LOCUS       NM_008624               4058 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus muscle and microspikes RAS (Mras), mRNA.
ACCESSION   NM_008624
VERSION     NM_008624.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4058)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4058)
  AUTHORS   Chen,S., Vedula,R.S., Cuevas-Navarro,A., Lu,B., Hogg,S.J., Wang,E.,
            Benbarche,S., Knorr,K., Kim,W.J., Stanley,R.F., Cho,H.,
            Erickson,C., Singer,M., Cui,D., Tittley,S., Durham,B.H.,
            Pavletich,T.S., Fiala,E., Walsh,M.F., Inoue,D., Monette,S.,
            Taylor,J., Rosen,N., McCormick,F., Lindsley,R.C., Castel,P. and
            Abdel-Wahab,O.
  TITLE     Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal
            Hematopoietic Transformation
  JOURNAL   Cancer Discov 12 (10), 2434-2453 (2022)
   PUBMED   35904492
REFERENCE   3  (bases 1 to 4058)
  AUTHORS   Fang,Y., Fan,W., Xu,X., Janoshazi,A.K., Fargo,D.C. and Li,X.
  TITLE     SIRT1 regulates cardiomyocyte alignment during maturation
  JOURNAL   J Cell Sci 135 (7) (2022)
   PUBMED   35260907
REFERENCE   4  (bases 1 to 4058)
  AUTHORS   Smith,S.B., Parisien,M., Bair,E., Belfer,I., Chabot-Dore,A.J.,
            Gris,P., Khoury,S., Tansley,S., Torosyan,Y., Zaykin,D.V.,
            Bernhardt,O., de Oliveira Serrano,P., Gracely,R.H., Jain,D.,
            Jarvelin,M.R., Kaste,L.M., Kerr,K.F., Kocher,T., Lahdesmaki,R.,
            Laniado,N., Laurie,C.C., Laurie,C.A., Mannikko,M., Meloto,C.B.,
            Nackley,A.G., Nelson,S.C., Pesonen,P., Ribeiro-Dasilva,M.C.,
            Rizzatti-Barbosa,C.M., Sanders,A.E., Schwahn,C., Sipila,K.,
            Sofer,T., Teumer,A., Mogil,J.S., Fillingim,R.B., Greenspan,J.D.,
            Ohrbach,R., Slade,G.D., Maixner,W. and Diatchenko,L.
  TITLE     Genome-wide association reveals contribution of MRAS to painful
            temporomandibular disorder in males
  JOURNAL   Pain 160 (3), 579-591 (2019)
   PUBMED   30431558
REFERENCE   5  (bases 1 to 4058)
  AUTHORS   Sanz-Rodriguez,M., Gruart,A., Escudero-Ramirez,J., de Castro,F.,
            Delgado-Garcia,J.M., Wandosell,F. and Cubelos,B.
  TITLE     R-Ras1 and R-Ras2 Are Essential for Oligodendrocyte Differentiation
            and Survival for Correct Myelination in the Central Nervous System
  JOURNAL   J Neurosci 38 (22), 5096-5110 (2018)
   PUBMED   29720552
REFERENCE   6  (bases 1 to 4058)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 4058)
  AUTHORS   Louahed,J., Grasso,L., De Smet,C., Van Roost,E., Wildmann,C.,
            Nicolaides,N.C., Levitt,R.C. and Renauld,J.C.
  TITLE     Interleukin-9-induced expression of M-Ras/R-Ras3 oncogene in
            T-helper clones
  JOURNAL   Blood 94 (5), 1701-1710 (1999)
   PUBMED   10477695
REFERENCE   8  (bases 1 to 4058)
  AUTHORS   Quilliam,L.A., Castro,A.F., Rogers-Graham,K.S., Martin,C.B.,
            Der,C.J. and Bi,C.
  TITLE     M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1,
            and p120 Ras GTPase-activating protein, interacts with the putative
            Ras effector AF6
  JOURNAL   J Biol Chem 274 (34), 23850-23857 (1999)
   PUBMED   10446149
REFERENCE   9  (bases 1 to 4058)
  AUTHORS   Matsumoto,K., Asano,T. and Endo,T.
  TITLE     Novel small GTPase M-Ras participates in reorganization of actin
            cytoskeleton
  JOURNAL   Oncogene 15 (20), 2409-2417 (1997)
   PUBMED   9395237
REFERENCE   10 (bases 1 to 4058)
  AUTHORS   Kogerman,P., Sy,M.S. and Culp,L.A.
  TITLE     CD44 protein levels and its biological activity are regulated in
            Balb/c 3T3 fibroblasts by serum factors and by transformation with
            the ras but not with the sis oncogene
  JOURNAL   J Cell Physiol 169 (2), 341-349 (1996)
   PUBMED   8908201
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX122916.1, CJ162751.1, AB004879.1, AK050469.1, AC157994.2 and
            BC023079.1.
