LOCUS       NM_008625               5322 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus mannose receptor, C type 1 (Mrc1), mRNA.
ACCESSION   NM_008625 XM_001003164 XM_001003168
VERSION     NM_008625.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5322)
  AUTHORS   Lehtonen,H., Jokela,H., Hofmann,J., Tola,L., Mehmood,A.,
            Ginhoux,F., Becher,B., Greter,M., Yegutkin,G.G., Salmi,M., Gerke,H.
            and Rantakari,P.
  TITLE     Early precursor-derived pituitary gland tissue-resident macrophages
            play a pivotal role in modulating hormonal balance
  JOURNAL   Cell Rep 44 (2), 115227 (2025)
   PUBMED   39841599
REFERENCE   2  (bases 1 to 5322)
  AUTHORS   Singh,S.S., Calvo,R., Kumari,A., Sable,R.V., Fang,Y., Tao,D.,
            Hu,X., Castle,S.G., Nahar,S., Li,D., Major,E., Sanchez,T.W.,
            Kato,R., Xu,X., Zhou,J., Liu,L., LeClair,C.A., Simeonov,A.,
            Baljinnyam,B., Henderson,M.J., Marugan,J. and Rudloff,U.
  TITLE     Fatty Acid Derivatization and Cyclization of the Immunomodulatory
            Peptide RP-182 Targeting CD206high Macrophages Improve Antitumor
            Activity
  JOURNAL   Mol Cancer Ther 23 (12), 1827-1841 (2024)
   PUBMED   39212669
REFERENCE   3  (bases 1 to 5322)
  AUTHORS   Du,S., Drieu,A., Cheng,Y., Storck,S.E., Rustenhoven,J.,
            Mamuladze,T., Bhattarai,B., Brioschi,S., Nguyen,K., Ou,F., Cao,J.,
            Rodrigues,P.F., Smirnov,I., DeNardo,D., Ginhoux,F., Cella,M.,
            Colonna,M. and Kipnis,J.
  TITLE     Brain-Engrafted Monocyte-derived Macrophages from Blood and
            Skull-Bone Marrow Exhibit Distinct Identities from Microglia
  JOURNAL   bioRxiv (2024)
   PUBMED   39211090
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5322)
  AUTHORS   Morimoto,K., Takahashi,R., Takahashi,G., Miyajima,M. and
            Nakajima,K.
  TITLE     Maternal immunoglobulins are distributed in the offspring's brain
            to support the maintenance of cortical interneurons in the
            postnatal period
  JOURNAL   Inflamm Regen 44 (1), 24 (2024)
   PUBMED   38750507
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5322)
  AUTHORS   Subileau,M. and Vittet,D.
  TITLE     Ontogenesis of the Mouse Ocular Surface Lymphatic Vascular Network
  JOURNAL   Invest Ophthalmol Vis Sci 64 (15), 7 (2023)
   PUBMED   38054922
REFERENCE   6  (bases 1 to 5322)
  AUTHORS   Takahashi,K., Donovan,M.J., Rogers,R.A. and Ezekowitz,R.A.
  TITLE     Distribution of murine mannose receptor expression from early
            embryogenesis through to adulthood
  JOURNAL   Cell Tissue Res 292 (2), 311-323 (1998)
   PUBMED   9560474
REFERENCE   7  (bases 1 to 5322)
  AUTHORS   Eichbaum,Q., Heney,D., Raveh,D., Chung,M., Davidson,M., Epstein,J.
            and Ezekowitz,R.A.
  TITLE     Murine macrophage mannose receptor promoter is regulated by the
            transcription factors PU.1 and SP1
  JOURNAL   Blood 90 (10), 4135-4143 (1997)
   PUBMED   9354684
REFERENCE   8  (bases 1 to 5322)
  AUTHORS   Narita,M., Bu,G., Herz,J. and Schwartz,A.L.
  TITLE     Two receptor systems are involved in the plasma clearance of
            tissue-type plasminogen activator (t-PA) in vivo
  JOURNAL   J Clin Invest 96 (2), 1164-1168 (1995)
   PUBMED   7635954
REFERENCE   9  (bases 1 to 5322)
  AUTHORS   Harris,N., Peters,L.L., Eicher,E.M., Rits,M., Raspberry,D.,
            Eichbaum,Q.G., Super,M. and Ezekowitz,R.A.
