LOCUS       NM_033564               3328 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus Mpv17 transgene, kidney disease mutant-like (Mpv17l),
            transcript variant 1, mRNA.
ACCESSION   NM_033564
VERSION     NM_033564.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3328)
  AUTHORS   Iida,R., Ueki,M. and Yasuda,T.
  TITLE     Knockout of M-LP/Mpv17L, a newly identified atypical PDE, induces
            physiological afferent cardiac hypertrophy in mice
  JOURNAL   Transgenic Res 32 (6), 575-582 (2023)
   PUBMED   37851308
  REMARK    GeneRIF: Knockout of M-LP/Mpv17L, a newly identified atypical PDE,
            induces physiological afferent cardiac hypertrophy in mice.
REFERENCE   2  (bases 1 to 3328)
  AUTHORS   Iida,R., Ueki,M. and Yasuda,T.
  TITLE     Deficiency of M-LP/Mpv17L leads to development of beta-cell
            hyperplasia and improved glucose tolerance via activation of the
            Wnt and TGF-beta pathways
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1868 (3), 166318 (2022)
   PUBMED   34883249
  REMARK    GeneRIF: Deficiency of M-LP/Mpv17L leads to development of
            beta-cell hyperplasia and improved glucose tolerance via activation
            of the Wnt and TGF-beta pathways.
REFERENCE   3  (bases 1 to 3328)
  AUTHORS   Krick,S., Shi,S., Ju,W., Faul,C., Tsai,S.Y., Mundel,P. and
            Bottinger,E.P.
  TITLE     Mpv17l protects against mitochondrial oxidative stress and
            apoptosis by activation of Omi/HtrA2 protease
  JOURNAL   Proc Natl Acad Sci U S A 105 (37), 14106-14111 (2008)
   PUBMED   18772386
  REMARK    GeneRIF: identify Mpv17l as a unique interacting protein and
            regulator of HtrA2 protease mediating antioxidant and antiapoptotic
            function in mitochondria
REFERENCE   4  (bases 1 to 3328)
  AUTHORS   Iida,R., Yasuda,T., Tsubota,E., Takatsuka,H., Matsuki,T. and
            Kishi,K.
  TITLE     Human Mpv17-like protein is localized in peroxisomes and regulates
            expression of antioxidant enzymes
  JOURNAL   Biochem Biophys Res Commun 344 (3), 948-954 (2006)
   PUBMED   16631601
REFERENCE   5  (bases 1 to 3328)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3328)
  AUTHORS   Iida,R., Yasuda,T., Tsubota,E., Takatsuka,H., Masuyama,M.,
            Matsuki,T. and Kishi,K.
  TITLE     A novel alternative spliced Mpv17-like protein isoform localizes in
            cytosol and is expressed in a kidney- and adult-specific manner
  JOURNAL   Exp Cell Res 302 (1), 22-30 (2005)
   PUBMED   15541722
  REMARK    GeneRIF: In mice, M-LPs is expressed exclusively in kidneys after 6
            weeks. Transfection with M-LPS up-regulates SOD2 and down-regulates
            cellular glutathione peroxidase (Gpx1) and plasma glutathione
            peroxidase (Gpx3) gene expression
REFERENCE   7  (bases 1 to 3328)
  AUTHORS   Iida,R., Yasuda,T., Tsubota,E., Takatsuka,H., Masuyama,M.,
            Matsuki,T. and Kishi,K.
  TITLE     M-LP, Mpv17-like protein, has a peroxisomal membrane targeting
            signal comprising a transmembrane domain and a positively charged
            loop and up-regulates expression of the manganese superoxide
            dismutase gene
  JOURNAL   J Biol Chem 278 (8), 6301-6306 (2003)
   PUBMED   12471025
  REMARK    GeneRIF: participates in reactive oxygen species metabolism
REFERENCE   8  (bases 1 to 3328)
  AUTHORS   Iida,R., Yasuda,T., Tsubota,E., Matsuki,T. and Kishi,K.
  TITLE     Cloning, mapping, genomic organization, and expression of mouse
            M-LP, a new member of the peroxisomal membrane protein Mpv17 domain
            family
  JOURNAL   Biochem Biophys Res Commun 283 (2), 292-296 (2001)
   PUBMED   11327696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC107769.7 and AF305634.1.
