LOCUS       NM_008626               5801 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Mus musculus mannose receptor, C type 2 (Mrc2), mRNA.
ACCESSION   NM_008626
VERSION     NM_008626.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5801)
  AUTHORS   Potter,A.S., Miyake,C.Y., Gonzaga-Jauregui,C., Aguilar-Sanchez,Y.,
            Hulsurkar,M.M., Lahiri,S.K., Moreira,L.M., Mehta,N., Azamian,M.S.,
            Lupski,J.R., Reilly,S., Lalani,S.R. and Wehrens,X.H.T.
  TITLE     Rare Variant in MRC2 Associated With Familial Supraventricular
            Tachycardia and Wolff-Parkinson-White Syndrome
  JOURNAL   Circ Genom Precis Med 17 (4), e004614 (2024)
   PUBMED   38953222
  REMARK    GeneRIF: Rare Variant in MRC2 Associated With Familial
            Supraventricular Tachycardia and Wolff-Parkinson-White Syndrome.
REFERENCE   2  (bases 1 to 5801)
  AUTHORS   Jenkins,L., Jungwirth,U., Avgustinova,A., Iravani,M., Mills,A.,
            Haider,S., Harper,J. and Isacke,C.M.
  TITLE     Cancer-Associated Fibroblasts Suppress CD8+ T-cell Infiltration and
            Confer Resistance to Immune-Checkpoint Blockade
  JOURNAL   Cancer Res 82 (16), 2904-2917 (2022)
   PUBMED   35749591
REFERENCE   3  (bases 1 to 5801)
  AUTHORS   Norregaard,K.S., Jurgensen,H.J., Ingvarsen,S.Z., Heltberg,S.S.,
            Hagensen,C.E., Gardsvoll,H., Madsen,D.H., Jensen,O.N.,
            Engelholm,L.H. and Behrendt,N.
  TITLE     The endocytic receptor uPARAP is a regulator of extracellular
            thrombospondin-1
  JOURNAL   Matrix Biol 111, 307-328 (2022)
   PUBMED   35878760
  REMARK    GeneRIF: The endocytic receptor uPARAP is a regulator of
            extracellular thrombospondin-1.
REFERENCE   4  (bases 1 to 5801)
  AUTHORS   Jungwirth,U., van Weverwijk,A., Evans,R.J., Jenkins,L., Vicente,D.,
            Alexander,J., Gao,Q., Haider,S., Iravani,M. and Isacke,C.M.
  TITLE     Impairment of a distinct cancer-associated fibroblast population
            limits tumour growth and metastasis
  JOURNAL   Nat Commun 12 (1), 3516 (2021)
   PUBMED   34112782
  REMARK    GeneRIF: Impairment of a distinct cancer-associated fibroblast
            population limits tumour growth and metastasis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5801)
  AUTHORS   Jurgensen,H.J., Silva,L.M., Krigslund,O., van Putten,S.,
            Madsen,D.H., Behrendt,N., Engelholm,L.H. and Bugge,T.H.
  TITLE     CCL2/MCP-1 signaling drives extracellular matrix turnover by
            diverse macrophage subsets
  JOURNAL   Matrix Biol Plus 1, 100003 (2019)
   PUBMED   33543002
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5801)
  AUTHORS   Sheikh,H., Yarwood,H., Ashworth,A. and Isacke,C.M.
  TITLE     Endo180, an endocytic recycling glycoprotein related to the
            macrophage mannose receptor is expressed on fibroblasts,
            endothelial cells and macrophages and functions as a lectin
            receptor
  JOURNAL   J Cell Sci 113 (Pt 6), 1021-1032 (2000)
   PUBMED   10683150
REFERENCE   7  (bases 1 to 5801)
  AUTHORS   Behrendt,N., Jensen,O.N., Engelholm,L.H., Mortz,E., Mann,M. and
            Dano,K.
  TITLE     A urokinase receptor-associated protein with specific collagen
            binding properties
  JOURNAL   J Biol Chem 275 (3), 1993-2002 (2000)
   PUBMED   10636902
REFERENCE   8  (bases 1 to 5801)
  AUTHORS   Weis,W.I., Taylor,M.E. and Drickamer,K.
  TITLE     The C-type lectin superfamily in the immune system
  JOURNAL   Immunol Rev 163, 19-34 (1998)
   PUBMED   9700499
  REMARK    Review article
REFERENCE   9  (bases 1 to 5801)
  AUTHORS   Takahashi,K., Donovan,M.J., Rogers,R.A. and Ezekowitz,R.A.
