LOCUS       NM_001382001            1263 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Mus musculus MAS-related GPR, member A2B (Mrgpra2b), transcript
            variant 1, mRNA.
ACCESSION   NM_001382001 XM_006540858
VERSION     NM_001382001.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1263)
  AUTHORS   Dong,X., Limjunyawong,N., Sypek,E.I., Wang,G., Ortines,R.V.,
            Youn,C., Alphonse,M.P., Dikeman,D., Wang,Y., Lay,M., Kothari,R.,
            Vasavda,C., Pundir,P., Goff,L., Miller,L.S., Lu,W., Garza,L.A.,
            Kim,B.S., Archer,N.K. and Dong,X.
  TITLE     Keratinocyte-derived defensins activate neutrophil-specific
            receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial
            infection
  JOURNAL   Immunity 55 (9), 1645-1662 (2022)
   PUBMED   35882236
  REMARK    GeneRIF: Keratinocyte-derived defensins activate
            neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis
            and bacterial infection.
REFERENCE   2  (bases 1 to 1263)
  AUTHORS   Callera,G.E., Antunes,T.T., Correa,J.W., Moorman,D., Gutsol,A.,
            He,Y., Cat,A.N., Briones,A.M., Montezano,A.C., Burns,K.D. and
            Touyz,R.M.
  TITLE     Differential renal effects of candesartan at high and ultra-high
            doses in diabetic mice-potential role of the ACE2/AT2R/Mas axis
  JOURNAL   Biosci Rep 36 (5), e00398 (2016)
   PUBMED   27612496
  REMARK    GeneRIF: Ultra-high doses did not influence the ACE2/AT2R/Mas axis
            and promoted renal injury with increased renal ERK1/2 activation
            and exaggerated fibronectin expression in db/db mice. Our study
            demonstrates dose-related effects of candesartan in diabetic
            nephropathy: intermediate-high dose candesartan is renoprotective,
            whereas ultra-high dose candesartan induces renal damage.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1263)
  AUTHORS   Guan,Y., Liu,Q., Tang,Z., Raja,S.N., Anderson,D.J. and Dong,X.
  TITLE     Mas-related G-protein-coupled receptors inhibit pathological pain
            in mice
  JOURNAL   Proc Natl Acad Sci U S A 107 (36), 15933-15938 (2010)
   PUBMED   20724664
  REMARK    GeneRIF: data suggest that members of the Mrgpr family, in
            particular MrgprC11, may constitute an endogenous inhibitory
            mechanism for regulating persistent pain in mice
REFERENCE   4  (bases 1 to 1263)
  AUTHORS   Santos,S.H., Fernandes,L.R., Mario,E.G., Ferreira,A.V., Porto,L.C.,
            Alvarez-Leite,J.I., Botion,L.M., Bader,M., Alenina,N. and
            Santos,R.A.
  TITLE     Mas deficiency in FVB/N mice produces marked changes in lipid and
            glycemic metabolism
  JOURNAL   Diabetes 57 (2), 340-347 (2008)
   PUBMED   18025412
  REMARK    GeneRIF: Mas deficiency in FVB/N mice leads to dramatic changes in
            glucose and lipid metabolisms, inducing a metabolic syndrome-like
            state.
REFERENCE   5  (bases 1 to 1263)
  AUTHORS   Bowman,T.V., McCooey,A.J., Merchant,A.A., Ramos,C.A., Fonseca,P.,
            Poindexter,A., Bradfute,S.B., Oliveira,D.M., Green,R., Zheng,Y.,
            Jackson,K.A., Chambers,S.M., McKinney-Freeman,S.L., Norwood,K.G.,
            Darlington,G., Gunaratne,P.H., Steffen,D. and Goodell,M.A.
  TITLE     Differential mRNA processing in hematopoietic stem cells
  JOURNAL   Stem Cells 24 (3), 662-670 (2006)
   PUBMED   16373690
REFERENCE   6  (bases 1 to 1263)
  AUTHORS   Zylka,M.J., Dong,X., Southwell,A.L. and Anderson,D.J.
  TITLE     Atypical expansion in mice of the sensory neuron-specific Mrg G
            protein-coupled receptor family
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 10043-10048 (2003)
   PUBMED   12909716
REFERENCE   7  (bases 1 to 1263)
  AUTHORS   Santos,R.A., Simoes e Silva,A.C., Maric,C., Silva,D.M.,
            Machado,R.P., de Buhr,I., Heringer-Walther,S., Pinheiro,S.V.,
            Lopes,M.T., Bader,M., Mendes,E.P., Lemos,V.S.,
            Campagnole-Santos,M.J., Schultheiss,H.P., Speth,R. and Walther,T.
  TITLE     Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled
            receptor Mas
  JOURNAL   Proc Natl Acad Sci U S A 100 (14), 8258-8263 (2003)
   PUBMED   12829792
  REMARK    GeneRIF: Deletion of the Mas protooncogene abolishes the binding of
            Ang-(1-7) to mouse kidneys. Mas is a functional receptor for
            Ang-(1-7)
REFERENCE   8  (bases 1 to 1263)
  AUTHORS   Han,S.K., Dong,X., Hwang,J.I., Zylka,M.J., Anderson,D.J. and
            Simon,M.I.
