LOCUS       NM_001093749            3430 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus myelin protein zero-like 3 (Mpzl3), mRNA.
ACCESSION   NM_001093749
VERSION     NM_001093749.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3430)
  AUTHORS   Wikramanayake,T.C., Nicu,C., Cheret,J., Czyzyk,T.A. and Paus,R.
  TITLE     Mitochondrially localized MPZL3 emerges as a signaling hub of
            mammalian physiology
  JOURNAL   Bioessays 43 (10), e2100126 (2021)
   PUBMED   34486148
  REMARK    GeneRIF: Mitochondrially localized MPZL3 emerges as a signaling hub
            of mammalian physiology.
REFERENCE   2  (bases 1 to 3430)
  AUTHORS   Worley,B.L., Auen,T., Arnold,A.C., Monia,B.P., Hempel,N. and
            Czyzyk,T.A.
  TITLE     Antisense oligonucleotide-mediated knockdown of Mpzl3 attenuates
            the negative metabolic effects of diet-induced obesity in mice
  JOURNAL   Physiol Rep 9 (9), e14853 (2021)
   PUBMED   33991450
  REMARK    GeneRIF: Antisense oligonucleotide-mediated knockdown of Mpzl3
            attenuates the negative metabolic effects of diet-induced obesity
            in mice.
REFERENCE   3  (bases 1 to 3430)
  AUTHORS   Nicu,C., Wikramanayake,T.C. and Paus,R.
  TITLE     Clues that mitochondria are involved in the hair cycle clock: MPZL3
            regulates entry into and progression of murine hair follicle
            cycling
  JOURNAL   Exp Dermatol 29 (12), 1243-1249 (2020)
   PUBMED   33040410
  REMARK    GeneRIF: Clues that mitochondria are involved in the hair cycle
            clock: MPZL3 regulates entry into and progression of murine hair
            follicle cycling.
REFERENCE   4  (bases 1 to 3430)
  AUTHORS   Wikramanayake,T.C., Hirt,P., Almastadi,M., Mitchell,H.,
            Tomic-Canic,M., Romero,L., Garcia,D. and Strbo,N.
  TITLE     Increased IL-17-expressing gammadelta T cells in seborrhoeic
            dermatitis-like lesions of the Mpzl3 knockout mice
  JOURNAL   Exp Dermatol 27 (12), 1408-1411 (2018)
   PUBMED   30307058
  REMARK    GeneRIF: MPZL3 and IL17 may have a role in the pathogenesis of
            seborrhoeic dermatitis-like skin inflammation.
REFERENCE   5  (bases 1 to 3430)
  AUTHORS   Inoue,S.I., Takahara,S., Yoshikawa,T., Niihori,T., Yanai,K.,
            Matsubara,Y. and Aoki,Y.
  TITLE     Activated Braf induces esophageal dilation and gastric epithelial
            hyperplasia in mice
  JOURNAL   Hum Mol Genet 26 (23), 4715-4727 (2017)
   PUBMED   28973166
REFERENCE   6  (bases 1 to 3430)
  AUTHORS   Czyzyk,T.A., Andrews,J.L., Coskun,T., Wade,M.R., Hawkins,E.D.,
            Lockwood,J.F., Varga,G., Sahr,A.E., Chen,Y., Brozinick,J.T.,
            Kikly,K. and Statnick,M.A.
  TITLE     Genetic ablation of myelin protein zero-like 3 in mice increases
            energy expenditure, improves glycemic control, and reduces hepatic
            lipid synthesis
  JOURNAL   Am J Physiol Endocrinol Metab 305 (2), E282-E292 (2013)
   PUBMED   23715724
  REMARK    GeneRIF: Mpzl3 has a novel physiological role in controlling body
            weight regulation, energy expenditure, glycemic control, and
            hepatic triglyceride synthesis in mice
REFERENCE   7  (bases 1 to 3430)
  AUTHORS   Cao,T., Racz,P., Szauter,K.M., Groma,G., Nakamatsu,G.Y.,
            Fogelgren,B., Pankotai,E., He,Q.P. and Csiszar,K.
  TITLE     Mutation in Mpzl3, a novel [corrected] gene encoding a predicted
            [corrected] adhesion protein, in the rough coat (rc) mice with
            severe skin and hair abnormalities
  JOURNAL   J Invest Dermatol 127 (6), 1375-1386 (2007)
   PUBMED   17273165
  REMARK    GeneRIF: novel gene encoding a predicted adhesion protein whose
            mutation in the rc/rc mice likely caused the rc phenotype
            Erratum:[J Invest Dermatol. 2007 Nov;127(11):2678]
REFERENCE   8  (bases 1 to 3430)
  AUTHORS   Hayashi,K., Cao,T., Passmore,H., Jourdan-Le Saux,C., Fogelgren,B.,
            Khan,S., Hornstra,I., Kim,Y., Hayashi,M. and Csiszar,K.
