LOCUS       NM_001083897            2356 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus myelin protein zero-like 1 (Mpzl1), transcript variant
            1, mRNA.
ACCESSION   NM_001083897
VERSION     NM_001083897.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2356)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2356)
  AUTHORS   Fu,Y., Sui,Y., Zhao,Y., Jiang,J., Wang,X., Cui,J., Fu,X., Xing,S.
            and Zhao,Z.J.
  TITLE     PZR promotes tumorigenicity of lung cancer cells by regulating cell
            migration and invasion via modulating oxidative stress and cell
            adhesion
  JOURNAL   Aging (Albany NY) 15 (11), 4949-4962 (2023)
   PUBMED   37279992
  REMARK    GeneRIF: PZR promotes tumorigenicity of lung cancer cells by
            regulating cell migration and invasion via modulating oxidative
            stress and cell adhesion.
REFERENCE   3  (bases 1 to 2356)
  AUTHORS   Yi,J.S., Perla,S., Enyenihi,L. and Bennett,A.M.
  TITLE     Tyrosyl phosphorylation of PZR promotes hypertrophic cardiomyopathy
            in PTPN11-associated Noonan syndrome with multiple lentigines
  JOURNAL   JCI Insight 5 (15), 137753 (2020)
   PUBMED   32584792
  REMARK    GeneRIF: Tyrosyl phosphorylation of PZR promotes hypertrophic
            cardiomyopathy in PTPN11-associated Noonan syndrome with multiple
            lentigines.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2356)
  AUTHORS   Lopez-Tello,J., Perez-Garcia,V., Khaira,J., Kusinski,L.C.,
            Cooper,W.N., Andreani,A., Grant,I., Fernandez de Liger,E.,
            Lam,B.Y., Hemberger,M., Sandovici,I., Constancia,M. and
            Sferruzzi-Perri,A.N.
  TITLE     Fetal and trophoblast PI3K p110alpha have distinct roles in
            regulating resource supply to the growing fetus in mice
  JOURNAL   Elife 8, e45282 (2019)
   PUBMED   31241463
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2356)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 2356)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 2356)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   8  (bases 1 to 2356)
  AUTHORS   Eminaga,S. and Bennett,A.M.
  TITLE     Noonan syndrome-associated SHP-2/Ptpn11 mutants enhance SIRPalpha
            and PZR tyrosyl phosphorylation and promote adhesion-mediated ERK
            activation
  JOURNAL   J Biol Chem 283 (22), 15328-15338 (2008)
   PUBMED   18378677
  REMARK    GeneRIF: SIRPalpha and PZR serve as scaffolds that facilitate
            plasma membrane recruitment and signaling of NS-associated SHP-2
            mutants.
REFERENCE   9  (bases 1 to 2356)
  AUTHORS   Kusano,K., Thomas,T.N. and Fujiwara,K.
  TITLE     Phosphorylation and localization of protein-zero related (PZR) in
            cultured endothelial cells
  JOURNAL   Endothelium 15 (3), 127-136 (2008)
   PUBMED   18568953
  REMARK    GeneRIF: Phosphorylation and localization of PZR in cultufred
            endothelial cells is reported.
REFERENCE   10 (bases 1 to 2356)
  AUTHORS   Roubelakis,M.G., Martin-Rendon,E., Tsaknakis,G., Stavropoulos,A.
            and Watt,S.M.
  TITLE     The murine ortholog of the SHP-2 binding molecule, PZR accelerates
            cell migration on fibronectin and is expressed in early embryo
            formation
  JOURNAL   J Cell Biochem 102 (4), 955-969 (2007)
   PUBMED   17440960
  REMARK    GeneRIF: describe the function of the mPZR isoforms in vivo,
            particularly with respect to their roles in regulating
            SHP-2-dependent cell migration during development.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB871672.1, AK169385.1 and CX210059.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090278.1, AK169385.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BB871672.1         1-12
            13-2295             AK169385.1         3-2285
            2296-2356           CX210059.1         643-703
FEATURES             Location/Qualifiers
     source          1..2356
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 72.94 cM"
     gene            1..2356
                     /gene="Mpzl1"
                     /gene_synonym="1110007A10Rik; PZR"
                     /note="myelin protein zero-like 1"
                     /db_xref="GeneID:68481"
                     /db_xref="MGI:MGI:1915731"
     exon            1..239
                     /gene="Mpzl1"
                     /gene_synonym="1110007A10Rik; PZR"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..961
                     /gene="Mpzl1"
                     /gene_synonym="1110007A10Rik; PZR"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; myelin protein zero-like protein 1; protein
                     zero-related"
                     /codon_start=1
                     /product="myelin protein zero-like protein 1 isoform a
                     precursor"
                     /protein_id="NP_001077366.1"
                     /db_xref="CCDS:CCDS35757.1"
                     /db_xref="GeneID:68481"
