LOCUS       NM_008622               1715 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Mus musculus MpV17 mitochondrial inner membrane protein (Mpv17),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_008622
VERSION     NM_008622.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1715)
  AUTHORS   Xu,T. and Chen,G.
  TITLE     MPV17 Prevents Myocardial Ferroptosis and Ischemic Cardiac Injury
            through Maintaining SLC25A10-Mediated Mitochondrial Glutathione
            Import
  JOURNAL   Int J Mol Sci 25 (19), 10832 (2024)
   PUBMED   39409161
  REMARK    GeneRIF: MPV17 Prevents Myocardial Ferroptosis and Ischemic Cardiac
            Injury through Maintaining SLC25A10-Mediated Mitochondrial
            Glutathione Import.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1715)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1715)
  AUTHORS   Tang,Q., Shi,W., Liu,M., Tang,L., Ren,W. and Shi,S.
  TITLE     Mitochondrial protein MPV17 promotes beta-cell apoptosis in
            diabetogenesis
  JOURNAL   Clin Sci (Lond) 137 (15), 1195-1208 (2023)
   PUBMED   37522959
  REMARK    GeneRIF: Mitochondrial protein MPV17 promotes beta-cell apoptosis
            in diabetogenesis.
REFERENCE   4  (bases 1 to 1715)
  AUTHORS   Guha,M., Srinivasan,S., Sheehan,M.M., Kijima,T., Ruthel,G.,
            Whelan,K., Tanaka,K., Klein-Szanto,A., Chandramouleeswaran,P.M.,
            Nakagawa,H. and Avadhani,N.G.
  TITLE     Esophageal 3D organoids of MPV17-/- mouse model of mitochondrial
            DNA depletion show epithelial cell plasticity and telomere
            attrition
  JOURNAL   Oncotarget 10 (58), 6245-6259 (2019)
   PUBMED   31692873
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1715)
  AUTHORS   Angireddy,R., Kazmi,H.R., Srinivasan,S., Sun,L., Iqbal,J.,
            Fuchs,S.Y., Guha,M., Kijima,T., Yuen,T., Zaidi,M. and Avadhani,N.G.
  TITLE     Cytochrome c oxidase dysfunction enhances phagocytic function and
            osteoclast formation in macrophages
  JOURNAL   FASEB J 33 (8), 9167-9181 (2019)
   PUBMED   31063702
REFERENCE   6  (bases 1 to 1715)
  AUTHORS   Muller,M., Smolders,J.W., Meyer zum Gottesberge,A.M., Reuter,A.,
            Zwacka,R.M., Weiher,H. and Klinke,R.
  TITLE     Loss of auditory function in transgenic Mpv17-deficient mice
  JOURNAL   Hear Res 114 (1-2), 259-263 (1997)
   PUBMED   9447939
REFERENCE   7  (bases 1 to 1715)
  AUTHORS   Schenkel,J., Zwacka,R.M., Rutenberg,C., Reuter,A., Waldherr,R. and
            Weiher,H.
  TITLE     Functional rescue of the glomerulosclerosis phenotype in Mpv17 mice
            by transgenesis with the human Mpv17 homologue
  JOURNAL   Kidney Int 48 (1), 80-84 (1995)
   PUBMED   7564095
REFERENCE   8  (bases 1 to 1715)
  AUTHORS   Zwacka,R.M., Reuter,A., Pfaff,E., Moll,J., Gorgas,K., Karasawa,M.
            and Weiher,H.
  TITLE     The glomerulosclerosis gene Mpv17 encodes a peroxisomal protein
            producing reactive oxygen species
  JOURNAL   EMBO J 13 (21), 5129-5134 (1994)
   PUBMED   7957077
REFERENCE   9  (bases 1 to 1715)
  AUTHORS   Karasawa,M., Zwacka,R.M., Reuter,A., Fink,T., Hsieh,C.L.,
            Lichter,P., Francke,U. and Weiher,H.
  TITLE     The human homolog of the glomerulosclerosis gene Mpv17: structure
            and genomic organization
  JOURNAL   Hum Mol Genet 2 (11), 1829-1834 (1993)
   PUBMED   8281143
REFERENCE   10 (bases 1 to 1715)
  AUTHORS   Weiher,H., Noda,T., Gray,D.A., Sharpe,A.H. and Jaenisch,R.
  TITLE     Transgenic mouse model of kidney disease: insertional inactivation
            of ubiquitously expressed gene leads to nephrotic syndrome
  JOURNAL   Cell 62 (3), 425-434 (1990)
   PUBMED   1696177
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY271802.1, BY088136.1, BY258057.1, CK622051.1, DV660230.1,
            CF731561.1, CD776211.1, CX633035.1 and BY415502.1.
            
            On Jun 29, 2014 this sequence version replaced NM_008622.5.
