LOCUS       NM_001368931           12859 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus myosin phosphatase Rho interacting protein (Mprip),
            transcript variant 3, mRNA.
ACCESSION   NM_001368931 XM_006533427
VERSION     NM_001368931.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 12859)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 12859)
  AUTHORS   Choi,H., Miller,M.R., Nguyen,H.N., Rohrbough,J.C., Koch,S.R.,
            Boatwright,N., Yarboro,M.T., Sah,R., McDonald,W.H., Reese,J.J.,
            Stark,R.J. and Lamb,F.S.
  TITLE     LRRC8A anion channels modulate vascular reactivity via association
            with myosin phosphatase rho interacting protein
  JOURNAL   FASEB J 37 (7), e23028 (2023)
   PUBMED   37310356
  REMARK    GeneRIF: LRRC8A anion channels modulate vascular reactivity via
            association with myosin phosphatase rho interacting protein.
REFERENCE   3  (bases 1 to 12859)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   4  (bases 1 to 12859)
  AUTHORS   Mulder,J., Ariaens,A., van Horck,F.P. and Moolenaar,W.H.
  TITLE     Inhibition of RhoA-mediated SRF activation by p116Rip
  JOURNAL   FEBS Lett 579 (27), 6121-6127 (2005)
   PUBMED   16243315
  REMARK    GeneRIF: p116Rip oligomerizes via its C-terminal coiled-coil domain
            and, when overexpressed, inhibits RhoA-induced SRF activation
            without affecting RhoA-GTP levels.
REFERENCE   5  (bases 1 to 12859)
  AUTHORS   Mulder,J., Ariaens,A., van den Boomen,D. and Moolenaar,W.H.
  TITLE     p116Rip targets myosin phosphatase to the actin cytoskeleton and is
            essential for RhoA/ROCK-regulated neuritogenesis
  JOURNAL   Mol Biol Cell 15 (12), 5516-5527 (2004)
   PUBMED   15469989
REFERENCE   6  (bases 1 to 12859)
  AUTHORS   Mulder,J., Poland,M., Gebbink,M.F., Calafat,J., Moolenaar,W.H. and
            Kranenburg,O.
  TITLE     p116Rip is a novel filamentous actin-binding protein
  JOURNAL   J Biol Chem 278 (29), 27216-27223 (2003)
   PUBMED   12732640
  REMARK    GeneRIF: p116Rip is an F-actin-binding protein with in vitro
            bundling activity and in vivo capability of disassembling the
            actomyosin-based cytoskeleton.
REFERENCE   7  (bases 1 to 12859)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
REFERENCE   8  (bases 1 to 12859)
  AUTHORS   Southard-Smith,E.M., Collins,J.E., Ellison,J.S., Smith,K.J.,
            Baxevanis,A.D., Touchman,J.W., Green,E.D., Dunham,I. and Pavan,W.J.
  TITLE     Comparative analyses of the Dominant megacolon-SOX10 genomic
            interval in mouse and human
  JOURNAL   Mamm Genome 10 (7), 744-749 (1999)
   PUBMED   10384052
REFERENCE   9  (bases 1 to 12859)
  AUTHORS   Gebbink,M.F., Kranenburg,O., Poland,M., van Horck,F.P., Houssa,B.
            and Moolenaar,W.H.
  TITLE     Identification of a novel, putative Rho-specific GDP/GTP exchange
            factor and a RhoA-binding protein: control of neuronal morphology
  JOURNAL   J Cell Biol 137 (7), 1603-1613 (1997)
   PUBMED   9199174
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596204.8.