            
            On Jan 24, 2014 this sequence version replaced NM_033564.2.
            
            Transcript Variant: This variant (1) encodes the logest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF305634.1, BC094450.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG   :: upstream AUG and CDS
                                                  extension is not conserved
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AC107769.7         41978-42007         c
            31-3066             AF305634.1         1-3036
            3067-3328           AC107769.7         33053-33314         c
FEATURES             Location/Qualifiers
     source          1..3328
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 9.64 cM"
     gene            1..3328
                     /gene="Mpv17l"
                     /gene_synonym="M-LP"
                     /note="Mpv17 transgene, kidney disease mutant-like"
                     /db_xref="GeneID:93734"
                     /db_xref="MGI:MGI:2135951"
     exon            1..359
                     /gene="Mpv17l"
                     /gene_synonym="M-LP"
                     /inference="alignment:Splign:2.1.0"
     exon            360..430
                     /gene="Mpv17l"
                     /gene_synonym="M-LP"
                     /inference="alignment:Splign:2.1.0"
     exon            431..460
                     /gene="Mpv17l"
                     /gene_synonym="M-LP"
                     /inference="alignment:Splign:2.1.0"
     exon            461..3328
                     /gene="Mpv17l"
                     /gene_synonym="M-LP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1434..1439
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mpv17l"
                     /gene_synonym="M-LP"
                     /note="hexamer: AATAAT"
     regulatory      1454..1459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mpv17l"
                     /gene_synonym="M-LP"
                     /note="hexamer: ATTACA"
     polyA_site      1454
                     /gene="Mpv17l"
                     /gene_synonym="M-LP"
                     /note="major polyA site"
     polyA_site      1470
                     /gene="Mpv17l"
                     /gene_synonym="M-LP"
     polyA_site      2297
                     /gene="Mpv17l"
                     /gene_synonym="M-LP"
                     /note="major polyA site"
     polyA_site      2412
                     /gene="Mpv17l"
                     /gene_synonym="M-LP"
     polyA_site      2466
                     /gene="Mpv17l"
                     /gene_synonym="M-LP"
     regulatory      3211..3216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mpv17l"
                     /gene_synonym="M-LP"
                     /note="hexamer: ATTAAA"
     polyA_site      3233
                     /gene="Mpv17l"
                     /gene_synonym="M-LP"
ORIGIN      
        1 gaaatgcatg cagtcaggtg tgcaggccct gagggcaccc ggggcaggta tggcgagctg
       61 gtggcgcgcg tttccacagg cagcacggcg ctatccgtgg cccactaacg tgctgctcta
      121 cgccgggctc ttctcggcgg gtgatgccct gcagcagcga ctgcggggag gcccagccga
      181 ctggcgccag acgcgtcgcg tggccactct ggccgtgacc ttccacggaa acttcaacta
      241 cgtgtggctg cgcctactgg agcgcgccct gccaggccgc gcgccgcgca cggtcctggc
      301 caaggtgcta tgcgatcaga ctgtcggagg gccgatagcc ctctctgcct tctacgtcgg
      361 catgagcgtt ctccagggga aggatgacat atttttggac ctgaagcaga aattctggaa
      421 tacgtataag agtggtctca tgtactggcc ctttgtgcag ctgaccaact tcagccttgt
      481 ccctgtgcac tggaggacag catatacggg actctgtgcc tttctctggg ccaccttcct
