LOCUS       NM_145379               2006 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus MAS-related GPR, member F (Mrgprf), mRNA.
ACCESSION   NM_145379
VERSION     NM_145379.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2006)
  AUTHORS   Kaur,H., Carvalho,J., Looso,M., Singh,P., Chennupati,R.,
            Preussner,J., Gunther,S., Albarran-Juarez,J., Tischner,D.,
            Classen,S., Offermanns,S. and Wettschureck,N.
  TITLE     Single-cell profiling reveals heterogeneity and functional
            patterning of GPCR expression in the vascular system
  JOURNAL   Nat Commun 8, 15700 (2017)
   PUBMED   28621310
  REMARK    Erratum:[Nat Commun. 2019 Mar 28;10(1):1448. doi:
            10.1038/s41467-019-09334-3.. PMID: 30923344]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2006)
  AUTHORS   Premzl,M.
  TITLE     Comparative genomic analysis of eutherian Mas-related G
            protein-coupled receptor genes
  JOURNAL   Gene 540 (1), 16-19 (2014)
   PUBMED   24583173
REFERENCE   3  (bases 1 to 2006)
  AUTHORS   Avula,L.R., Buckinx,R., Alpaerts,K., Costagliola,A., Adriaensen,D.,
            Van Nassauw,L. and Timmermans,J.P.
  TITLE     The effect of inflammation on the expression and distribution of
            the MAS-related gene receptors MrgE and MrgF in the murine ileum
  JOURNAL   Histochem Cell Biol 136 (5), 569-585 (2011)
   PUBMED   21912971
  REMARK    GeneRIF: The number of enteric neurons expressing MrgE and MrgF
            receptors was significantly reduced during intestinal
            schistosomiasis and ileitis.
REFERENCE   4  (bases 1 to 2006)
  AUTHORS   Lee,S., Cho,H.J., Park,J.J., Kim,Y.S., Hwang,S., Sun,R. and
            Song,M.J.
  TITLE     The ORF49 protein of murine gammaherpesvirus 68 cooperates with RTA
            in regulating virus replication
  JOURNAL   J Virol 81 (18), 9870-9877 (2007)
   PUBMED   17634244
  REMARK    GeneRIF: ORF49 protein promoted the ability of RTA to activate
            downstream target promoters and enhanced murine gammaherpesvirus 68
            replication
REFERENCE   5  (bases 1 to 2006)
  AUTHORS   Zylka,M.J., Dong,X., Southwell,A.L. and Anderson,D.J.
  TITLE     Atypical expansion in mice of the sensory neuron-specific Mrg G
            protein-coupled receptor family
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 10043-10048 (2003)
   PUBMED   12909716
REFERENCE   6  (bases 1 to 2006)
  AUTHORS   Han,S.K., Dong,X., Hwang,J.I., Zylka,M.J., Anderson,D.J. and
            Simon,M.I.
  TITLE     Orphan G protein-coupled receptors MrgA1 and MrgC11 are
            distinctively activated by RF-amide-related peptides through the
            Galpha q/11 pathway
  JOURNAL   Proc Natl Acad Sci U S A 99 (23), 14740-14745 (2002)
   PUBMED   12397184
REFERENCE   7  (bases 1 to 2006)
  AUTHORS   Dong,X., Han,S., Zylka,M.J., Simon,M.I. and Anderson,D.J.
  TITLE     A diverse family of GPCRs expressed in specific subsets of
            nociceptive sensory neurons
  JOURNAL   Cell 106 (5), 619-632 (2001)
   PUBMED   11551509
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC132081.3.
            
            On Nov 17, 2006 this sequence version replaced NM_145379.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019711.1, BF579272.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AC132081.3         130747-130830
            85-199              AC132081.3         133652-133766
            200-2006            AC132081.3         137589-139395
FEATURES             Location/Qualifiers
     source          1..2006
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 89.05 cM"
     gene            1..2006
                     /gene="Mrgprf"
                     /gene_synonym="Mgrc; MrgF"
                     /note="MAS-related GPR, member F"
                     /db_xref="GeneID:211577"
                     /db_xref="MGI:MGI:2384823"
     exon            1..84
                     /gene="Mrgprf"
                     /gene_synonym="Mgrc; MrgF"
                     /inference="alignment:Splign:2.1.0"
     exon            85..199
                     /gene="Mrgprf"
                     /gene_synonym="Mgrc; MrgF"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1183
                     /gene="Mrgprf"
                     /gene_synonym="Mgrc; MrgF"
