaa gtatgaagag gacctagaca ctaaaaccag
     1021 aaaggactgg ctgcccaaac ttgaggtcca gagttatgat ttggactgga caggagcacc
     1081 agcagctgtg gtgataggtg gggagacgca tggagtgagc ctggaatccc tgcaactggc
     1141 cgagagtacc ggtggcaaga gactgctgat ccccgttgta cctggtgtgg acagtctgaa
     1201 ctcagccatg gctgcgagca tcctgctctt tgaagggaaa aggcagctga ggataaaggt
     1261 ggaagacttg agcagggaca ggagttacca ctgaaggagc acaggaatcc tcagtgggag
     1321 gggaagggca cctccagccc ctcctctgct aggaggctgg ccaaggtgac aacacaggag
     1381 ccagggggta ggcactgcca ccattgtgtg gtacttaaaa aaaaagagtt tctattagtg
     1441 tctgctgttc cttattaaac aacaaaggtc aaaattcttt ttcattttac cc
//
