LOCUS       NM_001411891            5794 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus MRE11A homolog A, double strand break repair nuclease
            (Mre11a), transcript variant 3, mRNA.
ACCESSION   NM_001411891 XM_006510048
VERSION     NM_001411891.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5794)
  AUTHORS   Hartlerode,A.J., Mostafa,A.M., Orban,S.K., Benedeck,R.,
            Campbell,K., Hoenerhoff,M.J., Ferguson,D.O. and Sekiguchi,J.M.
  TITLE     Reduced levels of MRE11 cause disease phenotypes distinct from
            ataxia telangiectasia-like disorder
  JOURNAL   Hum Mol Genet 33 (18), 1605-1617 (2024)
   PUBMED   38888340
  REMARK    GeneRIF: Reduced levels of MRE11 cause disease phenotypes distinct
            from ataxia telangiectasia-like disorder.
REFERENCE   2  (bases 1 to 5794)
  AUTHORS   Tang,Z., Liang,Z., Zhang,B., Xu,X., Li,P., Li,L., Lu,L.Y. and
            Liu,Y.
  TITLE     MRE11 is essential for the long-term viability of undifferentiated
            spermatogonia
  JOURNAL   Cell Prolif 57 (9), e13685 (2024)
   PUBMED   38894566
  REMARK    GeneRIF: MRE11 is essential for the long-term viability of
            undifferentiated spermatogonia.
REFERENCE   3  (bases 1 to 5794)
  AUTHORS   Ubieto-Capella,P., Ximenez-Embun,P., Gimenez-Llorente,D.,
            Losada,A., Munoz,J. and Mendez,J.
  TITLE     A rewiring of DNA replication mediated by MRE11 exonuclease
            underlies primed-to-naive cell de-differentiation
  JOURNAL   Cell Rep 43 (4), 114024 (2024)
   PUBMED   38581679
  REMARK    GeneRIF: A rewiring of DNA replication mediated by MRE11
            exonuclease underlies primed-to-naive cell de-differentiation.
REFERENCE   4  (bases 1 to 5794)
  AUTHORS   Bunke,L.E., Larsen,C.I.S., Pita-Aquino,J.N., Jones,I.K. and
            Majumder,K.
  TITLE     The DNA Damage Sensor MRE11 Regulates Efficient Replication of the
            Autonomous Parvovirus Minute Virus of Mice
  JOURNAL   J Virol 97 (5), e0046123 (2023)
   PUBMED   37098896
  REMARK    GeneRIF: The DNA Damage Sensor MRE11 Regulates Efficient
            Replication of the Autonomous Parvovirus Minute Virus of Mice.
REFERENCE   5  (bases 1 to 5794)
  AUTHORS   Liu,W., Zheng,M., Zhang,R., Jiang,Q., Du,G., Wu,Y., Yang,C., Li,F.,
            Li,W., Wang,L., Wu,J., Shi,L., Li,W., Zhang,K., Zhou,Z., Liu,R.,
            Gao,Y., Huang,X., Fan,S., Zhi,X., Jiang,D. and Chen,C.
  TITLE     RNF126-Mediated MRE11 Ubiquitination Activates the DNA Damage
            Response and Confers Resistance of Triple-Negative Breast Cancer to
            Radiotherapy
  JOURNAL   Adv Sci (Weinh) 10 (5), e2203884 (2023)
   PUBMED   36563124
  REMARK    GeneRIF: RNF126-Mediated MRE11 Ubiquitination Activates the DNA
            Damage Response and Confers Resistance of Triple-Negative Breast
            Cancer to Radiotherapy.
            Erratum:[Adv Sci (Weinh). 2025 Jan 30:e2417701. doi:
            10.1002/advs.202417701.. PMID: 39888281]
REFERENCE   6  (bases 1 to 5794)
  AUTHORS   Dmitrieva,N.I., Bulavin,D.V. and Burg,M.B.