  TITLE     The exon-intron structure and chromosomal localization of the mouse
            macrophage mannose receptor gene Mrc1: identification of a
            Ricin-like domain at the N-terminus of the receptor
  JOURNAL   Biochem Biophys Res Commun 198 (2), 682-692 (1994)
   PUBMED   8297379
REFERENCE   10 (bases 1 to 5322)
  AUTHORS   Harris,N., Super,M., Rits,M., Chang,G. and Ezekowitz,R.A.
  TITLE     Characterization of the murine macrophage mannose receptor:
            demonstration that the downregulation of receptor expression
            mediated by interferon-gamma occurs at the level of transcription
  JOURNAL   Blood 80 (9), 2363-2373 (1992)
   PUBMED   1421407
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z11974.1, AL845290.7, AK079897.1 and BE197931.1.
            
            On Mar 13, 2009 this sequence version replaced NM_008625.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z11974.1, BC141338.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2574              Z11974.1           1-2574
            2575-2576           AL845290.7         67579-67580
            2577-4815           Z11974.1           2577-4815
            4816-5227           AK079897.1         779-1190
            5228-5322           BE197931.1         1-95                c
FEATURES             Location/Qualifiers
     source          1..5322
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 10.46 cM"
     gene            1..5322
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /note="mannose receptor, C type 1"
                     /db_xref="GeneID:17533"
                     /db_xref="MGI:MGI:97142"
     exon            1..160
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..4470
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /note="macrophage mannose receptor 1; MMR"
                     /codon_start=1
                     /product="macrophage mannose receptor 1 precursor"
                     /protein_id="NP_032651.2"
                     /db_xref="CCDS:CCDS15700.1"
                     /db_xref="GeneID:17533"
                     /db_xref="MGI:MGI:97142"
                     /translation="MRLLLLLAFISVIPVSVQLLDARQFLIYNEDHKRCVDALSAISV
                     QTATCNPEAESQKFRWVSDSQIMSVAFKLCLGVPSKTDWASVTLYACDSKSEYQKWEC
                     KNDTLFGIKGTELYFNYGNRQEKNIKLYKGSGLWSRWKVYGTTDDLCSRGYEAMYSLL
                     GNANGAVCAFPFKFENKWYADCTSAGRSDGWLWCGTTTDYDKDKLFGFCPLHFEGSER
                     LWNKDPLTGILYQINSKSALTWHQARASCKQQNADLLSVTEIHEQMYLTGLTSSLSSG
                     LWIGLNSLSVRSGWQWAGGSPFRYLNWLPGSPSSEPGKSCVSLNPGKNAKWENLECVQ
                     KLGYICKKGNNTLNPFIIPSASDVPTGCPNQWWPYAGHCYRIHREEKKIQKYALQACR
                     KEGGDLASIHSIEEFDFIFSQLGYEPNDELWIGLNDIKIQMYFEWSDGTPVTFTKWLP
                     GEPSHENNRQEDCVVMKGKDGYWADRACEQPLGYICKMVSQSHAVVPEGADKGCRKGW
                     KRHGFYCYLIGSTLSTFTDANHTCTNEKAYLTTVEDRYEQAFLTSLVGLRPEKYFWTG
                     LSDVQNKGTFRWTVDEQVQFTHWNADMPGRKAGCVAMKTGVAGGLWDVLSCEEKAKFV
                     CKHWAEGVTRPPEPTTTPEPKCPENWGTTSKTSMCFKLYAKGKHEKKTWFESRDFCKA
                     IGGELASIKSKDEQQVIWRLITSSGSYHELFWLGLTYGSPSEGFTWSDGSPVSYENWA
                     YGEPNNYQNVEYCGELKGDPGMSWNDINCEHLNNWICQIQKGKTLLPEPTPAPQDNPP
                     VTADGWVIYKDYQYYFSKEKETMDNARAFCKKNFGDLATIKSESEKKFLWKYINKNGG
