LOCUS       NM_001304739             446 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus myoregulin (Mrln), mRNA.
ACCESSION   NM_001304739 NR_038041
VERSION     NM_001304739.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 446)
  AUTHORS   Zhao,Y., Cao,F., Yu,X., Chen,C., Meng,J., Zhong,R., Zhang,Y. and
            Zhu,D.
  TITLE     Linc-RAM is required for FGF2 function in regulating myogenic cell
            differentiation
  JOURNAL   RNA Biol 15 (3), 404-412 (2018)
   PUBMED   29364044
  REMARK    GeneRIF: Results demonstrate that the FGF2-mediated repression of
            Linc-RAM expression occurs through MyoD via the Ras/Raf/Mek/Erk
            signaling pathway during myogenic differentiation. Present data
            provide convincing evidence that Linc-RAM is a lineage-specific
            lncRNA that plays regulatory roles in modulating muscle cell
            differentiation via FGF2-mediated signaling.
REFERENCE   2  (bases 1 to 446)
  AUTHORS   Yu,X., Zhang,Y., Li,T., Ma,Z., Jia,H., Chen,Q., Zhao,Y., Zhai,L.,
            Zhong,R., Li,C., Zou,X., Meng,J., Chen,A.K., Puri,P.L., Chen,M. and
            Zhu,D.
  TITLE     Long non-coding RNA Linc-RAM enhances myogenic differentiation by
            interacting with MyoD
  JOURNAL   Nat Commun 8, 14016 (2017)
   PUBMED   28091529
  REMARK    GeneRIF: Linc-RAM regulates expression of myogenic genes by
            directly binding MyoD, which in turn promotes the assembly of the
            MyoD-Baf60c-Brg1 complex on the regulatory elements of target
            genes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 446)
  AUTHORS   Anderson,D.M., Makarewich,C.A., Anderson,K.M., Shelton,J.M.,
            Bezprozvannaya,S., Bassel-Duby,R. and Olson,E.N.
  TITLE     Widespread control of calcium signaling by a family of
            SERCA-inhibiting micropeptides
  JOURNAL   Sci Signal 9 (457), ra119 (2016)
   PUBMED   27923914
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 446)
  AUTHORS   Anderson,D.M., Anderson,K.M., Chang,C.L., Makarewich,C.A.,
            Nelson,B.R., McAnally,J.R., Kasaragod,P., Shelton,J.M., Liou,J.,
            Bassel-Duby,R. and Olson,E.N.
  TITLE     A micropeptide encoded by a putative long noncoding RNA regulates
            muscle performance
  JOURNAL   Cell 160 (4), 595-606 (2015)
   PUBMED   25640239
  REMARK    GeneRIF: The human and mouse MLN genes consist of three exons that
            span 16.5 and 15.0 kb, respectively, with the ORF located in exon
            3; findings identify MLN as an important regulator of skeletal
            muscle physiology.
REFERENCE   5  (bases 1 to 446)
  AUTHORS   Zangrando,J., Zhang,L., Vausort,M., Maskali,F., Marie,P.Y.,
            Wagner,D.R. and Devaux,Y.
  TITLE     Identification of candidate long non-coding RNAs in response to
            myocardial infarction
  JOURNAL   BMC Genomics 15 (1), 460 (2014)
   PUBMED   24917243
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY282836.1, AK009351.1 and
            AC122923.4.
            
            On Feb 6, 2015 this sequence version replaced NR_038041.1.
            
            Summary: This gene encodes a small peptide that shares structural
            similarity to the small peptides sarcolipin and phospholamban,
            which are key regulators of sarcoplasmic reticulum Ca(2+)-ATPases
            (SERCAs). This protein is thought to have a similar function to
            these peptides, regulating Ca(2+) reuptake in the sarcoplasmic
            reticulum by inhibiting the Ca(2+) pump activity of SERCAs.
            [provided by RefSeq, Feb 2015].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX523793.1, BX634786.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BY282836.1         1-20
            21-443              AK009351.1         1-423
            444-446             AC122923.4         165004-165006       c
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 36.68 cM"
     gene            1..446
                     /gene="Mrln"
                     /gene_synonym="2310015B20Rik; Linc-RAM; Mln"
                     /note="myoregulin"
                     /db_xref="GeneID:69563"
                     /db_xref="MGI:MGI:1916813"
     exon            1..96
                     /gene="Mrln"
                     /gene_synonym="2310015B20Rik; Linc-RAM; Mln"
                     /inference="alignment:Splign:2.1.0"
     exon            97..211
                     /gene="Mrln"
                     /gene_synonym="2310015B20Rik; Linc-RAM; Mln"
                     /inference="alignment:Splign:2.1.0"
     exon            212..446
                     /gene="Mrln"
                     /gene_synonym="2310015B20Rik; Linc-RAM; Mln"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..371
                     /gene="Mrln"
                     /gene_synonym="2310015B20Rik; Linc-RAM; Mln"
                     /codon_start=1
                     /product="myoregulin"
                     /protein_id="NP_001291668.1"
                     /db_xref="CCDS:CCDS88021.1"
                     /db_xref="GeneID:69563"
                     /db_xref="MGI:MGI:1916813"
                     /translation="MSGKSWVLISTTSPQSLEDEILGRLLKILFVLFVDLMSIMYVVI
                     TS"
     regulatory      422..427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrln"
                     /gene_synonym="2310015B20Rik; Linc-RAM; Mln"
                     /note="hexamer: AATAAA"
     polyA_site      446
                     /gene="Mrln"
                     /gene_synonym="2310015B20Rik; Linc-RAM; Mln"
                     /note="major polyA site"
ORIGIN      
        1 agtgagcttt tcgtccatgg agagcagatg gtgtttttga aaggaagggc ggccattccc
       61 aggactttgg acttggctcc gttgcacccc tgaacagaac caacgttgct aggagaacac
      121 ctgtgcccca gcactttggt ccagcaaggg caggagagga gagctggaaa ctggtagagc
      181 tgtgctacct gctacctcct gaggctctca gggagcagga gaatctgaac atgagtggca
      241 agagctgggt actgatctct actacttcgc cccagagcct ggaagatgag attctgggac
      301 ggcttctgaa aattctcttc gttttgttcg ttgacttaat gtccattatg tatgtcgtca
      361 taacgtccta gcaacctgac tttctttact ccgtgtgtaa gtttcaaacc aaatgcgagc
      421 aaataaagat ctacatttta atctga
//