  TITLE     High NaCl causes Mre11 to leave the nucleus, disrupting DNA damage
            signaling and repair
  JOURNAL   Am J Physiol Renal Physiol 285 (2), F266-F274 (2003)
   PUBMED   12684226
  REMARK    GeneRIF: following high NaCl, Mre11 exits from the nucleus, DNA
            double-strand breaks accumulate in the S and G2 phases of the cell
            cycle, and DNA repair is inhibited.
REFERENCE   7  (bases 1 to 5794)
  AUTHORS   Franchitto,A., Pichierri,P., Piergentili,R., Crescenzi,M.,
            Bignami,M. and Palitti,F.
  TITLE     The mammalian mismatch repair protein MSH2 is required for correct
            MRE11 and RAD51 relocalization and for efficient cell cycle arrest
            induced by ionizing radiation in G2 phase
  JOURNAL   Oncogene 22 (14), 2110-2120 (2003)
   PUBMED   12687013
REFERENCE   8  (bases 1 to 5794)
  AUTHORS   Bender,C.F., Sikes,M.L., Sullivan,R., Huye,L.E., Le Beau,M.M.,
            Roth,D.B., Mirzoeva,O.K., Oltz,E.M. and Petrini,J.H.
  TITLE     Cancer predisposition and hematopoietic failure in Rad50(S/S) mice
  JOURNAL   Genes Dev 16 (17), 2237-2251 (2002)
   PUBMED   12208847
  REMARK    GeneRIF: The data indicate that even subtle perturbation of Mre11
            complex functions results in severe genotoxic stress, and that the
            complex is critically important for homeostasis of proliferative
            tissues.
REFERENCE   9  (bases 1 to 5794)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 5794)
  AUTHORS   Xiao,Y. and Weaver,D.T.
  TITLE     Conditional gene targeted deletion by Cre recombinase demonstrates
            the requirement for the double-strand break repair Mre11 protein in
            murine embryonic stem cells
  JOURNAL   Nucleic Acids Res 25 (15), 2985-2991 (1997)
   PUBMED   9224597
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT030247.6 and AC136743.5.
            
            On Sep 9, 2022 this sequence version replaced XM_006510048.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.8976.1,
                                           SRR10223969.8608.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               CT030247.6         33701-33833         c
            134-231             CT030247.6         32980-33077         c
            232-364             CT030247.6         31498-31630         c
            365-525             CT030247.6         27775-27935         c
            526-613             CT030247.6         22650-22737         c
            614-755             CT030247.6         21324-21465         c
            756-870             CT030247.6         18838-18952         c
            871-1056            CT030247.6         15559-15744         c
            1057-1228           CT030247.6         12981-13152         c
            1229-1309           CT030247.6         8624-8704           c
            1310-1436           CT030247.6         6552-6678           c
            1437-1540           CT030247.6         3237-3340           c
            1541-1714           CT030247.6         1539-1712           c
            1715-1777           AC136743.5         109440-109502
            1778-1994           AC136743.5         115165-115381
            1995-2075           AC136743.5         116559-116639
            2076-2134           AC136743.5         119381-119439
            2135-2199           AC136743.5         120921-120985
