LOCUS       NM_001081287            4975 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus membrane protein, palmitoylated 7 (MAGUK p55 subfamily
            member 7) (Mpp7), transcript variant 1, mRNA.
ACCESSION   NM_001081287 XM_885755
VERSION     NM_001081287.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4975)
  AUTHORS   Vishal,M., Sharma,A., Kaurani,L., Alfano,G., Mookherjee,S.,
            Narta,K., Agrawal,J., Bhattacharya,I., Roychoudhury,S., Ray,J.,
            Waseem,N.H., Bhattacharya,S.S., Basu,A., Sen,A., Ray,K. and
            Mukhopadhyay,A.
  TITLE     Genetic association and stress mediated down-regulation in
            trabecular meshwork implicates MPP7 as a novel candidate gene in
            primary open angle glaucoma
  JOURNAL   BMC Med Genomics 9, 15 (2016)
   PUBMED   27001270
  REMARK    GeneRIF: MPP7 as a novel candidate gene for Primary open angle
            glaucoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4975)
  AUTHORS   Cai,Y., Yoneda,M., Tomita,T., Kurotani,R., Okamoto,M., Kido,T.,
            Abe,H., Mitzner,W., Guha,A. and Kimura,S.
  TITLE     Transgenically-expressed secretoglobin 3A2 accelerates resolution
            of bleomycin-induced pulmonary fibrosis in mice
  JOURNAL   BMC Pulm Med 15, 72 (2015)
   PUBMED   26178733
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4975)
  AUTHORS   Xiao,S.M., Kung,A.W., Gao,Y., Lau,K.S., Ma,A., Zhang,Z.L.,
            Liu,J.M., Xia,W., He,J.W., Zhao,L., Nie,M., Fu,W.Z., Zhang,M.J.,
            Sun,J., Kwan,J.S., Tso,G.H., Dai,Z.J., Cheung,C.L., Bow,C.H.,
            Leung,A.Y., Tan,K.C. and Sham,P.C.
  TITLE     Post-genome wide association studies and functional analyses
            identify association of MPP7 gene variants with site-specific bone
            mineral density
  JOURNAL   Hum Mol Genet 21 (7), 1648-1657 (2012)
   PUBMED   22171069
REFERENCE   4  (bases 1 to 4975)
  AUTHORS   Nakano,Y., Jahan,I., Bonde,G., Sun,X., Hildebrand,M.S.,
            Engelhardt,J.F., Smith,R.J., Cornell,R.A., Fritzsch,B. and Banfi,B.
  TITLE     A mutation in the Srrm4 gene causes alternative splicing defects
            and deafness in the Bronx waltzer mouse
  JOURNAL   PLoS Genet 8 (10), e1002966 (2012)
   PUBMED   23055939
REFERENCE   5  (bases 1 to 4975)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human MPP7 gene and mouse
            Mpp7 gene in silico
  JOURNAL   Int J Mol Med 13 (2), 333-338 (2004)
   PUBMED   14719143
REFERENCE   6  (bases 1 to 4975)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK027937.1, AK078849.1, CN457430.1, AV260217.2 and AC138529.2.
            
            On Jun 6, 2009 this sequence version replaced NM_001081287.1.
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 3. Both variants 1 and 3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.7280961.1,
                                           SRR17253011.493493.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AK027937.1         5-6
            3-1243              AK078849.1         2-1242
            1244-1731           CN457430.1         1-488
            1732-2100           AV260217.2         261-629
            2101-4975           AC138529.2         17580-20454
FEATURES             Location/Qualifiers
     source          1..4975
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 4.53 cM"
     gene            1..4975
                     /gene="Mpp7"
                     /gene_synonym="1110068J02Rik; 2810038M04Rik;
                     5430426E14Rik; Gm955"
                     /note="membrane protein, palmitoylated 7 (MAGUK p55
                     subfamily member 7)"
                     /db_xref="GeneID:75739"
                     /db_xref="MGI:MGI:1922989"
     exon            1..131
                     /gene="Mpp7"
                     /gene_synonym="1110068J02Rik; 2810038M04Rik;
                     5430426E14Rik; Gm955"
