LOCUS       NM_153095               1088 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus MAS-related GPR, member A1 (Mrgpra1), mRNA.
ACCESSION   NM_153095
VERSION     NM_153095.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1088)
  AUTHORS   Perner,C., Flayer,C.H., Zhu,X., Aderhold,P.A., Dewan,Z.N.A.,
            Voisin,T., Camire,R.B., Chow,O.A., Chiu,I.M. and Sokol,C.L.
  TITLE     Substance P Release by Sensory Neurons Triggers Dendritic Cell
            Migration and Initiates the Type-2 Immune Response to Allergens
  JOURNAL   Immunity 53 (5), 1063-1077 (2020)
   PUBMED   33098765
REFERENCE   2  (bases 1 to 1088)
  AUTHORS   Meixiong,J., Vasavda,C., Green,D., Zheng,Q., Qi,L., Kwatra,S.G.,
            Hamilton,J.P., Snyder,S.H. and Dong,X.
  TITLE     Identification of a bilirubin receptor that may mediate a component
            of cholestatic itch
  JOURNAL   Elife 8, e44116 (2019)
   PUBMED   30657454
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1088)
  AUTHORS   Chen,Z., Donnelly,C.R., Dominguez,B., Harada,Y., Lin,W.,
            Halim,A.S., Bengoechea,T.G., Pierchala,B.A. and Lee,K.F.
  TITLE     p75 Is Required for the Establishment of Postnatal Sensory Neuron
            Diversity by Potentiating Ret Signaling
  JOURNAL   Cell Rep 21 (3), 707-720 (2017)
   PUBMED   29045838
REFERENCE   4  (bases 1 to 1088)
  AUTHORS   Azimi,E., Reddy,V.B., Pereira,P.J.S., Talbot,S., Woolf,C.J. and
            Lerner,E.A.
  TITLE     Substance P activates Mas-related G protein-coupled receptors to
            induce itch
  JOURNAL   J Allergy Clin Immunol 140 (2), 447-453 (2017)
   PUBMED   28219706
  REMARK    GeneRIF: We deduce that substance P activates MrgprA1 on sensory
            neurons rather than NK-1R to induce itch
REFERENCE   5  (bases 1 to 1088)
  AUTHORS   Agulhon,C., Fiacco,T.A. and McCarthy,K.D.
  TITLE     Hippocampal short- and long-term plasticity are not modulated by
            astrocyte Ca2+ signaling
  JOURNAL   Science 327 (5970), 1250-1254 (2010)
   PUBMED   20203048
REFERENCE   6  (bases 1 to 1088)
  AUTHORS   Dykes,I.M., Lanier,J., Eng,S.R. and Turner,E.E.
  TITLE     Brn3a regulates neuronal subtype specification in the trigeminal
            ganglion by promoting Runx expression during sensory
            differentiation
  JOURNAL   Neural Dev 5, 3 (2010)
   PUBMED   20096094
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1088)
  AUTHORS   Luo,W., Wickramasinghe,S.R., Savitt,J.M., Griffin,J.W., Dawson,T.M.
            and Ginty,D.D.
  TITLE     A hierarchical NGF signaling cascade controls Ret-dependent and
            Ret-independent events during development of nonpeptidergic DRG
            neurons
  JOURNAL   Neuron 54 (5), 739-754 (2007)
   PUBMED   17553423
REFERENCE   8  (bases 1 to 1088)
  AUTHORS   Zylka,M.J., Dong,X., Southwell,A.L. and Anderson,D.J.
  TITLE     Atypical expansion in mice of the sensory neuron-specific Mrg G
            protein-coupled receptor family
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 10043-10048 (2003)
   PUBMED   12909716
REFERENCE   9  (bases 1 to 1088)
  AUTHORS   Han,S.K., Dong,X., Hwang,J.I., Zylka,M.J., Anderson,D.J. and
            Simon,M.I.
  TITLE     Orphan G protein-coupled receptors MrgA1 and MrgC11 are
            distinctively activated by RF-amide-related peptides through the
            Galpha q/11 pathway
  JOURNAL   Proc Natl Acad Sci U S A 99 (23), 14740-14745 (2002)
   PUBMED   12397184
  REMARK    GeneRIF: is activated by RF-amide-related peptides through the
            Galpha q/11 pathway
REFERENCE   10 (bases 1 to 1088)
  AUTHORS   Dong,X., Han,S., Zylka,M.J., Simon,M.I. and Anderson,D.J.