            2200-2275           AC136743.5         122665-122740
            2276-5794           AC136743.5         123631-127149
FEATURES             Location/Qualifiers
     source          1..5794
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 4.33 cM"
     gene            1..5794
                     /gene="Mre11a"
                     /gene_synonym="Mre11; Mre11b"
                     /note="MRE11A homolog A, double strand break repair
                     nuclease"
                     /db_xref="GeneID:17535"
                     /db_xref="MGI:MGI:1100512"
     exon            1..133
                     /gene="Mre11a"
                     /gene_synonym="Mre11; Mre11b"
                     /inference="alignment:Splign:2.1.0"
     exon            134..231
                     /gene="Mre11a"
                     /gene_synonym="Mre11; Mre11b"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..2332
                     /gene="Mre11a"
                     /gene_synonym="Mre11; Mre11b"
                     /note="isoform 1 is encoded by transcript variant 3;
                     double-strand break repair protein MRE11A; meiotic
                     recombination 11 homolog A; mmMRE11A; MRE11 homolog 1;
                     MRE11 homolog A; meiotic recombination 11 homolog 1"
                     /codon_start=1
                     /product="double-strand break repair protein MRE11 isoform
                     1"
                     /protein_id="NP_001398820.1"
                     /db_xref="GeneID:17535"
                     /db_xref="MGI:MGI:1100512"
                     /translation="MSPTDPLDDEDTFKILVATDIHLGFMEKDAVRGNDTFVTFDEIL
                     RLALENEVDFILLGGDLFHENKPSRKTLHSCLELLRKYCMGDRPVQFEVISDQSVNFG
                     FSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDVLSCAGFVNHFGRSMSVE
                     KVDISPVLLQKGSTKLALYGLGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQ
                     NRSKHGNTNFIPEQFLDDFIDLVIWGHEHECKIGPIKNEQQLFYVSQPGSSVVTSLSP
                     GEAVKKHVGLLRIKGRKMNMQKLPLRTVRRFFIEDVVLANHPNLFNPDNPKVTQAIQS
                     FCLEKIEEMLDSAERERLGNPQQPGKPLIRLRVDYSGGFEPFNVLRFSQKFVDRVANP
                     KDVIHFFRHREQKGKTGEEINFGMLITKPASEGATLRVEDLVKQYFQTAEKNVQLSLL
                     TERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRES
                     RQRNTNEEDDEVREAMSRARALRSQSETSTSAFSAEDLSFDTSEQTANDSDDSLSAVP
                     SRGRGRGRGRRGARGQSSAPRGGSQRGRDTGLEITTRGRSSKATSSTSRNMSIIDAFR
                     STRQQPSRNVAPKNYSETIEVDDSDEDDIFPTNSRADQRWSGTTSSKRMSQSQTAKGV
                     DFESDEDDDDDPFMSSSCPRRNRR"
     exon            232..364
                     /gene="Mre11a"
                     /gene_synonym="Mre11; Mre11b"
                     /inference="alignment:Splign:2.1.0"
     exon            365..525
                     /gene="Mre11a"
                     /gene_synonym="Mre11; Mre11b"
                     /inference="alignment:Splign:2.1.0"
     exon            526..613
                     /gene="Mre11a"
                     /gene_synonym="Mre11; Mre11b"
                     /inference="alignment:Splign:2.1.0"
     exon            614..755
                     /gene="Mre11a"
                     /gene_synonym="Mre11; Mre11b"
                     /inference="alignment:Splign:2.1.0"
     exon            756..870
