LOCUS       NM_175534               3777 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus MAS-related GPR, member E (Mrgpre), mRNA.
ACCESSION   NM_175534
VERSION     NM_175534.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3777)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3777)
  AUTHORS   Xu,M., Li,J., Zhang,Z., Liu,L., Wan,F., Tang,Z. and Lan,L.
  TITLE     Mas-related G protein-coupled receptor D is involved in modulation
            of murine gastrointestinal motility
  JOURNAL   Exp Physiol 106 (12), 2502-2516 (2021)
   PUBMED   34647371
  REMARK    GeneRIF: Mas-related G protein-coupled receptor D is involved in
            modulation of murine gastrointestinal motility.
REFERENCE   3  (bases 1 to 3777)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3777)
  AUTHORS   Premzl,M.
  TITLE     Comparative genomic analysis of eutherian Mas-related G
            protein-coupled receptor genes
  JOURNAL   Gene 540 (1), 16-19 (2014)
   PUBMED   24583173
REFERENCE   5  (bases 1 to 3777)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 3777)
  AUTHORS   Avula,L.R., Buckinx,R., Alpaerts,K., Costagliola,A., Adriaensen,D.,
            Van Nassauw,L. and Timmermans,J.P.
  TITLE     The effect of inflammation on the expression and distribution of
            the MAS-related gene receptors MrgE and MrgF in the murine ileum
  JOURNAL   Histochem Cell Biol 136 (5), 569-585 (2011)
   PUBMED   21912971
  REMARK    GeneRIF: The number of enteric neurons expressing MrgE and MrgF
            receptors was significantly reduced during intestinal
            schistosomiasis and ileitis.
REFERENCE   7  (bases 1 to 3777)
  AUTHORS   Cox,P.J., Pitcher,T., Trim,S.A., Bell,C.H., Qin,W. and Kinloch,R.A.
  TITLE     The effect of deletion of the orphan G - protein coupled receptor
            (GPCR) gene MrgE on pain-like behaviours in mice
  JOURNAL   Mol Pain 4, 2 (2008)
   PUBMED   18197975
  REMARK    GeneRIF: The data suggests that MrgE may play a role in selective
            pain behavioural responses in mice.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3777)
  AUTHORS   Zylka,M.J., Dong,X., Southwell,A.L. and Anderson,D.J.
  TITLE     Atypical expansion in mice of the sensory neuron-specific Mrg G
            protein-coupled receptor family
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 10043-10048 (2003)
   PUBMED   12909716
REFERENCE   9  (bases 1 to 3777)
  AUTHORS   Han,S.K., Dong,X., Hwang,J.I., Zylka,M.J., Anderson,D.J. and
            Simon,M.I.
  TITLE     Orphan G protein-coupled receptors MrgA1 and MrgC11 are
            distinctively activated by RF-amide-related peptides through the
            Galpha q/11 pathway
  JOURNAL   Proc Natl Acad Sci U S A 99 (23), 14740-14745 (2002)
   PUBMED   12397184
REFERENCE   10 (bases 1 to 3777)
  AUTHORS   Dong,X., Han,S., Zylka,M.J., Simon,M.I. and Anderson,D.J.
  TITLE     A diverse family of GPCRs expressed in specific subsets of
            nociceptive sensory neurons
  JOURNAL   Cell 106 (5), 619-632 (2001)
   PUBMED   11551509
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133657.1, AJ320231.1 and CD807098.1.
