LOCUS       NM_028479               1973 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus MRG/MORF4L binding protein (Mrgbp), transcript variant
            1, mRNA.
ACCESSION   NM_028479 XM_902385 XM_902395 XM_924241 XM_924252 XM_992850
            XM_992877
VERSION     NM_028479.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1973)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1973)
  AUTHORS   Jacquet,K., Fradet-Turcotte,A., Avvakumov,N., Lambert,J.P.,
            Roques,C., Pandita,R.K., Paquet,E., Herst,P., Gingras,A.C.,
            Pandita,T.K., Legube,G., Doyon,Y., Durocher,D. and Cote,J.
  TITLE     The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1
            through Direct H4K20me Binding and H2AK15 Acetylation
  JOURNAL   Mol Cell 62 (3), 409-421 (2016)
   PUBMED   27153538
REFERENCE   3  (bases 1 to 1973)
  AUTHORS   Kole,C., Berdugo,N., Da Silva,C., Ait-Ali,N., Millet-Puel,G.,
            Pagan,D., Blond,F., Poidevin,L., Ripp,R., Fontaine,V., Wincker,P.,
            Zack,D.J., Sahel,J.A., Poch,O. and Leveillard,T.
  TITLE     Identification of an Alternative Splicing Product of the Otx2 Gene
            Expressed in the Neural Retina and Retinal Pigmented Epithelial
            Cells
  JOURNAL   PLoS One 11 (3), e0150758 (2016)
   PUBMED   26985665
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1973)
  AUTHORS   Wajapeyee,N., Malonia,S.K., Palakurthy,R.K. and Green,M.R.
  TITLE     Oncogenic RAS directs silencing of tumor suppressor genes through
            ordered recruitment of transcriptional repressors
  JOURNAL   Genes Dev 27 (20), 2221-2226 (2013)
   PUBMED   24105743
REFERENCE   5  (bases 1 to 1973)
  AUTHORS   Gowher,H., Brick,K., Camerini-Otero,R.D. and Felsenfeld,G.
  TITLE     Vezf1 protein binding sites genome-wide are associated with pausing
            of elongating RNA polymerase II
  JOURNAL   Proc Natl Acad Sci U S A 109 (7), 2370-2375 (2012)
   PUBMED   22308494
REFERENCE   6  (bases 1 to 1973)
  AUTHORS   Doyon,Y., Selleck,W., Lane,W.S., Tan,S. and Cote,J.
  TITLE     Structural and functional conservation of the NuA4 histone
            acetyltransferase complex from yeast to humans
  JOURNAL   Mol Cell Biol 24 (5), 1884-1896 (2004)
   PUBMED   14966270
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669926.6, BC116734.1 and BC085320.1.
            
            On Oct 5, 2017 this sequence version replaced NM_028479.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC116734.1, SRR12282455.9838170.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AL669926.6         168375-168456
            83-1274             BC116734.1         1-1192
            1275-1973           BC085320.1         2492-3190
FEATURES             Location/Qualifiers
     source          1..1973
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.12 cM"
     gene            1..1973
                     /gene="Mrgbp"
                     /gene_synonym="1600027N09Rik"
                     /note="MRG/MORF4L binding protein"
                     /db_xref="GeneID:73247"
                     /db_xref="MGI:MGI:1920497"
     exon            1..316
                     /gene="Mrgbp"
                     /gene_synonym="1600027N09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            317..661
                     /gene="Mrgbp"
                     /gene_synonym="1600027N09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             514..1128
                     /gene="Mrgbp"
                     /gene_synonym="1600027N09Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     MRG-binding protein"
                     /codon_start=1
                     /product="MRG/MORF4L-binding protein isoform 1"
                     /protein_id="NP_082755.1"
                     /db_xref="CCDS:CCDS17178.1"
                     /db_xref="GeneID:73247"
                     /db_xref="MGI:MGI:1920497"
                     /translation="MGEAEVGGTGAPGDKGPGEAAPSPAEETVVWSPEVEVCLFHAML
                     GHKPVGVNRHFHMICIRDKFSQNIGRQVPSKVIWDHLSTMYDMQALHESEILPFPNPE