  TITLE     Progressive hair loss and myocardial degeneration in rough coat
            mice: reduced lysyl oxidase-like (LOXL) in the skin and heart
  JOURNAL   J Invest Dermatol 123 (5), 864-871 (2004)
   PUBMED   15482472
REFERENCE   9  (bases 1 to 3430)
  AUTHORS   Ruvinsky,I., Chertkov,O., Borue,X.V., Agulnik,S.I.,
            Gibson-Brown,J.J., Lyle,S.R. and Silver,L.M.
  TITLE     Genetics analysis of mouse mutations Abnormal feet and tail and
            rough coat, which cause developmental abnormalities and alopecia
  JOURNAL   Mamm Genome 13 (12), 675-679 (2002)
   PUBMED   12514744
REFERENCE   10 (bases 1 to 3430)
  AUTHORS   Park,Y.G., Hayasaka,S., Takagishi,Y., Inouye,M., Okumoto,M. and
            Oda,S.
  TITLE     Histological characteristics of the pelage skin of rough fur mice
            (C3H/HeJ- ruf/ruf)
  JOURNAL   Exp Anim 50 (2), 179-182 (2001)
   PUBMED   11381623
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122305.4 and EF102773.1.
            
            On Feb 13, 2018 this sequence version replaced NM_001093749.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF102773.1, ERR3363660.2372475.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AC122305.4         65228-65263
            37-881              EF102773.1         1-845
            882-3430            AC122305.4         84936-87484
FEATURES             Location/Qualifiers
     source          1..3430
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.84 cM"
     gene            1..3430
                     /gene="Mpzl3"
                     /gene_synonym="5430427F17Rik; A530065I17Rik; rc; ruf"
                     /note="myelin protein zero-like 3"
                     /db_xref="GeneID:319742"
                     /db_xref="MGI:MGI:2442647"
     exon            1..138
                     /gene="Mpzl3"
                     /gene_synonym="5430427F17Rik; A530065I17Rik; rc; ruf"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..776
                     /gene="Mpzl3"
                     /gene_synonym="5430427F17Rik; A530065I17Rik; rc; ruf"
                     /note="myelin protein zero-like protein 3; Ig-like
                     domain-containing protein UNQ2966"
                     /codon_start=1
                     /product="myelin protein zero-like protein 3 precursor"
                     /protein_id="NP_001087218.1"
                     /db_xref="CCDS:CCDS52781.1"
                     /db_xref="GeneID:319742"
                     /db_xref="MGI:MGI:2442647"
                     /translation="MQLARGTVGGRGCALFPLLSILVVQGARIVLSLEISADAHVRGY
                     VGEKIKLKCTFKSSSDVTDKLTIDWTYRPPSSSRTESIFHYQSFQYPTTAGTFRDRIS
                     WAGNVYKGDASISISNPTLKDNGTFSCAVKNPPDVYHNIPLTELTVTERGFGTMLSSV
                     ALLSILVFVPSAVVVILLLVRMGRKATGVQKRSRSGYKKSSIEVSDDTDQEDSNDCMT
                     RLCVRCAECLDSDYEEEAY"
     exon            139..305
                     /gene="Mpzl3"
                     /gene_synonym="5430427F17Rik; A530065I17Rik; rc; ruf"
                     /inference="alignment:Splign:2.1.0"
     exon            306..516
                     /gene="Mpzl3"
                     /gene_synonym="5430427F17Rik; A530065I17Rik; rc; ruf"
                     /inference="alignment:Splign:2.1.0"
     exon            517..682
                     /gene="Mpzl3"
                     /gene_synonym="5430427F17Rik; A530065I17Rik; rc; ruf"
                     /inference="alignment:Splign:2.1.0"
     exon            683..746
                     /gene="Mpzl3"
                     /gene_synonym="5430427F17Rik; A530065I17Rik; rc; ruf"
                     /inference="alignment:Splign:2.1.0"
     exon            747..3430
                     /gene="Mpzl3"
                     /gene_synonym="5430427F17Rik; A530065I17Rik; rc; ruf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accacctgca tggtccccgg gaggcgtaaa gagggtgtgt aagtatcgga agagctgtcg
       61 ggatgcagct ggcaagagga acagtaggag gccgtggctg cgctctcttt ccactgctga
      121 gcatcctagt cgtccagggt gcgcgtatcg tcctctcctt ggagataagt gccgatgctc
