LOCUS       NM_001005423            2445 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus melanoregulin (Mreg), transcript variant 1, mRNA.
ACCESSION   NM_001005423 XM_355212
VERSION     NM_001005423.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2445)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2445)
  AUTHORS   Rout,A.K., Wu,X., Starich,M.R., Strub,M.P., Hammer,J.A. and
            Tjandra,N.
  TITLE     The Structure of Melanoregulin Reveals a Role for Cholesterol
            Recognition in the Protein's Ability to Promote Dynein Function
  JOURNAL   Structure 26 (10), 1373-1383 (2018)
   PUBMED   30174147
  REMARK    GeneRIF: Mreg contains six alpha helices forming a fishhook-like
            fold in which positive and negative charges occupy opposite sides
            of the protein's surface and sandwich a putative, cholesterol
            recognition sequence (CRAC motif). Mreg containing a point mutation
            within its CRAC motif still targets to late endosomes/lysosomes,
            but no longer promotes their microtubule minus end-directed
            transport.
REFERENCE   3  (bases 1 to 2445)
  AUTHORS   Whittaker Hawkins,R.F., Patenaude,A., Dumas,A., Jain,R.,
            Tesfagiorgis,Y., Kerfoot,S., Matsui,T., Gunzer,M., Poubelle,P.E.,
            Larochelle,C., Pelletier,M. and Vallieres,L.
  TITLE     ICAM1+ neutrophils promote chronic inflammation via ASPRV1 in B
            cell-dependent autoimmune encephalomyelitis
  JOURNAL   JCI Insight 2 (23), 96882 (2017)
   PUBMED   29212956
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2445)
  AUTHORS   Xie,W.R., Jen,H.I., Seymour,M.L., Yeh,S.Y., Pereira,F.A.,
            Groves,A.K., Klisch,T.J. and Zoghbi,H.Y.
  TITLE     An Atoh1-S193A Phospho-Mutant Allele Causes Hearing Deficits and
            Motor Impairment
  JOURNAL   J Neurosci 37 (36), 8583-8594 (2017)
   PUBMED   28729444
REFERENCE   5  (bases 1 to 2445)
  AUTHORS   Reyes-Reveles,J., Dhingra,A., Alexander,D., Bragin,A., Philp,N.J.
            and Boesze-Battaglia,K.
  TITLE     Phagocytosis-dependent ketogenesis in retinal pigment epithelium
  JOURNAL   J Biol Chem 292 (19), 8038-8047 (2017)
   PUBMED   28302729
REFERENCE   6  (bases 1 to 2445)
  AUTHORS   Moore,K.J., Swing,D.A., Copeland,N.G. and Jenkins,N.A.
  TITLE     The murine dilute suppressor gene encodes a cell autonomous
            suppressor
  JOURNAL   Genetics 138 (2), 491-497 (1994)
   PUBMED   7828830
REFERENCE   7  (bases 1 to 2445)
  AUTHORS   Moore,K.J., Swing,D.A., Copeland,N.G. and Jenkins,N.A.
  TITLE     Interaction of the murine dilute suppressor gene (dsu) with
            fourteen coat color mutations
  JOURNAL   Genetics 125 (2), 421-430 (1990)
   PUBMED   2379821
  REMARK    Erratum:[Genetics 1990 Sep;126(1):285]
REFERENCE   8  (bases 1 to 2445)
  AUTHORS   Moore,K.J., Seperack,P.K., Strobel,M.C., Swing,D.A., Copeland,N.G.
            and Jenkins,N.A.
  TITLE     Dilute suppressor dsu acts semidominantly to suppress the coat
            color phenotype of a deletion mutation, dl20J, of the murine dilute
            locus
  JOURNAL   Proc Natl Acad Sci U S A 85 (21), 8131-8135 (1988)
   PUBMED   3141922
REFERENCE   9  (bases 1 to 2445)
  AUTHORS   Moore,K.J., Swing,D.A., Rinchik,E.M., Mucenski,M.L., Buchberg,A.M.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     The murine dilute suppressor gene dsu suppresses the coat-color
            phenotype of three pigment mutations that alter melanocyte
            morphology, d, ash and ln
  JOURNAL   Genetics 119 (4), 933-941 (1988)
   PUBMED   3410303
REFERENCE   10 (bases 1 to 2445)
  AUTHORS   Sweet,H.O.
