LOCUS       NM_207540               1180 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus MAS-related GPR, member X1 (Mrgprx1), mRNA.
ACCESSION   NM_207540 XM_001002827
VERSION     NM_207540.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1180)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1180)
  AUTHORS   Cao,Z., Huang,C., Lu,F., Jiang,X., Hu,Y., Cao,C. and Liu,Z.
  TITLE     Meis1 Regulates Nociceptor Development and Behavioral Response to
            Tactile Stimuli
  JOURNAL   Front Mol Neurosci 15, 901466 (2022)
   PUBMED   35875660
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1180)
  AUTHORS   Li,X., Yang,H., Han,Y., Yin,S., Shen,B., Wu,Y., Li,W. and Cao,Z.
  TITLE     Tick peptides evoke itch by activating MrgprC11/MRGPRX1 to
            sensitize TRPV1 in pruriceptors
  JOURNAL   J Allergy Clin Immunol 147 (6), 2236-2248 (2021)
   PUBMED   33358893
REFERENCE   4  (bases 1 to 1180)
  AUTHORS   Grundy,L., Caldwell,A., Garcia-Caraballo,S., Grundy,D.,
            Spencer,N.J., Dong,X., Castro,J., Harrington,A.M. and Brierley,S.M.
  TITLE     Activation of MrgprA3 and MrgprC11 on Bladder-Innervating Afferents
            Induces Peripheral and Central Hypersensitivity to Bladder
            Distension
  JOURNAL   J Neurosci 41 (17), 3900-3916 (2021)
   PUBMED   33727332
  REMARK    GeneRIF: Activation of MrgprA3 and MrgprC11 on Bladder-Innervating
            Afferents Induces Peripheral and Central Hypersensitivity to
            Bladder Distension.
REFERENCE   5  (bases 1 to 1180)
  AUTHORS   Steele,H.R., Xing,Y., Zhu,Y., Hilley,H.B., Lawson,K., Nho,Y.,
            Niehoff,T. and Han,L.
  TITLE     MrgprC11+ sensory neurons mediate glabrous skin itch
  JOURNAL   Proc Natl Acad Sci U S A 118 (15) (2021)
   PUBMED   33876765
  REMARK    GeneRIF: MrgprC11(+) sensory neurons mediate glabrous skin itch.
REFERENCE   6  (bases 1 to 1180)
  AUTHORS   Han,S.K., Dong,X., Hwang,J.I., Zylka,M.J., Anderson,D.J. and
            Simon,M.I.
  TITLE     Orphan G protein-coupled receptors MrgA1 and MrgC11 are
            distinctively activated by RF-amide-related peptides through the
            Galpha q/11 pathway
  JOURNAL   Proc Natl Acad Sci U S A 99 (23), 14740-14745 (2002)
   PUBMED   12397184
REFERENCE   7  (bases 1 to 1180)
  AUTHORS   Battaglia,M. and Gorski,J.
  TITLE     Overlap of direct and indirect alloreactive T-cell repertoires when
            MHC polymorphism is limited to the peptide binding groove
  JOURNAL   Hum Immunol 63 (2), 91-100 (2002)
   PUBMED   11821156
REFERENCE   8  (bases 1 to 1180)
  AUTHORS   Dong,X., Han,S., Zylka,M.J., Simon,M.I. and Anderson,D.J.
  TITLE     A diverse family of GPCRs expressed in specific subsets of
            nociceptive sensory neurons
  JOURNAL   Cell 106 (5), 619-632 (2001)
   PUBMED   11551509
REFERENCE   9  (bases 1 to 1180)
  AUTHORS   Smith,K.G., Light,A., O'Reilly,L.A., Ang,S.M., Strasser,A. and
            Tarlinton,D.
  TITLE     bcl-2 transgene expression inhibits apoptosis in the germinal
            center and reveals differences in the selection of memory B cells
            and bone marrow antibody-forming cells
  JOURNAL   J Exp Med 191 (3), 475-484 (2000)
   PUBMED   10662793
REFERENCE   10 (bases 1 to 1180)
  AUTHORS   Pittoggi,C., Renzi,L., Zaccagnini,G., Cimini,D., Degrassi,F.,
            Giordano,R., Magnano,A.R., Lorenzini,R., Lavia,P. and Spadafora,C.
  TITLE     A fraction of mouse sperm chromatin is organized in nucleosomal
            hypersensitive domains enriched in retroposon DNA
  JOURNAL   J Cell Sci 112 (Pt 20), 3537-3548 (1999)
   PUBMED   10504302
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY152435.1.