                     /inference="alignment:Splign:2.1.0"
     exon            132..278
                     /gene="Mpp7"
                     /gene_synonym="1110068J02Rik; 2810038M04Rik;
                     5430426E14Rik; Gm955"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..1972
                     /gene="Mpp7"
                     /gene_synonym="1110068J02Rik; 2810038M04Rik;
                     5430426E14Rik; Gm955"
                     /note="isoform 1 is encoded by transcript variant 1; MAGUK
                     p55 subfamily member 7"
                     /codon_start=1
                     /product="MAGUK p55 subfamily member 7 isoform 1"
                     /protein_id="NP_001074756.2"
                     /db_xref="CCDS:CCDS50217.1"
                     /db_xref="GeneID:75739"
                     /db_xref="MGI:MGI:1922989"
                     /translation="MPALATGSACDMGLYELLAALPAQLQPHVDSQEDLTFLWDVFGE
                     KSLHSLVKIHEKLHCYEKQNPLPILHGAAALADDLTEELQNKLPNSEIRELLKLLSKP
                     NVKALLSVHDTVAQKSYDPVLPPVPDDIDDEEDSVKIIRLVKNSEPLGATIKKDEQTG
                     AITVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPEEIIKILSQSKGAITFKIIP
                     STKEETPSKEGKIFIKALFDYDPKEDKAIPCKEAGLSFRKGDILQIMSQDDVTWWQAK
                     HEGDANPRAGLIPSKHFQERRLALRRPEIVVQPLKLSNTKSSGFRRSFRLSRKNKKIN
                     KSMYECKKSEQYDTADVPTYEEVTPYRRQIHDKYRLIVLVGPVGVGLNELKRKLLMSD
                     AQHYGVIVPHTTRARRSQESDGVEYIFISKHLFETDVQNNKFIEYGEYKNNYYGTSID
                     SVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRD
                     DQGTAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDKLETDT
                     HWVPVSWLHS"
     exon            279..397
                     /gene="Mpp7"
                     /gene_synonym="1110068J02Rik; 2810038M04Rik;
                     5430426E14Rik; Gm955"
                     /inference="alignment:Splign:2.1.0"
     exon            398..475
                     /gene="Mpp7"
                     /gene_synonym="1110068J02Rik; 2810038M04Rik;
                     5430426E14Rik; Gm955"
                     /inference="alignment:Splign:2.1.0"
     exon            476..556
                     /gene="Mpp7"
                     /gene_synonym="1110068J02Rik; 2810038M04Rik;
                     5430426E14Rik; Gm955"
                     /inference="alignment:Splign:2.1.0"
     exon            557..688
                     /gene="Mpp7"
                     /gene_synonym="1110068J02Rik; 2810038M04Rik;
                     5430426E14Rik; Gm955"
                     /inference="alignment:Splign:2.1.0"
     exon            689..770
                     /gene="Mpp7"
                     /gene_synonym="1110068J02Rik; 2810038M04Rik;
                     5430426E14Rik; Gm955"
                     /inference="alignment:Splign:2.1.0"
     exon            771..856
                     /gene="Mpp7"
                     /gene_synonym="1110068J02Rik; 2810038M04Rik;
                     5430426E14Rik; Gm955"
                     /inference="alignment:Splign:2.1.0"
     exon            857..931
                     /gene="Mpp7"
                     /gene_synonym="1110068J02Rik; 2810038M04Rik;
                     5430426E14Rik; Gm955"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1128
                     /gene="Mpp7"
                     /gene_synonym="1110068J02Rik; 2810038M04Rik;
                     5430426E14Rik; Gm955"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1193
                     /gene="Mpp7"
                     /gene_synonym="1110068J02Rik; 2810038M04Rik;
                     5430426E14Rik; Gm955"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1364
                     /gene="Mpp7"
                     /gene_synonym="1110068J02Rik; 2810038M04Rik;
                     5430426E14Rik; Gm955"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1445