  TITLE     Dilute suppressor, a new suppressor gene in the house mouse
  JOURNAL   J Hered 74 (4), 305-306 (1983)
   PUBMED   6886377
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120136.9.
            
            On Oct 20, 2022 this sequence version replaced NM_001005423.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY628210.1, BC068125.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-243               AC120136.9         128913-129155       c
            244-403             AC120136.9         108939-109098       c
            404-494             AC120136.9         80968-81058         c
            495-658             AC120136.9         79218-79381         c
            659-2445            AC120136.9         76129-77915         c
FEATURES             Location/Qualifiers
     source          1..2445
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 36.39 cM"
     gene            1..2445
                     /gene="Mreg"
                     /gene_synonym="dsu; Gm974; Wdt2"
                     /note="melanoregulin"
                     /db_xref="GeneID:381269"
                     /db_xref="MGI:MGI:2151839"
     exon            1..243
                     /gene="Mreg"
                     /gene_synonym="dsu; Gm974; Wdt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..793
                     /gene="Mreg"
                     /gene_synonym="dsu; Gm974; Wdt2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     whn-dependent transcript 2; dilute suppressor protein"
                     /codon_start=1
                     /product="melanoregulin isoform 1"
                     /protein_id="NP_001005423.1"
                     /db_xref="CCDS:CCDS15032.1"
                     /db_xref="GeneID:381269"
                     /db_xref="MGI:MGI:2151839"
                     /translation="MGLRRWLRSACCCCPCRCLEEPARPEKEPLVSGNNPYSSFGATL
                     ERDDEKNLWSMPHDVSHTEADDDRILYNLIVIRNQQTKDSEEWQRLNYDIYTLRQIRR
                     EVRNRWRRILEDLGFQREADSLLSVTKLSTMSDSKNTRKAREMLLKLAEETSIFPASW
                     ELSERYLLVVDRLIALDAAEDFFKIASQMYPKKPGVPCLVDGQRKLHCLPFPSP"
     exon            244..403
                     /gene="Mreg"
                     /gene_synonym="dsu; Gm974; Wdt2"
                     /inference="alignment:Splign:2.1.0"
     exon            404..494
                     /gene="Mreg"
                     /gene_synonym="dsu; Gm974; Wdt2"
                     /inference="alignment:Splign:2.1.0"
     exon            495..658
                     /gene="Mreg"
                     /gene_synonym="dsu; Gm974; Wdt2"
                     /inference="alignment:Splign:2.1.0"
     exon            659..2445
                     /gene="Mreg"
                     /gene_synonym="dsu; Gm974; Wdt2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2418..2423
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mreg"
                     /gene_synonym="dsu; Gm974; Wdt2"
                     /note="hexamer: ATTAAA"
     polyA_site      2445
                     /gene="Mreg"
                     /gene_synonym="dsu; Gm974; Wdt2"
                     /note="major polyA site"