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 2. Variants 1, 2, and 4 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013452.1, M36411.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BY271802.1         1-9
            10-29               BY088136.1         1-20
            30-248              BY258057.1         1-219
            249-527             CK622051.1         191-469
            528-749             DV660230.1         249-470
            750-1125            CF731561.1         144-519
            1126-1425           CD776211.1         1-300               c
            1426-1711           CX633035.1         296-581
            1712-1715           BY415502.1         364-367
FEATURES             Location/Qualifiers
     source          1..1715
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.12 cM"
     gene            1..1715
                     /gene="Mpv17"
                     /gene_synonym="Tg.Mpv17"
                     /note="MpV17 mitochondrial inner membrane protein"
                     /db_xref="GeneID:17527"
                     /db_xref="MGI:MGI:97138"
     exon            1..61
                     /gene="Mpv17"
                     /gene_synonym="Tg.Mpv17"
                     /inference="alignment:Splign:2.1.0"
     exon            62..136
                     /gene="Mpv17"
                     /gene_synonym="Tg.Mpv17"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..597
                     /gene="Mpv17"
                     /gene_synonym="Tg.Mpv17"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein Mpv17; mitochondrial inner membrane protein Mpv17"
                     /codon_start=1
                     /product="mitochondrial inner membrane protein Mpv17
                     isoform 1"
                     /protein_id="NP_032648.1"
                     /db_xref="CCDS:CCDS19175.1"
                     /db_xref="GeneID:17527"
                     /db_xref="MGI:MGI:97138"
                     /translation="MALWRAYQRALAAHPWKVQVLTAGSLMGVGDMISQQLVERRGLQ
                     QHQAGRTLTMVSLGCGFVGPVVGGWYKVLDHLIPGTTKVHALKKMLLDQGGFAPCFLG
                     CFLPLVGILNGMSAQDNWAKLKRDYPDALITNYYLWPAVQLANFYLVPLHYRLAVVQC
                     VAIVWNSYLSWKAHQF"
     exon            137..252
                     /gene="Mpv17"
                     /gene_synonym="Tg.Mpv17"
                     /inference="alignment:Splign:2.1.0"
     exon            253..345
                     /gene="Mpv17"
                     /gene_synonym="Tg.Mpv17"
                     /inference="alignment:Splign:2.1.0"
     exon            346..441
                     /gene="Mpv17"
                     /gene_synonym="Tg.Mpv17"
                     /inference="alignment:Splign:2.1.0"
     exon            442..474
                     /gene="Mpv17"
                     /gene_synonym="Tg.Mpv17"
                     /inference="alignment:Splign:2.1.0"
     exon            475..527
                     /gene="Mpv17"
                     /gene_synonym="Tg.Mpv17"
                     /inference="alignment:Splign:2.1.0"
     exon            528..1715
                     /gene="Mpv17"
                     /gene_synonym="Tg.Mpv17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagtccct ggaccagctt cggtcacgtg agagaaggtt ctgcgcagag ctggcactca
       61 gggagcatgg cactctggcg agcataccag agagccctgg cagcacatcc gtggaaagtc
      121 caggttctga cagctggatc actgatgggc gtaggtgaca tgatctcaca gcagctggtg
      181 gagaggcggg gtctccagca acaccaggca ggccgcactc tgaccatggt atccctgggc
      241 tgtggctttg tgggccctgt cgtcggaggc tggtacaaag ttttagacca cttaatcccg
      301 ggcaccacga aggtgcatgc actgaagaag atgttgttag atcagggggg ctttgcccca
      361 tgtttcctag gctgctttct cccactggtc gggatactca atggaatgtc agcccaggac
      421 aattgggcca aactgaagcg ggactaccct gatgccctca tcaccaacta ctatctctgg
      481 cctgctgtgc agttagccaa cttctacctg gtccccctgc attacaggtt ggctgttgtc
      541 cagtgtgttg ctattgtctg gaactcctac ctatcctgga aggcacatca gttctaagcg
      601 tgccttgttc catggtttgc accttgtact gatgcaccgt gaccctggaa tgcttggaca
      661 gcttcttcaa actaaccaca tcaggactgg agcggtgact cagctgttag aagcacggat
      721 tatctgctct acagaggacc taaatttggt tccaagcacc cacatcgggt ggctcacaac
      781 tccctatgtc tcaagctcca ggagatctga tgttctcttc tggcctctga agcacctgca
      841 caaacatgta tatacccacg aatagacacg catttgtaat taagcacaca atgaaatctt
      901 taaaaggaag gagtgtgtca gcttccatgc tatggggttg ctgatcagaa tagggtgacc
      961 actctgaagt ggcacatttc actttaacca ctaagacatt tataatattg ctgtcactct
     1021 ggcccttagc tgatggggac acactataag aattgtgtcc tgggggctgg agagatggct
     1081 cagcctgtaa gagcactgac tgctcttcag aagctcctga gttcaaatcc cagcaaccac
     1141 atggtggctc acaaccatct gtaaagagat ctgacgccct cttctggagt gtctgaagac
     1201 agctacagtg tactcatatt taattaatta attaataatt aattaattaa tatagaattg
     1261 tgtcctggaa gccaggcatg gtggtacatg ccttcaatcc cagcacttgg gaggcagagg
     1321 caggcagatt tctgagttca aggtcagcct agtctacaga gtgagttcca ggacagccag
     1381 ggctatacag agaaaccctg tgtcaggaaa aaaaacaaaa aaacaaaacc aaaaaaaaaa
     1441 aaatgaaagt ctgtgtcagt ctcaacctag tgacaatcct gcctcagctt ctcagcttct
     1501 caaatgctgg attagagaat tgtgtcttgg gctacagata tcgctcagtg attaagagca
     1561 ctgactgctc ttccagaggt cctgagttca agtcccagca atcacatggt ggctcacaac
     1621 catctgtaat ggggtctgat gccctcttct ggtgtgtctg aagacagcta cagtgtactc
     1681 atatacatta aataaataaa tcttttttta aaatc
//