                     QSPYFIGMLISMDKKFIWMDGSKVDFVAWATGEPNFANDDENCVTMYTNSGFWNDINC
                     GYPNNFICQRHNSSINATAMPTTPTTPGGCKEGWHLYKNKCFKIFGFANEEKKSWQDA
                     RQACKGLKGNLVSIENAQEQAFVTYHMRDSTFNAWTGLNDINAEHMFLWTAGQGVHYT
                     NWGKGYPGGRRSSLSYEDADCVVVIGGNSREAGTWMDDTCDSKQGYICQTQTDPSLPV
                     SPTTTPKDGFVTYGKSSYSLMKLKLPWHEAETYCKDHTSLLASILDPYSNAFAWMKMH
                     PFNVPIWIALNSNLTNNEYTWTDRWRVRYTNWGADEPKLKSACVYMDVDGYWRTSYCN
                     ESFYFLCKKSDEIPATEPPQLPGKCPESEQTAWIPFYGHCYYFESSFTRSWGQASLEC
                     LRMGASLVSIETAAESSFLSYRVEPLKSKTNFWIGMFRNVEGKWLWLNDNPVSFVNWK
                     TGDPSGERNDCVVLASSSGLWNNIHCSSYKGFICKMPKIIDPVTTHSSITTKADQRKM
                     DPQPKGSSKAAGVVTVVLLIVIGAGVAAYFFYKKRHALHIPQEATFENTLYFNSNLSP
                     GTSDTKDLMGNIEQNEHAII"
     exon            161..562
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            563..736
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            737..901
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1015
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1162
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1348
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1506
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1617
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1733
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1882
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2082
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2210
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2298
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2443
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2485
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2649
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            2650..2717
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            2718..2818
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            2819..2961
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            2962..3076
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            3077..3243
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            3244..3346
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            3347..3579
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            3580..3745
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            3746..3895
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            3896..4009
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            4010..4174
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            4175..4216
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            4217..5318
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5200..5205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /note="hexamer: AATAAA"
     regulatory      5207..5212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /note="hexamer: ATTAAA"
     polyA_site      5223
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /note="major polyA site"
     polyA_site      5229
                     /gene="Mrc1"
                     /gene_synonym="CD206; MR"
                     /note="major polyA site"
ORIGIN      
        1 gaccttggac tgagcaaagg ggcaacctgg ggacctggtt gtattctttg cctttcccag
