LOCUS       NM_153067               1295 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus MAS-related GPR, member A3 (Mrgpra3), mRNA.
ACCESSION   NM_153067
VERSION     NM_153067.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1295)
  AUTHORS   Cao,Z., Huang,C., Lu,F., Jiang,X., Hu,Y., Cao,C. and Liu,Z.
  TITLE     Meis1 Regulates Nociceptor Development and Behavioral Response to
            Tactile Stimuli
  JOURNAL   Front Mol Neurosci 15, 901466 (2022)
   PUBMED   35875660
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1295)
  AUTHORS   Grundy,L., Caldwell,A., Garcia-Caraballo,S., Grundy,D.,
            Spencer,N.J., Dong,X., Castro,J., Harrington,A.M. and Brierley,S.M.
  TITLE     Activation of MrgprA3 and MrgprC11 on Bladder-Innervating Afferents
            Induces Peripheral and Central Hypersensitivity to Bladder
            Distension
  JOURNAL   J Neurosci 41 (17), 3900-3916 (2021)
   PUBMED   33727332
  REMARK    GeneRIF: Activation of MrgprA3 and MrgprC11 on Bladder-Innervating
            Afferents Induces Peripheral and Central Hypersensitivity to
            Bladder Distension.
REFERENCE   3  (bases 1 to 1295)
  AUTHORS   Xing,Y., Chen,J., Hilley,H., Steele,H., Yang,J. and Han,L.
  TITLE     Molecular Signature of Pruriceptive MrgprA3+ Neurons
  JOURNAL   J Invest Dermatol 140 (10), 2041-2050 (2020)
   PUBMED   32234460
  REMARK    GeneRIF: Molecular Signature of Pruriceptive MrgprA3(+) Neurons.
REFERENCE   4  (bases 1 to 1295)
  AUTHORS   Shi,H., Yu,G., Geng,X., Gu,L., Yang,N., Wang,C., Zhu,C., Yang,Y.,
            Yu,L., Hu,D., Yuan,X., Lan,L., Wu,G. and Tang,Z.
  TITLE     MrgprA3 shows sensitization to chloroquine in an
            acetone-ether-water mice model
  JOURNAL   Neuroreport 28 (17), 1127-1133 (2017)
   PUBMED   29064954
  REMARK    GeneRIF: Results showed that the scratching bouts induced by
            chloroquine increased significantly under the acetone-ether-water
            (AEW) chronic pruritus; the density of MrgprA3 sensory fibers in
            the AEW-treated skin area and the number of MrgprA3 neurons in
            dorsal root ganglia from the AEW model mice also increased
            significantly. Further analysis showed that the MrgprA3 in mRNA
            level was also increased after AEW treatment.
REFERENCE   5  (bases 1 to 1295)
  AUTHORS   Chen,Z., Donnelly,C.R., Dominguez,B., Harada,Y., Lin,W.,
            Halim,A.S., Bengoechea,T.G., Pierchala,B.A. and Lee,K.F.
  TITLE     p75 Is Required for the Establishment of Postnatal Sensory Neuron
            Diversity by Potentiating Ret Signaling
  JOURNAL   Cell Rep 21 (3), 707-720 (2017)
   PUBMED   29045838
REFERENCE   6  (bases 1 to 1295)
  AUTHORS   Liu,Q., Tang,Z., Surdenikova,L., Kim,S., Patel,K.N., Kim,A., Ru,F.,
            Guan,Y., Weng,H.J., Geng,Y., Undem,B.J., Kollarik,M., Chen,Z.F.,
            Anderson,D.J. and Dong,X.
  TITLE     Sensory neuron-specific GPCR Mrgprs are itch receptors mediating
            chloroquine-induced pruritus
  JOURNAL   Cell 139 (7), 1353-1365 (2009)
   PUBMED   20004959
REFERENCE   7  (bases 1 to 1295)
  AUTHORS   Luo,W., Wickramasinghe,S.R., Savitt,J.M., Griffin,J.W., Dawson,T.M.
            and Ginty,D.D.
  TITLE     A hierarchical NGF signaling cascade controls Ret-dependent and
            Ret-independent events during development of nonpeptidergic DRG
            neurons
  JOURNAL   Neuron 54 (5), 739-754 (2007)
   PUBMED   17553423
REFERENCE   8  (bases 1 to 1295)
  AUTHORS   Zylka,M.J., Dong,X., Southwell,A.L. and Anderson,D.J.
  TITLE     Atypical expansion in mice of the sensory neuron-specific Mrg G
            protein-coupled receptor family
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 10043-10048 (2003)
   PUBMED   12909716
REFERENCE   9  (bases 1 to 1295)
  AUTHORS   Han,S.K., Dong,X., Hwang,J.I., Zylka,M.J., Anderson,D.J. and
            Simon,M.I.
