LOCUS       NM_205795                966 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus MAS-related GPR, member B4 (Mrgprb4), mRNA.
ACCESSION   NM_205795 XM_145609
VERSION     NM_205795.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 966)
  AUTHORS   Xing,Y., Nho,Y., Lawson,K., Steele,H. and Han,L.
  TITLE     Regional Differences in Itch Transmission
  JOURNAL   J Invest Dermatol 144 (11), 2605-2608 (2024)
   PUBMED   38735364
REFERENCE   2  (bases 1 to 966)
  AUTHORS   Jiang,H., Cui,H., Chen,M., Li,F., Shen,X., Guo,C.J., Hoekel,G.E.,
            Zhu,Y., Han,L., Wu,K., Holtzman,M.J. and Liu,Q.
  TITLE     Divergent sensory pathways of sneezing and coughing
  JOURNAL   Cell 187 (21), 5981-5997 (2024)
   PUBMED   39243765
REFERENCE   3  (bases 1 to 966)
  AUTHORS   Zhang,D., Turecek,J., Choi,S., Delisle,M., Pamplona,C.L.,
            Meltzer,S. and Ginty,D.D.
  TITLE     C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway
  JOURNAL   bioRxiv (2024)
   PUBMED   38915692
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 966)
  AUTHORS   Wolfson,R.L., Abdelaziz,A., Rankin,G., Kushner,S., Qi,L., Mazor,O.,
            Choi,S., Sharma,N. and Ginty,D.D.
  TITLE     DRG afferents that mediate physiologic and pathologic
            mechanosensation from the distal colon
  JOURNAL   Cell 186 (16), 3368-3385 (2023)
   PUBMED   37541195
REFERENCE   5  (bases 1 to 966)
  AUTHORS   Elias,L.J., Succi,I.K., Schaffler,M.D., Foster,W., Gradwell,M.A.,
            Bohic,M., Fushiki,A., Upadhyay,A., Ejoh,L.L., Schwark,R.,
            Frazer,R., Bistis,B., Burke,J.E., Saltz,V., Boyce,J.E., Jhumka,A.,
            Costa,R.M., Abraira,V.E. and Abdus-Saboor,I.
  TITLE     Touch neurons underlying dopaminergic pleasurable touch and sexual
            receptivity
  JOURNAL   Cell 186 (3), 577-590 (2023)
   PUBMED   36693373
REFERENCE   6  (bases 1 to 966)
  AUTHORS   Luo,W., Wickramasinghe,S.R., Savitt,J.M., Griffin,J.W., Dawson,T.M.
            and Ginty,D.D.
  TITLE     A hierarchical NGF signaling cascade controls Ret-dependent and
            Ret-independent events during development of nonpeptidergic DRG
            neurons
  JOURNAL   Neuron 54 (5), 739-754 (2007)
   PUBMED   17553423
REFERENCE   7  (bases 1 to 966)
  AUTHORS   Chen,C.L., Broom,D.C., Liu,Y., de Nooij,J.C., Li,Z., Cen,C.,
            Samad,O.A., Jessell,T.M., Woolf,C.J. and Ma,Q.
  TITLE     Runx1 determines nociceptive sensory neuron phenotype and is
            required for thermal and neuropathic pain
  JOURNAL   Neuron 49 (3), 365-377 (2006)
   PUBMED   16446141
REFERENCE   8  (bases 1 to 966)
  AUTHORS   Zylka,M.J., Dong,X., Southwell,A.L. and Anderson,D.J.
  TITLE     Atypical expansion in mice of the sensory neuron-specific Mrg G
            protein-coupled receptor family
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 10043-10048 (2003)
   PUBMED   12909716
REFERENCE   9  (bases 1 to 966)
  AUTHORS   Han,S.K., Dong,X., Hwang,J.I., Zylka,M.J., Anderson,D.J. and
            Simon,M.I.