                     /note="mas-related gene F protein; G protein-coupled
                     receptor RTA; Mas-related G protein-coupled receptor c"
                     /codon_start=1
                     /product="mas-related G-protein coupled receptor member F"
                     /protein_id="NP_663354.1"
                     /db_xref="CCDS:CCDS22056.1"
                     /db_xref="GeneID:211577"
                     /db_xref="MGI:MGI:2384823"
                     /translation="MAGNCSWEAHSTNQNKMCPGMSEARELYSRGFLTIEQIATLPPP
                     AVTNYIFLLLCLCGLVGNGLVLWFFGFSIKRTPFSIYFLHLASADGMYLFSKAVIALL
                     NMGTFLGSFPDYIRRVSRIVGLCTFFTGVSLLPAISIERCVSVIFPTWYWRRRPKRLS
                     AGVCALLWMLSFLVTSIHNYFCMFLGHEAPGTVCRNMDIALGILLFFLFCPLMVLPCL
                     ALILHVECRARRRQRSAKLNHVVLAIVSVFLVSSIYLGIDWFLFWVFQIPAPFPEYVT
                     DLCICINSSAKPIVYFLAGRDKSQRLWEPLRVVFQRALRDGAEPGDAASSTPNTVTME
                     MQCPSGNAS"
     exon            200..2006
                     /gene="Mrgprf"
                     /gene_synonym="Mgrc; MrgF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1957..1962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrgprf"
                     /gene_synonym="Mgrc; MrgF"
                     /note="hexamer: AATAAA"
     regulatory      1972..1977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrgprf"
                     /gene_synonym="Mgrc; MrgF"
                     /note="hexamer: AATACA"
     polyA_site      1977
                     /gene="Mrgprf"
                     /gene_synonym="Mgrc; MrgF"
                     /note="major polyA site"
     polyA_site      2001
                     /gene="Mrgprf"
                     /gene_synonym="Mgrc; MrgF"
ORIGIN      
        1 agcctgctgc ccgtgggtca gcaaactcgg agtcccagga gaagatctct acgaagggaa
       61 ctcggaggat caggacagcc acaggctttt gctaggcagg aacacatact gctgagctcc
      121 caacaggagc ctggactcct cactcctgga gatggccgga aactgttcat gggaagctca
      181 ctccaccaac cagaacaaga tgtgtcctgg tatgagcgag gctcgggagc tctacagcag
      241 aggatttctg accattgagc agattgctac gctccctccg ccagctgtca caaactatat
      301 cttcctgctg ctttgcctgt gtggcctggt gggaaacggg ctggtcctct ggtttttcgg
      361 cttctccatc aagaggaccc ctttctccat ctacttcctg cacctggcca gcgccgatgg
      421 gatgtacctc ttcagcaagg ccgtgattgc tctcctgaac atggggacct tcctgggctc
      481 cttccccgac tacattcgaa gagtgtcccg gatcgtgggg ctctgcacat tcttcacagg
      541 tgtgagcctc ctgccagcca ttagcatcga acgctgtgtg tctgtcatct tccccacctg
      601 gtactggcgt cggaggccca agcgcctgtc agctggggtc tgtgccctgc tctggatgct
      661 atcattcctg gttaccagta tccacaatta cttctgtatg ttcctgggcc acgaggcccc
      721 tggtacagtc tgccgcaaca tggacatcgc cctgggcatc ttgctgttct ttctcttctg
      781 cccactcatg gtacttccct gcctggcgct catcctgcac gtagagtgcc gagcacggcg
      841 ccgccaacgc tctgccaagc tcaatcacgt ggtcctggcg atcgtctctg tcttcctcgt
      901 atcatccatc tacttgggga tcgactggtt cctcttctgg gtcttccaga tcccagcccc
      961 cttccccgag tacgtcactg acttgtgtat ctgcatcaac agcagtgcca aacccatcgt
     1021 ctacttcctg gctgggagag acaagtcaca gcgcctgtgg gaacctctca gggtggtctt
     1081 ccagcgggct ctccgggatg gtgcggagcc gggggacgct gctagcagca cacccaacac
     1141 ggtcaccatg gaaatgcagt gcccctctgg gaacgcatcc tgagaggcca acttctgggg
     1201 caaggctgca gcagagagcg gccagtagct tccagagaca ctctgcccga gggcaggagt
     1261 agggcagctg cccctgtgct gccagggaga agacctgcct taacactctt gtcaggggtg
     1321 gccaggaggc tgagcagcca cctctggaca gaccctgtgg cctctgctcc ccaaccattc
     1381 tgcttctgtg actcagtgta ccaaagttgc cctcaccagc atggtagggt cccttcttaa
     1441 cagaagctca agagcgaagg caagaaggag gtcacctcct caaacgtgac tcatcgagca
     1501 tcaccctccc tgggccagca gcctcagccc cacccccagg gagttgttca gcctcccaag
     1561 gctgcatcag aacaaaccct agagaacggt gctatctgga actgggtcct gtccactggc
     1621 attgcactct gcaaacaagc ccctgcccct ttgatgagtc acctagtgac tttaatggga
     1681 tgggatctgg ccttggcaag ccatgtgaga cagaaaggac cttctgtcac catgggtagc
     1741 tgactgcttt tctgacccca cccacccacc ccaaccagcc agctctgggt agctgactgc
     1801 actcagcatc ttccaggcca ctgtagtcca ctgctaagtc ctcaatctcc tgtacccatt
     1861 tcaaagtgga ctctggcccc ctggaggctg ccaccacgat gtcactcatc atccagcaca
     1921 gtggcctgtg tagccaaagg aagttttata aaagataata aagtatatat caatacacat
     1981 ttttttaaac tttgcagtga agcagg
//
