LOCUS       NM_008209               2555 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus major histocompatibility complex, class I-related
            (Mr1), transcript variant 1, mRNA.
ACCESSION   NM_008209
VERSION     NM_008209.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2555)
  AUTHORS   Walkenhorst,M., Sonner,J.K., Meurs,N., Engler,J.B., Bauer,S.,
            Winschel,I., Woo,M.S., Raich,L., Winkler,I., Vieira,V., Unger,L.,
            Salinas,G., Lantz,O., Friese,M.A. and Willing,A.
  TITLE     Protective effect of TCR-mediated MAIT cell activation during
            experimental autoimmune encephalomyelitis
  JOURNAL   Nat Commun 15 (1), 9287 (2024)
   PUBMED   39468055
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2555)
  AUTHORS   Siewert,L.K., Fromm,K., Dehio,C. and Pinschewer,D.D.
  TITLE     Cutting Edge: Redundant Roles for MHC Class II-, CD1d-, and
            MR1-restricted T Cells in Clearing Bartonella Infection
  JOURNAL   J Immunol 213 (5), 553-558 (2024)
   PUBMED   38984869
  REMARK    GeneRIF: Cutting Edge: Redundant Roles for MHC Class II-, CD1d-,
            and MR1-restricted T Cells in Clearing Bartonella Infection.
REFERENCE   3  (bases 1 to 2555)
  AUTHORS   El Morr,Y., Furstenheim,M., Mestdagh,M., Franciszkiewicz,K.,
            Salou,M., Morvan,C., Dupre,T., Vorobev,A., Jneid,B., Premel,V.,
            Darbois,A., Perrin,L., Mondot,S., Colombeau,L., Bugaut,H., du
            Halgouet,A., Richon,S., Procopio,E., Maurin,M., Philippe,C.,
            Rodriguez,R., Lantz,O. and Legoux,F.
  TITLE     MAIT cells monitor intestinal dysbiosis and contribute to host
            protection during colitis
  JOURNAL   Sci Immunol 9 (96), eadi8954 (2024)
   PUBMED   38905325
REFERENCE   4  (bases 1 to 2555)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2555)
  AUTHORS   Ruf,B., Bruhns,M., Babaei,S., Kedei,N., Ma,L., Revsine,M.,
            Benmebarek,M.R., Ma,C., Heinrich,B., Subramanyam,V., Qi,J.,
            Wabitsch,S., Green,B.L., Bauer,K.C., Myojin,Y., Greten,L.T.,
            McCallen,J.D., Huang,P., Trehan,R., Wang,X., Nur,A., Murphy
            Soika,D.Q., Pouzolles,M., Evans,C.N., Chari,R., Kleiner,D.E.,
            Telford,W., Dadkhah,K., Ruchinskas,A., Stovroff,M.K., Kang,J.,
            Oza,K., Ruchirawat,M., Kroemer,A., Wang,X.W., Claassen,M.,
            Korangy,F. and Greten,T.F.
  TITLE     Tumor-associated macrophages trigger MAIT cell dysfunction at the
            HCC invasive margin
  JOURNAL   Cell 186 (17), 3686-3705 (2023)
   PUBMED   37595566
REFERENCE   6  (bases 1 to 2555)
  AUTHORS   Yamaguchi,H. and Hashimoto,K.
  TITLE     Association of MR1 protein, an MHC class I-related molecule, with
            beta(2)-microglobulin
  JOURNAL   Biochem Biophys Res Commun 290 (2), 722-729 (2002)
   PUBMED   11785959
  REMARK    GeneRIF: MR1 protein can associate with beta(2)-microglobulin
REFERENCE   7  (bases 1 to 2555)
  AUTHORS   Riegert,P., Wanner,V. and Bahram,S.
  TITLE     Genomics, isoforms, expression, and phylogeny of the MHC class
            I-related MR1 gene
  JOURNAL   J Immunol 161 (8), 4066-4077 (1998)
   PUBMED   9780177
REFERENCE   8  (bases 1 to 2555)
  AUTHORS   Yamaguchi,H., Kurosawa,Y. and Hashimoto,K.