  TITLE     Orphan G protein-coupled receptors MrgA1 and MrgC11 are
            distinctively activated by RF-amide-related peptides through the
            Galpha q/11 pathway
  JOURNAL   Proc Natl Acad Sci U S A 99 (23), 14740-14745 (2002)
   PUBMED   12397184
REFERENCE   10 (bases 1 to 1295)
  AUTHORS   Dong,X., Han,S., Zylka,M.J., Simon,M.I. and Anderson,D.J.
  TITLE     A diverse family of GPCRs expressed in specific subsets of
            nociceptive sensory neurons
  JOURNAL   Cell 106 (5), 619-632 (2001)
   PUBMED   11551509
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY042193.1.
            
            On Apr 27, 2010 this sequence version replaced NM_153067.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY042193.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1295              AY042193.1         16-1310
FEATURES             Location/Qualifiers
     source          1..1295
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 30.91 cM"
     gene            1..1295
                     /gene="Mrgpra3"
                     /gene_synonym="Mrga3"
                     /note="MAS-related GPR, member A3"
                     /db_xref="GeneID:233222"
                     /db_xref="MGI:MGI:2684085"
     exon            1..79
                     /gene="Mrgpra3"
                     /gene_synonym="Mrga3"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1058
                     /gene="Mrgpra3"
                     /gene_synonym="Mrga3"
                     /note="Mas-related gene A3; G protein-coupled receptor
                     MRGA3"
                     /codon_start=1
                     /product="mas-related G-protein coupled receptor member
                     A3"
                     /protein_id="NP_694707.2"
                     /db_xref="CCDS:CCDS21297.2"
                     /db_xref="GeneID:233222"
                     /db_xref="MGI:MGI:2684085"
                     /translation="MGESNTSAGFLARNTSASTMTPTTTNSMNETIPGSIDIETLIPD
                     LMIIIFGLVGLTGNAIVFWLLGFRMHRTAFLVYILNLALADFLFLLCHIINSTVDLLK
                     FTLPKGIFAFCFHTIKRVLYITGLSMLSAISTERCLSVLCPIWYHCRRPEHTSTVMCA
                     VIWVLSLLICILDGYFCGYLDNHYFNYSVCQAWDIFIGAYLMFLFVVLCLSTLALLAR
                     LFCGARNMKFTRLFVTIMLTVLVFLLCGLPWGITWFLLFWIAPGVFVLDYSPLLVLTA
                     INSCANPIIYFFVGSFRQRLNKQTLKMVLQKALQDTPETPENMVEMSRNKAEP"
     exon            80..1295
                     /gene="Mrgpra3"
                     /gene_synonym="Mrga3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagaaatatt ctgtagtgac tgtatccttc cttctacaca agccagcaag ctacatccag
       61 caagaggaat gggagaaagc aacaccagtg cagggtttct ggcccgaaac acctcagcct
      121 cgacaatgac acccacaaca acaaattcaa tgaacgaaac catccctgga agtattgaca
      181 tcgagaccct gatcccagac ttgatgatca tcatcttcgg actggtcggg ctgacaggaa
      241 atgcgattgt gttctggctc cttggcttcc gcatgcacag gactgccttc ttagtctaca
      301 tcctaaactt ggccctggct gacttcctct tccttctctg tcacatcata aattccacag
      361 tggatcttct caagtttacc ctacccaaag gaatttttgc cttttgtttt cacactatca
      421 aaagggttct ctatatcaca ggcctgagca tgctcagtgc catcagcact gagcgctgcc
      481 tgtctgtcct gtgccccatc tggtatcact gccgccgccc agaacacaca tcaactgtca
      541 tgtgtgctgt gatctgggtc ctgtccctgt tgatctgcat tctggatggt tatttctgcg
      601 gttacttaga taaccattat ttcaattact ctgtgtgtca ggcatgggac atctttatcg
      661 gagcatacct gatgtttttg tttgtagtcc tctgtctgtc caccctggct ctactggcca
      721 ggttgttctg tggtgctagg aatatgaaat ttaccagatt attcgtgacc atcatgctga
      781 ccgttttggt ttttcttctc tgtgggttgc cctggggcat cacctggttc ctgttattct
      841 ggattgcacc tggtgtgttt gtactagatt atagccctct tctggtccta actgctatta
      901 acagctgtgc caaccccatt atttacttct tcgtgggctc cttcaggcaa cggttgaata
      961 aacagaccct caaaatggtt ctccagaaag ccctgcagga cactcctgag acacctgaaa
     1021 acatggtgga gatgtcaaga aacaaagcag agccgtgatg aagagcctct gcctagactt
     1081 cagaggtgga tttggagtga gcactgccct gctgcacttg accactgtcc actctcctct
     1141 cagcttactg acttgacatg cctcactggt ccaccaacac cttccaaagc tctccactga
     1201 cttagtattt atacctctcc caaacaatag cattattcaa aaactataat ttctgcatcc
     1261 ttctttacat taataaaatt cccatactaa gttca
//