  TITLE     Orphan G protein-coupled receptors MrgA1 and MrgC11 are
            distinctively activated by RF-amide-related peptides through the
            Galpha q/11 pathway
  JOURNAL   Proc Natl Acad Sci U S A 99 (23), 14740-14745 (2002)
   PUBMED   12397184
REFERENCE   9  (bases 1 to 1263)
  AUTHORS   Dong,X., Han,S., Zylka,M.J., Simon,M.I. and Anderson,D.J.
  TITLE     A diverse family of GPCRs expressed in specific subsets of
            nociceptive sensory neurons
  JOURNAL   Cell 106 (5), 619-632 (2001)
   PUBMED   11551509
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138678.24.
            
            On Apr 22, 2020 this sequence version replaced XM_006540858.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164135,
                              SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AC138678.24        101523-101617
            96-1263             AC138678.24        126131-127298
FEATURES             Location/Qualifiers
     source          1..1263
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 30.86 cM"
     gene            1..1263
                     /gene="Mrgpra2b"
                     /gene_synonym="MrgA2; Mrgpra2"
                     /note="MAS-related GPR, member A2B"
                     /db_xref="GeneID:235712"
                     /db_xref="MGI:MGI:3033098"
     exon            1..95
                     /gene="Mrgpra2b"
                     /gene_synonym="MrgA2; Mrgpra2"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1083
                     /gene="Mrgpra2b"
                     /gene_synonym="MrgA2; Mrgpra2"
                     /note="isoform 1 is encoded by transcript variant 1; G
                     protein-coupled receptor MrgA2; MAS-related GPR, member
                     A2; mas-related G-protein coupled receptor member A2;
                     Mas-related gene A2; mas-related G-protein coupled
                     receptor member A2B"
                     /codon_start=1
                     /product="mas-related G-protein coupled receptor member
                     A2B isoform 1"
                     /protein_id="NP_001368930.1"
                     /db_xref="GeneID:235712"
                     /db_xref="MGI:MGI:3033098"
                     /translation="MGESSNGEAFLAFKTSASPTAPVTTNPMDETLPGSINIRILIPK
                     LMIIIFGLVGLMGNAIVFWLLGFHLRRNAFSVYILNLALADFLFLLSSIIASTLFLLK
                     VSYLSIIFHLCFNTIMMVVYITGISMLSAISTECCLSVLCPTWYRCHRPVHTSTVMCA
                     VIWVLSLLICILNSYFCAVLHTRYDNDNECLATNIFTASYMIFLLVVLCLSSLALLAR
                     LFCGAGQMKLTRFHVTILLTLLVFLLCGLPFVIYCILLFKIKDDFHVLDVNLYLALEV
                     LTAINSCANPIIYFFVGSFRHQLKHQTLKMVLQSALQDTPETAENMVEMSSNKAEP"
     exon            96..1263
                     /gene="Mrgpra2b"
                     /gene_synonym="MrgA2; Mrgpra2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacttctcc agagcaaacg aatatcctgt agtaactgta gttttcctcc tacacaagcc
       61 agcaagctat atccagcaag aggaatgggg gaaagcagca atggtgaagc atttcttgcc
      121 tttaagacct cagcctcacc aacagcacca gtgacaacaa atccaatgga cgaaaccctc
      181 cctggaagta tcaacattag gattctgatc ccaaaattga tgatcatcat cttcggactg
      241 gtcggactga tgggaaacgc cattgtgttc tggctcctgg gcttccactt gcgcaggaat
      301 gccttctcag tctacatcct aaacttggcc ctggctgact tccttttcct cctcagtagt
      361 atcatagctt ccaccctgtt tcttctcaaa gtttcctacc tcagcatcat ctttcacttg
      421 tgctttaaca ccattatgat ggttgtctac atcacaggga taagcatgct cagtgccatc
      481 agcactgagt gctgcctgtc tgtcctgtgc cccacctggt atcgctgcca ccgtccagta
      541 catacatcaa ctgtcatgtg tgctgtgatc tgggtcctat ccctgttgat ctgcattctg
      601 aatagctatt tctgtgctgt cttacatacc agatatgata atgacaatga gtgtctggca
      661 actaacatct ttaccgcctc gtacatgata tttttgcttg tggtcctctg tctgtccagc
      721 ctggctctgc tggccaggtt gttctgtggc gctgggcaga tgaagcttac cagatttcat
      781 gtgaccatct tgctgaccct tttggttttt ctcctctgcg ggttgccctt tgtcatctac
      841 tgcatcctgt tattcaagat taaggatgat ttccatgtat tagatgttaa tctttatcta
      901 gcattagaag tcctgactgc tattaacagc tgtgccaacc ccatcatcta cttcttcgtg
      961 ggctctttca gacatcagtt gaagcaccag accctcaaaa tggttctcca gagtgcactg
     1021 caggacactc ctgagacagc tgaaaacatg gtagagatgt caagtaacaa agcagagcct
     1081 tgatgaagag cctctacctg gacctcagag gtggctttgg agtgagcact gccctgctgc
     1141 acttgaccac tgtccactct tctctcagct tactgatttg acatgcctca gtggtccacc
     1201 aacaacttca acatctctcc actaacttag tttttctacc cctcctgaat aaaagcatta
     1261 atc
//