                     /gene="Mre11a"
                     /gene_synonym="Mre11; Mre11b"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1056
                     /gene="Mre11a"
                     /gene_synonym="Mre11; Mre11b"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1228
                     /gene="Mre11a"
                     /gene_synonym="Mre11; Mre11b"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1309
                     /gene="Mre11a"
                     /gene_synonym="Mre11; Mre11b"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1436
                     /gene="Mre11a"
                     /gene_synonym="Mre11; Mre11b"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1540
                     /gene="Mre11a"
                     /gene_synonym="Mre11; Mre11b"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1714
                     /gene="Mre11a"
                     /gene_synonym="Mre11; Mre11b"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1777
                     /gene="Mre11a"
                     /gene_synonym="Mre11; Mre11b"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1994
                     /gene="Mre11a"
                     /gene_synonym="Mre11; Mre11b"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2075
                     /gene="Mre11a"
                     /gene_synonym="Mre11; Mre11b"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2134
                     /gene="Mre11a"
                     /gene_synonym="Mre11; Mre11b"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2199
                     /gene="Mre11a"
                     /gene_synonym="Mre11; Mre11b"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2275
                     /gene="Mre11a"
                     /gene_synonym="Mre11; Mre11b"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..5794
                     /gene="Mre11a"
                     /gene_synonym="Mre11; Mre11b"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2633
                     /gene="Mre11a"
                     /gene_synonym="Mre11; Mre11b"
                     /note="major polyA site"
     regulatory      5744..5749
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mre11a"
                     /gene_synonym="Mre11; Mre11b"
                     /note="hexamer: ATTAAA"
     polyA_site      5763
                     /gene="Mre11a"
                     /gene_synonym="Mre11; Mre11b"
     regulatory      5770..5775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mre11a"
                     /gene_synonym="Mre11; Mre11b"
                     /note="hexamer: AATAAA"
     polyA_site      5794
                     /gene="Mre11a"
                     /gene_synonym="Mre11; Mre11b"
ORIGIN      
        1 ggatgccgct ctcccgcgcc taattcaggt ttctgggagc ggttttcttg tggttctgga
       61 gactcccgcc cccttttcct gaggtagaga tggcttgtgg cctccctggt cgactctgac
      121 aagtccatgt tggagtttgg attcgagtgg tttttctgac atacctgaac acttggagag
      181 gaacctggta cagaggaact ctactataaa aatgagcccc acagatccac ttgacgatga
      241 agacacattt aaaatcctgg ttgccactga tattcatctt ggatttatgg agaaagatgc
      301 agttagagga aatgatacat ttgtgacatt tgatgaaatc ttaagacttg ccctggaaaa
      361 tgaagtggat tttattttgt taggtggtga tcttttccat gaaaacaagc cctcgaggaa
      421 aaccctgcac agctgcttgg agctgcttag gaagtactgt atgggtgacc gccctgtgca