  TITLE     Expanded genomic organization of conserved mammalian MHC class
            I-related genes, human MR1 and its murine ortholog
  JOURNAL   Biochem Biophys Res Commun 250 (3), 558-564 (1998)
   PUBMED   9784382
REFERENCE   9  (bases 1 to 2555)
  AUTHORS   Yamaguchi,H., Hirai,M., Kurosawa,Y. and Hashimoto,K.
  TITLE     A highly conserved major histocompatibility complex class I-related
            gene in mammals
  JOURNAL   Biochem Biophys Res Commun 238 (3), 697-702 (1997)
   PUBMED   9325151
REFERENCE   10 (bases 1 to 2555)
  AUTHORS   Hashimoto,K., Hirai,M. and Kurosawa,Y.
  TITLE     A gene outside the human MHC related to classical HLA class I genes
  JOURNAL   Science 269 (5224), 693-695 (1995)
   PUBMED   7624800
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK041171.1, CJ049462.1, AF010448.1 and AF010451.1.
            
            On Sep 6, 2017 this sequence version replaced NM_008209.4.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF010448.1, AK162712.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AK041171.1         2-2
            2-123               CJ049462.1         2-123
            124-2521            AF010448.1         1-2398
            2522-2555           AF010451.1         3186-3219
FEATURES             Location/Qualifiers
     source          1..2555
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 66.45 cM"
     gene            1..2555
                     /gene="Mr1"
                     /gene_synonym="H2ls"
                     /note="major histocompatibility complex, class I-related"
                     /db_xref="GeneID:15064"
                     /db_xref="MGI:MGI:1195463"
     exon            1..183
                     /gene="Mr1"
                     /gene_synonym="H2ls"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1154
                     /gene="Mr1"
                     /gene_synonym="H2ls"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; major histocompatibility complex class
                     I-related gene protein; MCH class I; MHC class I-related
                     gene protein; class I histocompatibility antigen-like
                     protein; histocompatibility-2 complex class 1-like
                     sequence"
                     /codon_start=1
                     /product="major histocompatibility complex class I-related
                     gene protein isoform 1 precursor"
                     /protein_id="NP_032235.1"
                     /db_xref="CCDS:CCDS15383.1"
                     /db_xref="GeneID:15064"
                     /db_xref="MGI:MGI:1195463"
                     /translation="MMLLLPLLAVFLVKRSHTRTHSLRYFRLAVSDPGPVVPEFISVG
                     YVDSHPITTYDSVTRQKEPKAPWMAENLAPDHWERYTQLLRGWQQTFKAELRHLQRHY
                     NHSGLHTYQRMIGCELLEDGSTTGFLQYAYDGQDFIIFNKDTLSWLAMDYVAHITKQA
                     WEANLHELQYQKNWLEEECIAWLKRFLEYGRDTLERTEHPVVRTTRKETFPGITTFFC
                     RAHGFYPPEISMTWMKNGEEIAQEVDYGGVLPSGDGTYQTWLSVNLDPQSNDVYSCHV
                     EHCGRQMVLEAPRESGDILRVSTISGTTILIIALAGVGVLIWRRSQELKEVMYQPTQV
                     NEGSSPS"
     exon            184..444
                     /gene="Mr1"
                     /gene_synonym="H2ls"
                     /inference="alignment:Splign:2.1.0"
     exon            445..720
                     /gene="Mr1"
                     /gene_synonym="H2ls"
                     /inference="alignment:Splign:2.1.0"
     exon            721..996
                     /gene="Mr1"
                     /gene_synonym="H2ls"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1095
                     /gene="Mr1"
                     /gene_synonym="H2ls"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..2547