                     /gene="Mpp7"
                     /gene_synonym="1110068J02Rik; 2810038M04Rik;
                     5430426E14Rik; Gm955"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1539
                     /gene="Mpp7"
                     /gene_synonym="1110068J02Rik; 2810038M04Rik;
                     5430426E14Rik; Gm955"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1648
                     /gene="Mpp7"
                     /gene_synonym="1110068J02Rik; 2810038M04Rik;
                     5430426E14Rik; Gm955"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1792
                     /gene="Mpp7"
                     /gene_synonym="1110068J02Rik; 2810038M04Rik;
                     5430426E14Rik; Gm955"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..4975
                     /gene="Mpp7"
                     /gene_synonym="1110068J02Rik; 2810038M04Rik;
                     5430426E14Rik; Gm955"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4805..4810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mpp7"
                     /gene_synonym="1110068J02Rik; 2810038M04Rik;
                     5430426E14Rik; Gm955"
                     /note="hexamer: AATAAA"
     polyA_site      4826
                     /gene="Mpp7"
                     /gene_synonym="1110068J02Rik; 2810038M04Rik;
                     5430426E14Rik; Gm955"
                     /note="major polyA site"
ORIGIN      
        1 gcaggagttg tggcgggtgc aaccggctag ttcatcctgc tgagctgtag ttgatccgat
       61 ctgcctccgg attgtcctca gttgtgatcc tgagctgtgg agctaagtgg cgcttggact
      121 gcggctgccg aggaggcttt taggacaact cttgggcgaa acacggctgt agtccattaa
      181 attgtctgga gctacctgag acaagagagt ggagggcggc cacatctctg cagcctgcat
      241 catgccagcg ctggccacag gatcggcttg cgacatgggt ctgtatgagc tgttggctgc
      301 tctgcctgcc cagctgcagc cacatgtgga tagccaggag gacctgacct tcctctggga
      361 cgtgtttggt gaaaagagcc tgcattcact ggtcaagatt catgaaaaac ttcactgcta
      421 tgagaagcag aatccgttgc ccattctcca tggtgcagca gcgttggctg atgatctgac
      481 tgaagagcta cagaacaagc taccaaacag tgagatcaga gagctgttga aactgctgtc
      541 aaaacccaat gtcaaggctt tgctgtcagt acatgatact gtggctcaaa agagttatga
      601 tcctgtattg cctcccgtgc ctgacgatat tgatgatgag gaagactctg tgaaaataat
      661 ccgcctggtc aaaaatagcg agcccctggg tgctaccatt aaaaaagatg agcagaccgg
      721 agcaatcact gtggcccgaa tcatgcgggg aggagctgca gatagaagtg gtcttattca
      781 cgtgggtgat gagctgaggg aagtgaatgg aatcccagtg gaagataaga ggcctgagga
      841 aataataaag attttgagtc agtccaaggg agcaattaca tttaagataa tacccagcac
      901 caaagaggag acaccttcga aagaaggcaa gatatttatc aaagccctct ttgactacga
      961 tcctaaggaa gacaaggcaa tcccgtgtaa agaggcaggg ctgtctttca ggaaggggga
     1021 cattcttcag attatgagcc aagatgatgt gacatggtgg caggctaagc atgaaggaga
     1081 tgccaacccc agagcgggcc tgattccctc caagcacttc caggaacgga gactggctct
     1141 gagacgacca gaaatagtag ttcagcctct gaaactttcc aacacgaaat catctggttt
     1201 tagaagaagt ttccgtctta gcagaaaaaa taagaaaata aataagtcca tgtatgaatg
     1261 caaaaagagt gagcagtatg acacggcaga tgtgcccaca tatgaggagg tgacacccta
     1321 ccggcggcag atccatgaca aatacagact cattgtcctg gttggtcctg tcggagtcgg
     1381 gctaaatgag ctgaagcgaa agctattgat gagtgatgca cagcactatg gtgtgatagt
     1441 gccccacacc actagagcaa gaagaagcca agagagtgat ggtgtggaat atatttttat
     1501 ttccaaacat ttgtttgaga cagatgtaca aaataacaag ttcattgagt atggtgaata
     1561 taaaaacaac tattatggta caagtataga ctcggttcgc tctgtcctag ctaagaacaa
     1621 ggtttgtctg ttggatgtcc agcctcatac agtgaagcat ttaaggacac tggagttcaa
     1681 accctatgtg atatttataa aacctccatc catagagcgt ttgagagaga caagaaaaaa
     1741 tgcaaagatt atttcaagca gagatgacca agggactgca aagcccttca cggaagaaga
     1801 ctttcaggaa atgattaaat cagcacagat aatggaaagt caatatggcc atctttttga
     1861 caaaatcata atcaatgatg atcttactgt ggcatttaat gagctaaaaa caacatttga