  TITLE     Distribution of murine mannose receptor expression from early
            embryogenesis through to adulthood
  JOURNAL   Cell Tissue Res 292 (2), 311-323 (1998)
   PUBMED   9560474
REFERENCE   10 (bases 1 to 5801)
  AUTHORS   Wu,K., Yuan,J. and Lasky,L.A.
  TITLE     Characterization of a novel member of the macrophage mannose
            receptor type C lectin family
  JOURNAL   J Biol Chem 271 (35), 21323-21330 (1996)
   PUBMED   8702911
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB665946.1, BC116642.1, BU053305.1 and AL645684.16.
            
            On Sep 2, 2006 this sequence version replaced NM_008626.2.
            
            Sequence Note: A downstream translational start codon is selected
            for this RefSeq based on its better conservation in mammalian
            species and on the presence of a predicted signal peptide in the
            protein N-terminus. An upstream in-frame start codon is also
            present but is poorly conserved, and use of the upstream start
            codon would result in a protein that is 35 aa longer at the
            N-terminus and lacks a predicted signal peptide. Leaky scanning by
            ribosomes may allow translation initiation at the downstream start
            codon.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U56734.1, BC116642.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                BB665946.1         1-74
            75-3091             BC116642.1         1-3017
            3092-3669           BU053305.1         154-731
            3670-4591           BC116642.1         3596-4517
            4592-5801           AL645684.16        14988-16197
FEATURES             Location/Qualifiers
     source          1..5801
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 68.73 cM"
     gene            1..5801
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /note="mannose receptor, C type 2"
                     /db_xref="GeneID:17534"
                     /db_xref="MGI:MGI:107818"
     exon            1..256
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            257..658
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            659..832
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            833..997
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1111
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1255
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1444
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1599
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1707
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1823
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1972
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2190
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2333
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2436
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2575
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2611
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..2772
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2840
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..2941
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..3084
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3085..3199
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..3363
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3364..3472
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3473..3711
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3712..3880
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3881..4027
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4028..4147
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4148..4327
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4328..4354
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4355..5801