            
            On Apr 17, 2007 this sequence version replaced NM_008624.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.238883.1,
                                           SRR1660817.221420.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849390, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-282               CX122916.1         1-282
            283-485             CJ162751.1         272-474
            486-1476            AB004879.1         470-1460
            1477-1936           AK050469.1         1321-1780
            1937-2686           AC157994.2         90300-91049
            2687-4058           BC023079.1         313-1684
FEATURES             Location/Qualifiers
     source          1..4058
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 51.63 cM"
     gene            1..4058
                     /gene="Mras"
                     /gene_synonym="2900078C09Rik"
                     /note="muscle and microspikes RAS"
                     /db_xref="GeneID:17532"
                     /db_xref="MGI:MGI:1100856"
     exon            1..403
                     /gene="Mras"
                     /gene_synonym="2900078C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            404..613
                     /gene="Mras"
                     /gene_synonym="2900078C09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             421..1047
                     /gene="Mras"
                     /gene_synonym="2900078C09Rik"
                     /EC_number="3.6.5.2"
                     /note="X-Ras; ras-related protein R-Ras3"
                     /codon_start=1
                     /product="ras-related protein M-Ras"
                     /protein_id="NP_032650.1"
                     /db_xref="CCDS:CCDS23433.1"
                     /db_xref="GeneID:17532"
                     /db_xref="MGI:MGI:1100856"
                     /translation="MATSAVPSENLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDP
                     TIEDSYLKHTEIDNQWAILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEH
                     VDRFHQLILRVKDRESFPMILVANKVDLMHLRKVTRDQGKEMATKYNIPYIETSAKDP
                     PLNVDKTFHDLVRVIRQQVPEKNQKKKKKTKWRGDRATGTHKLQCVIL"
     exon            614..767
                     /gene="Mras"
                     /gene_synonym="2900078C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            768..867
                     /gene="Mras"
                     /gene_synonym="2900078C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            868..947
                     /gene="Mras"
                     /gene_synonym="2900078C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            948..4032
                     /gene="Mras"
                     /gene_synonym="2900078C09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1454..1459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mras"
                     /gene_synonym="2900078C09Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1476
                     /gene="Mras"
                     /gene_synonym="2900078C09Rik"
     regulatory      4013..4018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mras"
                     /gene_synonym="2900078C09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4030
                     /gene="Mras"
                     /gene_synonym="2900078C09Rik"
                     /note="major polyA site"
ORIGIN      
        1 cgcggagccg tcagtcggcg gcgcggggcc cggcgggcgc ggcgctccct cctcccggtg
       61 cgagcgagga ggcggtggcc cagggcggga gcccagcccc ggcgggagcg cgcggcgagc
      121 cgcccggcaa ccctgagggg aggaggccgc cgggcgcttt gttccgttcc ggggctggag
      181 gtgtggccgg ttccgcgttc gccgggctgc gctgcgctgc acccggctgc acccgggcag
      241 cgggctccgg ctgtgcgtgg cctctgcccc ctaccaccgg ctctggctta acggtgtgca
      301 gcggagaagt cgctcaccac tccgacccaa gtgggaaggg cctagccgcc gcttagacag
      361 actcctttga ttgtagtcat cctggggttc ctcggctgcc cgggcctgac taccagaaac
      421 atggcgacca gcgctgttcc aagtgaaaac cttcccacat ataaactagt agtggtggga
      481 gatggtggtg tgggcaagag tgcgctcact attcagtttt tccagaagat ctttgtgcct
      541 gactacgacc ccaccattga agactcctac ctgaagcata cagagattga caatcagtgg
      601 gccatcttgg atgttctgga cacagccggg caggaggagt tcagtgccat gcgggaacaa