                     RNFVLPDEIIQEVREGKVVIEEEMKEEMKEDVDPHSGADDVFSSSGSLGKALEKSSKD
                     KEKNSSDLGCKEGADKRKRSRVTDKVLTANSNPSSPSAAKRRRT"
     exon            662..783
                     /gene="Mrgbp"
                     /gene_synonym="1600027N09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            784..865
                     /gene="Mrgbp"
                     /gene_synonym="1600027N09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            866..940
                     /gene="Mrgbp"
                     /gene_synonym="1600027N09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1944
                     /gene="Mrgbp"
                     /gene_synonym="1600027N09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1572..1577
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrgbp"
                     /gene_synonym="1600027N09Rik"
                     /note="hexamer: AATAGA"
     polyA_site      1595
                     /gene="Mrgbp"
                     /gene_synonym="1600027N09Rik"
                     /note="major polyA site"
     regulatory      1683..1688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrgbp"
                     /gene_synonym="1600027N09Rik"
                     /note="hexamer: AAGAAA"
     polyA_site      1711
                     /gene="Mrgbp"
                     /gene_synonym="1600027N09Rik"
     polyA_site      1831
                     /gene="Mrgbp"
                     /gene_synonym="1600027N09Rik"
ORIGIN      
        1 gctgaagcct ggccacagac tgctgtctgg ctctgagctc tgagctgtcc cagacaatga
       61 gacaggtcag agccagcacc ctccatggtt ccctgctgtg agcattgtct ggttacaggc
      121 ctgaatgagg ggcaagtgga gtgtcaggac tggattcaag gcttgtggca gccagcaagt
      181 gatccttatc aagacccaag agttcagagc tacagtggcc ccatagcaca aaggagaaca
      241 aaggttctca acatcttagt ctgagaggca tcagtcagaa aagggattct gatgcctggc
      301 aatggctgag gaatggagcc gtaggcagta aaaggttcaa ccaccaggag tcgctgctgc
      361 accggaagcc agtcttcgct gcgcctgcgc ggacgcgggc acgcggcgtt ctccagcccg
      421 gcgagtgcgc gccctccaca ccaagtgcgc ctgcgcggag cctgtagtat tttccccctt
      481 ctcgcgccgg gcgctcgtca atcgccggcg gccatggggg aggccgaggt gggcggcacg
      541 ggcgccccag gcgacaaggg cccaggcgag gcagccccga gccctgctga ggagacggtg
      601 gtgtggagcc ctgaggtgga agtgtgcctc ttccacgcca tgctgggcca caagcctgtc
      661 ggggtgaatc ggcacttcca catgatttgt atccgagaca agttcagcca gaatattggg
      721 cgccaggttc catccaaggt gatctgggac catctgagca ctatgtacga catgcaggca
      781 ctgcacgagt ctgagattct tccattccca aatccagaga ggaactttgt ccttccagat
      841 gagatcattc aggaagtccg agaaggaaaa gtggtcattg aagaagaaat gaaggaggag
      901 atgaaggagg atgtggaccc ccacagtggg gctgatgatg ttttttcatc ttcagggagc
      961 ttggggaaag cattagaaaa atccagcaaa gacaaagaga agaactcctc agacttgggg
     1021 tgcaaagaag gggcagacaa gcggaagcgc agccgggtca ctgacaaggt cctgactgcc
     1081 aacagcaatc cctccagccc cagtgctgcc aagaggcgcc gcacatagac acctcatcct
     1141 caggtggcca cagagatgct ccaactgcct gtctccaggt ccctgggtga atgtggccat
     1201 ccagcagaga tgctagtggg gcttccgctg tgtcatcaga cctccagagc acctgattgg
     1261 cccaaaagac cagcaagacc cttgtctact ctgcagatgg tgaagccttt gaggcagcct
     1321 cttgctttct cctgtgggtc ccttgtgccc acagtgtgta gagaagagca ggtgcatggg
     1381 gccaggggac caagagtcag caagcaataa gacgccaccc tcactgtcct caggagccag
     1441 gcatcctccc tgggtgccca ctctttgcat ctgcttttcc tgtaagactc cactgtgcac
     1501 tggcatccag agaaggtgtc tttggagttc acacagcaca cactgtgcac agaaggcctc
     1561 cccatctggg aaatagaact ggatattttg cctcattcac ttgtactgta atagtgtata
     1621 taacttagtt ggtatttcac tatttaattt ttaagaagcc tattttacta gtgttttgta
     1681 tgaagaaaaa tactgcagaa gttaaacctg tgatgtgttt ttttgagctg ttttgtttta
     1741 aggtaactac tgaaataagt ctggctgttt ttatatgcca gatacagaga atttttagcg
     1801 gttatttttg taattttagt aacttggaaa agaccaaaaa agggagtgga acaaaggaac
     1861 cgccattaga ctgaaaaaac aatggcctga tggttgaagt acattttcat ttgcagaata
     1921 ttaaagcact aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
