LOCUS       NM_001315499            1916 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus myelin protein zero (Mpz), transcript variant 1, mRNA.
ACCESSION   NM_001315499 XM_006496694
VERSION     NM_001315499.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1916)
  AUTHORS   Zerad,L., Gacem,N., Gayda,F., Day,L., Sinigaglia,K., Richard,L.,
            Parisot,M., Cagnard,N., Mathis,S., Bole-Feysot,C., O'Connell,M.A.,
            Pingault,V., Dambroise,E., Keegan,L.P., Vallat,J.M. and
            Bondurand,N.
  TITLE     Overexpression of Egr1 Transcription Regulator Contributes to
            Schwann Cell Differentiation Defects in Neural Crest-Specific Adar1
            Knockout Mice
  JOURNAL   Cells 13 (23), 1952 (2024)
   PUBMED   39682701
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1916)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1916)
  AUTHORS   Guo,Y., Xiang,P., Sun,X., Liu,W., Zhou,J., Yin,B., Hou,L.,
            Qiang,B., Li,H., Shu,P. and Peng,X.
  TITLE     Docking protein 6 (DOK6) selectively docks the neurotrophic
            signaling transduction to restrain peripheral neuropathy
  JOURNAL   Signal Transduct Target Ther 9 (1), 32 (2024)
   PUBMED   38351062
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1916)
  AUTHORS   Shackleford,G., Marziali,L.N., Sasaki,Y., Claessens,A., Ferri,C.,
            Weinstock,N.I., Rossor,A.M., Silvestri,N.J., Wilson,E.R.,
            Hurley,E., Kidd,G.J., Manohar,S., Ding,D., Salvi,R.J., Feltri,M.L.,
            D'Antonio,M. and Wrabetz,L.
  TITLE     A new mouse model of Charcot-Marie-Tooth 2J neuropathy replicates
            human axonopathy and suggest alteration in axo-glia communication
  JOURNAL   PLoS Genet 18 (11), e1010477 (2022)
   PUBMED   36350884
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1916)
  AUTHORS   Yamaguchi,Y. and Baba,H.
  TITLE     Phylogenetically Conserved Sequences Around Myelin P0 Stop Codon
            are Essential for Translational Readthrough to Produce L-MPZ
  JOURNAL   Neurochem Res 43 (1), 227-237 (2018)
   PUBMED   29081003
REFERENCE   6  (bases 1 to 1916)
  AUTHORS   Yamaguchi,Y., Hayashi,A., Campagnoni,C.W., Kimura,A., Inuzuka,T.
            and Baba,H.
  TITLE     L-MPZ, a novel isoform of myelin P0, is produced by stop codon
            readthrough
  JOURNAL   J Biol Chem 287 (21), 17765-17776 (2012)
   PUBMED   22457349
  REMARK    GeneRIF: L-MPZ, a novel isoform of myelin P0, is produced by stop
            codon readthrough.
REFERENCE   7  (bases 1 to 1916)
  AUTHORS   Beier,H. and Grimm,M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   8  (bases 1 to 1916)
  AUTHORS   Giese,K.P., Martini,R., Lemke,G., Soriano,P. and Schachner,M.
  TITLE     Mouse P0 gene disruption leads to hypomyelination, abnormal
            expression of recognition molecules, and degeneration of myelin and
            axons
  JOURNAL   Cell 71 (4), 565-576 (1992)
   PUBMED   1384988
REFERENCE   9  (bases 1 to 1916)
  AUTHORS   Oakey,R.J., Watson,M.L. and Seldin,M.F.
  TITLE     Construction of a physical map on mouse and human chromosome 1:
            comparison of 13 Mb of mouse and 11 Mb of human DNA
  JOURNAL   Hum Mol Genet 1 (8), 613-620 (1992)
   PUBMED   1301170
REFERENCE   10 (bases 1 to 1916)
  AUTHORS   Garbay,B. and Bonnet,J.
