LOCUS       NM_007962               3216 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus myelin protein zero-like 2 (Mpzl2), transcript variant
            1, mRNA.
ACCESSION   NM_007962
VERSION     NM_007962.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3216)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3216)
  AUTHORS   Dungan,M. and Carrithers,M.D.
  TITLE     Regulation of expansion of CD11c+ B cells and anti-viral immunity
            by epithelial V-like antigen
  JOURNAL   Immunobiology 225 (2), 151883 (2020)
   PUBMED   31818507
REFERENCE   3  (bases 1 to 3216)
  AUTHORS   Muthu,V., Rohacek,A.M., Yao,Y., Rakowiecki,S.M., Brown,A.S.,
            Zhao,Y.T., Meyers,J., Won,K.J., Ramdas,S., Brown,C.D.,
            Peterson,K.A. and Epstein,D.J.
  TITLE     Genomic architecture of Shh-dependent cochlear morphogenesis
  JOURNAL   Development 146 (18) (2019)
   PUBMED   31488567
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3216)
  AUTHORS   Lopez-Tello,J., Perez-Garcia,V., Khaira,J., Kusinski,L.C.,
            Cooper,W.N., Andreani,A., Grant,I., Fernandez de Liger,E.,
            Lam,B.Y., Hemberger,M., Sandovici,I., Constancia,M. and
            Sferruzzi-Perri,A.N.
  TITLE     Fetal and trophoblast PI3K p110alpha have distinct roles in
            regulating resource supply to the growing fetus in mice
  JOURNAL   Elife 8, e45282 (2019)
   PUBMED   31241463
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3216)
  AUTHORS   Bademci,G., Abad,C., Incesulu,A., Rad,A., Alper,O., Kolb,S.M.,
            Cengiz,F.B., Diaz-Horta,O., Silan,F., Mihci,E., Ocak,E., Najafi,M.,
            Maroofian,R., Yilmaz,E., Nur,B.G., Duman,D., Guo,S., Sant,D.W.,
            Wang,G., Monje,P.V., Haaf,T., Blanton,S.H., Vona,B., Walz,K. and
            Tekin,M.
  TITLE     MPZL2 is a novel gene associated with autosomal recessive
            nonsyndromic moderate hearing loss
  JOURNAL   Hum Genet 137 (6-7), 479-486 (2018)
   PUBMED   29982980
  REMARK    GeneRIF: We show that Mpzl2 is expressed in mouse inner ear, and
            the protein localizes in the auditory inner and outer hair cells,
            with an asymmetric subcellular localization. We thus present MPZL2
            as a novel gene associated with sensorineural hearing loss.
REFERENCE   6  (bases 1 to 3216)
  AUTHORS   Sewell,W., Sparrow,D.B., Smith,A.J., Gonzalez,D.M., Rappaport,E.F.,
            Dunwoodie,S.L. and Kusumi,K.
  TITLE     Cyclical expression of the Notch/Wnt regulator Nrarp requires
            modulation by Dll3 in somitogenesis
  JOURNAL   Dev Biol 329 (2), 400-409 (2009)
   PUBMED   19268448
REFERENCE   7  (bases 1 to 3216)
  AUTHORS   Chatterjee,G., Carrithers,L.M. and Carrithers,M.D.
  TITLE     Epithelial V-like antigen regulates permeability of the blood-CSF
            barrier
  JOURNAL   Biochem Biophys Res Commun 372 (3), 412-417 (2008)
   PUBMED   18498762
  REMARK    GeneRIF: These results suggest that EVA expressed in choroid plexus
            cells may regulate the permeability of the blood-CSF barrier.
REFERENCE   8  (bases 1 to 3216)
  AUTHORS   DeMonte,L., Porcellini,S., Tafi,E., Sheridan,J., Gordon,J.,
            Depreter,M., Blair,N., Panigada,M., Sanvito,F., Merati,B.,
            Albientz,A., Barthlott,T., Ozmen,L., Blackburn,C.C. and
            Guttinger,M.
  TITLE     EVA regulates thymic stromal organisation and early thymocyte
            development
  JOURNAL   Biochem Biophys Res Commun 356 (2), 334-340 (2007)
   PUBMED   17362876
REFERENCE   9  (bases 1 to 3216)
  AUTHORS   Guttinger,M., Sutti,F., Panigada,M., Porcellini,S., Merati,B.,
            Mariani,M., Teesalu,T., Consalez,G.G. and Grassi,F.
  TITLE     Epithelial V-like antigen (EVA), a novel member of the
            immunoglobulin superfamily, expressed in embryonic epithelia with a
            potential role as homotypic adhesion molecule in thymus
            histogenesis
  JOURNAL   J Cell Biol 141 (4), 1061-1071 (1998)
   PUBMED   9585423
REFERENCE   10 (bases 1 to 3216)
  AUTHORS   Teesalu,T., Grassi,F. and Guttinger,M.
