LOCUS       NM_026510               1443 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus mitochondrial rRNA methyltransferase 2 (Mrm2), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_026510
VERSION     NM_026510.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1443)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1443)
  AUTHORS   Lee,K.W., Okot-Kotber,C., LaComb,J.F. and Bogenhagen,D.F.
  TITLE     Mitochondrial ribosomal RNA (rRNA) methyltransferase family members
            are positioned to modify nascent rRNA in foci near the
            mitochondrial DNA nucleoid
  JOURNAL   J Biol Chem 288 (43), 31386-31399 (2013)
   PUBMED   24036117
  REMARK    GeneRIF: RNMTL1, MRM1, and MRM2 (FtsJ2) as members of the RNA
            methyltransferase family that may be responsible for the three
            known 2'-O-ribose modifications of the 16 S rRNA core of the large
            mitochondrial ribosome subunit.
REFERENCE   3  (bases 1 to 1443)
  AUTHORS   Eichler,D.C.
  TITLE     Characterization of a nucleolar 2'-O-methyltransferase and its
            involvement in the methylation of mouse precursor ribosomal RNA
  JOURNAL   Biochimie 76 (12), 1115-1122 (1994)
   PUBMED   7748946
  REMARK    Review article
REFERENCE   4  (bases 1 to 1443)
  AUTHORS   Segal,D.M. and Eichler,D.C.
  TITLE     A nucleolar 2'-O-methyltransferase. Specificity and evidence for
            its role in the methylation of mouse 28 S precursor ribosomal RNA
  JOURNAL   J Biol Chem 266 (36), 24385-24389 (1991)
   PUBMED   1761539
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK009656.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009656.1, AK145808.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1443
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 78.94 cM"
     gene            1..1443
                     /gene="Mrm2"
                     /gene_synonym="2310037B18Rik; Ftsj2"
                     /note="mitochondrial rRNA methyltransferase 2"
                     /db_xref="GeneID:68017"
                     /db_xref="MGI:MGI:1915267"
     exon            1..46
                     /gene="Mrm2"
                     /gene_synonym="2310037B18Rik; Ftsj2"
                     /inference="alignment:Splign:2.1.0"
     exon            47..336
                     /gene="Mrm2"
                     /gene_synonym="2310037B18Rik; Ftsj2"
                     /inference="alignment:Splign:2.1.0"
     exon            337..1443
                     /gene="Mrm2"
                     /gene_synonym="2310037B18Rik; Ftsj2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1367..1372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrm2"
                     /gene_synonym="2310037B18Rik; Ftsj2"
                     /note="hexamer: AAGAAA"
     regulatory      1404..1409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrm2"
                     /gene_synonym="2310037B18Rik; Ftsj2"
                     /note="hexamer: AACAAA"
     polyA_site      1428
                     /gene="Mrm2"
                     /gene_synonym="2310037B18Rik; Ftsj2"
                     /note="major polyA site"
     polyA_site      1443
                     /gene="Mrm2"
                     /gene_synonym="2310037B18Rik; Ftsj2"
ORIGIN      
        1 gacttccggc ggcgggagga aaccaccagc aagcagcaat ggccgggcat ctgaagctgg
       61 taggcgttcc ccttaaggtt cggaggttac acacagcagt gtgtcactac aggggccgga
      121 ccggcgctga gcacctgtgg ctcacgcggc atctaaagga tccgtttgtg aaggccgcaa
      181 aggtggagag ttaccgctgc cgcagtgcct tcaaactcct ggagatgaat gagaagcatc
      241 agatcctgag gcccggtctc cgggtgctgg actgcggggc agctccggga gcctggagtc
      301 aggtggcagt gcagcgcgtc aatgccacag gcgcagattc cagctctcct gtgggctttg
      361 tgcttggggt cgatctcctt cacatattcc ctttggcggg agcaactttt ctatgccctg
      421 ctgatgtgac tgaccccaga actttccaga agattctaga actgcttccc agcaggagag
      481 cagatgtgat tctgagtgac atggcaccga atgccactgg gatcagagac ctcgatcacg
      541 ataagctcat cagcttgtgc cttacccttg tggacatggc tgtggacatc ctgcatcccg
      601 gagggacact gctgtgtaaa acctgggccg gaagtaaaag ccacctgctg cagaagagac
      661 tgacccagga attccagagc acaagggtgg tgaaaccgga ggccagcagg aaagagtctt
      721 cggaggtgta cctgttagcc acccagtacc gtggggggaa gggcaccagg aggccgtgag
      781 tctgccctgc cattctgggg gtgcttccgg aggagcgtgg attcaagctg ccttgtggat
      841 atgaccagca ccccaaggca cctctgcttt taaagagata agcaaatatt ttcaagggcc
      901 gtgaaaaagt gctaagaatg ggcagcgcca tggcgcagtg aggaaagggg gattgctgct
      961 aagcctgaca gtctgagtgc agcatccggg accccagagc agcgagagcg cgtgcacgca
     1021 cacgcaggct gcacacaata tgaacagata tattggtact gttagttttt ggcaatttgt
     1081 ctgggaagaa agaatctgac tgtggaattc ctccatcggc tcacaggctg agccagggag
     1141 acattgatga gtgactgacg tggcagggcc cagccctgtg cgggtgctgc catcccttgg
     1201 caggtagcct gagttgtatg agaaagcggg gtgagcagga ctgaggaaca agccagtcat
     1261 ccatacccca ctccccgtct ccagttgctg ctgcctccag gttcccaccc cgagaaccca
     1321 ctttgatttc cttcagtgat ggactgtggt tgggatgagt gaggcaaaga aaccctttcc
     1381 ttccaaggct tttaaatgct gaaaacaaag cagtcttctc tatcatgatt ttatttttct
     1441 ggc
//