  TITLE     Orphan G protein-coupled receptors MrgA1 and MrgC11 are
            distinctively activated by RF-amide-related peptides through the
            Galpha q/11 pathway
  JOURNAL   Proc Natl Acad Sci U S A 99 (23), 14740-14745 (2002)
   PUBMED   12397184
REFERENCE   10 (bases 1 to 966)
  AUTHORS   Dong,X., Han,S., Zylka,M.J., Simon,M.I. and Anderson,D.J.
  TITLE     A diverse family of GPCRs expressed in specific subsets of
            nociceptive sensory neurons
  JOURNAL   Cell 106 (5), 619-632 (2001)
   PUBMED   11551509
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY042202.1.
            
            On Mar 22, 2004 this sequence version replaced XM_145609.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC107202.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..966
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 31.11 cM"
     gene            1..966
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="MAS-related GPR, member B4"
                     /db_xref="GeneID:233230"
                     /db_xref="MGI:MGI:3033119"
     CDS             1..966
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="MrgB4 G protein-coupled receptor"
                     /codon_start=1
                     /product="mas-related G-protein coupled receptor member
                     B4"
                     /protein_id="NP_991364.1"
                     /db_xref="CCDS:CCDS21301.1"
                     /db_xref="GeneID:233230"
                     /db_xref="MGI:MGI:3033119"
                     /translation="MGTTTLAWNINNTAENGSYTEMFSCITKFNTLNFLTVIIAVVGL
                     AGNGIVLWLLAFHLHRNAFSVYVLNLAGADFLYLFTQVVHSLECVLQLDNNSFYILLI
                     VTMFAYLAGLCMIAAISAERCLSVMWPIWYHCQRPRHTSAIMCALVWVSSLLLSLVVG
                     LGCGFLFSYYDYYFCITLNFITAAFLIVLSVVLSVSSLALLVKIVWGSHRIPVTRFFV
                     TIALTVVVFIYFGMPFGICWFLLSRIMEFDSIFFNNVYEIIEFLSCVNSCANPIIYFL
                     VGSIRQHRLRWQSLKLLLQRAMQDTPEEESGERGPSQRSGELETV"
     exon            1..966
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggtacaa ccaccctggc ctggaacatt aacaacaccg ctgaaaatgg aagttacact
       61 gaaatgttct cctgtatcac caagttcaat accctgaatt ttcttactgt catcatagct
      121 gtggttggcc tggcaggaaa cggcatagtg ctatggcttc tagccttcca cctgcatagg
      181 aatgccttct ctgtctatgt cctcaatctg gctggtgctg atttcttgta ccttttcact
      241 caagttgtgc attccctgga atgtgtcctt cagttagata ataactcctt ttatattctc
      301 ctcattgtaa caatgtttgc ttaccttgca ggtttgtgta tgattgcagc catcagtgct
      361 gaacgctgcc tatctgttat gtggcctatc tggtatcact gccaaagacc aagacacaca
      421 tcagccatca tgtgtgctct ggtctgggtt tcctctctat tgttgagcct cgtggtaggg
      481 ctaggctgtg gttttctgtt cagttattat gattattatt tctgtattac tttgaatttt
      541 atcactgctg catttttaat agtgttatct gtggttcttt ctgtatctag cctggccctg
      601 ttggtgaaga ttgtgtgggg gtcacacagg attcctgtga ccaggttctt tgtgaccatt
      661 gctctcacag tggtggtctt catatacttt ggcatgccct ttggtatctg ctggttcctc
      721 ttatcaagga ttatggagtt tgatagcatt ttctttaaca atgtttatga aataatagaa
      781 ttcctgtcct gtgttaacag ctgtgccaat cccatcattt acttccttgt tggctccatt
      841 agacaacaca ggttgcgatg gcagtctctg aagctacttc ttcagagagc catgcaggac
      901 actcctgagg aagagagtgg agagaggggt ccttcgcaaa ggtctgggga actggaaaca
      961 gtctag
//