      661 tacatgcgca caggggatgg cttcctcatt gtctactccg tcaccgacaa ggccagcttc
      721 gagcacgtgg accgcttcca ccagctcatt ctgcgtgtca aggacaggga gtcattccca
      781 atgatcctcg tggccaacaa ggtggatctg atgcacctaa ggaaagtcac cagggaccaa
      841 ggaaaagaaa tggcaaccaa atacaatatc ccatatatag agaccagtgc caaggacccg
      901 cctctcaacg tggataaaac cttccatgac ctagttagag taattaggca acaggttcca
      961 gagaaaaacc agaagaagaa aaagaagaca aaatggcgag gagacagggc caccggcact
     1021 cacaaactgc agtgtgtcat cttgtgacag cctgaagccc tgggcatagc aaccgtgaac
     1081 tgccagcccc tgggaccagc ccactgccta actgcactga gaaccacttc taactacagc
     1141 ccttggctct ggactgggca ttggaaggga atgagggagg agggggcaga agcaggccgg
     1201 ggctggcttt gctgcctctc ccaggagaca gggctacagc ttccaaacct tttgtgtgtt
     1261 gactgagccc agttcccagt ctcttggtgg gcttgtttct tttaactcca tagggctggt
     1321 ttgctatgga agtgcttacc cacatacaac gcaccagaca agccatgagc aagcttcctc
     1381 cctgtcccat ccccagtgtc tgagctcttg tgtcttttgt agatttttaa attatttgag
     1441 taatgattat tttattaaag aggtctgtgc ccattgcctg gcgaagcccc aagtctttgg
     1501 cagacctctg ataaatgtct gcaatagggc tgttgtcttc ttaaccgagt gttcctagca
     1561 gtgccaaact ccatcctgga tgagaggcag aagtaggtgg agtcttatca gaagcctggg
     1621 gtcaaaccca ggaagcaaac agaccccaga gactggagag agggggtgga tttacctgga
     1681 gggctttggt acagttgaaa acaaacaaac aaacaacggc agagattaga aaacaacccc
     1741 cctcactact acaccccacc ctcaatccca cccccactga agtgagagct agctgggacc
     1801 ggttcacccc tgaggggatt tcctttcctt gagtgtgtgg tgaggccagt gactggcttt
     1861 gcaaaaggac tcatttgctt tccatgctgt gggtaaattc tatgttcaga tatggacagt
     1921 gtccctgttt gctctcagac tatgtattcc tgtgcctctg acacaaactt agggacatgt
     1981 tcaaggaggt ggatgtgaca ccatccagaa agctctgaac tgaaagtgct caatactatt
     2041 atctcagaag ccccaggacc tgaagccatt tccacccgag tcagctgacc attaccttta
     2101 taagtccagc cgatgagcaa accccttcta gcaggtacgg ctgcggctgc ctttcggtac
     2161 acactttctt tgcgctctta ggtcaaaggg gaagaaagct gagctgagga catgatccac
     2221 acactcattt gagcagggac acctcccgcc acaatgcact cctccctctc tggtgctgct
     2281 agtggggtag aggggctttt tccagctaag acccgtatgg aggaacagca agaacaaagt
     2341 acaccctgtg agagggttgg gagtggaggt ggctggcgta gtgagtgagg gcatctgcca
     2401 gctcaccttg cagaacggag gctcccacca gggggctggg ccagtgtgga gaagggaact
     2461 cacggaagga aatccaagga aaccaggcac cgagtagggt gtccagcctc gtgattcctt
     2521 tccaacccag agagtcctaa attgttcaca cgcagggtca tcaggacaga aggccccatg
     2581 caagggacaa ctctgctaca gaaggaaatg actgacgctt ttgctagcta gagatcaaac
     2641 ttcctactca ccaaactgcc acccgccccg attttttttt ttttttctgt tcctgaaaag
     2701 gatactagag ggcatgtcag atgaggtatt caccatttct cagatccggt aatacttatg
     2761 aatattttca acatgaaaag aaccaggctt tctccagccc tgggctccct aagccacacc
     2821 catagccact gcagcccaga gagaggaaag atggaaggga gggtcaggat gctctacact
     2881 cagggcagca gccactgcca gagaagccat gtcctgccac ctgctaccgg cacaccctca
     2941 cttccgtgga ccagccagcg cctctcctgt gccgagtgga gactcttccc ggaagcagac
     3001 tagaccaaag ccctgaggag tgagtcacac agctgaccag aagggaggct cccagcgccc
     3061 ccacccctct cagcagaagc agtgcattca ggttcgtcat ccagggcatc cattctaaac
     3121 tgcccatgtc ctaaactgac cccacacgca ggtggacaaa atggccgact tctggccatc
     3181 tctggtccag ggctttcatc ttccacaatc ctgtttcccc cacgtgtggc atgggtagat
     3241 gacactccag aattagaaat gagccctctg acagagtttc cagggaggcc gagtaaaaga
     3301 tgctcagtgc atctccatcg ccagctgaca ggggacgtca ggagacctgg ttggctgtga
     3361 taccgcatga ccgaggaccc cttgggtctg tactgagctc tcattccgag gttccctgta
     3421 gttttttcag aaatgtgtgt tcccatcaca tctgatgtat accttccctg caatcccctc
     3481 acctctgcct ctcttgtgtg ccgattttct tccattactc tgccacctct ttataggttc
     3541 atttgccccc cccagccatc ccctctcccc cagtatgggg ctatgctatg gccccctcct
     3601 tcccaagcac catgccacac agggaacatc tggatgctcc ccttaggagc tcctcacacc
     3661 cttccatggc tcttgctgtg gagtacctga ttggatgcgt gtgacctgtc ttgcctgcca
     3721 ggagacatga cccactgacc atgccagctc taaccccaaa gcccctcaga gccatcacac
     3781 taagtccaga gccgcagagg ggtccctcct tttagcagcc cacctggttg gagagtccac
     3841 attgggtcag gtttacccac aatgccagat acttgaaaca atgagccctt tgcgtgacag
     3901 tattagcagg tggcagttgt cgtgtgagga gcgagagtga tgcctggaca tcttgttgac
     3961 gcttgagcct tttatgtact ttttatcaag tctttgtgta tctctactta ttaataaaga
     4021 aacaatcaga gaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