            
            On Nov 16, 2022 this sequence version replaced NM_001368931.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-442               AL596204.8         150486-150927       c
            443-520             AL596204.8         117231-117308       c
            521-586             AL596204.8         116411-116476       c
            587-738             AL596204.8         85731-85882         c
            739-823             AL596204.8         81842-81926         c
            824-1058            AL596204.8         77370-77604         c
            1059-1569           AL596204.8         75852-76362         c
            1570-1711           AL596204.8         72173-72314         c
            1712-1819           AL596204.8         71336-71443         c
            1820-1876           AL596204.8         69607-69663         c
            1877-1945           AL596204.8         68614-68682         c
            1946-2035           AL596204.8         64798-64887         c
            2036-2145           AL596204.8         63806-63915         c
            2146-2716           AL596204.8         60374-60944         c
            2717-2833           AL596204.8         58325-58441         c
            2834-6637           AL596204.8         52107-55910         c
            6638-6785           AL596204.8         48907-49054         c
            6786-6903           AL596204.8         47909-48026         c
            6904-7063           AL596204.8         46547-46706         c
            7064-7183           AL596204.8         45360-45479         c
            7184-7270           AL596204.8         44135-44221         c
            7271-7433           AL596204.8         43388-43550         c
            7434-7519           AL596204.8         41732-41817         c
            7520-12859          AL596204.8         32579-37918         c
FEATURES             Location/Qualifiers
     source          1..12859
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.76 cM"
     gene            1..12859
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /note="myosin phosphatase Rho interacting protein"
                     /db_xref="GeneID:26936"
                     /db_xref="MGI:MGI:1349438"
     exon            1..442
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..7591
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /note="isoform 3 is encoded by transcript variant 3; p116
                     Rho interacting protein; Rho interacting protein 3;
                     Rho-interacting protein 3 (p116RIP) (RIP3)"
                     /codon_start=1
                     /product="myosin phosphatase Rho-interacting protein
                     isoform 3"
                     /protein_id="NP_001355860.1"
                     /db_xref="GeneID:26936"
                     /db_xref="MGI:MGI:1349438"
                     /translation="MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQAKP
                     IYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQ
                     CTDVVDGEARTGQKFSLCILTPDKEHFIRAETKEIISGWLEMLMVYPRTNKQNQKKKR
                     KVEPPTPQEPGPAKMAVTSSSGGSSGSSSSIPSAEKVPTTKSTLWQEEMRAKDQPDGT
                     SLSPAQSPSQSQPPAACTPREPGLESKEDESTISGDRVDGGRKVRVESGYFSLEKAKQ
                     DLRAEEQLPPLLSPPSPSTPHSRYGCPGSPSQELSHPLHSPGLPAPSRMVYSICPASL
                     GEASRSPNHMDSSSAGGWGTEILGSTFAFKASRQYAALADVPKAIRISHREAFQVERR
                     RLEHRTRARSPGREEVARLFGNERRRSQVIEKFEALDIEKAEHMETNMLILTTPSSDT
