LOCUS       NM_026423               2149 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus methylthioribose-1-phosphate isomerase 1 (Mri1), mRNA.
ACCESSION   NM_026423
VERSION     NM_026423.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2149)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2149)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK047287.1 and AK013882.1.
            
            On Nov 19, 2009 this sequence version replaced NM_026423.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK047287.1, BC025049.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AK047287.1         4-35
            33-1242             AK013882.1         2-1211
            1243-2149           AK047287.1         1246-2152
FEATURES             Location/Qualifiers
     source          1..2149
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 40.74 cM"
     gene            1..2149
                     /gene="Mri1"
                     /gene_synonym="2410018C20Rik"
                     /note="methylthioribose-1-phosphate isomerase 1"
                     /db_xref="GeneID:67873"
                     /db_xref="MGI:MGI:1915123"
     exon            1..435
                     /gene="Mri1"
                     /gene_synonym="2410018C20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1174
                     /gene="Mri1"
                     /gene_synonym="2410018C20Rik"
                     /EC_number="5.3.1.23"
                     /note="translation initiation factor eIF-2B subunit
                     alpha/beta/delta-like protein; M1Pi; MTR-1-P isomerase;
                     methylthioribose-1-phosphate isomerase homolog;
                     S-methyl-5-thioribose-1-phosphate isomerase"
                     /codon_start=1
                     /product="methylthioribose-1-phosphate isomerase"
                     /protein_id="NP_080699.3"
                     /db_xref="CCDS:CCDS22473.1"
                     /db_xref="GeneID:67873"
                     /db_xref="MGI:MGI:1915123"
                     /translation="MTLEAIRYSPGSLQILDQLQLPEHCHYEALSSVQQASEAIRAMK
                     VRGAPAIALVGCLSLAVELRAGAGGPGLAALVAFVRDQLRLLVAARPTAVNMARAARD
                     LGQVAAQEAEREGATEETVRERVIRFAEDMLEKDLKDNRSIGDLGARHLLEQTNPRGG
                     KVTVLTHCNTGALATAGYGTALGVIRSLHEMGRLEHTFCTETRPYNQGARLTAFELVY
                     EQIPATLITDSMAAAAMAHRGVSAVVVGADRVVANGDTANKIGTYQLAIVAKHHGVPF
                     YVAAPSSSCDLHLETGKEIVIEERPSQELTDLNGVRIAAQGIRVWNPAFDVTPHELIT
                     GGIITELGVFAPEELRGALSASVFSEGQTLDSPWV"
     exon            436..611
                     /gene="Mri1"
                     /gene_synonym="2410018C20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            612..788
                     /gene="Mri1"
                     /gene_synonym="2410018C20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            789..1013
                     /gene="Mri1"
                     /gene_synonym="2410018C20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..2149
                     /gene="Mri1"
                     /gene_synonym="2410018C20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1219..1224
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mri1"
                     /gene_synonym="2410018C20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1245
                     /gene="Mri1"
                     /gene_synonym="2410018C20Rik"
                     /note="major polyA site"
     regulatory      1684..1689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mri1"
                     /gene_synonym="2410018C20Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1703
                     /gene="Mri1"
                     /gene_synonym="2410018C20Rik"
ORIGIN      
        1 ggcaggacgc aactccgccc cgcagcctgt gcaggattcc tcgtggccct gcagggtagg
       61 caacatgaca ctggaagcga tccgctactc gcccggctcg ctgcagatcc tcgaccagct
      121 gcagctgcca gagcactgcc actatgaggc actgagctcc gtgcagcagg ctagtgaagc
      181 catccgcgcc atgaaggtgc gcggagcccc ggccatcgcg ctggtcggct gcctcagcct
      241 ggccgtggag ctgcgggccg gcgccggcgg tcccggactc gctgctctgg tggccttcgt
      301 gcgagaccag ctgcgcctct tagtcgccgc ccggcccacc gctgtcaaca tggcccgcgc
      361 cgcccgcgat ctgggtcaag tggcagccca ggaggcggaa cgagagggtg ccactgaaga
      421 gaccgtgcgg gaaagagtga tccgcttcgc cgaggatatg ttggagaagg acctcaaaga
      481 caaccggagc atcggggact tgggagcccg ccatctccta gagcagacca accccagggg
      541 tggcaaggtg accgtgctga cccactgtaa cacgggtgct ctggccactg ctggctatgg
      601 tacagcgtta ggtgtgatcc gctcactgca tgagatgggc cgattggagc ataccttctg
      661 cacagagacc cggccctaca accagggagc ccggctgacg gccttcgagc tggtgtacga
      721 gcagatccct gcaactctca tcactgacag catggcggcg gctgccatgg cacaccgggg
      781 tgtgtcagcc gtggtggtgg gagctgaccg tgttgttgcc aatggagaca cagccaacaa
      841 aataggcacc tatcagctgg ccattgtcgc caaacaccac ggtgtcccct tctatgtggc
      901 tgcccccagt tcatcctgtg acctccatct ggagactgga aaggagattg tcatagagga
      961 acgccccagc caggagctaa ctgacctgaa tggagtcagg attgctgcac agggaatccg
     1021 ggtttggaat cctgcctttg atgtcacccc ccacgaactc atcacaggtg gcatcatcac
     1081 tgaactgggt gtctttgccc ctgaggagct ccgaggagcc ctaagtgcct ccgtcttctc
     1141 agagggacag accctagata gtccctgggt gtgactggct ggccctccgt gccctgccct
     1201 gacttcctct ggttttataa taaagttctc aaatggctac ccaaagttca tcttcaccca
     1261 cactccctct tccagctgca ggaacagata tggtttgcca ggttctgcag agtttcagca
     1321 tccacagcaa agctgcctaa ggtcgcgtcc caggctcatc cttggaatga tctatgcatg
     1381 ggatgaaaga cagatgtggc ggtcacacac ctgtaatctc agcacctggg aggctcaggc
     1441 aggaagattt ggagtttagg ctaccctggg ctacagattc aaacagacaa acaaaagtag
     1501 agataatcag gatgttctct tagttacatt tgaatttttt tgttgttgtt gattctattt
     1561 tgttttgttt tgttttttct agacaggatt tttctgtgtc tccttggcta tcctggaaca
     1621 atctgtagat caggctggct tcaaactcag agatcctcct gcctctgtct cccaagtgct
     1681 gggattaaat gcatgcacca ctactggcta tttactttta tttatgtgtg agtgttttac
     1741 atgcaaaccc ctggtgctct cccagaccag aaaagggtac cagatctcct ggaactggaa
     1801 ttacaagtgg ttgtgagctg ccatatggga gctgggaccc aggaactaaa cctctgtgct
     1861 agaacaagtc ctataaaaga agacaccaaa gttcagtaat caagataaat atttgtgttt
     1921 taaggcagtc tctttgtagc tctggctgcc cttggacttg ctctatggac caggctaccc
     1981 tagaactcac aaagatccac ctacctctgc ctcttgagca aaaggtcaaa agtgtgagcc
     2041 cctacaacct gctttgcttt attcttgaga gtctgtgaac ctggaattca gctatcaggc
     2101 tagactccag gggtcctccc gcttcagcca acttagcact gggatagca
//