     1921 caaactagag actgataccc attgggtccc agtgagttgg ttacattcat aactcagaga
     1981 aatgtcctta attgtctttt tacagagttg catggttaga tcaactacca tggttttggt
     2041 aggatttttt ttttaataat tagtatcact gtcacagatg taaagtcttc aatgtcaaag
     2101 tcaaaatttc agtgctggtt tgtttatgtc tttcacagcc ttatttgaag cacataagtg
     2161 tacaatctaa gtcaaaatct gcacaatgct atagtcttag caaaacttgt atttactggt
     2221 tttctttaat ctgtttcttt gtgagaggca gtaggtatca aagttcatgc ctcacttggg
     2281 ctcaggtgtg ctcacagccc ttcactgggc atgcttacag ttgaaagcat gggcttggca
     2341 gccttgagca aatccacaga tttaactgag ctggaaataa gactctcctt taaaaaatat
     2401 gttcttcatg tgcacatctt taaaacaaag aagaaactca aatcttttct tgaggaagta
     2461 actcacatat tatagcttag gaaatcctta tgagtacata ttagtgatgc caccaatatt
     2521 atataagaaa aatctaattc tcctgtttaa gatgagagtc tcactatgtt gtcaacacta
     2581 gccttgaact cagcctttgt ttgcctcagc ctcctgagta cgggaacatg ccgctgcatc
     2641 aggcttaaaa acgacttaac tgatactaca gatgtagata caaacttttc ctcatggttt
     2701 agtaaaaatg gctctgtctt agggcaagaa atgattacac agcaccactt gctttaatct
     2761 atcattcttc agaagacatt tctggagtca gaaagttttc ttctcttgct ttggaatttc
     2821 tcaacaaatt ataacaatga gataagtatt caaaaacatg taacacgtgt tagagcacag
     2881 tgaaggaaga ggtgctcatg tttctggtgt gcaatcacca cacatgtaaa ttgtcctaaa
     2941 gtgtgtttta gaaaccttat attgtgttaa atttttgtca acaaaatgat taacaccagc
     3001 cagattgcat ttcaacctat tccaaaggaa ggtgggtttt taaatgtttc aatgacattg
     3061 ttcctttttc tataatgcct taggtctcta gcaagtgaat gatttgcaat actacaaata
     3121 tccatagttc aatcttagag caggttcctg ccagtactct gagcagtaca gattagtcaa
     3181 tggaagattc atcacatcta tgacttgcat acaaaaaatt attcttgttg ctttgtaaag
     3241 agtttaaata ttatgtttaa agaaaaaata aaatgtaggg aaattttata tatttgtgag
     3301 atatttgaaa ggcatgtttt taaattatca aatgaggcta ttcataagat aaattgtatg
     3361 taaagatata atttaaaata gttttatggg ccgggcgtgg tggcacacgc ctttaatccc
     3421 agcacttggg aggcagagac aggtggattt ctgagttcga ggccagcctg gtctacagaa
     3481 tgagttccag gacagccaga gctacacaga gaaaccctgt ctcgaaaaaa acaaaaacaa
     3541 aaacaaataa acaaatatat atatatatat atatatagtt ttataagcaa gatcaacatt
     3601 ccatgtaaat attggacctt ttggcagata ggtccacaca catattacat gttcactgct
     3661 gtttggtggt gtccgtggct agctttcctt aagacaatgt caaatttctg tgtgaagcag
     3721 aaacaaaaac ttttctagtg acctcattac atgttcaagc ccaacagtca gatgattgga
     3781 ctaatgaaca cagttcatgg aagttctgtg cttattaatt aaagccatgc agctcaaaca
     3841 cagagagaaa ggctactgaa tttctactct gatatcactg ctttgtgtgg actgtctaga
     3901 agcacaagtc ttaaaaagtt ggtttggatg gaatgtcctg tcccttgctc gatgtgtaca
     3961 cttctctaaa ggaactttct agaccaagaa tggtgagaag tgtgtccagc ataggacatt
     4021 ctgaaatagt ttaggtatcc catgttcata cctcaggtat ctttgctgat tgtttttctt
     4081 catctggtga ctgctctctt cagtttttat tttgggttag tgcttgggaa atttggggta
     4141 ggtagtgaag gtgatggaat gtcatgaaaa tataaatgtc tgcacctgtt agaccacagc
     4201 tgagcatctt tctttaaaaa ataaataaac agaaataaag cagtttaaga aatcaggtgg
     4261 catgtagcct tacctgttct atttcttgat gcttataaag agatttaatt taaacataaa
     4321 agccaggcca agataccaac agcatttggc cttgctgtgc tctctgacct cagcactccc
     4381 accaccaagg agaaaaatac tttgctccta gctttcagca gcttgtttct ggggtgcagt
     4441 gccagccact attagaaaag cagggtttca ttgtttatcc atttaaagtt gaacctggta
     4501 tgaggtgctt tttttctcct ctatctccca ggtagaatgg cctaaaagta aagagataaa
     4561 cttgaaacaa taaccatggc tttactgagt aatgtggaaa cttggcatct ataaggctga
     4621 cattcctggt actatataat catcaagtgt acctaaactg tagtaattta aagtgagcaa
     4681 acatgtaaac tcagatttac aaaactatgg aatcaaaaat gtccctgaag attcagattt
     4741 tcatttattt ccctgtggcc tatgatggat ttatagataa atgtaatgga aagtttttta
     4801 ttttaataaa gtatcttcaa acaatatatc tgcttgaaag ttgtttagca cttgaatatg
     4861 ctataattgt tctaccctgt gctgcttttt ccgtggtgga acaaattcca tcctttggta
     4921 ttatataatt tatttgatct ttccatgcct aaaattaaac attatatttc tcttc
//