            
            On Oct 30, 2009 this sequence version replaced NM_175534.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096766.1, AK133657.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               AK133657.1         3-291
            290-2177            AJ320231.1         1-1888
            2178-2323           CD807098.1         440-585
            2324-3777           AJ320231.1         2033-3486
FEATURES             Location/Qualifiers
     source          1..3777
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 88.31 cM"
     gene            1..3777
                     /gene="Mrgpre"
                     /gene_synonym="C130069N09Rik; Ebrt3; Mgrf; MrgE"
                     /note="MAS-related GPR, member E"
                     /db_xref="GeneID:244238"
                     /db_xref="MGI:MGI:2441884"
     exon            1..310
                     /gene="Mrgpre"
                     /gene_synonym="C130069N09Rik; Ebrt3; Mgrf; MrgE"
                     /inference="alignment:Splign:2.1.0"
     exon            311..3761
                     /gene="Mrgpre"
                     /gene_synonym="C130069N09Rik; Ebrt3; Mgrf; MrgE"
                     /inference="alignment:Splign:2.1.0"
     CDS             360..1292
                     /gene="Mrgpre"
                     /gene_synonym="C130069N09Rik; Ebrt3; Mgrf; MrgE"
                     /note="G protein-coupled receptor MrgE; evolutionary
                     breakpoint transcript 3 protein; Mas-related G
                     protein-coupled receptor f"
                     /codon_start=1
                     /product="mas-related G-protein coupled receptor member E"
                     /protein_id="NP_780743.1"
                     /db_xref="CCDS:CCDS22046.1"
                     /db_xref="GeneID:244238"
                     /db_xref="MGI:MGI:2441884"
                     /translation="MTSLSVHTDSPSTQGEMAFNLTILSLTELLSLGGLLGNGVALWL
                     LNQNVYRNPFSIYLLDVACADLIFLCCHMVAIIPELLQDQLNFPEFVHISLTMLRFFC
                     YIVGLSLLAAISTEQCLATLFPAWYLCRRPRYLTTCVCALIWVLCLLLDLLLSGACTQ
                     FFGAPSYHLCDMLWLVVAVLLAALCCTMCVTSLLLLLRVERGPERHQPRGFPTLVLLA
                     VLLFLFCGLPFGIFWLSKNLSWHIPLYFYHFSFFMASVHSAAKPAIYFFLGSTPGQRF
                     REPLRLVLQRALGDEAELGAGREASQGGLVDMTV"
     regulatory      3741..3746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrgpre"
                     /gene_synonym="C130069N09Rik; Ebrt3; Mgrf; MrgE"
                     /note="hexamer: AATAAA"
     polyA_site      3761
                     /gene="Mrgpre"
                     /gene_synonym="C130069N09Rik; Ebrt3; Mgrf; MrgE"
                     /note="major polyA site"
ORIGIN      
        1 gagctatcct ggttttctcc aagtaccagg cttgccagga agactgcagg aaggagctgg
       61 ctacctcctg ctatccacac ctgagcagaa gctgaaccca gcttgcaaac aaggtcccta
      121 gagaggctat ttcctgacca gccctatccc ctccgacacc atgtgacact gaggagccag
      181 ccggctgacg cggagtctga gcgcctgcct gcagcccggc agctccggca gcagctggag
      241 cctccgcctg gccaggaatt tcctggctag tttctccaag acccggggtg gagcagggag
      301 aagcagaacg gggtgtccgg agagagaaaa cgcaacacag acttctgcag acatcagcca
      361 tgacgtccct gagcgtgcac acagattctc ccagcaccca gggagaaatg gctttcaacc
      421 tgaccatcct gtccctcaca gagctcctca gcctgggcgg gctgctgggc aatggagtgg
      481 ccctctggct gctcaaccaa aatgtctaca ggaacccctt ctccatctat ctcttggatg
      541 tggcctgcgc cgacctcatc ttcctctgct gccacatggt ggccatcatc cctgagctgc
      601 tgcaggacca gctgaacttc cctgaatttg tacatatcag cctgaccatg ctgcggttct
      661 tctgctacat tgtgggcctg agcctcctgg cggccatcag cacggagcag tgcctggcca
      721 ctctcttccc tgcctggtac ctgtgccgcc gcccacgcta cctgaccacc tgtgtgtgtg
      781 cgctcatctg ggtgctctgc ctgctactgg acctgctgct gagcggcgcc tgcacccagt