                     RQGRSERRAIPRKRDFASEAPTAPLSDACPLSPHRRAKSLDRRSTESSMTPDLLNFKK
                     GWLTKQYEDGQWKKHWFVLADQSLRYYRDSVAEEAADLDGEINLSTCYDVTEYPVQRN
                     YGFQIHTKEGEFTLSAMTSGIRRNWIQTIMKHVLPASAPDVTSSLPEGKNKSTSFETC
                     SRSTEKQEAEPGEPDPEQKKSRARERRREGRSKTFDWAEFRPIQQALAQERASAVGSS
                     DSGDPGCLEAEPGELERERARRREERRKRFGMLDTIDGPGMEDTALRMDIDRSPGLLG
                     TPDLKTQNVHVEIEQRWHQVETTPLREEKQVPIAPLHLSLEDRSERLSTHELTSLLEK
                     ELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQTEVATSPSGAWQRLHRVN
                     QDLQSELEAQCRRQELITQQIQTLKHSYGEAKDAIRHHEAEIQTLQTRLGNAAAELAI
                     KEQALAKLKGELKMEQGKVREQLEEWQHSKAMLSGQLRASEQKLRSTEARLLEKTQEL
                     RDLETQQALQRDRQKEVQRLQECIAELSQQLGTSEQAQRLMEKKLKRNYTLLLESCEQ
                     EKQALLQNLKEVEDKASAYEDQLQGHVQQVEALQKEKLSETCKGSEQVHKLEEELEAR
                     EASIRQLAQHVQSLHDERDLIKHQFQELMERVATSDGDVAELQEKLRGKEVDYQNLEH
                     SHHRVSVQLQSVRTLLREKEEELKHIKETHERVLEKKDQDLNEALVKMIALGSSLEET
                     EIKLQEKEECLRRFVSDSPKDAKEPLSTTEPTEEGSGILPLGSVTRVFPGFPHSQPED
                     EDPSAGLGEEGSSGSLSREENTILPKSADMPEREGHLQSTSKSDPGAPIKRPRIRFST
                     IQCQRYIHPEGCAKAWTSSTSSDTSQDQSPSEDSVSSEATPNTLPAAADAETYISIIH
                     SLETKLYVTEEKLKDVTVRLESQQGQSQEALLALHQQWAGTEAQLREQLRASLLQASA
                     LASQLEQERQQKATNIEHHPGELEDFQAKNSQALTCLENCWKKLRSLPWADQEEGQDA
                     CAASLANIESMLVSAIKALQPWASPAESRTQAEQEKEHPIESGMAAPVQQPCQPILNE
                     QEHRKLLSAQIVLEASLINQIADSLKNTTSDVYGVLCELTQSGEWPLKEESAAPSAGA
                     PVEIWAKKVLVNGEFWSQVESLSKHLGTLGEETACTSGDRQQHTPQSLADATWIRAEL
                     SYATQSVRELFHHRLQSIQETLQGTQAALQQHKCMLGEILGAYQTPDFERVIQQILET
                     LRHPTGREDQVQTSWDQNPLGEILRPGTDGSQEPLQALHQSPEVLAAIQDELAQQLRE
                     KASILEEISAALPVLPPTEPLGGCQRLLRMSQHLSYESCLEGLGQYSSLLVQDAIIQA
                     QVCYAACRIRLEYEKELRFYKKACQEAKGASGQKRAQAVGALKEEYEELLHKQKSEYQ
                     KVITLIEKENTELKAKVSQMDHQQRCLQEAENKHSESMFALQGRYEEEIRCMVEQLSH
                     TENTLQAERSRVLSQLDASVKDRQAMEQHHVQQMKMLEDRFQLKVRELQAVHQEELRA
                     LQEHYIWSLRGALSLYQPSHPDSSLAPGPSEPRAVPAAKDEAESMSGLRERIQELEAQ
                     MGVMREELGHKELEGDVAALQEKYQRDFESLKATCERGFAAMEETHQKKIEDLQRQHQ
                     RELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSINSDIEAL
                     RRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQ
                     ELNNRLAAEITRLRTLLTGDGGGESTGLPLTQGKDAYELEVLLRVKESEIQYLKQEIS
                     SLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEALGEKSPE
                     GTTVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKSLKEGLTVQERLKLFESRDLKK
                     D"
     exon            443..520
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            521..586
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            587..738
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            739..823
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1058
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1569
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1711
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1819
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1876
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..1945
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2035
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2145