                     /gene="Mr1"
                     /gene_synonym="H2ls"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1339..1344
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mr1"
                     /gene_synonym="H2ls"
                     /note="hexamer: AATATA"
     polyA_site      1362
                     /gene="Mr1"
                     /gene_synonym="H2ls"
                     /note="major polyA site"
ORIGIN      
        1 cacagtgctc agttaccaag tgtaagtaag tcggtagagt acaagttctc aaaagattca
       61 tcaggggtct gtcactgtct gaggttaaaa aaaaaaatcg gaaaagcaaa ggacttcagc
      121 acgggttgat gatgctcctg ttacctctgc tcgctgtatt cttggtgaag cgaagccata
      181 ctcggaccca ctcgctgaga tattttcgtc tagctgtttc cgatcctggt cccgtcgtcc
      241 ctgaatttat ctctgttggg tatgtggact cacaccctat cactacatac gacagtgtca
      301 ctcgacagaa ggagccgaaa gctccatgga tggcagagaa cctggcacct gatcactggg
      361 agaggtacac tcagctgcta aggggctggc agcagacatt caaggcggag ctgaggcacc
      421 tacagaggca ctacaaccac tcagggcttc acacctacca gagaatgatt ggctgtgagt
      481 tgctagaaga tggcagcacc acagggtttc tccagtatgc atatgatgga caagatttca
      541 tcatcttcaa taaagacacc ctctcctggt tggccatgga ttatgtggct cacatcacca
      601 agcaagcatg ggaggccaac ctgcatgagt tgcaatacca aaagaactgg ctggaagaag
      661 aatgcattgc ctggctaaag aggttcttgg aatatggaag agatacccta gaaagaacag
      721 agcatccagt ggtaagaaca actcgaaagg aaacttttcc agggattaca actttcttct
      781 gcagagctca tggcttctac ccaccagaaa tttccatgac atggatgaaa aatggggaag
      841 aaattgccca agaagtggat tacggagggg tacttcccag cggggatgga acctatcaaa
      901 cgtggctgtc agttaatctg gatcctcaga gcaatgatgt ttattcttgt catgtggagc
      961 actgtggtcg ccaaatggtt ctggaggccc ctcgggaatc aggggacatc cttcgagtga
     1021 gcacgatctc tggaaccaca attctcatca tcgccctggc tggagttggt gttctgatct
     1081 ggagaaggtc acaagaacta aaagaagtca tgtaccaacc cacccaagtg aatgagggaa
     1141 gctctccctc ttaggagcca caatctctgc tctcaggcat ccgcatgtct tggccatact
     1201 cctgatgcaa ccggggactg taaaactgag cacttgtgac aggaagatag gagctacaaa
     1261 tttttcttca ttctttggct ccagaagagc tgtcaacttt taggctcttg atagactcct
     1321 ttatcacagt caactttaaa tatagtttgt ctcatgaccc aatacttccc aatattgtag
     1381 ttctcaatag tgatttacaa gtagatcaca gagtatcaga gccgcaagca actttctcac
     1441 ctaagcagga gatgtcttct aaaatgtcat agacttgagc attagccttc actcaacatt
     1501 atgtgcaagt tcccccattc tactacaaaa cagcctttct tgttcatttt ctctcctgag
     1561 aatgtttacc atgtaagaac tttgaccact atggctctca tgtttgagaa tctataagta
     1621 gggttgagcc aacccatgaa aatagccagc aagtttctac agcagccttt gagtggacga
     1681 gtcactatat acatatcatg gcccaagggg aggcagaagt atccagttca tggtggctct
     1741 gtcagaaagc aaggaatatt gcatgtttgt ctggctacat ttatggcaat gacttccttt
     1801 gcttttactg tttctgtgag aaattagaac aataatttat caagctgagt gtgatgggaa
     1861 tcttagaagc ccagtactca ggaagctgaa gcaggtagat tttacatttg gggctagctt
     1921 gagctacaca atgaaaccct atctgaaata aaccaaaaca acaacaacag caacacactt
     1981 aacagaacta aaacaatcat taccagacat attgtcccct cccatggaac ggcagaccta
     2041 gactcacttg caatatttca acatgaaata atagtgtttg gctggagatg tccaggtggg
     2101 tgaagatgtc tgttgccaag catgtccacc tgaggtcaga caccctgacc cacacacaca
     2161 gtgaaagaaa aaaactgact cctgaaagtt gccctctgac ctctccatga gtgctaaact
     2221 aaggttttta tttttgtttt tgttttaatc tgacaaaatg tgttcatatg cttatgtctc
     2281 aaaacgagtt ctctttactc tggtattgga gactgaacca gtacagaaaa gacaggagtt
     2341 agaattgaac ctttgggggt ttagggtgta gctcagtggc agagaatttt cttagcatgt
     2401 atgaggccct gaggtcagtc ttcagcactt tgaacacaca cacatacaca caccaccacc
     2461 accaccacca ctaataacaa acaaaaacta aaactttgga tctttcttct gtaagtggtt
     2521 ttaaattaaa ttgtttctta atactttaaa aaaaa
//
