LOCUS       NM_001143683            2940 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus metallophosphoesterase domain containing 2 (Mpped2),
            transcript variant 1, mRNA.
ACCESSION   NM_001143683
VERSION     NM_001143683.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2940)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2940)
  AUTHORS   Lee,D.R., Rhodes,C., Mitra,A., Zhang,Y., Maric,D., Dale,R.K. and
            Petros,T.J.
  TITLE     Transcriptional heterogeneity of ventricular zone cells in the
            ganglionic eminences of the mouse forebrain
  JOURNAL   Elife 11, e71864 (2022)
   PUBMED   35175194
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2940)
  AUTHORS   Moreau,M.X., Saillour,Y., Cwetsch,A.W., Pierani,A. and Causeret,F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (bases 1 to 2940)
  AUTHORS   Favor,J., Bradley,A., Conte,N., Janik,D., Pretsch,W., Reitmeir,P.,
            Rosemann,M., Schmahl,W., Wienberg,J. and Zaus,I.
  TITLE     Analysis of Pax6 contiguous gene deletions in the mouse, Mus
            musculus, identifies regions distinct from Pax6 responsible for
            extreme small-eye and belly-spotting phenotypes
  JOURNAL   Genetics 182 (4), 1077-1088 (2009)
   PUBMED   19474196
REFERENCE   5  (bases 1 to 2940)
  AUTHORS   Kleinjan,D.A., Seawright,A., Elgar,G. and van Heyningen,V.
  TITLE     Characterization of a novel gene adjacent to PAX6, revealing
            synteny conservation with functional significance
  JOURNAL   Mamm Genome 13 (2), 102-107 (2002)
   PUBMED   11889558
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL773516.3 and AL512587.13.
            
            On Oct 7, 2017 this sequence version replaced NM_001143683.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1, 2, and 3
            all encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK165186.1, SRR7652917.573524.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-641               AL773516.3         27618-28258
            642-889             AL773516.3         33725-33972
            890-1071            AL512587.13        7813-7994
            1072-1297           AL512587.13        46746-46971
            1298-1413           AL512587.13        124601-124716
            1414-1527           AL512587.13        127768-127881
            1528-2940           AL512587.13        130061-131473
FEATURES             Location/Qualifiers
     source          1..2940
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 55.8 cM"
     gene            1..2940
                     /gene="Mpped2"
                     /gene_synonym="239Fb; 2700082O15Rik"
                     /note="metallophosphoesterase domain containing 2"
                     /db_xref="GeneID:77015"
                     /db_xref="MGI:MGI:1924265"
     exon            1..641
                     /gene="Mpped2"
                     /gene_synonym="239Fb; 2700082O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            642..889
                     /gene="Mpped2"
                     /gene_synonym="239Fb; 2700082O15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             762..1646
                     /gene="Mpped2"
                     /gene_synonym="239Fb; 2700082O15Rik"
                     /note="isoform a is encoded by transcript variant 1;
                     metallophosphoesterase MPPED2; metallophosphoesterase
                     domain-containing protein 2"
                     /codon_start=1
                     /product="metallophosphoesterase MPPED2 isoform a"
                     /protein_id="NP_001137155.1"
                     /db_xref="CCDS:CCDS50654.1"
                     /db_xref="GeneID:77015"
                     /db_xref="MGI:MGI:1924265"
                     /translation="MAHGIPSQGKVTITVDEYSSNPTQAFTHYNINQSRFQPPHVHMV
                     DPIPYDTPKPAGHTRFVCISDTHSRTDGIQMPYGDILLHTGDFTELGLPSEVKKFNDW
                     LGNLPYEYKIVIAGNHELTFDKEFMADLVKQDYYRFPSVSKLKPEDFDNVQSLLTNSI
                     YLQDSEVTVKGFRIYGAPWTPWFNGWGFNLPRGQSLLDKWNLIPEGIDILMTHGPPLG
                     FRDWVPKELQRVGCVELLNTVQRRIRPKLHVFGGIHEGYGIMTDGYTTYINASTCTVS
                     FQPTNPPIIFDLPNPQGS"
     exon            890..1071
                     /gene="Mpped2"
                     /gene_synonym="239Fb; 2700082O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1297
                     /gene="Mpped2"
                     /gene_synonym="239Fb; 2700082O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1413
