LOCUS       NM_175531               2089 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus MAS-related GPR, member B2 (Mrgprb2), mRNA.
ACCESSION   NM_175531
VERSION     NM_175531.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2089)
  AUTHORS   Son,H., Zhang,Y., Shannonhouse,J., Gomez,R. and Kim,Y.S.
  TITLE     PACAP38/mast-cell-specific receptor axis mediates repetitive
            stress-induced headache in mice
  JOURNAL   J Headache Pain 25 (1), 87 (2024)
   PUBMED   38802819
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2089)
  AUTHORS   Ji,Z., Li,J., Tao,S., Li,H., Kong,X., Huang,B., Feng,Z., Wei,X.,
            Zheng,Z., Chen,J., Chen,B., Liu,J. and Zhao,F.
  TITLE     Mrgprb2-mediated mast cell activation exacerbates Modic changes by
            regulating immune niches
  JOURNAL   Exp Mol Med 56 (5), 1178-1192 (2024)
   PUBMED   38689089
  REMARK    GeneRIF: Mrgprb2-mediated mast cell activation exacerbates Modic
            changes by regulating immune niches.
REFERENCE   3  (bases 1 to 2089)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2089)
  AUTHORS   Shao,Y., Xiao,Z., Jin,Y., Zhu,Y., Shen,Y., Jin,T., Tang,H. and
            Wang,D.
  TITLE     New insight into prurigo nodularis: Proadrenomedullin N-terminal 20
            peptide mediates mouse mast cell activation via Mrgprb2
  JOURNAL   Skin Res Technol 30 (2), e13588 (2024)
   PUBMED   38284237
  REMARK    GeneRIF: New insight into prurigo nodularis: Proadrenomedullin
            N-terminal 20 peptide mediates mouse mast cell activation via
            Mrgprb2.
REFERENCE   5  (bases 1 to 2089)
  AUTHORS   Al Hamwi,G., Namasivayam,V., Buschbell,B., Gedschold,R., Golz,S.
            and Muller,C.E.
  TITLE     Proinflammatory chemokine CXCL14 activates MAS-related G
            protein-coupled receptor MRGPRX2 and its putative mouse ortholog
            MRGPRB2
  JOURNAL   Commun Biol 7 (1), 52 (2024)
   PUBMED   38184723
  REMARK    GeneRIF: Proinflammatory chemokine CXCL14 activates MAS-related G
            protein-coupled receptor MRGPRX2 and its putative mouse ortholog
            MRGPRB2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2089)
  AUTHORS   Liu,R., Che,D., Zhao,T., Pundir,P., Cao,J., Lv,Y., Wang,J., Ma,P.,
            Fu,J., Wang,N., Wang,X., Zhang,T., Dong,X. and He,L.
  TITLE     MRGPRX2 is essential for sinomenine hydrochloride induced
            anaphylactoid reactions
  JOURNAL   Biochem Pharmacol 146, 214-223 (2017)
   PUBMED   28987593
REFERENCE   7  (bases 1 to 2089)
  AUTHORS   Gaudenzio,N., Sibilano,R., Marichal,T., Starkl,P., Reber,L.L.,
            Cenac,N., McNeil,B.D., Dong,X., Hernandez,J.D., Sagi-Eisenberg,R.,
            Hammel,I., Roers,A., Valitutti,S., Tsai,M., Espinosa,E. and
            Galli,S.J.
  TITLE     Different activation signals induce distinct mast cell
            degranulation strategies
  JOURNAL   J Clin Invest 126 (10), 3981-3998 (2016)
   PUBMED   27643442
REFERENCE   8  (bases 1 to 2089)
  AUTHORS   McNeil,B.D., Pundir,P., Meeker,S., Han,L., Undem,B.J., Kulka,M. and
            Dong,X.
  TITLE     Identification of a mast-cell-specific receptor crucial for
            pseudo-allergic drug reactions
  JOURNAL   Nature 519 (7542), 237-241 (2015)
   PUBMED   25517090
  REMARK    GeneRIF: basic secretagogues activate mouse mast cells in vitro and
            in vivo through a single receptor, Mrgprb2, the orthologue of the
            human G-protein-coupled receptor MRGPRX2
REFERENCE   9  (bases 1 to 2089)
  AUTHORS   Premzl,M.
  TITLE     Comparative genomic analysis of eutherian Mas-related G
            protein-coupled receptor genes
  JOURNAL   Gene 540 (1), 16-19 (2014)
   PUBMED   24583173
REFERENCE   10 (bases 1 to 2089)
  AUTHORS   Dong,X., Han,S., Zylka,M.J., Simon,M.I. and Anderson,D.J.
  TITLE     A diverse family of GPCRs expressed in specific subsets of
            nociceptive sensory neurons
  JOURNAL   Cell 106 (5), 619-632 (2001)
   PUBMED   11551509
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029369.1, BC107391.2 and BX519265.1.