      481 gtttgaggtc atcagtgatc agtcagtcaa ctttggtttt agtaagtttc catgggtgaa
      541 ctaccaggat ggcaatctca acatttccat tccagtattt agtatccacg gcaaccatga
      601 tgatcccacg ggggcagatg ccctctgtgc cctggatgtt ttaagctgtg ctgggtttgt
      661 gaatcacttt ggacggtcaa tgtcggtgga gaaggttgac attagtccgg ttctgctgca
      721 gaaaggaagc acaaaactcg ctctgtacgg cttaggctcc attccagatg aaaggctcta
      781 tcggatgttt gtgaataaaa aagtaacaat gttgagacca aaggaagatg agaactcatg
      841 gtttaactta tttgtgattc atcagaacag gagtaagcat ggaaacacca acttcattcc
      901 agagcagttt ttggatgact tcatcgacct cgttatctgg ggccatgaac atgagtgtaa
      961 aattggccca atcaaaaatg agcagcagct cttctatgtg tctcagcccg gaagctcagt
     1021 ggtgacgtcc ctttcccctg gagaagctgt gaagaaacat gtaggcttgc tgcgcattaa
     1081 agggagaaag atgaacatgc agaagctgcc tctccgcacc gtgcggcggt tcttcataga
     1141 agacgtggtt ctggctaacc acccaaacct gttcaaccct gacaatccta aggtgaccca
     1201 ggccatccag agcttctgtc tggagaagat tgaagaaatg cttgacagtg ctgagcggga
     1261 acgactgggg aatcctcagc agccggggaa gcctcttatc cgactacggg tggactatag
     1321 tggaggcttt gaacctttca acgttcttcg ttttagccag aagtttgtgg atcgagtcgc
     1381 taacccaaaa gatgtcatcc actttttcag gcacagggaa caaaagggaa aaacaggaga
     1441 agagatcaac tttgggatgc tcatcacaaa acctgcttca gaaggagcaa cgcttagagt
     1501 agaagacctc gtaaagcagt atttccaaac tgcagagaag aatgttcagc tctcgctgct
     1561 gacagaaaga gggatgggcg aagcagttca agagtttgtg gacaaggaag agaaagatgc
     1621 catcgaggaa ttagtgaagt accagctgga gaaaacacag cggtttctta aggagcgcca
     1681 tattgatgct ctggaagaca agattgatga ggaggtccga cgtttccgag aaagcagaca
     1741 gagaaatacc aacgaagaag atgatgaagt tcgagaggcc atgagcagag cccgggccct
     1801 cagatcacag tcagagacct ccacctcagc ctttagtgct gaggacctga gctttgatac
     1861 atcggagcag acagcaaatg actctgatga cagcctgtca gcagtgccga gcagaggccg
     1921 aggccgaggc cgagggcgaa gaggagccag agggcagagc tcggcaccta gaggaggctc
     1981 tcagagaggc cgagacactg ggctggagat cactactcga ggcaggagct caaaggccac
     2041 ctcatcaaca tctagaaaca tgtccattat agacgctttc agatctaccc gacaacagcc
     2101 ttctagaaat gtagccccta agaattactc agagaccatt gaggtggatg actctgacga
     2161 agatgacatt tttcctacca attccagggc tgatcaaagg tggtcgggca caacatctag
     2221 caaacggatg tcccagagcc agacagccaa aggggtagac tttgaatcag atgaggatga
     2281 tgacgatgac cctttcatga gcagtagttg cccaagaaga aaccgaagat aatgttttta
     2341 atggaactta gaaattgcat gatgcaggaa gaaatcaaag caccacatac tgacttcaca
     2401 gctgaagatg tttaagtctg ggcttatatt ttatcgtttt ctgaacggtg actcccttaa
     2461 gccatttcct agcccaatga taaggagatt gcagctcttc ttagccttta acctggttgt
     2521 tattgtctgg ggctgctctg ccatatcgag aacattaact tcctgacaga actgtgtttt
     2581 ctgcttgtaa gaacttggct aaaatcccat tcttaaatga tgattagaga aaacccctcc
     2641 gttgttcatt tctgcttcat gatcagaggc tgtcagcctc tgtgccacag ctagcagttg
     2701 atgggaaagc ttacagactt gagtggcatg tgctgtaacc atctcctaga tctccagaaa
     2761 gccaggccct cctgtgtggg gggcacccag caccctgctt gttatcaagt gtggatatca
     2821 gagcttgcta gaggaccgtc tactaggacc agaagggtct tatatttaaa taattagtag
     2881 aaggtttttg ttaagaacat tttggctgtt ttggttttga tttttattca tgttatagca
     2941 gagattcaga tcctgtgccc attgggcagg actcattttc ttgatggctc tgtcagtaat
     3001 gacaagctct ttttctttct cgtatacttg tcaggaagaa aaggctaata gaatttttct
     3061 gttttcttaa aaataccgga aagctttttt aggcaaagca gcatctgacc ttgtggttag
