LOCUS       NM_203490               3117 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus MAS-related GPR, member D (Mrgprd), mRNA.
ACCESSION   NM_203490 XM_146172
VERSION     NM_203490.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3117)
  AUTHORS   Dey,S., Kovalenko,A. and Yaron,A.
  TITLE     Protocol for semiautomated analysis of sensory neuronal innervation
            of the mouse footpad skin
  JOURNAL   STAR Protoc 5 (4), 103312 (2024)
   PUBMED   39298322
REFERENCE   2  (bases 1 to 3117)
  AUTHORS   Cooper,A.H., Barry,A.M., Chrysostomidou,P., Lolignier,R., Wang,J.,
            Redondo Canales,M., Titterton,H.F., Bennett,D.L. and Weir,G.A.
  TITLE     Peripheral nerve injury results in a biased loss of sensory neuron
            subpopulations
  JOURNAL   Pain 165 (12), 2863-2876 (2024)
   PUBMED   39158319
REFERENCE   3  (bases 1 to 3117)
  AUTHORS   Jiang,H., Cui,H., Chen,M., Li,F., Shen,X., Guo,C.J., Hoekel,G.E.,
            Zhu,Y., Han,L., Wu,K., Holtzman,M.J. and Liu,Q.
  TITLE     Divergent sensory pathways of sneezing and coughing
  JOURNAL   Cell 187 (21), 5981-5997 (2024)
   PUBMED   39243765
REFERENCE   4  (bases 1 to 3117)
  AUTHORS   Zhu,Y., Meerschaert,K.A., Galvan-Pena,S., Bin,N.R., Yang,D.,
            Basu,H., Kawamoto,R., Shalaby,A., Liberles,S.D., Mathis,D.,
            Benoist,C. and Chiu,I.M.
  TITLE     A chemogenetic screen reveals that Trpv1-expressing neurons control
            regulatory T cells in the gut
  JOURNAL   Science 385 (6708), eadk1679 (2024)
   PUBMED   39088603
REFERENCE   5  (bases 1 to 3117)
  AUTHORS   Zhang,D., Turecek,J., Choi,S., Delisle,M., Pamplona,C.L.,
            Meltzer,S. and Ginty,D.D.
  TITLE     C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway
  JOURNAL   bioRxiv (2024)
   PUBMED   38915692
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3117)
  AUTHORS   Zylka,M.J., Rice,F.L. and Anderson,D.J.
  TITLE     Topographically distinct epidermal nociceptive circuits revealed by
            axonal tracers targeted to Mrgprd
  JOURNAL   Neuron 45 (1), 17-25 (2005)
   PUBMED   15629699
REFERENCE   7  (bases 1 to 3117)
  AUTHORS   Shinohara,T., Harada,M., Ogi,K., Maruyama,M., Fujii,R., Tanaka,H.,
            Fukusumi,S., Komatsu,H., Hosoya,M., Noguchi,Y., Watanabe,T.,
            Moriya,T., Itoh,Y. and Hinuma,S.
  TITLE     Identification of a G protein-coupled receptor specifically
            responsive to beta-alanine
  JOURNAL   J Biol Chem 279 (22), 23559-23564 (2004)
   PUBMED   15037633
REFERENCE   8  (bases 1 to 3117)
  AUTHORS   Zylka,M.J., Dong,X., Southwell,A.L. and Anderson,D.J.
  TITLE     Atypical expansion in mice of the sensory neuron-specific Mrg G
            protein-coupled receptor family
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 10043-10048 (2003)
   PUBMED   12909716
REFERENCE   9  (bases 1 to 3117)
  AUTHORS   Han,S.K., Dong,X., Hwang,J.I., Zylka,M.J., Anderson,D.J. and
            Simon,M.I.
  TITLE     Orphan G protein-coupled receptors MrgA1 and MrgC11 are
            distinctively activated by RF-amide-related peptides through the
            Galpha q/11 pathway
  JOURNAL   Proc Natl Acad Sci U S A 99 (23), 14740-14745 (2002)
   PUBMED   12397184
REFERENCE   10 (bases 1 to 3117)
  AUTHORS   Dong,X., Han,S., Zylka,M.J., Simon,M.I. and Anderson,D.J.