                     /db_xref="MGI:MGI:1915731"
                     /translation="MAEAVGAVALIAAPARRRWLWSVLAAMLGLLTARISALEVHTPK
                     EIFVVNGTQGKLTCTFDSPNTTGWLTTVSWSFQPDGTDSAVSFFHYSQGQVYIGDYPP
                     FKDRVTWAGDLDKKDASINIENIQAVHNGTYICDVKNPPDIVVRPGHIRLHVVEIDNL
                     LVFLVWVVVGTVTAVVLGLTLLISLVLVVLYRRKHSKRDYTGCSTSERLSPVKQAPRK
                     CPSDTEGLVKSPPSAGSHQGPVIYAQLDHSGGHHSGKINKSESVVYADIRKD"
     exon            240..406
                     /gene="Mpzl1"
                     /gene_synonym="1110007A10Rik; PZR"
                     /inference="alignment:Splign:2.1.0"
     exon            407..620
                     /gene="Mpzl1"
                     /gene_synonym="1110007A10Rik; PZR"
                     /inference="alignment:Splign:2.1.0"
     exon            621..753
                     /gene="Mpzl1"
                     /gene_synonym="1110007A10Rik; PZR"
                     /inference="alignment:Splign:2.1.0"
     exon            754..859
                     /gene="Mpzl1"
                     /gene_synonym="1110007A10Rik; PZR"
                     /inference="alignment:Splign:2.1.0"
     exon            860..2356
                     /gene="Mpzl1"
                     /gene_synonym="1110007A10Rik; PZR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2274..2279
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mpzl1"
                     /gene_synonym="1110007A10Rik; PZR"
                     /note="hexamer: AATACA"
     polyA_site      2297
                     /gene="Mpzl1"
                     /gene_synonym="1110007A10Rik; PZR"
                     /note="major polyA site"
     regulatory      2336..2341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mpzl1"
                     /gene_synonym="1110007A10Rik; PZR"
                     /note="hexamer: GATAAA"
     polyA_site      2356
                     /gene="Mpzl1"
                     /gene_synonym="1110007A10Rik; PZR"
ORIGIN      
        1 ggcggttggc cactggggcc gggagcgggg agcggtggcg tggaggtgtc ctcgcgctcg
       61 cagccgcgat ccggacagag ctgtgtggtc taaggcaagc cagccgaccg cagcgggaag
      121 ccgggcggaa cggagcggcg ggagcaggat ggcagaggcc gtcggagccg tggcactgat
      181 tgcggccccg gcccgccggc gctggctgtg gtcggtgcta gccgcgatgc tcgggctgtt
      241 gacagctaga atatcagcct tggaggtcca tactcctaaa gaaatctttg tggtgaatgg
      301 gacacaaggg aagctgactt gcacattcga ttctcctaac acaactggat ggttgaccac
      361 ggtctcctgg agcttccagc cagacggcac cgacagcgcc gtgtcgtttt tccactactc
      421 acaaggacag gtgtacattg gggattatcc accatttaaa gaccgagtca cctgggctgg
      481 ggaccttgac aagaaagatg catcaatcaa tatagaaaat attcaggctg ttcacaatgg
      541 cacctatatc tgcgatgtca aaaatcctcc tgacattgtt gtgcggcctg gacacattag
      601 gctccacgtg gtggaaatag acaacctgtt ggtgttcctg gtttgggtgg tggtgggcac
      661 tgtcactgct gtggtccttg gcctcactct gctcatcagc ttggtcctgg tcgtcctcta
      721 cagaaggaaa cattcgaagc gggattatac cggctgcagt acctcagagc gtttgtcacc
      781 agttaagcag gctccacgga agtgtccctc cgacacagag ggtctagtaa agagtccgcc
      841 ttccgccgga tctcaccagg gcccagtcat ttacgcacag ttagaccact ctggcggaca
      901 ccacagcggc aagattaata agtcagagtc ggttgtgtat gcggacatcc ggaaagacta
      961 agagaacacc caaacatttc caaactggac gcttgtgcag aaaatgtcca taaccgcatg
     1021 tggccttgag gactcgggca aggacaagca catgtatact cggagagagc agaaaatatg
     1081 tatagaggat atgtatattc tatttaatct tcctgatgtg agaggccaac gttgcatggt
     1141 gaagtggtat gagtctacgt atgtgtaaat tgtcttgctg tttctgtata ttctttcaga
     1201 gtcatttcta gctggaaagt tttagaagca tcccgtggtc ccatgcgtgg gatggtttgc
     1261 cttattgaag actctgcaga accgttagtc tttccgacag acgtggcctt tttcatctaa
     1321 gggctcaacc agtctaagca tttcttgtag ttagagagtg aggtgttcag tggaagtgtg
     1381 tctctcacag tatcaggacc gttttgttct gtgcccgtgc tagctgatag acaccgtcgg
     1441 ttaaccacgc cacccgagga cagtctgaga agttagtgtt gatgcttttc tttatatgag
     1501 ggaattctga gctgagattg tccttgtcac catcctgcta ttagctacga tctcacaatg
     1561 agttcttgtc agcgtgcaga cagcagagct ggctgaggct gtggtcgtgg ttaaaagggt
     1621 acagattaca gagccccagc atgacaatag cgtgtggaag gcagcatctt cctttctcct
     1681 cctcttaggg acgctatcaa tgaactgcac actctagata cctcctgaca ccaggttctt
     1741 taccatctcc ttgtggtgct gagaccgtgt atatggtgct agtgctctgt gggctttgtt
     1801 caaatgacac ctcttcttaa gggctttcta catctggctc catgatctcc ctgcccagtc
     1861 agaaccaaat cctctgttgg ccaagccaac cttcttccct aggcagaaac cgttggctgc
     1921 tggccggcct tcctggactg agcctgcagc ctggttccag ctgctcgcag gacagtgtgc
     1981 aggcctcatg gcctaactcc acacaccacc tcccttggag tattcggtct ctttcctgca
     2041 actctgcgtt ctgggcctgg ctacagataa cagtgaggcc acgtccagat ggcagacctg
     2101 tgcttcctgt gtcttctgag cagaagaatg cattcgaatt gagaagagac acctaaaagg
     2161 gatggctttt agaattcctg cctgtatttt ctcctggaaa tgtgtccagc tggagagata
     2221 ccaagttcat tgttactttt tgatattttc atttgtacgt ctgtgaatat tttaatacat
     2281 ctttttcgat ttctgaatgg tgttgtctgc ttgtttttaa ccaaatggaa aaagagataa
     2341 agccctttca tctgaa
//