  TITLE     P0 protein in normal, trembler heterozygous/homozygous mice during
            active PNS myelination
  JOURNAL   Neuroreport 3 (7), 594-596 (1992)
   PUBMED   1384766
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BB849278.1, BY339244.1,
            AC163497.14, AK157960.1 and AA920638.1.
            
            On Oct 7, 2015 this sequence version replaced XM_006496694.2.
            
            Summary: This gene is specifically expressed in Schwann cells of
            the peripheral nervous system and encodes a type I transmembrane
            glycoprotein that is a major structural protein of the peripheral
            myelin sheath. The encoded protein contains a large hydrophobic
            extracellular domain and a smaller basic intracellular domain,
            which are essential for the formation and stabilization of the
            multilamellar structure of the compact myelin. Mutations in the
            orthologous gene in human are associated with myelinating
            neuropathies. A recent study showed that two isoforms are produced
            from the same mRNA by use of alternative in-frame translation
            termination codons via a stop codon readthrough mechanism.
            Alternatively spliced transcript variants have also been found for
            this gene. [provided by RefSeq, Oct 2015].
            
            Transcript Variant: This variant (1) encodes two isoforms, which
            result from the use of alternative in-frame translation termination
            codons. The shorter isoform (MPZ, also known as P0) results from
            translation termination at the upstream UAG stop codon, while the
            longer isoform (L-MPZ) results from UAG stop codon readthrough to
            the downstream UGA termination codon. This RefSeq represents the
            shorter isoform (MPZ). Variants 1 and 2 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141226.1, AK157960.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               BB849278.1         1-135
            136-362             BY339244.1         128-354
            363-463             AC163497.14        61378-61478         c
            464-1246            AK157960.1         463-1245
            1247-1891           AC163497.14        59172-59816         c
            1892-1916           AA920638.1         394-418
FEATURES             Location/Qualifiers
     source          1..1916
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.05 cM"
     gene            1..1916
                     /gene="Mpz"
                     /gene_synonym="Mpp; P-zero; P0"
                     /note="myelin protein zero"
                     /db_xref="GeneID:17528"
                     /db_xref="MGI:MGI:103177"
     exon            1..131
                     /gene="Mpz"
                     /gene_synonym="Mpp; P-zero; P0"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..811
                     /gene="Mpz"
                     /gene_synonym="Mpp; P-zero; P0"
                     /note="isoform MPZ precursor is encoded by transcript
                     variant 1; myelin protein P0; myelin peripheral protein"
                     /codon_start=1
                     /product="myelin protein P0 isoform MPZ precursor"
                     /protein_id="NP_001302428.1"
                     /db_xref="CCDS:CCDS15479.1"
                     /db_xref="GeneID:17528"
                     /db_xref="MGI:MGI:103177"
                     /translation="MAPGAPSSSPSPILAALLFSSLVLSPALAIVVYTDREIYGAVGS
                     QVTLHCSFWSSEWVSDDISFTWRYQPEGGRDAISIFHYAKGQPYIDEVGTFKERIQWV
                     GDPRWKDGSIVIHNLDYSDNGTFTCDVKNPPDIVGKTSQVTLYVFEKVPTRYGVVLGA
                     VIGGILGVVLLLLLLFYLIRYCWLRRQAALQRRLSAMEKGRFHKSSKDSSKRGRQTPV