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2716
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2833
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..6637
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            6638..6785
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            6786..6903
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            6904..7063
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            7064..7183
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            7184..7270
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            7271..7433
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            7434..7519
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            7520..12859
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8209..8214
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /note="hexamer: ATTAAA"
     polyA_site      8226
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /note="major polyA site"
     regulatory      12838..12843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
                     /note="hexamer: AATAAA"
     polyA_site      12859
                     /gene="Mprip"
                     /gene_synonym="9530046C02; Gm34094; mKIAA0864; p116Rip;
                     Rhoip3; RIP3"
ORIGIN      
        1 ggttcgttcg cggtggcggc gggcgccggg tgagcgcgac ggctggactt gccggccggc
       61 gccttggggg cggccgcggt ggagccagcg gccggaggcc gcgtccgtcc atgggcccac
      121 agcggccggg cggcggggcg gggcgcgagg cggcgcgcgc gctctgaggc cgcggcgagc
      181 aggcggggcg cggcgcgaga ggggaggcct ttccgggcct gcggcggcca gcgcaaaatg
      241 cggcggcggc cgcgctgagt ccccgacccc cgggagagcg ctgggccgtg gcggcccgct
      301 ccgcggccgc ctagccgaca tgtcggcggc caaggaaaac ccgtgcagga aatttcaggc
      361 caacatcttc aacaagagca agtgtcagaa ctgcttcaag ccccgcgagt cgcatctgct
      421 caacgacgag gacctgacgc aggcaaaacc catttatggt ggctggctgc tcctggctcc
      481 agatggcact gactttgaca acccagtgca ccggtcacgg aaatggcagc gacgattctt
      541 catcctttat gagcatggcc tcttgcgata tgccctggat gagatgccca ccaccctccc
      601 tcagggcacc atcaacatga accagtgcac agatgtggtg gatggggagg cccgcacagg
      661 gcagaagttc tccctctgca tcctgacacc tgacaaggaa cattttatca gggcagaaac
      721 caaggagatc atcagtgggt ggttagagat gctcatggtg tatcctcgaa ccaacaagca
      781 gaaccagaag aagaaacgga aagtagagcc acctacccca caggagcctg ggcctgctaa
      841 gatggctgtc actagcagta gtggcggcag cagtggtagc agcagcagca ttcccagtgc
      901 tgagaaagtt cccaccacca aatccacact ctggcaggaa gaaatgagag ccaaagacca
      961 acctgatggg accagcctga gtccagctca aagtcccagc caaagccagc ctcctgctgc
     1021 ttgcacccca cgggaaccag gactagaaag caaagaagat gaaagcacca taagtgggga
     1081 ccgtgtggat ggtggtcgga aagtacgggt agagagcggc tacttctccc tggagaaggc
     1141 caagcaggac ctgagggctg aggagcagct gcccccacta ctctccccac ccagccccag
     1201 caccccacac agcaggtatg gttgtcctgg atcgccctca caggaactca gccaccccct
     1261 tcactcccca ggtcttccag ccccaagccg aatggtctac agcatctgcc ctgccagcct
     1321 gggtgaggcc agcaggtcac ctaaccacat ggactccagc agtgctgggg ggtggggaac
     1381 agagatactg gggagcacct ttgcctttaa agccagcagg cagtatgccg ccctggccga
     1441 cgtccctaag gccatccgga tcagccatcg agaagccttc caggtggaga gaaggcggtt
     1501 ggagcatagg actcgggccc ggagccctgg cagggaagag gtggcccgtc tatttggcaa
     1561 cgagcggagg aggtcccagg taattgagaa atttgaggcc ttggacattg aaaaagcaga
     1621 gcacatggaa accaacatgc tgattctgac cactccatca agtgacactc gtcagggccg
     1681 cagtgagaga cgggccatcc ctagaaagcg ggactttgcc agcgaagccc ccacagctcc
