LOCUS       NM_001384209            1271 bp    mRNA    linear   ROD 07-APR-2024
DEFINITION  Mus musculus MAS-related GPR, member A2A (Mrgpra2a), transcript
            variant 1, mRNA.
ACCESSION   NM_001384209 XM_006541100
VERSION     NM_001384209.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1271)
  AUTHORS   Dong,X., Limjunyawong,N., Sypek,E.I., Wang,G., Ortines,R.V.,
            Youn,C., Alphonse,M.P., Dikeman,D., Wang,Y., Lay,M., Kothari,R.,
            Vasavda,C., Pundir,P., Goff,L., Miller,L.S., Lu,W., Garza,L.A.,
            Kim,B.S., Archer,N.K. and Dong,X.
  TITLE     Keratinocyte-derived defensins activate neutrophil-specific
            receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial
            infection
  JOURNAL   Immunity 55 (9), 1645-1662 (2022)
   PUBMED   35882236
  REMARK    GeneRIF: Keratinocyte-derived defensins activate
            neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis
            and bacterial infection.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138678.24.
            
            On Jun 8, 2020 this sequence version replaced XM_006541100.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164135,
                              SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AC138678.24        138941-139035
            96-1271             AC138678.24        163605-164780
FEATURES             Location/Qualifiers
     source          1..1271
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 30.84 cM"
     gene            1..1271
                     /gene="Mrgpra2a"
                     /gene_synonym="Mrga2; Mrgpra2"
                     /note="MAS-related GPR, member A2A"
                     /db_xref="GeneID:668727"
                     /db_xref="MGI:MGI:3821888"
     exon            1..95
                     /gene="Mrgpra2a"
                     /gene_synonym="Mrga2; Mrgpra2"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1083
                     /gene="Mrgpra2a"
                     /gene_synonym="Mrga2; Mrgpra2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Mas-related G-protein coupled receptor member A2"
                     /codon_start=1
                     /product="MAS-related GPR, member A2A isoform 1"
                     /protein_id="NP_001371138.1"
                     /db_xref="GeneID:668727"
                     /db_xref="MGI:MGI:3821888"
                     /translation="MGESSNGEAFLAFKTSASPTAPVTTNPMDETLPGSINIRILIPK
                     LMIIIFGLVGLMGNAIVFWLLGFHLRRNAFSVYILNLALADFLFLLSSIIASTLFLLK
                     VSYLSIIFHLCFNTIIMVVYITGISMLSAISTECCLSVLCPTWYRCHRPVHTSTVMCA
                     VIWVLSLLICILNSYFCAVLHTRYDNDNECLATNIFTASYMIFLLVVLCLSSLALLAR
                     LFCGAGQMKLTRFHVTILLTLLVFLLCGLPFVIYCILLFKIKDDFHVLDVNLYLALEV
                     LTAINSCANPIIYFFVGSFRHRLKHQTLKMVLQSALQDTPETAENMVEMSSNKAEP"
     exon            96..1271
                     /gene="Mrgpra2a"
                     /gene_synonym="Mrga2; Mrgpra2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacttctcc agagcaaacg aatatcctgt agtaactgta gttttcctcc tacacaagcc
       61 agcaagctat atccagcaag aggaatgggg gaaagcagca atggtgaagc atttcttgcc
      121 tttaagacct cagcctcacc aacagcacca gtgacaacaa atccaatgga cgaaaccctc
      181 cctggaagta tcaacattag gattctgatc ccaaaattga tgatcatcat cttcggactg
      241 gtcggactga tgggaaacgc cattgtgttc tggctcctgg gcttccactt gcgcaggaat
      301 gccttctcag tctacatcct aaacttggcc ctggctgact tccttttcct cctcagtagt
      361 atcatagctt ccaccctgtt tcttctcaaa gtttcctacc tcagcatcat ctttcacttg
      421 tgctttaaca ccattataat ggttgtctac atcacaggga taagcatgct cagtgccatc
      481 agcactgagt gctgcctgtc tgtcctgtgc cccacctggt atcgctgcca ccgtccagta
      541 catacatcaa ctgtcatgtg tgctgtgatc tgggtcctat ccctgttgat ctgcattctg
      601 aatagctatt tctgtgctgt cttacatacc agatatgata atgacaatga gtgtctggca
      661 actaacatct ttaccgcctc gtacatgata tttttgcttg tggtcctctg tctgtccagc
      721 ctggctctgc tggccaggtt gttctgtggc gctgggcaga tgaagcttac cagatttcat
      781 gtgaccatct tgctgaccct tttggttttt ctcctctgcg ggttgccctt tgtcatctac
      841 tgcatcctgt tattcaagat taaggatgat ttccatgtat tagatgttaa tctttatcta
      901 gcattagaag tcctgactgc tattaacagc tgtgccaacc ccatcatcta cttcttcgtg
      961 ggctctttca gacatcggtt gaagcaccag accctcaaaa tggttctcca gagtgcactg
     1021 caggacactc ctgagacagc tgaaaacatg gtagagatgt caagtaacaa agcagagcct
     1081 tgatgaagag cctctacctg gatctcagag gtggctttgg agtgagcact gccctgctgc
     1141 acttgaccac tgtccactct tctctcagct tactgatttg acatgcctca gtggtccacc
     1201 aacaacttca acatctctcc actaacttag tttttctacc cctcctgaat aaaagcatta
     1261 atcagaaagt a
//