       61 tctccctctt ctccctcatt ggaagatcca ctctgggcca tgaggcttct cctgcttctg
      121 gcttttatct ctgtcatccc tgtctctgtt cagctattgg acgcgaggca atttttaatc
      181 tataatgaag atcacaagcg ctgcgtggac gctctaagtg ccatctcagt tcagacggca
      241 acttgcaacc cggaagctga atcccagaaa ttccgctggg tgtcagattc tcagatcatg
      301 agtgttgctt tcaaattatg tttgggagtg ccatcaaaaa ctgactgggc ttccgtcacc
      361 ctgtatgcct gtgattcgaa aagtgaatat cagaaatggg agtgtaagaa tgacacactc
      421 tttggaatca agggcacaga gttatatttt aattatggca acagacaaga gaagaatatc
      481 aagctttaca aaggttcggg attgtggagc agatggaagg tctatggaac cacggatgac
      541 ctgtgctcga gaggatatga agccatgtac tccttactgg gcaatgcaaa tggagccgtc
      601 tgtgcatttc cattcaagtt tgaaaacaag tggtatgcag actgcacctc tgccgggcgc
      661 tcggacggat ggctctggtg tggaaccacc actgactacg acaaagacaa gctgtttgga
      721 ttttgtccat tgcactttga gggaagcgag agattatgga acaaagatcc actgactggc
      781 attctttacc agataaactc caagtctgct ttaacctggc atcaggcaag ggcaagctgc
      841 aagcagcaga atgctgacct cctgagtgtc acggagatcc acgagcaaat gtacctcaca
      901 ggattaacca gttccttgag ctcgggactc tggattggac tcaacagtct gagtgtacgc
      961 agtggttggc agtgggctgg aggaagccca ttccggtatc tgaactggct accaggaagt
     1021 ccatcatcag agcctggaaa gagctgtgtg tcactaaacc ctggaaaaaa tgccaagtgg
     1081 gaaaatctgg aatgtgttca gaagcttggc tacatttgta aaaagggaaa caataccttg
     1141 aacccattta tcattccctc agcaagcgat gtgcctaccg gctgccctaa tcagtggtgg
     1201 ccctatgcag gccactgcta caggatccat agggaagaga agaagatcca gaaatatgct
     1261 ttgcaagctt gtaggaagga gggtggggac ctggcaagta tccacagcat tgaggagttt
     1321 gacttcatct tctcccagct cggatatgag ccaaatgatg agctgtggat tggtttaaat
     1381 gacatcaaga ttcagatgta ctttgagtgg agtgatggaa ccccagtgac atttactaaa
     1441 tggcttcctg gagagccaag ccatgagaac aacagacagg aggactgcgt ggttatgaaa
     1501 ggcaaggatg gatactgggc ggacagagcc tgtgagcaac cactaggtta catctgtaag
     1561 atggtatcac aaagccatgc tgtagtaccg gagggtgcag acaaaggctg ccggaaaggc
     1621 tggaaacggc atgggtttta ctgctacttg attggatcca ctctatccac cttcactgat
     1681 gcaaaccaca catgcacaaa tgaaaaggct tatttaacaa cagttgaaga cagatatgaa
     1741 caagcattcc tgactagttt ggttggattg aggcctgaaa aatatttttg gacaggactc
     1801 tcagatgttc aaaacaaagg gacgtttcgg tggactgtgg acgagcaggt gcagtttaca
     1861 cactggaatg ccgacatgcc aggacgaaag gcgggatgtg ttgccatgaa aaccggagtg
     1921 gcaggtggct tatgggatgt tttgagttgt gaagaaaagg caaaatttgt gtgcaaacat
     1981 tgggcagaag gagtgactcg cccaccagag cccacaacaa ctcctgaacc caaatgtcca
     2041 gaaaactggg gtaccaccag taaaaccagc atgtgtttca aactgtatgc aaaaggaaag
     2101 catgaaaaga aaacgtggtt tgaatctcga gatttttgca aagctatagg tggagagctg
     2161 gcgagcatca agagtaaaga tgaacagcaa gtgatttgga ggctgattac gagcagtgga
     2221 agctaccatg agctgttttg gttgggactg acctatggaa gtccttcaga ggggttcacc
     2281 tggagtgatg gttctcccgt ttcctatgaa aattgggctt acggtgaacc aaataattac
     2341 caaaatgttg aatattgtgg tgagctgaaa ggtgaccctg gcatgtcctg gaatgatatc
     2401 aactgtgaac acctcaacaa ctggatttgt cagatacaaa aagggaaaac actactacct
     2461 gagcccacac ctgctccaca agacaatcca ccagttactg cagatgggtg ggttatttac
     2521 aaagactacc agtactattt tagcaaagag aaggaaacca tggacaacgc gcgagcattt
     2581 tgcaagaaga attttggtga tcttgctaca attaaaagtg aaagtgaaaa gaagtttcta
     2641 tggaaatata taaacaagaa tggtgggcag tcaccatatt ttattggcat gttaatcagc