      541 atgcttttca cagcagagcg gcgatggtac actgcagtcc atattcatct tccttcgcag
      601 gaaggaggcg agtgataagt ccccagagaa gtgacgagtc tggacttcct tcctaggact
      661 cagttctgtt tcttcatcgg tctcaatcac tggcagcagg cctgcttcac tgaccagtta
      721 cgggctccat catgaggaca ttccataggc ccacttgatt tgaaattatc aatgattatt
      781 ttaactttta tccaaacctt tcccagtcat tccagtctga aaggcttatt ctctggtatt
      841 ttcacatctt taatgctttg gttaaaaact ataacagtga catgtgacat tttagaatta
      901 ttaatatttc cattctaata tatggccaat tgaatttaaa aaaaaaactc cagtttagat
      961 tgtatttcta gcctaaactc tcaggctgtt tcctacacac tgtgaaatct gattatcttt
     1021 tgttcttata gtaaatttct atgcatataa aattcagtca tgaaggttga ataatcagat
     1081 aatttataat aacccagata atttataata attattgtgc caacattaaa attctgtaag
     1141 tagatgtttt taatcttcaa aggaggagta gtgttggata tattctgtat agaatacctt
     1201 attgatactg tctacttttt ttaaagaagg atctcaggct gccgtggaac tcactagata
     1261 ccccagcggg gcctcagctc tacaagtgct gagattacag gcatgaatca tcatgtctta
     1321 ctcttctgct tttatattat atatatccac atacaggttt ttaaaattga tgtcttctag
     1381 ctttgagaag atacagttga ccaaatgccc ttattcctgg atatatgaaa taaaataatt
     1441 ggtttctgaa tgaattacag caaatgaaaa ttctagaaaa cgaatcattt ctttcctctc
     1501 taaggaagaa ctctaattca cactagacca gtctacacag tttgtagcaa ccctcctgcc
     1561 tctgcattct aaatatttgg attacagaca tgagccacca tgcctggctt tgtgtgtata
     1621 tgtggtattt aagtggaacc aggaccttac acaaacaagt gctctgccac tggctgcatc
     1681 ccaggatcct aatagtagtc ttttataatt cagtgcttta aaattcttta tctttacact
     1741 ttaaaatgga cacaaaaatt ctcaactagt ctttcacatt tatttagttt gcctaatctc
     1801 agccagagcc ttcaggtttc agagttatgc aaataaccac acatggaggt gtgtgcctgt
     1861 ctattcagaa agttaatgga ggaggatcat ttcagcccgg gagttcaaga ctagactgga
     1921 aaaaccagca aatttctgtt aaaaccacaa agataaaaaa tttaaaacta tgaatgtctt
     1981 aagaaatttc agcaatctca cctgaaaatt gcccccatgg ttctgttgct tccactggca
     2041 tacatgacaa attttgagat gtgaaacact gaattctgag tttatcttgt gaatgtataa
     2101 ggtcaatttc ataattcata cttaaatttc taagcaatta atttatatgg tttgtaatat
     2161 gtttgtataa attataagca tgtacttttt aagagtctaa gttatggaat gtaatagaaa
     2221 ttgttgggat ggcatgaagg tatatccctg tattttcact tgtaaattgc tgaactctaa
     2281 gctacttact ggcaggattt gggtattgtc atttttatgg cccatcgcca gttttctatg
     2341 tgtgtttgtc cttcctacct gcccaaaaag atgattctca agcagccctc agtgccaaag
     2401 ggcaacccta aacaattgat ttgtccttgt cctgacaaga ttgatgctga ttggttcaga
     2461 ctgtaatgtg actttttgta taataatgag ctgacagctg gaactggggc agaagtatgg
     2521 ggcataactt ctgtgcaggc agacacacag gcagagatgc aggagacaag gacagatgag
     2581 gagggtttag aaggaggcaa aagtgaggaa ggaggcagaa gggggatgga tggagcagga
     2641 agcatgaagt gagaaccaca tggagagatg gtgtggtggt ttgaatatgc ttggcccatg
     2701 ggaagtggca ctattatgag gtgtggtttg ttaaaggaag tgtgtcactt tgtgggtgga
     2761 ctttgaggtc ctatgctcac tcaagctctg ccctgtaagg agagaccctc ctcctggttg
     2821 cctgtggaag agaatcccct tctgtctgtc ttcagatcaa gatgcagaac tctcgggctg
     2881 gtgagatggc tcagtgggta ggagcacccg actgctcttc cgaaggtccg gagttcaaat
     2941 cccagcaacc acatggtggc tcacaaccat ccgtaatgag atctgactcc ctcttctgga
     3001 gtgtctgagg acagctacag tgtacttaca tttaataaat aaataaatct ttaaaaatat
     3061 atatttaaaa aaaaaaaaaa aaaaaaagat gcagaactct cagctccttc tccagcacga
     3121 tgtctgcctg catgctgcca tgtttcctgc cttaatgaac tgaacctatg aacttgatgg
     3181 actgaaccta tgaaactgta agcatccaca attaaatgtt tataaaagtt gtattagagg
     3241 caggcggatt tctgagtttg aggtcagcct ggtcttgtga gttccaggac agccagagct
     3301 atacagagaa accctgcctc gaaaaacc
//