  TITLE     Expression pattern of the epithelial v-like antigen (Eva)
            transcript suggests a possible role in placental morphogenesis
  JOURNAL   Dev Genet 23 (4), 317-323 (1998)
   PUBMED   9883583
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY230064.1, AK167263.1, AK032788.1 and BY387940.1.
            
            On Nov 15, 2007 this sequence version replaced NM_007962.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032788.1, AK170816.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-237               BY230064.1         1-237
            238-2677            AK167263.1         2-2441
            2678-3198           AK032788.1         2458-2978
            3199-3216           BY387940.1         464-481
FEATURES             Location/Qualifiers
     source          1..3216
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.84 cM"
     gene            1..3216
                     /gene="Mpzl2"
                     /gene_synonym="Eva; Eva1"
                     /note="myelin protein zero-like 2"
                     /db_xref="GeneID:14012"
                     /db_xref="MGI:MGI:1289160"
     exon            1..451
                     /gene="Mpzl2"
                     /gene_synonym="Eva; Eva1"
                     /inference="alignment:Splign:2.1.0"
     CDS             394..1041
                     /gene="Mpzl2"
                     /gene_synonym="Eva; Eva1"
                     /note="epithelial V-like antigen 1; myelin protein
                     zero-like protein 2"
                     /codon_start=1
                     /product="myelin protein zero-like protein 2 precursor"
                     /protein_id="NP_031988.2"
                     /db_xref="CCDS:CCDS23126.1"
                     /db_xref="GeneID:14012"
                     /db_xref="MGI:MGI:1289160"
                     /translation="MYGKSPALVLPLLLSLQLTALCPTEAVEIYTSGALEAVNGTDVR
                     LKCTFSSFAPVGDALTVTWNFRPRDGGREQFVFYYHMDPFRPMSGRFKDRVVWDGNPE
                     RYDVSILLWKLQFDDNGTYTCQVKNPPDVDGLVGTIRLSVVHTVPFSEIYFLAVAIGS
                     ACALMIIVVIVVVLFQHFRKKRWADSADKAEGTKSKEEEKLNQGNKVSVFVEDTD"
     exon            452..618
                     /gene="Mpzl2"
                     /gene_synonym="Eva; Eva1"
                     /inference="alignment:Splign:2.1.0"
     exon            619..829
                     /gene="Mpzl2"
                     /gene_synonym="Eva; Eva1"
                     /inference="alignment:Splign:2.1.0"
     exon            830..977
                     /gene="Mpzl2"
                     /gene_synonym="Eva; Eva1"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1050
                     /gene="Mpzl2"
                     /gene_synonym="Eva; Eva1"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..3216
                     /gene="Mpzl2"
                     /gene_synonym="Eva; Eva1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3166..3171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mpzl2"
                     /gene_synonym="Eva; Eva1"
                     /note="hexamer: AATAAA"
     regulatory      3180..3185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mpzl2"
                     /gene_synonym="Eva; Eva1"
                     /note="hexamer: AATAAA"
     polyA_site      3181
                     /gene="Mpzl2"
                     /gene_synonym="Eva; Eva1"
                     /note="major polyA site"
     polyA_site      3188
                     /gene="Mpzl2"
                     /gene_synonym="Eva; Eva1"
                     /note="major polyA site"
     polyA_site      3200
                     /gene="Mpzl2"
                     /gene_synonym="Eva; Eva1"
ORIGIN      
        1 agtctgggac atttcaaact ggcaccacct cctctggctg cttgtgaggc catccggagg
       61 ccagggctcg gtcagatgaa cggaaaagta aagagaggac cgcagagtct gagacctttg