     1741 tctctcagat gcttgtcccc tgtctccaca ccgaagagcc aagtcattgg acaggaggtc
     1801 cacagaatcc tccatgacgc ctgacctgct gaatttcaag aaaggctggc taaccaagca
     1861 gtatgaggat ggccagtgga agaaacactg gtttgtcctg gcagatcaga gcctgagata
     1921 ctacagggat tccgtggctg aggaggcagc tgacctagat ggagaaatta acttgtccac
     1981 ttgctatgat gtcactgagt atccagtcca gagaaactat ggctttcaga tacataccaa
     2041 ggagggtgag ttcaccctct cagccatgac atctggcata cgacggaact ggatccagac
     2101 cattatgaaa catgtgctcc cagcatctgc cccagatgtg accagctcat tgcctgaggg
     2161 aaagaataaa agcacatctt ttgagacctg ctcaaggtca actgagaagc aagaagctga
     2221 gccaggagag ccagatcctg aacaaaagaa gagccgtgct cgagagcgga ggcgggaggg
     2281 tcgctccaag acctttgact gggctgaatt ccgccctata caacaggccc tggctcaaga
     2341 aagggccagc gctgttgggt cttctgattc tggtgaccct gggtgtcttg aagccgagcc
     2401 aggtgagctg gagcgtgaac gagctcgacg tcgagaagaa cgccgcaagc gctttgggat
     2461 gctggacacc attgatggac caggaatgga ggacacagcc ctacgtatgg acatcgaccg
     2521 gagcccaggg ctgctgggaa cccctgacct caagacacag aatgtccacg tggaaattga
     2581 gcagcgttgg catcaagtgg agaccacccc tctcagggag gagaaacagg tgcccattgc
     2641 ccctctgcac ctatccttgg aggacagaag tgagcggctc tccacacatg agctcacctc
     2701 tctgctagag aaggagctgg agcagagcca gaaagaagcc tcggatcttc tagagcagaa
     2761 ccggcttcta caggaccagt taagggtggc cctgggcaga gaacagagtg cccgggaggg
     2821 ctatgtgctg cagactgaag tggccacctc tccatcgggt gcctggcaga ggctccatag
     2881 agtcaaccaa gacctgcaaa gtgagctgga agctcagtgc cggcggcagg agctcatcac
     2941 acagcagatt cagaccctga aacacagcta tggggaggcc aaggatgcaa tccgccacca
     3001 tgaggctgag attcagaccc tgcagacgag acttggtaat gccgctgcag agctggccat
     3061 taaggagcag gctctagcca agctcaaggg tgagctgaag atggagcagg gcaaggttcg
     3121 tgagcagctg gaggaatggc agcacagcaa ggccatgctg agtggccagc tgagggccag
     3181 tgagcagaaa ctcagaagta cagaagcccg gctgttagag aagacacagg aactcagaga
     3241 cctggaaaca caacaggcat tgcaacggga tcgacagaag gaggtgcaga ggctgcagga
     3301 atgcattgct gagctcagcc aacagctggg taccagtgag caagcccagc gtctgatgga
     3361 gaagaagtta aagaggaact atacattgtt gctggagagc tgtgagcaag aaaagcaggc
     3421 actgctgcag aacctgaagg aagtagagga caaggccagt gcctatgagg atcagctaca
     3481 aggccatgtg cagcaggtgg aggccctcca gaaagagaag ctgagtgaaa cgtgcaaagg
     3541 cagtgagcag gtacataagc tagaggaaga gctggaggcc cgagaggcca gtatccgcca
     3601 gttagcccag catgtacaga gcctccatga tgaacgggat ctcatcaagc atcagtttca
     3661 agagctcatg gaacgtgtgg ccacatccga tggggatgtg gctgagctcc aagagaagct
     3721 gaggggaaag gaagttgact atcagaacct tgagcactca caccacaggg tctctgtcca
     3781 gctacagagc gtgcgcactc tgctgagaga aaaggaagaa gagctgaagc acattaagga
     3841 aacacatgag agagttctgg aaaagaaaga ccaagacctc aatgaagctt tagttaaaat
     3901 gattgccttg ggcagcagct tagaggaaac agaaattaag ctgcaggaaa aggaagagtg
     3961 tctaaggagg tttgtgagtg attctccaaa ggatgccaag gagcctctga gtaccacaga
     4021 gccaacagag gagggcagtg gcattttgcc cttaggctca gtcaccagag tatttcctgg
     4081 ctttcctcac tctcagccag aggatgaaga tccaagtgct ggcctggggg aagaagggag
     4141 cagtggtagc ctcagcagag aggaaaacac catactccca aagtcagctg atatgcccga
     4201 gagggagggg catctgcaga gcacatctaa gtctgatcca ggagctccta taaaaaggcc
     4261 aagaatcagg ttctccacaa tccagtgtca aagatacata caccccgagg ggtgtgcaaa
     4321 ggcatggact agcagcacat catcagatac cagccaggac cagtcaccct cagaggatag
     4381 tgtgtcctca gaagctaccc cgaacacact gccagcagct gcagatgctg aaacctacat
     4441 ctctataatc cactctctgg agacgaagct ctatgtcaca gaggaaaagc tcaaagacgt