  TITLE     A diverse family of GPCRs expressed in specific subsets of
            nociceptive sensory neurons
  JOURNAL   Cell 106 (5), 619-632 (2001)
   PUBMED   11551509
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY042191.1 and AC163020.9.
            
            On Jul 25, 2009 this sequence version replaced NM_153095.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is supported by available conservation data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY042191.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-610               AY042191.1         1-610
            611-1088            AC163020.9         15484-15961
FEATURES             Location/Qualifiers
     source          1..1088
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 30.8 cM"
     gene            1..1088
                     /gene="Mrgpra1"
                     /gene_synonym="MrgA1"
                     /note="MAS-related GPR, member A1"
                     /db_xref="GeneID:233221"
                     /db_xref="MGI:MGI:3033095"
     exon            1..44
                     /gene="Mrgpra1"
                     /gene_synonym="MrgA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1029
                     /gene="Mrgpra1"
                     /gene_synonym="MrgA1"
                     /note="RF-amide G protein-coupled receptor"
                     /codon_start=1
                     /product="mas-related G-protein coupled receptor member
                     A1"
                     /protein_id="NP_694735.2"
                     /db_xref="CCDS:CCDS21295.2"
                     /db_xref="GeneID:233221"
                     /db_xref="MGI:MGI:3033095"
                     /translation="MGESSTCAGFLALNTSASPTAPTTTNPMDNTIPGGINITILIPN
                     LMIIIFGLVGLTGNGIVFWLLGFCLHRNAFSVYILNLALADFFFLLGHIIDSILLLLN
                     VFYPITFLLCFYTIMMVLYIAGLSMLSAISTERCLSVLCPIWYHCHRPEHTSTVMCAV
                     IWVLSLLICILNSYFCGFLNTQYKNENGCLALSFFTAAYLMFLFVVLCLSSLALVARL
                     FCGTGQIKLTRLYVTIILSILVFLLCGLPFGIHWFLLFKIKDDFHVFDLGFYLASVVL
                     TAINSCANPIIYFFVGSFRHRLKHQTLKMVLQNALQDTPETAKIMVEMSRSKSEP"
     exon            45..1088
                     /gene="Mrgpra1"
                     /gene_synonym="MrgA1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagaagcca gagagctaca tccagcaaga ggaatggggg aaagcagcac ctgtgcaggg
       61 tttctagccc taaacacatc ggcctcgcca acagcaccca caacaactaa tccaatggac
      121 aataccatcc ctggaggtat caacatcacg attctgatcc caaacttgat gatcatcatc
      181 ttcggactgg tcgggctgac aggaaatggc attgtgttct ggctcctggg cttctgtttg
      241 cacaggaacg ccttctcagt ctacatccta aacttagctc tagctgactt cttcttcctc
      301 ctaggtcaca tcatagattc catactgctt cttctcaatg ttttctaccc aattaccttt
      361 ctcttgtgct tttacacgat catgatggtt ctctatatcg caggcctgag catgctcagt
      421 gccatcagca ctgagcgctg cctgtctgta ctgtgcccca tctggtatca ctgtcaccgc
      481 ccagaacaca catcaactgt catgtgtgct gtcatctggg tcctgtccct gttgatctgc
      541 attctgaata gttatttctg cggtttctta aatacccaat ataaaaatga aaatgggtgt
      601 ctggcattga gcttctttac tgctgcatac ctgatgtttt tgtttgtggt cctctgtctg
      661 tccagcctgg ctctggtggc caggttgttc tgtggtactg ggcagataaa gcttaccaga
      721 ttgtatgtaa ccattattct gagcattttg gtttttctcc tttgcggatt gccctttggc
      781 atccactggt ttctgttatt caagattaag gatgattttc atgtatttga tcttggattt
      841 tatctggcat cagttgtcct gactgctatt aatagctgtg ccaaccccat catttacttc
      901 ttcgtgggat ccttcaggca tcggttgaag caccagaccc tcaaaatggt tctccagaat
      961 gcactgcaag acactcctga gacagccaaa atcatggtgg agatgtcaag aagcaaatca
     1021 gagccatgat gaagagcctt tgcctggccc ttagaggtgg ctttggggtg agcattgccc
     1081 tgctgcac
//