                     LYAMLDHSRSTKAASEKKSKGLGESRKDKK"
     exon            132..298
                     /gene="Mpz"
                     /gene_synonym="Mpp; P-zero; P0"
                     /inference="alignment:Splign:2.1.0"
     exon            299..512
                     /gene="Mpz"
                     /gene_synonym="Mpp; P-zero; P0"
                     /inference="alignment:Splign:2.1.0"
     exon            513..648
                     /gene="Mpz"
                     /gene_synonym="Mpp; P-zero; P0"
                     /inference="alignment:Splign:2.1.0"
     exon            649..709
                     /gene="Mpz"
                     /gene_synonym="Mpp; P-zero; P0"
                     /inference="alignment:Splign:2.1.0"
     exon            710..1898
                     /gene="Mpz"
                     /gene_synonym="Mpp; P-zero; P0"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1871..1876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mpz"
                     /gene_synonym="Mpp; P-zero; P0"
                     /note="hexamer: AATAAA"
     polyA_site      1878
                     /gene="Mpz"
                     /gene_synonym="Mpp; P-zero; P0"
                     /note="major polyA site"
     polyA_site      1893
                     /gene="Mpz"
                     /gene_synonym="Mpp; P-zero; P0"
ORIGIN      
        1 tcagttcctt gtcccccgct ctctccaccc cacagacact ctgggccttt gccctacccc
       61 agctatggct cccggggctc cctcctccag ccccagccct atcctggctg ccctgctctt
      121 ctcttctttg gtgctctctc cagccctggc cattgtggtt tacacggaca gggaaatcta
      181 tggtgccgtg ggctcccagg tgaccctgca ctgctccttc tggtccagtg aatgggtctc
      241 agatgacatc tcttttacct ggcgctacca gcctgaaggg ggccgagatg ccatttcgat
      301 cttccactat gccaagggac aaccttacat cgatgaggtg gggaccttca aagagcgcat
      361 ccagtgggta ggggaccctc gctggaagga tggctccatt gtcatacaca acctagacta
      421 cagtgacaac ggcactttca catgtgatgt caaaaaccca ccggacatag tgggcaagac
      481 ctctcaggtc acgctctatg tctttgaaaa agtgcccact aggtatgggg tggtgttggg
      541 agcagtgatc gggggcatcc tcggggtggt gctgttgctg ctgttgctct tctacctgat
      601 tcggtactgc tggctgcgca ggcaggctgc cctgcagaga aggctcagtg ccatggagaa
      661 ggggagattt cacaaatctt cgaaggactc ctcgaagcga gggcggcaga cgccagtgct
      721 gtatgccatg ctggaccaca gccgaagcac caaagctgcc agtgagaaga aatcaaaagg
      781 gctgggggag tctcgcaagg ataagaaata gcggttagcg ggccgggcgg ggggtcgggg
      841 gtctgcgacg gagtcctcca aaggctctca ggtggtggtc atcgagatgg agcttcgcaa
      901 agatgagcag agctcggagc tccggcctgc agtcaagtcc cccagtagaa ccagcctcaa
      961 gaacgccctc aagaacatga tgggcctgga ctcggacaag tgaccgtcac atccaggccc
     1021 tgtcagagca ggggacctag gctcctcttt ttcccgggtc taggtgcttt cctcttgctc
     1081 ctcagccctg ccctgccctt acctcccaat gagatgtaaa gtttcattcc aaccttcctt
     1141 tccaagtctt gtactcctcc ttcgccttta cccctcggct ttccaggagc ctagggacta
     1201 accctactcc tcgcctgccc caagggctgt gtgtttggtg cctgtctctc agacaccgag
     1261 aagaaaggga ccttgatagc ctctgcccaa ctccaggcca cttggccttc ccatctctcc
     1321 cccccccgcc ccccccccca gctgatcccc tggctccttc ctgctctccc tttcctacct
     1381 tctggtggcc cagctccaca ctctgtcctc gggctcaaat ccacatcgtg cagagcagac
     1441 tctccatcag ggtttattta ggttgctgag tattttttat ttgcccatcc attctttcgt
     1501 ttgtttacct gagcccacgg ccccatgacc gaggaccaat gacgtcatgt ggcttttgca
     1561 gttccccact aagtctttac tggagagcca ggcaggcaag cagcgcataa tcgatgccct
     1621 ctgaccacta cggagcacag ttctgggact ccgagatttg gggaaggaaa gaaaaaaaaa
     1681 tggatcctca caggtcaggg gtgcagtagg gggctttaag aaatgtcttc aaaataaata
     1741 atcagaacag gaaacgccag cgagaatggg aaggaaagga agtggctaca cccccgggca
     1801 cagtggactg ttaggacttt tctacattct gtatatttct cctaccatct ccaaatgtcc
     1861 ttaaatgttt aataaacact gacatttcca gaagctgcaa aaaaaaaaaa aaaaaa
//