     4501 aactgtgagg ctggaaagcc agcaggggca gagtcaggag gcattgcttg cactgcacca
     4561 gcagtgggct ggcacagagg cacagttgcg agagcagctc cgtgccagcc tgttacaggc
     4621 tagcgctctg gcctctcagc tagagcagga aagacaacag aaggccacaa acattgaaca
     4681 ccaccctggg gagctggaag acttccaagc caaaaatagc caagccctga catgcttaga
     4741 aaactgctgg aaaaagctaa ggtctttgcc atgggctgac caggaggagg gccaggatgc
     4801 atgtgcagcc tccctggcta acatagagag tatgcttgtg agtgccatca aggcccttca
     4861 accatgggct tcccctgcag agagcaggac gcaggctgag caagagaagg agcaccccat
     4921 agaaagtggt atggcagccc ctgtgcagca gccctgtcag cccatcttga atgagcagga
     4981 acacaggaag ctgctttctg ctcagatagt cctggaggcc tcactcatca accagatagc
     5041 tgactctcta aaaaatacca cttcagatgt ctatggtgtt ctctgtgagc ttactcagtc
     5101 aggggagtgg ccactgaagg aagaaagtgc tgccccctct gctggggctc cagtggagat
     5161 ctgggccaag aaggtactgg tgaatggtga gttctggagc caggtcgagt cactaagtaa
     5221 acacctaggg acactgggag aagaaacagc ctgcacatca ggagacaggc agcagcatac
     5281 tccccaaagt ctggctgatg ccacatggat tcgtgcagag ctcagctatg ccacacaatc
     5341 agtaagagaa ttgttccacc ataggctgca gagcatacag gagaccctac aagggaccca
     5401 ggcagcccta cagcagcaca agtgcatgct gggagaaatc ttgggagcct accaaacccc
     5461 agactttgaa agagtaatac agcagatctt agaaaccctc aggcatccaa ctggcaggga
     5521 ggaccaggta cagacatcct gggaccagaa cccattagga gagatactga ggccaggcac
     5581 agatggctcc caagagcctt tgcaggcttt gcatcagagc cctgaagtcc ttgctgccat
     5641 tcaggatgag ctggcccagc agctgagaga aaaggctagc atccttgagg agatttcagc
     5701 tgccttgcca gtcctgcctc ctacagagcc acttgggggt tgccagaggc ttctgcggat
     5761 gtcccagcat ctctcatatg aatcttgtct agagggcctt ggtcagtatt cttcattact
     5821 ggttcaagat gcaattattc aagctcaagt gtgctatgca gcatgcagaa ttcggctgga
     5881 gtatgaaaaa gagctgagat tttacaagaa ggcctgtcag gaggctaagg gggcttcagg
     5941 ccagaaacgt gcacaagcag ttggggccct gaaggaagag tatgaagaac ttctccacaa
     6001 gcagaagagt gagtaccaga aggttatcac cctcattgaa aaagaaaaca ctgagctcaa
     6061 ggccaaagtg agccagatgg accatcagca gagatgtcta caagaagcag aaaacaaaca
     6121 cagtgagagc atgtttgccc tacagggcag gtatgaagag gagatcaggt gcatggtgga
     6181 acagctgagc cacactgaaa ataccctgca ggctgagcgt agccgggttc tcagccagct
     6241 agacgcctca gtcaaagaca ggcaggccat ggaacagcat catgtgcagc aaatgaagat
     6301 gctggaggac aggttccagc tgaaggttcg ggagctacag gctgttcatc aggaggaatt
     6361 gagggccttg caggaacact acatatggag cctgcgggga gccctcagcc tctaccaacc
     6421 ctcacaccca gattcctcac tggcccctgg gccatctgag cccagagctg tgccagcagc
     6481 caaggatgag gccgagtcca tgtccgggct gcgagaacgt atccaggagc tggaagccca
     6541 aatgggtgtc atgcgagagg agctgggcca caaagagctg gagggtgatg tggccgccct
     6601 gcaggagaag taccagcggg actttgagag tctcaaggct acatgtgagc gaggctttgc
     6661 cgccatggag gagacacatc agaagaagat tgaagaccta cagaggcaac accagcggga
     6721 gctagagaag ctgcgggagg aaaaagaccg cctcctggct gaggagacag ctgccaccat
     6781 atcagccatt gaagccatga agaatgctca ccgagaggag atggaacgag agttagagaa
     6841 gagccagcgg tctcagatca gcagcatcaa ttcagacata gaagccctga ggcgacagta
     6901 cctggaggag ctgcagtcag tgcagcggga gctggaagtc ctttcagagc agtactccca
     6961 aaagtgcctg gagaatgcac acctagccca ggcgctggag gccgagcgtc aggccctgcg
     7021 gcaatgccag cgtgagaacc aggagctcaa cgcccacaac caggagctga ataaccgcct
     7081 ggctgcggag atcacacggt tgcggacact actgactgga gacggtggtg gggagtccac
     7141 tgggttgcct ctcacacagg gcaaggatgc ctatgagtta gaggtcttgt tgcgggtcaa
     7201 agagtcagaa atccagtacc tgaaacagga gatcagctcc ctcaaggatg aactccagac
     7261 agccctgcgg gataagaagt atgctagtga caagtacaaa gacatctaca ctgagctcag