                     /gene="Mpped2"
                     /gene_synonym="239Fb; 2700082O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1527
                     /gene="Mpped2"
                     /gene_synonym="239Fb; 2700082O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..2940
                     /gene="Mpped2"
                     /gene_synonym="239Fb; 2700082O15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2914..2919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mpped2"
                     /gene_synonym="239Fb; 2700082O15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2936
                     /gene="Mpped2"
                     /gene_synonym="239Fb; 2700082O15Rik"
                     /note="major polyA site"
ORIGIN      
        1 tggcccgccc ccatctcccc gacccctatc attttaacgc tgatcacaca cgatggtgaa
       61 cttgcagctc agcttcctgc cgcctgcttg acccagggag caccagcagc ctgcgggcct
      121 cgccctccgc tctccctcct ctcctggaaa ccccgcggcc tcggggcgtg ggtggggggt
      181 tcgagtgggc cggaactacg gcaggggcgt gcagggcgcg gggtcccagc ggggagctca
      241 cagcaagcgg cgcctgggcg gccctgcttc ctggagctgt gctcctttga ccccagtggc
      301 agtccctgtc actgcaccgc tcgcgctccc ttcgctcgcc gcgccctcgc tgcctctcct
      361 cgccccctcg ctccttctct tcccagatcg aggctgctcc ggtcctctcc acctccccac
      421 gcagcgaccc cgcgtcccgc tcgcaccgcg cccctgtgct gccctcccag gccctggatc
      481 ggcggcgggg acctccgggg tcgaaggttc tggcccgccc gcgcccctcg cccctgccgc
      541 ccccagcgct gctccaagcc ggctcgggtt gcttggcgat ggctcgcccg cacaccgggc
      601 gctgaaggca tcccggggac ccggagcgca gcccgggaaa gaacgcacag tggtattgat
      661 gagtagaccc ttggattcag aggttggctg aaacccatca tgcccgcttc cagcttttgc
      721 tccggagagt tgtgaattgc tcatgcctgt agggaggaag gatggcacat gggattcctt
      781 ctcaaggcaa agttaccata acggtggatg agtatagctc aaaccccacc caggcattca
      841 cacactacaa catcaaccag agcagattcc agccgccaca tgtacatatg gtcgacccca
      901 tcccatatga cactccaaaa ccagcgggcc acacgcggtt tgtctgcatc tcagacacac
      961 actccagaac agatggtatc cagatgcctt atggggacat ccttctccac acaggcgatt
     1021 tcaccgagct gggactgccc tcagaggtta agaagtttaa tgactggtta ggaaacctgc
     1081 catatgaata taaaattgtg attgctggga atcatgaact gacatttgat aaggaattca
     1141 tggcagacct cgttaaacag gactactacc gtttcccttc tgtgtccaaa ttgaaaccag
     1201 aggactttga caatgttcag tccctcctga caaacagtat ttacttgcaa gattcagagg
     1261 taaccgtgaa aggattcagg atatacggtg caccctggac cccgtggttt aatggatggg
     1321 gctttaacct acccagaggc cagtctctgc tggacaaatg gaacctaatc cctgagggca
     1381 tcgacatact catgacacac ggacctcctc taggttttcg agactgggtt ccaaaggaac
     1441 ttcaaagggt gggctgcgtg gagctcttaa acacagtcca gaggcgcatt cggcccaagc
     1501 tccatgtgtt cggtgggatt cacgaagggt acggcatcat gaccgacggt tacaccacct
     1561 acatcaatgc ctcaacctgt acagtcagct ttcaaccgac caaccctcca atcatatttg
     1621 accttccaaa cccacagggc tcctaaagca ctcagcatcc cgttggaatg tgagggacgg
     1681 tctacaaact gccatttttc taattataaa ctcacattct ctgatttgtt tatttctaaa
     1741 tcctgtgagt tctttttgta aattgttgga acaggaggga aaagaaaaaa gaaaaaaaaa
     1801 aagatgctag cgttgtgccg cctctttttt gcttttttga gtggggtatc catttgaaat
     1861 caaaggaaca ttgtgaattt gtaaaatgac ttctgtttgc tcaaaggcca cgccattgta
     1921 aattgttagt atttgccaaa ggacagccaa gctttcttta aaaaaaaaat gattatttta
     1981 aaaagtctta tttgaatatg ctttaagctg aaaggaaaag attaaaaaaa aaaaaaagac
     2041 agaaagaaac acaaaagcag tgttttgaaa aatcacccag atttgcacaa ctctgagtat
     2101 tgtttgatat gttttaattt tcaatgtttt gttgttgttt tcttggtatt gcctcatttt
     2161 tattttacaa atgtggcccc aatttagagc aatctcaaca gaagttggtt aggaaaaacc
     2221 ttagcttctc tctggctata aagaagactg tgtctgaggt gggggaagaa cagccctcat
     2281 gcagaggctt agccagagat ccatatcatg atgctaccaa ctctcactgt ttgtttcttt
     2341 taaattattt gagctttaaa aataaggaaa caagaatctg tcaagagatg gtcatgcaag
     2401 gaaaaagaaa gtgtgcagac tccctttcca tgtggattta tatatatata tatataacta
     2461 ttttttgtgc attacgactc agttgggagt ttaatcttgc caaggacagt acaactgcaa
     2521 agccacatcg gtagcagcac accagacgtc tgaaggaact gacccattct ttcttcaaac
     2581 tcaaggtctt aaagaacttg agtccagtct aggtacagta accagtgtgt atagactcca
     2641 gtggatgcat cggaagcgaa ctaaataagg cttagtcgtc ctttctattt aaaggccctg
     2701 ttttgtcttc tcactcccct ccccctccca ttttgcactg tgtgttgatg caatcttcgc
     2761 tagcacaaaa tattgttgct aataatcctt tctggtctcc cattgtcgat gccattgagc
     2821 gctattctat tttatgttac cttcaaattt aggaaagcag ttgttttctt taaatttatt
     2881 gtgatactct atatctagcg gcctttatat gcaaataaaa ttgcaagatt tttaaatcgg
//