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5772..5777
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /note="hexamer: AATAAA"
     polyA_site      5798
                     /gene="Mrc2"
                     /gene_synonym="Endo180; mKIAA0709; uPARAP"
                     /note="major polyA site"
ORIGIN      
        1 tccgggaggc atcacttcgt ccggacccgg aggaggatgc gatcccctcg ccggcggtca
       61 tctgagcaca gcgctagggc tgtctctgca cgcagccctg ccgtgcgccc tccgtactct
      121 cgtcctccga gcgccgcagg gatggtaccc atccgacctg ccctcgcgcc ctggcctcgt
      181 cacctgctgc gctgcgtctt gcttctcggg ggactgcgtc tcggccaccc ggcggactcc
      241 gccgccgccc tcctggagcc tgatgtcttc ctcatcttca gccaggggat gcagggctgt
      301 ctggaggccc agggtgtgca ggtccgagtc accccagtct gcaatgccag tctccctgcc
      361 cagcgctgga agtgggtctc ccggaaccga ctcttcaacc tgggtgccac acagtgcctg
      421 ggtacaggct ggccagtcac caacaccaca gtttccttgg gcatgtatga gtgtgacaga
      481 gaggccttga gtcttcgatg gcagtgtcgt acactagggg accagttgtc cctgcttctg
      541 ggggctcgtg caagcaatgc atccaagcct ggcaccctgg agcgcggtga ccagacccgc
      601 agtggccatt ggaacatcta tggcagtgaa gaagacctat gtgctcgacc ttactatgag
      661 gtctacacca tccagggaaa ctcacacgga aagccgtgca ctatcccctt caaatacgac
      721 aaccagtggt tccacggctg caccagcact ggcagagaag atgggcacct gtggtgtgcc
      781 accacccagg actacggcaa agatgagcgc tggggcttct gccccatcaa gagtaacgac
      841 tgtgagacct tctgggacaa agaccagctg actgacagct gttaccagtt taacttccaa
      901 tccacactgt cctggaggga ggcctgggcc agctgcgagc agcagggtgc agacttgctg
      961 agtatcacgg agatccacga gcagacctac atcaacgggc tcctcacggg ctacagctcc
     1021 acgctatgga ttggccttaa tgacctggat accagtggag gctggcagtg gtcagacaac
     1081 tcacccctca agtacctcaa ctgggagagt gatcagccgg acaacccagg tgaggagaac
     1141 tgtggagtga tccggactga gtcctcaggc ggctggcaga accatgactg cagcatcgcc
     1201 ctgccctatg tttgcaagaa gaaacccaac gctacggtcg agcccatcca gccagaccgg
     1261 tggaccaatg tcaaggtgga atgtgacccc agctggcagc ccttccaggg ccactgctac
     1321 cgcctgcagg ccgagaagcg cagctggcag gagtccaaga gggcgtgtct gcggggtggg
     1381 ggtgacctcc ttagcatcca cagcatggct gagctggagt tcatcaccaa acagatcaag
     1441 caagaggtgg aggagctatg gattggcctc aatgatttga aactgcagat gaattttgag
     1501 tggtccgacg ggagcctcgt gagcttcacc cactggcacc cctttgagcc caacaacttt
     1561 cgtgacagcc tggaggactg tgtcaccatc tgggggccgg aaggacgctg gaacgacagt
     1621 ccctgtaacc agtccttgcc atccatttgc aagaaggcag gccggctgag ccagggcgct
     1681 gcggaggagg accacggctg ccggaagggt tggacgtggc atagcccatc ctgctactgg
     1741 ctgggagagg accaagtgat ctacagtgat gcccggcgcc tgtgtactga ccatggctct
     1801 cagctggtca ccatcaccaa caggtttgag caggccttcg tcagcagcct catctataac
     1861 tgggagggcg aatacttctg gacagccctg caagacctca acagtactgg ctccttccgt
     1921 tggctcagtg gggatgaagt catatatacc cattggaatc gagaccagcc tgggtacaga
     1981 cgtggaggct gtgtggctct ggccactggc agtgccatgg gactgtggga ggtgaagaac
     2041 tgcacatcgt tccgggctcg ctacatctgc cgacagagcc tgggcacacc ggtcacacca
     2101 gagctgcctg ggccagaccc cacgcccagc ctcactggct cctgtcccca gggctgggtc
     2161 tcagacccca aactccgaca ctgctataag gtgttcagct cagagcggct gcaggagaag
     2221 aagagttgga tccaggccct gggggtctgc cgggagttgg gggcccagct gctgagtctg
     2281 gccagctatg aggaggagca ctttgtggcc cacatgctca acaagatctt tggtgagtca
     2341 gagcctgaga gccatgagca gcactggttt tggattggcc tgaaccgcag agaccctaga
     2401 gagggtcaca gctggcgctg gagcgacggt ctagggtttt cctaccacaa ttttgcccgg
     2461 agccgacatg atgacgatga tatccgaggc tgtgcagtgc tggacctggc ctccctgcag
     2521 tgggtaccca tgcagtgcca gacgcagctt gactggatct gcaagatccc tagaggtgtg
     2581 gatgtgcggg aaccagacat tggtcgacaa ggccgtctgg agtgggtacg ctttcaggag
     2641 gccgagtaca agttttttga gcaccactcc tcgtgggcgc aggcacagcg catctgcacc
     2701 tggttccagg cagatctgac ctccgttcac agccaagcag aactggactt cctggggcaa
