LOCUS       NM_145433               2490 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus mitochondrial rRNA methyltransferase 1 (Mrm1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_145433 NM_178359
VERSION     NM_145433.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2490)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2490)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2490)
  AUTHORS   Lee,K.W., Okot-Kotber,C., LaComb,J.F. and Bogenhagen,D.F.
  TITLE     Mitochondrial ribosomal RNA (rRNA) methyltransferase family members
            are positioned to modify nascent rRNA in foci near the
            mitochondrial DNA nucleoid
  JOURNAL   J Biol Chem 288 (43), 31386-31399 (2013)
   PUBMED   24036117
  REMARK    GeneRIF: RNMTL1, MRM1, and MRM2 (FtsJ2) as members of the RNA
            methyltransferase family that may be responsible for the three
            known 2'-O-ribose modifications of the 16 S rRNA core of the large
            mitochondrial ribosome subunit.
REFERENCE   4  (bases 1 to 2490)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC005625.1.
            
            On Aug 15, 2003 this sequence version replaced NM_178359.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005625.1, AK163986.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2490              BC005625.1         1-2490
FEATURES             Location/Qualifiers
     source          1..2490
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.34 cM"
     gene            1..2490
                     /gene="Mrm1"
                     /gene_synonym="A530065E19Rik"
                     /note="mitochondrial rRNA methyltransferase 1"
                     /db_xref="GeneID:217038"
                     /db_xref="MGI:MGI:2443470"
     exon            1..679
                     /gene="Mrm1"
                     /gene_synonym="A530065E19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1106
                     /gene="Mrm1"
                     /gene_synonym="A530065E19Rik"
                     /note="rRNA methyltransferase 1, mitochondrial;
                     mitochondrial large ribosomal RNA ribose methylase; 16S
                     rRNA [Gm1145] 2'-O-methyltransferase; 16S rRNA
                     (guanosine(1145)-2'-O)-methyltransferase; mitochondrial
                     rRNA methyltransferase 1 homolog"
                     /codon_start=1
                     /product="rRNA methyltransferase 1, mitochondrial
                     precursor"
                     /protein_id="NP_663408.2"
                     /db_xref="CCDS:CCDS36260.1"
                     /db_xref="GeneID:217038"
                     /db_xref="MGI:MGI:2443470"
                     /translation="MRRLWTVGCFSRLIARHFSSVARRGERPGGEELSRLLLDDLAPA
                     QRLERLFGLSPCLLALRAARRRVARLLLQAGKAGLQGERAELLRVAEARGIPVLRPRR
                     QKLDALCGYQVHQGVCMEVSPLRPRPCDEAADTSSGDDPQQLWLVLEGLQDPRNLGAV
                     MRSAHFLGVDRVITSQRNSCPLTPVVSKASAGAMEVMDVFATPDLPGFLQAKAQQGWL
                     VVGTVGCPGPEISQSSKVPITSCLEFVWDRPTLLVLGSEGSGLSQEVFASCQLLLTIL
                     PRRHLPPGLESLNVSVATGILLHSICSQKKGFPVQERGQLLQDS"
     exon            680..773
                     /gene="Mrm1"
                     /gene_synonym="A530065E19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            774..906
                     /gene="Mrm1"
                     /gene_synonym="A530065E19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1026
                     /gene="Mrm1"
                     /gene_synonym="A530065E19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..2477