      121 cgcagagggc tggagtgtgg agaggggcgg gagggagaat caggaggagg gcgctgggtg
      181 cggaggcccc acctttcatt ccagagctgt accggccggg gcgggatgag tcacgactgg
      241 ttggctccgc tgtgcgcctt cccataggtg agggactcgg acctctccgt gggtaaactg
      301 tgccgcctgc tcgtcctagc cttggccttg gttgggtgct ggagtcctgg gtctgccggg
      361 tttggcctct ggggccacga ctggctttcc ctgatgtatg gcaagagccc cgcgcttgtg
      421 cttccacttc tcctgagttt acagctcaca gccctttgtc ctacagaagc tgtggaaatt
      481 tacacctccg gggccctgga ggcagtcaac gggacagatg ttcggttaaa atgcactttc
      541 tccagctttg cccctgtggg agatgcgcta actgtgacgt ggaatttccg acctcgagat
      601 gggggtcgtg agcagtttgt attctactac cacatggacc ccttcaggcc catgagcgga
      661 cggttcaaag accgggtggt ctgggacgga aaccccgagc gatatgacgt ctccatcttg
      721 ctctggaagc tgcagtttga cgacaatggg acatacacct gccaggtgaa gaatccacct
      781 gatgttgatg gtctggttgg gacgatccgg ctcagcgttg tgcacactgt gcccttctct
      841 gagatctact tcctggccgt ggccattggc tctgcgtgcg cactgatgat catcgtagtg
      901 atcgtggtag tcctcttcca gcacttccgg aaaaagcgat gggcggacag tgctgataaa
      961 gccgagggga caaaatcaaa agaagaggaa aaactcaacc aaggaaacaa ggtctctgtt
     1021 tttgtggaag atacagacta acacttcgag aagctgagga tttttgagga caccatcagc
     1081 accccttgaa atcaatagaa atgtttccag cgatgacctg tctgtcgtcc tacaggttct
     1141 gcagcacaaa cctgcccaga tgagcaacgc ccctgcctgg cagctttggg ttctgcctga
     1201 gctactagac tcagacttac cttcgttgct acggttctat ctaattccag agtgcaattg
     1261 tgtgttagct tttgcaaacc aagaggttac atatttgtcc ttccacattc ctatggtgtg
     1321 tgactcccat atttctgtgc atcagagggg taagaagcca actagcttgt ctgccagaac
     1381 ataccttctc atattttagt ttctttagaa cagcacacag gtgtgctcag gggtctgaag
     1441 agatagctca tctatcctct tgcagaagat cccagttcag ttcccagcat ccatttggtg
     1501 gctcacaacc atcagtaccc agttttaggg gaggtgacac tctcttctgg tgtctgcagg
     1561 cactgaatgc atgtgataca tgcaggcaga tacccccccc ccaagataaa aataaattaa
     1621 gtcataaaaa gatgagctaa ccattccagc cacttttgat taataccaaa atccaaagtc
     1681 acacaggaag tctgattttc atggctatct ttaaatggaa acatcttgtt ttactgattt
     1741 tttttcagta tcctaggttt attgttttgt caattattcc aaggtttata gatgacagcg
     1801 caaatctaag cacaataatg acaaaaggtc acaagaacac caggacacca gcaagtgcta
     1861 ccaggatgaa tctctcagca tcacttttgt atttatttat ttatttttag tcaggttctc
     1921 actatgtagt gctggctgct ctagagctga ctatgcagtg ttggcctgaa acctagagac
     1981 accccctgcc tcagctctca agtgcttcac tcaagggtgt acccccacat ctagcccgac
     2041 tgtaggtttg taatgagcac agacagcgtg cttgctgtgt gctccctttt acccccagct
     2101 caacattctc ttcatttgca gactggagcc cttaagcaat ttattagaag acttcgtgat
     2161 acacgataac tttaaaagaa aatagacttg tgaagaaggc caactcaaag caaatgacca
     2221 tttttttttt cagtcttatg tgtgagaact ggaagagatt atttaaaata cttttggttt
     2281 taattcacct tactttaagg agaatttgcc atgggccaaa gactacctaa atggaaataa
     2341 ccaattttat ttttcccttt atttgagtat aaagcaaact tttcaagtgg cctatggaaa
     2401 gaagagggat ggctttcttc tttgtgtctg gttacatggt ctgtgcacac tagcattgtt
     2461 tggagaacag agaccatcta aaagttcagg tccagggtga atctttgcga tgtgatggtt
     2521 tagtcttcac tgactgggcc acacagacta tttcttttta acaaactgga atttccaaaa
     2581 gattctattt ctacatattg gatcttgtaa ttttacccag tctttacaaa caaattggca
     2641 taatttaaat ataaattttg gtcttgaaat tcattctata catcttgttc cactttttaa
     2701 aatgcctaaa aaaggttttg tttttatttc tctccctccc ccccccttaa aaattaagac
     2761 agggtctcac tactatatag ttctgtctat cctagaactt gctctgtaga ccaggctgtc
     2821 cttgaactca gagatcctac tgcctctgcc tccctagtgc taggaataag ggcatgttcc
     2881 accataccct ggtctaaaat tttgatacct agttttgaag ctacaagtta gagctatatt
     2941 ttctcttgtg aatataacaa ctggatattt ctttaaacag atggcctgtg tatatttcat
     3001 atttgtaatg aagtagttaa aaactcacag agaatgtctc cagggaactt gcagcttgtg
     3061 tcttgtttga atactcatgg gatatcaggt tcttgttcag tgtctccttc ctaagagtac
     3121 ttttgtactg taacttattt tttattatgc atgaatcact gtgtaaataa acccttagta
     3181 ataaagaact atgattttta ttatttgctt acaaac
//