  TITLE     A diverse family of GPCRs expressed in specific subsets of
            nociceptive sensory neurons
  JOURNAL   Cell 106 (5), 619-632 (2001)
   PUBMED   11551509
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132081.3 and AC225443.3.
            
            On Aug 23, 2018 this sequence version replaced NM_203490.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY762266.1, BC137950.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-449               AC132081.3         144673-145121
            450-1840            AC132081.3         151230-152620
            1841-3117           AC225443.3         3985-5261
FEATURES             Location/Qualifiers
     source          1..3117
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 89.06 cM"
     gene            1..3117
                     /gene="Mrgprd"
                     /gene_synonym="Gm499; Mgrd; MrgD; TGR7"
                     /note="MAS-related GPR, member D"
                     /db_xref="GeneID:211578"
                     /db_xref="MGI:MGI:3033142"
     exon            1..449
                     /gene="Mrgprd"
                     /gene_synonym="Gm499; Mgrd; MrgD; TGR7"
                     /inference="alignment:Splign:2.1.0"
     exon            450..3117
                     /gene="Mrgprd"
                     /gene_synonym="Gm499; Mgrd; MrgD; TGR7"
                     /inference="alignment:Splign:2.1.0"
     CDS             452..1417
                     /gene="Mrgprd"
                     /gene_synonym="Gm499; Mgrd; MrgD; TGR7"
                     /note="beta-alanine receptor; G-protein coupled receptor
                     TGR7; G protein-coupled receptor MrgD; Mas-related G
                     protein-coupled receptor d"
                     /codon_start=1
                     /product="mas-related G-protein coupled receptor member D"
                     /protein_id="NP_987075.1"
                     /db_xref="CCDS:CCDS22057.1"
                     /db_xref="GeneID:211578"
                     /db_xref="MGI:MGI:3033142"
                     /translation="MNSTLDSSPAPGLTISPTMDLVTWIYFSVTFLAMATCVGGMAGN
                     SLVIWLLSCNGMQRSPFCVYVLNLAVADFLFLFCMASMLSLETGPLLIVNISAKIYEG
                     MRRIKYFAYTAGLSLLTAISTQRCLSVLFPIWYKCHRPRHLSSVVSGALWALAFLMNF
                     LASFFCVQFWHPNKHQCFKVDIVFNSLILGIFMPVMILTSTILFIRVRKNSLMQRRRP
                     RRLYVVILTSILVFLTCSLPLGINWFLLYWVDVKRDVRLLYSCVSRFSSSLSSSANPV
                     IYFLVGSQKSHRLQESLGAVLGRALRDEPEPEGRETPSTCTNDGV"
ORIGIN      
        1 attgagaagg gagaggctac caggatgatg ccagaaggag tggtccttgc tagaatcctc
       61 aaaagccccc agtatcaaag gaatctgggt ggggcaggag agggccatac tggggaggcc
      121 cattagtctt cagctaggct cctgtgggcg caggtctcca cagggtggac gggcatcttt
      181 ccggcactta tatctaggat tccttctcac acttctgaaa ggaagccaag gtccttgagg
      241 ggggtccccc aaatcaaggg ttctatgtgg ctgggagcag tagagacaga caggaccatc
      301 cttgcttagt ggaagagaca ctgagtcagg acctgcagaa gcagctgaga agcccaggcc
      361 tcacggtgct gctggaaaca cttctaggga tcacagccaa gagggatcac catctttgcg
      421 gaaggacaga ttggcacact caggagcagg aatgaactcc actcttgaca gcagcccagc
      481 tccaggtctg accatcagtc ccaccatgga ccttgtgacc tggatctact tttcagtgac