     7321 cattgccaag gccaaggctg actgcgacat cagcaggctg aaggagcagc tgaaagcagc
     7381 cacagaggca ctgggcgaga aatctcctga aggcactact gtgtcaggat atgacataat
     7441 gaaatctaaa agcaatcctg acttcctgaa gaaagacaga tcctgtgtta cccggcaact
     7501 cagaaacatc aggtccaaga gtctgaagga aggcctgacg gtgcaggagc gcttgaagct
     7561 ctttgaatcc agggacttga agaaagatta gctgcatcca ttccactgac acatccttcc
     7621 cagctggtgg cagcacaagc caagcgtggt tttcatcttc acctgtgcat ctcattgttg
     7681 ctgtcattaa ctgtggggat ggatgcatga gagactgctg tggggtgctt gctccagtcc
     7741 ctccctgtca attccaactt cctgttgtct ttatcacagc ttttttccca tggtattctc
     7801 agattagtca cgcgcaagca gtagagtggg acggtttccc cgctgatacc tgagcagccc
     7861 ccttgtcctc ccagcacact cactgtcagt attaaggcac agcagcctgt taataagcta
     7921 gccctgcctc agagtgcaca tgtggggacc tgccagtggc tctgctctgc cgcacacagc
     7981 ggagcaccac ccttgatggt cagagcagag ccaccgaatg ttgtaggctg gcctgatttc
     8041 tgaggggcct aggaaagtgt ccagcctggc ccacttcctt ttgatgtggg agggggacag
     8101 cattttgtac ctggccactg atgcagctta gaaccatacc cagataatcc ggcaaatcct
     8161 tcacaacctg gaaaatgttg aaagcaacca ttcctatttt ggttttttat taaatcttgc
     8221 acaaaagccc cggcccctct cattccttcc tccgctcgtg cctcccttgc tgtgctaatc
     8281 ctggtcttct ggtggcccgg aagagtgact tgcagcctga agcttcagac ttgtcaagtg
     8341 tgatgggtcc tcaaagtcct ctggagggga acattgctgg ggtttaatct gtctgaaaag
     8401 aagctgccat gctgcttggc agggtgagga gaagcccgtg tgcaaagaca gactgtcagg
     8461 actggtgata gcagcagtgt gtgctcagga ccctcgttag tctgggctct ggaagggtcc
     8521 cttgaattgt ctgcttctca tggagccatt gacagggagc ctgtgctaac tctgcttttc
     8581 tagctgaaca ggacctgaaa ctacccaaag cagtctgcag cattttcttt aaaaaacaaa
     8641 ccaacaaaaa catttttctc tattctcata agaaaacatt catactgtaa gatgcagcac
     8701 acaggagtcc ccatgtcaga tgggagaggc aatagcctca tagctagata tgcgatctgg
     8761 cttcttagtc ctggcttgtt agtgttaagt gggtcagatg gatggtctct gagcgtacaa
     8821 attcaactca tgagtcccct aaaggttcta catgagttga cgtacaaggt ctagctggcc
     8881 taatagacag gcaggtcgaa acttcaagat aacggatttg ttacatacca aagtgtgcca
     8941 ctgaccagca ggcaagccct gggctcccct tttcacacgt ttttaagttc cactctggca
     9001 catgctcagt ggtcatttat gttttcagca ttatgggcaa gtcagacctg ttaaaacaag
     9061 ctttgagctc agagtgggct agccttcagg agcctggggt tgtgcgttga ggactcctgt
     9121 tctctcatac ggtttccttg cagctatcct gctgcccttg ggaccctctg gccccattgc
     9181 attatcttcc tgccttgtgc ttcctgggat gctacaaaga gcctgcggaa gatgccaagc
     9241 ctaccattca aaaggacact tgatcttttg ctcttcacct cagaatccta ggatatgaac
     9301 tttgctgaag gtacaagtac ctacatgtca gaggcaaggg ctgggagaca ggcacgctgc
     9361 acccatctaa tctgtcactc agggctccta ctgcaggctc gtttttgctg tgatagagca
     9421 cacactgctc tagggcttgt ttcacgtgtg ggtatctggt atgttggcca aatgctgaac
     9481 tggcagacat tcctggatca tcccccactg tctacgccag tctgagcagt aacatgtgca
     9541 ggatcagggt gcatcttgat tttcttgatg gtgacttctg gcaaaaatga accaaacaag
     9601 aagttggtct tcctgagtcc ctgaactgcc ggcccactgc agcagtttat tttagactgc
     9661 cacatgtctt ctgtccattc ccttccctca ctccctgagc caggttcact tttgcctgac
     9721 ccctctacag gcttcccatt ccctggaaag aagttgaagt tggtgtgttc agagaagagg
     9781 tatggaatgt gcaaatggag ttggttcagg catatgtaaa agaggatgct tggctgagaa
     9841 tgggtagtgt agatcaagaa gtcacaggct gctcccagta cagtcagtca gtggcatgct
     9901 ttcttttaca catttgtggt ctaccagcat ctacaagcaa actaccatta cagggaacat
     9961 accatttgac agtgaatgta aatatatgct taaattacat cttgcaagcc tggcatggtg
    10021 gtgcacgcct ttaatcccag cactcgggag gcagaggcag gcagatttct gagttcgagg
