LOCUS       NM_029844               1118 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus melanocortin 2 receptor accessory protein (Mrap),
            transcript variant 1, mRNA.
ACCESSION   NM_029844
VERSION     NM_029844.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1118)
  AUTHORS   Oikonomakos,I., Tedesco,M., Motamedi,F.J., Peitzsch,M., Nef,S.,
            Bornstein,S.R., Schedl,A., Steenblock,C. and Neirijnck,Y.
  TITLE     In vitro differentiation of mouse pluripotent stem cells into
            corticosteroid-producing adrenocortical cells
  JOURNAL   Stem Cell Reports 19 (9), 1289-1303 (2024)
   PUBMED   39178848
REFERENCE   2  (bases 1 to 1118)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1118)
  AUTHORS   Wang,M., Xu,J., Lei,X.W., Zhang,C., Liu,S.Y., Jin,L.N. and Zhang,C.
  TITLE     Selective Interactions of Mouse Melanocortin Receptor Accessory
            Proteins with Somatostatin Receptors
  JOURNAL   Cells 11 (2), 267 (2022)
   PUBMED   35053382
  REMARK    GeneRIF: Selective Interactions of Mouse Melanocortin Receptor
            Accessory Proteins with Somatostatin Receptors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1118)
  AUTHORS   Novoselova,T.V., Hussain,M., King,P.J., Guasti,L., Metherell,L.A.,
            Charalambous,M., Clark,A.J.L. and Chan,L.F.
  TITLE     MRAP deficiency impairs adrenal progenitor cell differentiation and
            gland zonation
  JOURNAL   FASEB J 32 (11), fj201701274RR (2018)
   PUBMED   29879378
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   5  (bases 1 to 1118)
  AUTHORS   Zhang,X., Saarinen,A.M., Campbell,L.E., De Filippis,E.A. and Liu,J.
  TITLE     Regulation of Lipolytic Response and Energy Balance by Melanocortin
            2 Receptor Accessory Protein (MRAP) in Adipocytes
  JOURNAL   Diabetes 67 (2), 222-234 (2018)
   PUBMED   29217655
  REMARK    GeneRIF: Data (including data from studies in transgenic mice)
            suggest that Mrap plays critical role in (1) regulation of
            lipolysis in adipose tissue, (2) regulation of enzyme expression in
            adipose tissue, and (3) whole-body energy balance.
REFERENCE   6  (bases 1 to 1118)
  AUTHORS   Sebag,J.A. and Hinkle,P.M.
  TITLE     Regions of melanocortin 2 (MC2) receptor accessory protein
            necessary for dual topology and MC2 receptor trafficking and
            signaling
  JOURNAL   J Biol Chem 284 (1), 610-618 (2009)
   PUBMED   18981183
  REMARK    GeneRIF: MRAP not only facilitates MC2 receptor trafficking but
            also allows properly localized receptor to bind ACTH and
            consequently signal.
REFERENCE   7  (bases 1 to 1118)
  AUTHORS   Wu,Y. and Smas,C.M.
  TITLE     Wdnm1-like, a new adipokine with a role in MMP-2 activation
  JOURNAL   Am J Physiol Endocrinol Metab 295 (1), E205-E215 (2008)
   PUBMED   18492766
REFERENCE   8  (bases 1 to 1118)
  AUTHORS   Cooray,S.N., Almiro Do Vale,I., Leung,K.Y., Webb,T.R.,
            Chapple,J.P., Egertova,M., Cheetham,M.E., Elphick,M.R. and
            Clark,A.J.
  TITLE     The melanocortin 2 receptor accessory protein exists as a homodimer
            and is essential for the function of the melanocortin 2 receptor in
            the mouse y1 cell line
  JOURNAL   Endocrinology 149 (4), 1935-1941 (2008)
   PUBMED   18162519
  REMARK    GeneRIF: The melanocortin 2 receptor accessory protein exists as a
            homodimer and is essential for the function of the melanocortin 2
            receptor in the mouse y1 cell line.
REFERENCE   9  (bases 1 to 1118)
  AUTHORS   Gardiner,K., Slavov,D., Bechtel,L. and Davisson,M.
  TITLE     Annotation of human chromosome 21 for relevance to Down syndrome:
            gene structure and expression analysis
  JOURNAL   Genomics 79 (6), 833-843 (2002)
   PUBMED   12036298
REFERENCE   10 (bases 1 to 1118)
  AUTHORS   Xu,A., Choi,K.L., Wang,Y., Permana,P.A., Xu,L.Y., Bogardus,C. and
            Cooper,G.J.