     3121 ttcaggctgc catactgcag cagtacagct tctgccggtg ttggtgccgg acctcctcca
     3181 ccagcagcac actggcttca gttgctgtaa acatctctga gtggatgatc ccagaactga
     3241 ccgaaacagc acacttatat ttttttactt gttttaggaa ggaaataaat aaaaatgtta
     3301 tcccttctga gataagataa ataatctcat tccctgtccc acactctaaa aacttctgct
     3361 ggtcttaatt ttataaggca agtgtgttca gtcactctga taaaatctga accctctagc
     3421 atgacaacat gatgttcttc atagttgtag acaccagtgc ttgggctaaa cagtgcctgt
     3481 ctggaacttg ccaagttttt gaagcccagc acctgacggt accaccaatc accaagtggt
     3541 ttaagttaga actataattc agtgctaatg agctgcttag aacaagcttt gtaactgatg
     3601 tgagcacagg gttgtcagca gggaacattg acagcacaag gcctggtcct gtgagatccc
     3661 ttcgggtagt tctccccacc ctccatctca atcacattaa acttgaagtg gattgaatgg
     3721 agatgaagtg aggggctctg tgagatggag gctagtggga ggtggtactc cctgacccac
     3781 tgaggtatag ccagcattag gtggtgcctt gtctgtgtgc cagtgagatg atcctaggtg
     3841 agtgacagtg aggttggtca ctaaagtccc tgagagtctc ctggaaaggt tagtgaggct
     3901 tttcctccat taaaaaatct cagctagccg ggcacggtgg tgcgcacctt taatcccagc
     3961 acttgggagg cagaggcagg cagatttctg agttccagga cagcctggtc tacaaagaga
     4021 gttccaggac agccaggcct atacagagaa acactgtctc gaaaaataaa aagcaaaaca
     4081 aaacaaaaaa tctcagctag agtataaaat gatgctgcta gctgctaggg gaagtgagtc
     4141 cctggcagtg tggaaatcta ccatgtgagc agcatgcagt ataacctggc agtatgggaa
     4201 gtacaaaggg gaaatagtgt tgattgaagg tcattgtgta atcagtgtac cacaaagttc
     4261 tctggggttt gtttagacag atctgacatt ggttctttgg tgacagtttt caggcctgtg
     4321 agtgtcagct ggatgaagtc ttgggacctg gaacaagttg ttctttagtg acaggtttct
     4381 gagagggagt gcacaggttc ggaaaataaa gattatagga acgctgggct caggaagtct
     4441 tgcagagctg actttatgcc aggcaggttt ctttagaagt acatcttaca tggtgtgttg
     4501 tgaggaaata gggcacaggc agaaagttac catacaacgg gatgaagtcc caggaagcta
     4561 atcaagccat gttgcacaag gtaccatggt agctcaaggg catcatagac tgagcacata
     4621 gtggccttgg aactgatgaa ttcagtctct tcagagggaa aagataagtt ctcaggaacc
     4681 aaaatcttaa ctccatcaag gccccagccc agagcttgcc aagtgtgcgt tgtgtgagga
     4741 cgacacagga ctgagctctc ttgtcctctc atgggccatc ttgagaaggc caggattcgg
     4801 cctgactccc aacagccttc cagatgattt ttgagcgccc catttgctct taaggatgtg
     4861 atagctccac gatgaatgga gacctttgtc ctttagctta ccaaagagtc catctctgca
     4921 tcccgtgagt acgcgtggag agcgagcgca ctgtacctcc agctgcttgc ctggcaagcc
     4981 tctgaacagc aagcagagtt taatttagga gcacgtgaat gttatcttta taaaccttca
     5041 aagttgctgg tgacagtaac tatagaaaag ccatgcctta acctgtgcag ggagtcctct
     5101 tgggcaggag ccagtggcac gagctcgcca tgcctgagga gcatgcatgg ctgcagttca
     5161 gagctcgcac tctggttctg ctgctgtatg cacttagacg gttacagcag ataatctccg
     5221 cacagtcttg tgcagtgact gagaatctag tcagcaaagc tgtaactatc ctccatcata
     5281 cgtgtaggct gcgtatttta cctgtcccta cccattacat aggatggctc atgtgatacg
     5341 ttttacatgt aaagattcaa ggagaatcaa cagttcaatg tctacgtaaa ggaaaaaaca
     5401 aacaaacaaa caaaaaactt ttactagaaa aatgaagtaa aaatgatttc ctggttagcc
     5461 gggcctgttg gcgcatgcct ttaatcccag cacttgggag gcagaggcag gcggatttct
     5521 gagttcgagg ccagcctggt ctacagagtg agttccagga cagccagagc tacacagaca
     5581 aaccctgtct tgaaaaacct aaataaataa ataaataaaa ataaaaataa taatagtcat
     5641 ctcctggcat aaagtgatat ttccccaaac tgagcgggtg tcttttttgt ctctgtcaga
     5701 catttaattc caattagtag tttgaggatt tttaagagct gacattaaaa tattacaaaa
     5761 gaattatcta ataaagattt gttttttttt tgaa
//