      841 tctttggagc acccagctac cacctgtgtg acatgctgtg gctggtggtg gcagttctcc
      901 tggctgccct gtgctgcacc atgtgtgtga ccagcctgct cctgctgctg cgggtggagc
      961 gtggtccaga gagacaccag cctcggggct tccccaccct ggtcctgctg gccgtcctgc
     1021 tcttcctctt ctgcggcctg ccctttggca tcttctggct gtccaagaac ctgtcctggc
     1081 acatccccct ctacttctat catttcagct tcttcatggc cagtgtgcac agtgcagcca
     1141 agcctgccat ctactttttc ttgggcagca cacctggcca gaggtttcgg gaacccctcc
     1201 ggctggtgct ccagcgggca cttggagatg aggctgagct gggagctggg agagaggctt
     1261 cccaaggggg acttgtggac atgactgtct aagcacagtg ggtcacaact gcagcttcag
     1321 cccatggggg tccaggggag ctgcctgatg taggtaaagc tgggatcaga gctccatcag
     1381 taagactctt gagggacatc tttgctgatg acccagtgct gtgtcccctg ggaggattct
     1441 gggaaggggc aagcagagag tgatgcttct gtggagggcc tggggttgtg tgtgttaggc
     1501 agagctcctg gaccacctca taacagctgc ttccatggac accctccctc cccacatggc
     1561 tacagtgagg ggacagagca ggcatgagac aagctagtcc tggtgggggg caactgttct
     1621 tctaccacta gcatcctcct agctagagtg tgcagtgact tttctcggtg cccaatgctc
     1681 cttcctttag tgagggataa atgacactga aactggacat tcagttaggt atggggaaat
     1741 aagtggcttg gaagttctca gcggctgaac ttggaagtcc taagtggcag aaggcatcct
     1801 cctgacctca catcactgcc agaaggcaat gctggcacag gcctgtcatc ccagctactt
     1861 gagagactgg ggcaggattg tagccccaga ctgggattta tctgtaactc tagttccagg
     1921 ggatctgtct ccgtcttttg gcttctgcag acactgcatg catgtggtac acatacatac
     1981 atacatacat acatacatac atgcatgcat gcatgcatgc atacatacat acatacatgt
     2041 gtgtgactcc aaatacgcgc acgcgcacac gcgcgcgcgc gcacacacac acacacacac
     2101 acacacacca cacacacaca cacacacaca cacacacaca ccacacacac acacacacac
     2161 acacacacac acacacacag agagagagag agagagagag agagagagag agaatagaat
     2221 tcaaggtcag attatgcttt agaggactca tcatctcagg aaaccaagcc cagagggaac
     2281 tgtgttgagg agagagacca ctggaggata taaacctcat ccaatgtttc agaaaaactg
     2341 gtggctcctg agtctgaatt tcaaagtgag gtcctctgca tgggcagcaa gccccctcct
     2401 gtcgctgtcc atatccaaag cacctctacc tagcaggaga gagcccaggg cttcagcacc
     2461 aggacagttc ctaccttatc ctcttttcgg gataggacct acccacctag caggggttct
     2521 ctgaggaagc agcctggttg caggccacca caggtgcctg agctcctgcc tagccaggag
     2581 cacagaaatg aaggggacca ccccccaatc cagtcacagg tggccgagaa ccagggcttg
     2641 ggagcccacc agtcctgaaa ggacttacca tcatccatgt atcatagtcc taactcagcc
     2701 cttacctttc tacttcctca ctgaatagtc aattgattac acatacgcac agtgttgttg
     2761 tgtccagcaa gtcccaagag gattttatta catcatcaac cctccagatc cacattcgtg
     2821 acatgctggt ctcctttgac atctgtgtgg gtgtaatact gacttggacc aggcccacag
     2881 atggagggac atttgatctc tgtcatgact aaacttgctc ctaagtctgg acacggacag
     2941 aagaaccctg cctggcatcc cggaattggc aactcactgc ccccacccca cgcaggttgt
     3001 gttgggatgc atcctgtggt atggtgcctt catctcaaat tctctggcaa gtctatctac
     3061 atgcagggac cccaggaagc taggagcttg ggagtgctgg tcttcctctt ccaaaggagt
     3121 tctttgtatc ccccacaaag gccttccctc ctccacactg gagcttagga gccgatgtgg
     3181 ctatctgtct gcctccagga caggattccc aacttcagtt cctcagcttg gggaactgag
     3241 agcacgaagg gaagtagcct gtccacaagt ccaattttgg cctctggaca cccacttctt
     3301 catgggggaa agcccatgcc agccttacag gtgtctcccc aactgggcac tagcccagag
     3361 tctttgaggc tcagagaagc ccgtgtctgc tcgagacaac ccgggacatg gcacagacct
     3421 tctactcctc tcctagctag cttcagctgt tgacagggca tagtccagag ttatctgagg
     3481 gagtctcagc tagggaactg tttgggtcag gttggcctgt gtgcactgtc ctgactgcta
     3541 atacatgtgg gagagctcac tccactgtga gcagaaccac ccgtaggcaa atggacctga
     3601 gctatataaa aagctagcta agcatcagcc caggggcaag tcagtaggtg gctttcctcc
     3661 ttgcttcctg cctttactcc tgcttgagtt tctgccctga ctgccctcag tgatggacgg
     3721 tgacctggaa gtgtaagcca aataaagctt ttcctcctca aaaaaaaaaa aaaaaaa
//