      541 attcctcgcc atggccacgt gtgtgggggg gatggcaggc aactcattgg tgatttggct
      601 cctgagctgc aatggcatgc agaggtctcc cttctgtgtc tatgtgctca acctggcggt
      661 ggctgacttc ctcttcttat tctgcatggc ctccatgctc agcctggaaa cagggcccct
      721 gctcatagtc aacatttctg ccaaaatcta tgaagggatg aggagaatca agtactttgc
      781 ctatacagca ggcctgagcc tgctgacagc catcagcacc cagcgctgcc tctccgtgct
      841 tttccccatc tggtataagt gccaccggcc ccggcacctg tcatcagtgg tatctggtgc
      901 actctgggca ctggccttcc tgatgaactt cctggcttct ttcttctgcg tccaattctg
      961 gcatcccaac aaacaccagt gcttcaaggt ggacattgtt ttcaacagtc ttatcctggg
     1021 gatcttcatg ccggtcatga tcctgaccag caccatcctc ttcatccggg tgcggaagaa
     1081 cagcctgatg cagagacggc ggccccggcg gctgtacgtg gtcatcctga cttccatcct
     1141 tgtcttcctc acctgttctc tgcccttggg catcaactgg ttcttactct actgggtgga
     1201 tgtgaaacgg gatgtgaggc tactttatag ctgcgtatca cgcttctctt cgtctttgag
     1261 cagcagtgcc aacccggtca tttacttcct cgtgggcagc cagaagagcc accggctgca
     1321 ggagtccctg ggtgctgtgc tggggcgggc actgcgggat gagcctgagc cagagggcag
     1381 agagacgcca tccacgtgta ctaatgatgg ggtctgaagg gagcccaacc aggaactcct
     1441 ccaaagcccc acccagccct tccctaaaag tacccagcaa gcctgcaatg caaaggcctt
     1501 gcacctcaaa atgtttgggt cacgttcctc tctgccaggg agggttcacc actatcacct
     1561 tgtgttccta atctaaacta agaggtgagg caatatatct ttctgtttta cctgtttaga
     1621 cacagatcct aactttgggt cccatcatgg gcaaggctgt ctgggaaatg gagtttccca
     1681 atggatagag catctcatgc aggttgaaac ggtttttccc accccccttg tctccctgag
     1741 atggcatctg tcctagtttc atttctgttg ctgtaacagg ttccctgaca aaaggtatca
     1801 caggggaaga agctgtttac ttggctcaca actacagatc atgacccatc atttcaggga
     1861 agtcaaggca taaatgtaag cagctagtga catcacacac aaagtcaaga acagaaagag
     1921 cacaaatgca taggtccatc ccctgcttgc ttgctctcag ctagcttatt acatcctctc
     1981 ttattctgct cacaattatc tgcctaggga atagtgttgc ccacagcggg ctggggcttc
     2041 ctgtgtcaat cgacagtcaa gacaatccct catagacacg cttacaagct aacctcaatt
     2101 cctcattgag gctcctttca tcccaagtga ttctaggttg tgtcaagttg acagttaaag
     2161 ctaaacagct tagcatattg gacctgggga tatactggta acatcattta gtgcacaaag
     2221 tagtgtctct gatgcacata tcaccgcacc tgcagcacat tgtgtgactt ttcctggcat
     2281 gacatgacac gcatcccaga tagggcacca atgaagacca aggaacaatc ccatccaatc
     2341 acagtctgat gaaacaatta acacacagaa gtgtggtcca ggggttactt atagagatgt
     2401 agttcagcat tacttacaga aatgtaggtg accctaaaac agacatgtca ctgataagtt
     2461 tctccccagc atggatgacc atttccagag gttctgtaga tgaagtgctc cccttactta
     2521 acctaccctt ctcttactag cacctcccta aaccatgaca agtgaagtgg ggttacatgc
     2581 atccaagagg aggtacaaga gaaagggaga gaagtctcta acccttacca ccctcctttc
     2641 ctaagggaat tcctgcaggc ttcattctga aagtctctgg tgcgaaatct gagctgctat
     2701 ctcactgtcc tcatcctcca cctgatccct gacccaccct cgggccctga cttggcctgt
     2761 ggggttcttt tgtacccctt gtcccctgag acatctgtgc cagttaacct tgtgacagga
     2821 gagggcagaa acacggtgag ccagaggttg ggaagagaga gggacagcac agaaagaggt
     2881 tgctgaacag gcaaagctct gcaggaggca ggcacagcat ggagcctgag tcaatagcct
     2941 tgcgttcctg cttcaggcca gctcctagaa gatctggagg cttctgcaca agccagtgtg
     3001 tcatgctcaa ggtgacagag atgctggtca ccccactgtg tgtacatata tcaaaattac
     3061 accttggacc ctataaacct gcatgattct tacatgttaa tagtaaatag taacaat
//