      181 acgtccgagg ctatgtggga gagaagatca agttgaaatg caccttcaag tcatcttcag
      241 atgtcactga caagctgacc atagactgga cataccgccc tcccagcagc agccgcacag
      301 agtctatttt tcactatcag tctttccagt acccgaccac agcgggcaca ttccgagacc
      361 ggatctcctg ggccggaaat gtctacaaag gggatgcgtc catcagtatc agcaacccca
      421 ctctaaagga caatgggacg ttcagctgtg ctgtgaagaa ccctccagac gtgtaccaca
      481 atatccccct aacagagctc acggtcacag aaagggggtt cggcaccatg ctgtcttctg
      541 tggcccttct ctccatcctc gtcttcgtcc cctcagcagt ggtggtcatt ctgctgctgg
      601 tgcgaatggg gaggaaggca acaggggtgc agaagaggag caggtctggc tataagaagt
      661 cttccattga agtttccgat gacactgacc aggaggacag caatgactgc atgacgaggc
      721 tttgtgtccg ctgtgcagag tgtctggatt cagactacga agaagaggcg tactgatgaa
      781 gtgtgcgcca tgcaagaagt gtcacctaac aacaggaaat acccattccc ctggccagga
      841 gtgccattgg cggggacagc agtgacagaa gatcctgaag gtcaccagtg aagaccctaa
      901 ggatcactta tttattgaag aaacgtttat gttgtattta taaaccgttc ggaaactcgc
      961 agaagggact catgacttcc cttcttaata cactctaact gaacaacgga attttgaaca
     1021 gaaacagtgc ttgggttacc ttcactcttg aatgtagttc atggtttctt ccagttgcct
     1081 gaaggagacc aaatgtctgt cactctgccg atgccaaaat tgtacttttt ttaatggtgt
     1141 ggagctggta gcttcctgat gatgtgccaa cgaacaacac gcccattcgg gatggatagc
     1201 cttggtttct tctccgatgt tctccggtca gcgttcagga tgcactacgt ggcttaacag
     1261 tcatcagctg tgtttagggg acatgcagta tttaaccccg attcctttct gctcagtagg
     1321 tttacaagct gtaggcttgt ttggactggg ccttttaagt attaaagcat tgtcaattta
     1381 cagtcaagga tacagttttt gatgcagaag aatctttctc atttgtcttg ctagctatac
     1441 tttgggccac agaatctttg ttattttgtg ttcctgcagc tgactaattt gtggtttcct
     1501 tcttgggttt taagttagag gcaagaaatg tctcttaaga aggtttttag tggcgactta
     1561 gaaaatagtt tttatagtcc tttgctttgg gtctttcacg tttcttgtgt tgtttagaac
     1621 tttggttctc agtggcacca gaagtgggta ttgtatctgc aggctggttt gctcggcact
     1681 ggagatgaga aagtggcgat gtgcgggata tttccccttg cttcactccg tgccttgtaa
     1741 cccatacctc tactctcctc tagcaactta gttgttattt taatttacac tgggttttct
     1801 gtaaaccact aagatgtgcc tgacttatcg gaaggacgag catgtgagca aacagcgctc
     1861 tccagagaga gtcactgatg acccctcccc cagccctggt tggttcaaca tggtggtctt
     1921 catggttctt cttaaagcag cttgcgaggc ctccatatta cagtgttata tactatgttt
     1981 ctcataaaag tcattctatt taccacgaag atcttacatt tgaaactctg tttgaaagac
     2041 ttgttaactt agcctgctga tccatgatta tgatttgcct ctggtcatgg aagctcttgc
     2101 aagaggcaga ggagggcctg gcattttaca tttctggtcg ttagattcca cagttctttg
     2161 ggctacttgt taaagatgta gttgtctgtg gccaagccag tgagacccgt tctgatggtc
     2221 caatagagaa aagaaaacat tcgtgcacca agcatgaata ccttgggcac gtgcagatct
     2281 gaagagagtg acccagttgg gagggggcat gctgtgggcc tcactgttct gacagtcatt
     2341 acaagaactc atttaaacca tcattctgtg gcaatgaggg agcagtttta gtttcttggg
     2401 atttttttgc aagcgtattg tgaggttttt tatctagctc agacattggt gagtccggtg
     2461 actagcagat gcctgatgaa tacttgtgta cactgttgtg tagcctgctt taaaatgggt
     2521 cttttctttt gtaaatgaca gggcaatcaa gtcctttcgt tgtaagggag tatgttagtg
     2581 attttattgg ctccatgggt ttgtggtcat atcggggctt aggctgccct cagtttcctc
     2641 tgccaaggtt tgtgctaaag ctttttgatc atcaggaaga caaagccatc tgtggagccc
     2701 tcctccttta agagtgagca tacacttaga gggtttgtct gacttactgt tttaatatct
     2761 tctaaggtga gattcccata ctttgtttcc ctttttgatg ctctgtggac tcaaacccca
     2821 gcgcattata gcattgtctg gaaagaggat ttaagtcttt cattatggtt atatcacctt
     2881 ctgagtttta cgcggtggac tcttaaaact attacaaaat gtgaatttat aacgtacttt
     2941 gttttccctc tgtgacctgt tatttcaggt cacttgagga catcttagcg gtctgcagtg
     3001 cccaagtcag cagtgggact tcagaaggaa aagttgccta cccttctccc atcctgctta
     3061 tgtgcatata tacatgtgtg tgcatgtgtg cgtgcatatg tatatcttac aacaacagaa
     3121 aacctggagg ccacatcttg atccagaatg ttctgttgtg ttgctgggct cccccattct
     3181 gaagaaggac tctaagaaga tccatggagt agatcaaagc tcttatttaa ttgcacagct
     3241 cacaactttg ctgccagaag tgcccactcc ggtgttggcc tccacaccgt tgtctctcac
     3301 tgacttttaa aattaaatta gactttttgt ttgcaggaga gtatgaactg taaggctttg
     3361 tgcacagaca ttgtgactca tggaagcttt actgcactgt agttaataaa cttctttgca
     3421 ccttgtggct
//