    10081 ccagcctggt ctacaaagtt agttccagga cagccagggc tatacagaga aaccctgtct
    10141 caaaaaaaaa aaacaaaaac aaaaacaaaa aaaaacaaaa aaaaaaaact tcatctttgc
    10201 acgtgtgatg ccgagcacat ctgccacaca gggctactgg ctgcaccttt tccagtatgg
    10261 ttgtggccac aatgccacaa taataggagg ccagagcccc atgaagtagg gagtccccag
    10321 agggaagaac gctaggaatg tgtgcattca ctgagtgtaa acaaaggtca gagttggcaa
    10381 actccattgg atctagcaga acactgaact gggcgcactc actcatgtct gtactcctac
    10441 cacctgacgc tccaaagtac aaggtcagtc tgggctacat agcaagacta tctcacatac
    10501 aggtgggcta agggcatgga tataaaatat ataaaatttg gggttcaact acagcactac
    10561 agagagcaca cttgtggtct ttggaacatt tgtccaaagg gagcctgaga gatttgacta
    10621 ggaaacaaat gggtatgaaa gatatttgaa ggaatgtgta ctactgttaa cctctctaca
    10681 gggggagatg gtgcgctgac ttctttctac cctggaactg cagagaaagc accgcctcac
    10741 tgctgccacc tagctggcgc cgagggaagt agctggctag cacacagcct gcactgttgg
    10801 gtgtgaacca gggcatcagc ttagttagat tcctgcaggc ctgccccaca cacctgacct
    10861 ccaactaagc ctggctctca aagacaggct ggataagcac ccagaggccc tatgcagcct
    10921 tcccactcat gccatactcc atgtaagtaa gccagtgcaa gctgcacacc aaagtctgct
    10981 ggcagctaca gggacaacag taacacccaa accccagact ctgctagtgg agagtcagta
    11041 gttacctctt ggccagcgga gggttagctg ttcatgctat gctgtaaaga tgacatcacc
    11101 tagtaagcta cttagaggct atcagtgtag ggactcatac agcctttctc attagagctc
    11161 ccagcataca tacaggacag cctatggcct gcacttcact tgctcagcct ttcctgtata
    11221 tcagagcaag caatattaag tatttctaag gcatggtgca ggaacttttg tgcaaagttt
    11281 gtgtgagttt taaaataccc cttttgaagg tatgtaaagg cagtgttcag tgcaaacccc
    11341 tctcaaatgt caagaccatt agttggcgag gcatggtagc acacacattt aattagcact
    11401 tgggaggcag agaagcaggc taagttcaag accaacctgg tctacataga gagttctaaa
    11461 agatttacac agtaaaaact gcctaaaaat taaacaacaa aaaagactat gttaataagt
    11521 aatgcctttt aaagttttgg ttactcaaca gactctgaag atatccttgc ccacactcac
    11581 agcaagctct gattcttgtt taaagtattc tgtgagactt gcatagagcc actcaaggaa
    11641 aaccagtact atgagggact cttggcacct tgccctcagg tttctcgggg tgtttttctt
    11701 aggggaactg gctggagcat acgctgcttc aggtccagga gcctagctct aacagcgggg
    11761 ctggacttga gtgcagagca gcccagctac ccatatctct agcgacctca ctgtatatag
    11821 catgagactc caggtagctc catgactgta tttctgtact ggtaaggagg tagcccatca
    11881 gtagagttaa aagtgggaca gtccaaaact aaaggacttc agggcctctc cagtttcgca
    11941 tgggtcacag gtcagcctgg agcagcttcc attgtggggc aggacctcat tgctggcatt
    12001 tgccataaag agataccact gttaagaatc ctagccacac aagcccactc cagcttgcca
    12061 cagctgacat gccattggct catctctcct ttacaaggta gtcagaccac acatctaatt
    12121 ttatttgagc aagctataga ttgtaaagaa cactaaattc actattatgt tttgtttcta
    12181 tcacaaactt tgatataaat gaattttaaa tcattttaag atttaccttt gatattaatg
    12241 ctttaattcc aggatccaaa accagttctg tggttactaa ctaatgtggc ttcatgcagg
    12301 tttgctgtgt agaatattaa gaaccgcagt cacagtggct ccttgacaat cagaactcta
    12361 ggtgaccttc cattactgct gcttgactgg gggtggggtg cgtgtttgtg aacagggcgc
    12421 ctggcagggc ctcttatatc tcgacagaaa caggcttgta ctaactcacc tgctatttag
    12481 gtattttgtc agaacaaaat agtcaatcca gctgccaact aaaaattaca tgtagaaggt
    12541 aatggagcct cactgagcca gagaggcttc aagcacagct tctcagagcc agttcaggcc
    12601 tctgtgtgta tgcacagggt gtggcttcct gcagacaaca tgtcccccaa ctcctcattc
    12661 caagatctta tggttcagtg taaggcattt cctacaaagt ttgtggtcag gttcgctata
    12721 attgaaatgt taatttgtag aaatatttat tcctttgtgt gacaagctag agtccttggc
    12781 tgtagctcac catttttact gtgtaaatac tgcttggttt tacatgaact gtatcataat
    12841 aaactatttt tgcattgcc
//