                     /gene="Mrm1"
                     /gene_synonym="A530065E19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2454..2459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrm1"
                     /gene_synonym="A530065E19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2477
                     /gene="Mrm1"
                     /gene_synonym="A530065E19Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggggacccac gtgggaggct gggaggtgac tgtcttggct cgagggtcag gttgtgggca
       61 gtccttgtga ggggacgaag tgtgggaggt caacgggtcc tccccagctg tctgtcagtg
      121 gagtctcggg cgctgctgga gcaatgcggc gactctggac ggtcgggtgc ttcagtcgcc
      181 tgattgcccg ccatttctcc tcggtggctc ggcgcgggga acggcctggc ggggaggagc
      241 tgagtcgctt gcttctggat gacctggcgc cggcccagcg gctggaacgt ctatttggct
      301 tgtccccatg cctcctggcc ttgcgggctg cccgtcggcg cgtggcccgg ctcctgctcc
      361 aggccggtaa ggctgggctg cagggggagc gagccgagct gctccgggtg gccgaggctc
      421 ggggcatccc tgtcttgagg cccaggcgtc agaaactgga tgccttgtgc ggctaccaag
      481 tgcaccaggg cgtgtgcatg gaggtgagcc cgctgcgacc ccggccttgc gatgaggcgg
      541 cagacacgag ctcaggcgac gaccctcagc agctgtggct cgtccttgag gggctccagg
      601 atccccgcaa tcttggggct gtgatgcgct ccgctcactt cctcggcgta gacagagtca
      661 tcaccagcca gagaaacagc tgtccgctta ctccagtagt cagcaaggcc agcgctgggg
      721 ctatggaggt gatggacgtg ttcgccactc ctgacctgcc cggttttttg caggccaagg
      781 cccagcaggg gtggctcgtg gtgggcacag tgggctgccc aggtcctgag atctcccagt
      841 cctccaaggt ccccatcact agctgcttag agttcgtctg ggaccggcct accctcctgg
      901 tgctgggcag tgagggctct ggtctgtccc aggaggtttt tgcctcctgc cagctgctcc
      961 ttactattct gcccagacgc cacctgcctc ctggtcttga gtccttgaat gtatctgtgg
     1021 ccacaggtat tcttctacac tccatttgca gtcagaagaa gggtttccct gtacaggaga
     1081 gaggacaact tctccaagac tcctgagaac ccttagctac gtctgaagga ctcagagagg
     1141 cccagtaccc aggactacta ccactgtggt cagaaaaacc ggccaaatgt gggctgacat
     1201 tgactgtctg agatgtgcgt gtgtaggaac cgcaatgagt cacacatccg tcctcaggct
     1261 tggatgtaat gggccctcta cttgtaagag cctgtttact ggctacagtc aggagaactt
     1321 tagagaccaa aagaagtttc gtatccagtt ggaaatggta gttcgctagt ttccaggacg
     1381 ggttaggaca gacagtatct gtcctggatc ccagtggaag tcagggggct gttcttggca
     1441 tgcggaggag caaggcagtc cagcgcaggg tgtgtgggat gtgagggtga gtttgtagag
     1501 ggaagctgac tgaacagatg catattcctg tctcttggga tgatggggat aggacaccag
     1561 atctcatcag cgagccctga gccgctgagc tgtcatgccc agtctctcca ttaggtggca
     1621 gtcttgctct ttgcaccatg gttttgcagg ccccttgcaa ggagagccct ctgtggaggt
     1681 gggagtggaa ggcttagaga tagggaaaat agccaacagc ttctagacac tggccagtcc
     1741 agccccgtgg agggaacctg tgatcccagg cccttgttgc ctctttgagt ctgagaggct
     1801 gtgaaatcag gattactttt gtggaatccg actaggcttg ccccgtcctc tagagtccca
     1861 caagtggagc agaagtgata ttgccaagta gtggtttcac tctgggctgc atgctggaac
     1921 acctaataag ctttaaagga acaaggccaa cacagcagct actgtgtgct gctgggaagg
     1981 gcaggaacac cctgggcagt accatttctt tttgtttttg aggcagttct gtgtatctat
     2041 ggtctcctga aacttgctat ttagccgagg ataaccttga acttttgatc ctcttacccc
     2101 actatgccca atttatatgt tgctgaggat agatcccaga gctttgtgca agctggcatt
     2161 cactctgcca acagagctac atctgagccc taggctggat aattctctgt tgtaggaacc
     2221 gtcctgagca tcgtgagagg tatccaccag atggcaagaa gtctgcaccc tatctctcat
     2281 tatgaaacca aaactgtctc cacacatgga cgggtatctg accgacagcc ctgagggtgg
     2341 gatgggagga cagcaaccct tgaattggaa tcctggatgt tgtaagagtt ggggtgagtt
     2401 gcctccatgc ctcctttata tcctcggaag atgtatgtag taggtgctca ataaataaac
     2461 actcctttcc tctgtaaaaa aaaaaaaaaa
//