  TITLE     Identification of novel putative membrane proteins selectively
            expressed during adipose conversion of 3T3-L1 cells
  JOURNAL   Biochem Biophys Res Commun 293 (4), 1161-1167 (2002)
   PUBMED   12054497
  REMARK    GeneRIF: Falp protein strictly localizes at a compact perinuclear
            membrane compartment (Falp protein)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126671.3.
            
            On Apr 20, 2018 this sequence version replaced NM_029844.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027543.1, SRR5189682.23265.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-463               AC126671.3         65359-65821         c
            464-563             AC126671.3         56405-56504         c
            564-1118            AC126671.3         54243-54797         c
FEATURES             Location/Qualifiers
     source          1..1118
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 51.9 cM"
     gene            1..1118
                     /gene="Mrap"
                     /gene_synonym="1110025G12Rik; C21ORF61; Falp; ORF61"
                     /note="melanocortin 2 receptor accessory protein"
                     /db_xref="GeneID:77037"
                     /db_xref="MGI:MGI:1924287"
     exon            1..463
                     /gene="Mrap"
                     /gene_synonym="1110025G12Rik; C21ORF61; Falp; ORF61"
                     /inference="alignment:Splign:2.1.0"
     CDS             358..741
                     /gene="Mrap"
                     /gene_synonym="1110025G12Rik; C21ORF61; Falp; ORF61"
                     /note="fat cell-specific low molecular weight protein; fat
                     tissue-specific low MW protein"
                     /codon_start=1
                     /product="melanocortin-2 receptor accessory protein"
                     /protein_id="NP_084120.1"
                     /db_xref="CCDS:CCDS28317.1"
                     /db_xref="GeneID:77037"
                     /db_xref="MGI:MGI:1924287"
                     /translation="MANGTDASVPLTSYEYYLDYIDLIPVDEKKLKANKHSIVIALWL
                     SLATFVVLLFLILLYMSWSGSPQMRHSPQPQPICSWTHSFNLPLCLRRASLQTTEEPG
                     RRAGTDQWLTQQSPSASAPGPLALP"
     exon            464..563
                     /gene="Mrap"
                     /gene_synonym="1110025G12Rik; C21ORF61; Falp; ORF61"
                     /inference="alignment:Splign:2.1.0"
     exon            564..1118
                     /gene="Mrap"
                     /gene_synonym="1110025G12Rik; C21ORF61; Falp; ORF61"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1092..1097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrap"
                     /gene_synonym="1110025G12Rik; C21ORF61; Falp; ORF61"
                     /note="hexamer: AATAAA"
     polyA_site      1118
                     /gene="Mrap"
                     /gene_synonym="1110025G12Rik; C21ORF61; Falp; ORF61"
                     /note="major polyA site"
ORIGIN      
        1 agaggcaaga gaggacggtc atgtccagca ctgctaggca ctttctgccg tcatctgagt
       61 tcttgcccag ttcctcatcc ttccacggag aggcaagcta gagccgaatg ggaagccgcg
      121 tctctagtag cctttggagg tttgtccagg agagacagga accagaagcc ctacagggga
      181 acggccccct gaccttccag ccatgcagct ctgataagta ggcaggcccc atgccgggag
      241 agccacagac aagccgggtg attctgatag aaattagtta agcaatcttg tctctggggc
      301 tcacggccca gctgtgggtg cgagcctctg acagacactg tcgtcaaagc cacagtcatg
      361 gccaacggga ccgacgcctc tgtcccgctc accagctatg agtattacct ggactacata
      421 gacctcattc ctgtggacga gaagaagctg aaagccaaca agcattccat tgtcatcgcc
      481 ctgtggttga gcctggctac cttcgtggtg ctcctctttc tcatcctgct ctacatgtcc
      541 tggtcgggct ccccacagat gaggcacagt ccccaacccc agccaatatg ttcatggact
      601 cacagcttca acctccctct gtgcctccgg agggcctccc tgcagacaac agaggagcca
      661 ggaaggagag ctggcactga ccagtggtta acgcagcaga gtccttctgc ctcagccccg
      721 gggcccctgg ctctccccta ggaccaggtc caggatggag gtcccagggc atcagctggc
      781 ctcacactca agcagtggtg agcctggaga cagagcgtct caactgtaga acggatgatg
      841 ccagagagcc agtcgggctc aagcaaacgg tgaactccaa ccaacccggg cagctacgtc
      901 ttttttaggg ccgtttacaa tggccttgaa tatagcagga aactgaccgg gacaaaacca
      961 agtttacaaa gaggaccatc acacacattg atagtgcagc taggatgcag gagctgccct
     1021 ggacacagct gtctctgttg agcaagctta gcctgcttgc tgcttacatt tgctttgggg
     1081 gtacacagga aaataaaatg tgaattagga taaagaaa
//