            
            On Oct 3, 2009 this sequence version replaced NM_207540.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY152435.1, BC150669.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1180              AY152435.1         7-1186
FEATURES             Location/Qualifiers
     source          1..1180
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 31.09 cM"
     gene            1..1180
                     /gene="Mrgprx1"
                     /gene_synonym="MrgC11; Mrgprc11"
                     /note="MAS-related GPR, member X1"
                     /db_xref="GeneID:404242"
                     /db_xref="MGI:MGI:3033139"
     exon            1..128
                     /gene="Mrgprx1"
                     /gene_synonym="MrgC11; Mrgprc11"
                     /inference="alignment:Splign:2.1.0"
     exon            129..1180
                     /gene="Mrgprx1"
                     /gene_synonym="MrgC11; Mrgprc11"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1122
                     /gene="Mrgprx1"
                     /gene_synonym="MrgC11; Mrgprc11"
                     /note="mas-related G-protein coupled receptor member C11;
                     sensory neuron-specific G-protein coupled receptor 1;
                     MAS-related GPR, member C11"
                     /codon_start=1
                     /product="mas-related G-protein coupled receptor member
                     X1"
                     /protein_id="NP_997423.1"
                     /db_xref="CCDS:CCDS21299.1"
                     /db_xref="GeneID:404242"
                     /db_xref="MGI:MGI:3033139"
                     /translation="MDPTISSHDTESTPLNETGHPNCTPILTLSFLVLITTLVGLAGN
                     TIVLWLLGFRMRRKAISVYILNLALADSFFLCCHFIDSLLRIIDFYGLYAHKLSKDIL
                     GNAAIIPYISGLSILSAISTERCLCVLWPIWYHCHRPRNMSAIICALIWVLSFLMGIL
                     DWFSGFLGETHHHLWKNVDFIITAFLIFLFMLLSGSSLALLLRILCGPRRKPLSRLYV
                     TIALTVMVYLICGLPLGLYLFLLYWFGVHLHYPFCHIYQVTAVLSCVNSSANPIIYFL
                     VGSFRQHRKHRSLKRVLKRALEDTPEEDEYTDSHLHKTTEISESRY"
ORIGIN      
        1 ctcttaataa cactttgact ggcatttatt aggggacaga aaaggatgtt ctagcatcca
       61 caaccccaga agacttcaaa ttcagcacaa gtcagctcct caactcctga cagagcattg
      121 gaaaaaaggg acaccactgg aagatttgtg agcatggatc caaccatctc atcccacgac
      181 acagaatcta caccactgaa tgaaactggt catcccaact gcactccaat cctgaccctg
      241 tccttcctgg tcctcatcac taccctggtt ggactggcag gaaacaccat tgtactctgg
      301 ctcctcggat tccgcatgcg caggaaagcc atctcagtct atatcctcaa cctggctctg
      361 gcagactcct tcttcctctg ctgtcacttc attgactctc tgctacggat cattgacttc
      421 tatggcctct atgcccataa attaagcaaa gatatcttag gcaatgcagc aatcatcccc
      481 tatatctcag gcctgagcat cctcagtgct attagcacag agcgctgcct gtgtgtattg
      541 tggccaatct ggtaccactg ccatcgccca agaaacatgt cagctatcat atgtgcccta
      601 atctgggttc tgtcctttct catgggcatc ctcgattggt tctcaggatt cctgggtgag
      661 actcatcatc atttgtggaa aaatgttgac tttattataa ctgcatttct gatattttta
      721 tttatgcttc tctctgggtc cagtctggcc ctactgctga ggattctctg tggtcccagg
      781 aggaaacccc tgtccaggct gtatgttacc atcgctctca cagtgatggt ctacctcatc
      841 tgtggcctgc ctcttgggct ttacttgttc ctgttatact ggtttggggt tcatttacat
      901 tatccctttt gtcacattta ccaagttact gctgtcttgt cctgtgtaaa cagctctgcc
      961 aaccccatca tttatttcct tgtaggctcc tttaggcagc atagaaagca taggtccctg
     1021 aaaagagttc ttaagagggc tctggaggac actcctgagg aggatgaata tacagacagc
     1081 catcttcata aaaccaccga gatttcagaa agcagatatt gaaagtcaat acaacattaa
     1141 cttactcttc tctcagaaac acctctatga ttgcaatgct
//