     2761 aacctgcaga agctgtcctc agaccaggag cagcactggt ggatcggcct gcacaccttg
     2821 gagagtgacg gacgcttcag gtggacagat ggttctatta taaacttcat ctcttgggca
     2881 ccgggaaaac ctagacccat tggcaaggac aagaagtgtg tatacatgac agccagacaa
     2941 gaggactggg gggaccagag gtgccatacg gctttgccct acatctgtaa gcgcagcaat
     3001 agctctggag agactcagcc ccaagacttg ccaccttcag ccttaggagg ctgcccctcc
     3061 ggttggaacc agttcctcaa taagtgtttc cgaatccagg gccaggaccc ccaggacagg
     3121 gtgaaatggt cagaggcaca gttctcctgt gaacagcaag aagcccagct ggtcaccatt
     3181 gcaaacccct tagagcaagc atttatcaca gccagcctcc ccaacgtgac ctttgacctt
     3241 tggattggcc tgcatgcctc tcagagggac ttccagtgga ttgaacaaga acccctgctc
     3301 tataccaact gggcaccagg agagccctct ggccccagcc ctgctcccag tggcaccaag
     3361 ccgaccagct gtgcggtgat cctgcacagc ccctcagccc acttcactgg ccgctgggat
     3421 gatcggagct gcacagagga gacgcatggc ttcatctgcc agaagggcac agacccctcg
     3481 ctaagcccat ccccagcagc aacaccccct gccccgggcg ctgagctctc ctatctcaac
     3541 cacaccttcc ggctgctgca gaagccactg cgctggaaag atgctctcct gctgtgtgag
     3601 agccgaaatg ccagcctggc acacgtgccc gatccctaca cacaagcctt cctcacacag
     3661 gctgcacggg ggctgcaaac accactgtgg atcgggctgg ccagtgagga gggctcacgg
     3721 aggtattcct ggctctcaga ggagcctctg aattatgtga gctggcaaga tgaggagccc
     3781 cagcactcgg gaggctgtgc ctacgtggat gtggatggaa cctggcgcac caccagctgt
     3841 gataccaagc tgcagggggc agtgtgtggg gtgagcaggg ggcccccacc ccgaaggata
     3901 aactaccgtg gcagctgtcc tcagggcttg gctgactcgt cctggattcc cttcagggag
     3961 cattgctatt ctttccacat ggaggtgctg ttgggccaca aggaggcgct gcagcgctgt
     4021 cagaaagctg gtgggacggt tctgtccatt cttgatgaga tggagaatgt gtttgtctgg
     4081 gagcacctgc agacagctga agcccaaagt cgaggtgcct ggttgggcat gaacttcaac
     4141 cccaaaggag gcacgctggt ctggcaagac aacacagctg tgaactattc taactggggg
     4201 ccccctggcc tgggccctag catgctaagc cacaacagct gctactggat ccagagcagc
     4261 agcggactgt ggcgccccgg ggcttgtacc aacatcacca tgggagttgt ctgcaagctc
     4321 cctagagtgg aagagaacag cttcttgcca tcagcagccc tccccgagag cccggttgcc
     4381 ctggtggtgg tgctgacagc ggtgctgctc ctcctggcct tgatgacggc agccctcatc
     4441 ctctaccggc gccgacagag tgcggagcgt gggtccttcg agggggcccg ctacagtcgc
     4501 agcagccact ctggccccgc agaggccacc gagaagaaca ttctggtgtc tgacatggaa
     4561 atgaacgaac agcaagaata gagccaaggg cgtggtcggg gtggagccaa agcgggggag
     4621 gcaggggccc caagggcgtg gtcggggtgg agccagagcg ggtaaggcag gggccccagg
     4681 tcagcaggcc cccatcaccc atcagcccag ttgtctttgg atggcaaccc ttgggagttg
     4741 ctactgggtg ccgggggcat agcttgccat ggggtgggag tacccagcct accatagagg
     4801 ctaggctgag acttggcagt gggtcatgtt cccctttccc ttgggcctgg gatcgtgtca
     4861 cctggacctg gaccccatgg caactggagg caatatgaga agggacatga gcttattcat
     4921 gtcttttcct ccccagatcc ctgagcctaa acctgctgac ctgcagccta ggattctttc
     4981 ctatctgtag gcctggaaag cctgccccgt cccttggggt ggctctctgt cacctctcct
     5041 actcggctac atcagctctg tctcctcacc ctgccctcgt gccttttttt ccacccagtg
     5101 cctccttctg agccatggcc ctgggacttg ggtgatctct ctctctctct ctctctctct
     5161 ctctctcatt ctctctctct ttctctctgg gtgggggtca gctgaagagg ctggccaagc
     5221 atctgtcact cctgtgcctg ctggaatgga cctagggtat ggcaggaggg agcctaggtg
     5281 gctcaggtgt acaaaccagg gcaccggtgt ggtgtctgct ggagtagaga tggaacttcg
     5341 gagagacacc ttatccactc acagggtgtc atctcctgct ggtcagggga gggctctgtc
     5401 cttgaaagag tcccctgtgg ggaccaaaat aagttcccta atgtctccgg cttctggctc
     5461 tggcttggag agagggaaga tggtttggag ggggaggggc gctggtgagg ctgtaacctg
     5521 ggacagcacc aggtgctacc atctggtgtg gcctaggaga ccaactcatg gaaccactca
     5581 gcaccttttt ccagaggaga gtcccagcca ggatggagag tgccagtccc cgtgtcccag
     5641 tgcaggacga tgtgaacaaa aactcaaagc ggaccctcta ttgtagttct tgattctcga
     5701 aatgtgctat tattgtttgt cttttttttt ttttttttaa agaaggaaaa agagaaaaag
     5761 aatagcaaac aaataaaaac cttccagagg cttgagaagt c
//