ORIGIN      
        1 aaacgcgcag ctcgcgtccc cacggccggc cgcggcgtga tgcgcacggc ccggcccgtg
       61 acgccgcggc cgtccctgtc cccgtccccg cgtccccgcc gccatcgcgc gcccggctcc
      121 gggatcccgg cgccgggcct cgctccccat ggggctgcgc cgctggctac ggagcgcctg
      181 ctgctgctgc ccgtgccggt gcctggagga gcccgcgcgg cccgagaagg agccgctggt
      241 cagtggtaac aatccgtatt cctcctttgg agcgactctg gagagggatg atgagaagaa
      301 tttatggagc atgcctcatg acgtgtccca cacagaggcg gatgacgata ggatcttgta
      361 taatttgata gtcattcgta atcagcagac caaagactca gaggaatggc aaagactcaa
      421 ctatgatatc tacaccctgc ggcagatccg cagggaagtg aggaaccgat ggagacgaat
      481 cttagaggac ttgggctttc aaagggaagc cgactctctg ttgtcagtga ccaaactcag
      541 caccatgagt gattctaaaa acacaaggaa agcccgggag atgctgttaa agctggctga
      601 agagacctct atcttccccg ccagctggga gctctccgag aggtacctct tggttgtgga
      661 ccggctcatt gctctcgatg ctgctgagga cttctttaag attgctagcc aaatgtaccc
      721 caagaaacct ggggtcccat gcctggtgga cggccagaga aaactgcact gccttccatt
      781 tccaagcccc tgaagggagg cccagaagag cggagttctt ttaccacgac acaggaattt
      841 accaaagttg gacggctgcc tacggtttcg agcgagccag gagagggcct tctccagtca
      901 aacactatcg tgaatcctac aaatataagg tcttcttcct caggaccttg gcctaaggat
      961 gctctggtta cattaaaaca cccggctgcc accatgcatc gagaaaggaa ggctaaagat
     1021 tagttggtgg gtgggtagtt cttcctggat agtcaggttc caagaacctg tggcctcatt
     1081 ggctatataa gctacagttg ttcattctgt gcaggactgg tgttttctaa tcaacacaat
     1141 ggcatgacta atagagaagg gtgtaaccga gccctcacct acatcaccaa cttcaaggta
     1201 gtcattatta ggtgtaatac tagacaagga gccccagact tcataaaacc ctaggcctcg
     1261 cgtgacctgt ttgattcgga aacacctgca gcagctgaga tgctgtttgg ggcgtccctc
     1321 tgagcatcag ggggtgttat ttacaagtat aggtgagcca gacagtagaa gtgtgcagac
     1381 gtgcagctaa gtgtcttcac ctgtgccacg aacaccccga accctcatct taacccccag
     1441 cactgacgtt acccagttgc ctcgactttt tttttttttt ttaacatgtt gcccatttct
     1501 gatacaaaag cccttggcat ttttatgaag aatagcatct gtaaactgga gtgtttggcc
     1561 tctacttcct atcttgaatc tgtgtcctga gggttgcagc tgcctaggga ccttttggtg
     1621 cagacttgca ggtatgcagg cagtggtgta tgctgacaga ggtcgctgct gggtcttcac
     1681 gctgaaggtg attttcagac tggagctctg ctagcagtgc agcttgccca cagaatgcca
     1741 agccccactt ccaagatcgt aaggagcttg ccaagaggac cggggctcgt tctgttgaaa
     1801 agcctttcaa gatttgtggg atttatctgt agacttctga gaacagtaga aatattttta
     1861 ttttttaatg attttgcact tctgaattca ggtggaaaat aaatttgtat tagtttgttc
     1921 aggggattgt gacttgaaaa atttcatatc ctgagggttt tttttttttt tttttgcttg
     1981 tatactccat gtttaaaata tttactagga aatacatgtc ccctgttcat taatatattg
     2041 tagactaatt taacaggtgc atttcaggga aattcttcct agtttaataa gtaagctaaa
     2101 agttttattt tattttttta gtatttagtg catattctct acttcatgct gtttaaaatt
     2161 agcctgcaaa tattttcagt cacttctgtg ggctattaga agataaagaa taaaataaac
     2221 aaaagacatc ctagaatgtt gtactgtttt aatctcagaa tttgttttgg cttttgtttt
     2281 ctttgatgtc aaaatagatg aaattgtctg tgtctgtgaa ttgtaaacca ttcaccatag
     2341 tttttattct ttggtaacaa acaagtaagg ataaaattat ctctgcagta acgaaaatac
     2401 gtgcaattac ccaaggaatt aaaagacttt gctgtgtgcc tttaa
//