     2701 atggataaga aattcatttg gatggatggg agcaaagtag attttgtggc ttgggctaca
     2761 ggagaaccca actttgcaaa tgatgatgaa aactgtgtaa cgatgtacac aaattcaggg
     2821 ttctggaatg acatcaactg tggttatcca aataacttca tctgccagag acataacagc
     2881 agcatcaatg ccactgccat gcctaccaca cccacgacac caggtggctg caaggaaggt
     2941 tggcatttgt acaagaacaa gtgctttaaa atttttggat ttgctaatga agaaaaaaaa
     3001 agctggcaag acgcacggca agcttgcaaa ggactgaaag gaaacctggt gtccatagaa
     3061 aatgcacaag agcaagcatt tgttacctat cacatgagag actccacttt caatgcctgg
     3121 actgggctga atgatatcaa cgcagaacac atgttcctgt ggacagctgg acaaggagtt
     3181 cattatacaa actgggggaa aggctatcct ggtggaagaa gaagtagcct atcttatgaa
     3241 gatgctgact gtgtagttgt gattggtggc aattcacgag aggcagggac ctggatggat
     3301 gacacctgtg acagtaaaca aggctatata tgtcaaacac agactgaccc ttccctgcct
     3361 gtttctccaa ccactactcc aaaagatggc tttgttacat atgggaaaag cagctattcc
     3421 cttatgaaat tgaagctacc atggcatgaa gcagagacat attgcaagga tcatacttcc
     3481 ctgcttgcta gcattctaga cccctacagt aatgcatttg catggatgaa aatgcaccca
     3541 tttaatgtac ccatatggat tgccctgaac agcaacttga ccaataatga atatacttgg
     3601 acggatagat ggagggtgcg gtacactaac tggggtgctg acgagccgaa gcttaagtca
     3661 gcatgtgttt acatggatgt tgatggctac tggagaacat catactgcaa tgaaagtttt
     3721 tattttctct gcaaaaaatc agacgaaatc cctgctactg aacctcctca actgcctggc
     3781 aagtgtccag agtcagaaca gactgcgtgg attcctttct atggccattg ctactatttt
     3841 gaatcttctt ttacgagaag ttggggtcag gcttctctgg aatgccttcg aatgggtgcc
     3901 tccctggttt ccatcgagac tgctgctgag tccagttttc tgtcataccg tgttgaacct
     3961 cttaaaagta aaaccaattt ttggataggc atgttccgaa atgttgaagg gaagtggctt
     4021 tggttgaacg acaatcctgt ctcctttgtc aactggaaaa caggcgatcc ctctggtgaa
     4081 cggaatgatt gtgtagttct agcttcatct tcgggccttt ggaataatat ccactgttct
     4141 tcgtacaaag gatttatttg taaaatgcca aaaattattg atcctgtaac tacacactca
     4201 tccattacaa ccaaagctga ccaaaggaag atggatcctc aacccaaggg ctcttctaaa
     4261 gcagcaggag tggtcaccgt ggtcctcctg attgtgatag gtgccggcgt tgcagcctat
     4321 ttcttttata agaaaaggca tgcgttgcac atacctcaag aggccacctt tgaaaacact
     4381 ctctacttca acagtaatct gagtccagga acaagtgaca cgaaagatct catgggcaac
     4441 atcgagcaga atgagcatgc gatcatttag catcctaatc tgactgtctc atattcgaag
     4501 ttcaagaagt ctgaactaaa gttttcaatt ttttaattca atatgattgt ttcttttttt
     4561 aaaaaaaatt agcactgggt tgcattggtt tgtccttttt cttcgcctaa ttgaacaata
     4621 attgctcatt tactatcctg gcaagattag agaaacaaaa aacagaagag ggataataat
     4681 gttgattgtt gattgccact tttgaagata cctttgatga atacacagca ctagcgtctt
     4741 aacactgcta cactggtggt aggtctcatg tcaaccctgc agatttcaag agttctagaa
     4801 acaaccacgt aagccactca gggtattttc aggacctccc agagatatgt tatacaccga
     4861 attgtaattc aacatttaaa agtccatgtt aaaatagaca agtccacata accccagatt
     4921 gaataagaat gtattcaggt ctttttcagc agtcctgatt catgtcagtt attgagaact
     4981 gtatttatcc acatgtagaa taataaagct actgagaatc ttgtttgtcc caggcaaggt
     5041 ttgacaggct gaatattgca aatgtgttct gtgttctgtt gtatgtatat taggaaggtg
     5101 actatgtgaa gagaaaaccc tgtaaatttg cataactggg tatacttaga taataaataa
     5161 tgctatttat tatctaatta atgtgatgaa ttaatgtgaa ataaaaatta aagatgacat
     5221 ctattttaat tttttgtgat cttgttaaat ataaatttgc ttgaacataa ggcttatttg
     5281 ctttacattt aactattaat aaagatgaac aacttgtaaa aa
//