            
            On May 1, 2009 this sequence version replaced NM_175531.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029369.1, BC107391.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AK029369.1         2-148
            148-852             BC107391.2         146-850
            853-2074            AK029369.1         854-2075
            2075-2089           BX519265.1         349-363
FEATURES             Location/Qualifiers
     source          1..2089
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 31.11 cM"
     gene            1..2089
                     /gene="Mrgprb2"
                     /gene_synonym="4833406I20Rik; Mgrg14"
                     /note="MAS-related GPR, member B2"
                     /db_xref="GeneID:243979"
                     /db_xref="MGI:MGI:2441674"
     exon            1..62
                     /gene="Mrgprb2"
                     /gene_synonym="4833406I20Rik; Mgrg14"
                     /inference="alignment:Splign:2.1.0"
     exon            63..2077
                     /gene="Mrgprb2"
                     /gene_synonym="4833406I20Rik; Mgrg14"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1083
                     /gene="Mrgprb2"
                     /gene_synonym="4833406I20Rik; Mgrg14"
                     /note="Mas-related G protein-coupled receptor g14"
                     /codon_start=1
                     /product="mas-related G-protein coupled receptor member
                     B2"
                     /protein_id="NP_780740.2"
                     /db_xref="CCDS:CCDS21303.1"
                     /db_xref="GeneID:243979"
                     /db_xref="MGI:MGI:2441674"
                     /translation="MSGDFLIKNLSTSAWKTNITVLNGSYYIDTSVCVTRNQAMILLS
                     IIISLVGMGLNAIVLWFLGIRMHTNAFTVYILNLAMADFLYLCSQFVICLLIAFYIFY
                     SIDINIPLVLYVVPIFAYLSGLSILSTISIERCLSVIWPIWYRCKRPRHTSAITCFVL
                     WVMSLLLGLLEGKACGLLFNSFDSYWCETFDVITNIWSVVFFGVLCGSSLTLLVRIFC
                     GSQRIPMTRLYVTITLTVLVFLIFGLPFGIYWILYQWISNFYYVEICNFYLEILFLSC
                     VNSCMNPIIYFLVGSIRHRRFRRKTLKLLLQRAMQDTPEEEQSGNKSSSEHPEELETV
                     QSCS"
     regulatory      2058..2063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrgprb2"
                     /gene_synonym="4833406I20Rik; Mgrg14"
                     /note="hexamer: ATTAAA"
     polyA_site      2077
                     /gene="Mrgprb2"
                     /gene_synonym="4833406I20Rik; Mgrg14"
                     /note="major polyA site"
ORIGIN      
        1 agaggactct tctctttgtc acagaccagt ttaacacttc ccataagaag aatagagcaa
       61 aggaacatga gtggagattt cctaatcaag aatctaagca cctcagcctg gaaaacgaac
      121 atcacagtgc tgaatggaag ctactacatc gatacttcag tttgtgtcac caggaaccaa
      181 gccatgattt tgctttccat catcatttcc ctggttggga tgggactaaa tgccatagtg
      241 ctgtggttcc tgggcatccg tatgcacacg aatgccttca ctgtctacat tctcaacctg
      301 gctatggctg actttcttta cctgtgctct cagtttgtaa tttgtcttct tattgccttt
      361 tatatcttct actcaattga catcaacatc cctttggttc tttatgttgt gccaatattt
      421 gcttatcttt caggtctgag cattctcagc accattagca ttgagcgctg cttgtctgta
      481 atatggccca tttggtatcg ctgtaaacgt ccaagacaca catcagctat cacatgtttt
      541 gtgctttggg ttatgtcctt attgttgggt ctcctggaag ggaaggcatg tggcttactg
      601 tttaatagct ttgactctta ttggtgtgaa acatttgatg ttatcactaa tatatggtca
      661 gttgtttttt ttggtgttct ctgtgggtct agcctcaccc tgcttgtcag gatcttctgt
      721 ggctcacagc gaattcctat gaccaggctg tatgtgacta ttacactcac agtcttggtc
      781 ttcctgatct ttggtcttcc ctttgggatc tattggatac tctatcagtg gattagcaat
      841 ttttattatg ttgaaatttg taatttttat cttgagatac tattcctatc ctgtgttaac
      901 agctgtatga accccatcat ttatttcctt gttggctcca ttaggcaccg aaggttcagg
      961 cggaagactc tcaagctact tctgcagaga gccatgcaag acacccctga ggaggaacaa
     1021 agtggaaata agagttcttc agaacaccct gaagaactgg aaactgttca gagctgcagc
     1081 tgacaactgc ttgatcagac aaaaatggtt ttgatggaaa tactttttct tatccgtgtg
     1141 gaccattttt acaaccttta ttcagtttgt tatctcatct tcaattgttt aattaggaca
     1201 ataatttttg taaaagttga gagaaatggg tcttgtcata ctaatactga atgtagcatt
     1261 tctgaagctg tgttacttag ggatttacca tctccttttc atgggactcc ttgtaagtat
     1321 tctgtggtag agaacttctc ctattgttga caaactctcc tttagaaggc aaatggaaat
     1381 acaaggaagg gctgtatttc tttacccact gaaatgtata atgagtacac aaatgttaca
     1441 tctagcaaat attcttttag aacacccttc tcaatgttta agacttaaat agaaacactt
     1501 tataatccta gtccttatta atttcttcag gttataaaga atatatgaag tgatagtttt
     1561 tttacgtaaa ttttttacta aacaaataaa atttctcaaa agaagactgt taaatctctc
     1621 ttaacccagc tgagtcctca ctgtgaacat caagttcact gtgtctctaa tttttaaaat
     1681 ttgaagagtg cacttagatt tggcaatgag atccatcaaa atccatgtcc acatgaaggt
     1741 gaagagagtc agacttctgt gtttctcttc acaatgcctt ctttagcatt ccatggtcga
     1801 gtgttttccc tttactccct gcctttgctg tgatttctgc tctctctgac tgtctaattc
     1861 ttcatgagaa gtttccacta ggtcctctag acaatcctgt ctcaaattta aatcaccctc
     1921 agataattta ttatgtgaat ttgttacttg cattgataac aatcattgta attgaatatg
     1981 aatatttttt gtaacacttt ctataaaata atatttgttt ttaagctgta ctatgtgata
     2041 ttttcagttg aagcataatt aaaagagttc aaccaaaaaa aaaaaaaaa
//
