LOCUS       NM_145143               2422 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus membrane protein, palmitoylated 4 (MAGUK p55 subfamily
            member 4) (Mpp4), transcript variant 2, mRNA.
ACCESSION   NM_145143
VERSION     NM_145143.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2422)
  AUTHORS   Xiao,J., Vemula,S.R., Xue,Y., Khan,M.M., Kuruvilla,K.P.,
            Marquez-Lona,E.M., Cobb,M.R. and LeDoux,M.S.
  TITLE     Motor phenotypes and molecular networks associated with germline
            deficiency of Ciz1
  JOURNAL   Exp Neurol 283 (Pt A), 110-120 (2016)
   PUBMED   27163549
REFERENCE   2  (bases 1 to 2422)
  AUTHORS   Abe,K., Yamamoto,R., Franke,V., Cao,M., Suzuki,Y., Suzuki,M.G.,
            Vlahovicek,K., Svoboda,P., Schultz,R.M. and Aoki,F.
  TITLE     The first murine zygotic transcription is promiscuous and uncoupled
            from splicing and 3' processing
  JOURNAL   EMBO J 34 (11), 1523-1537 (2015)
   PUBMED   25896510
REFERENCE   3  (bases 1 to 2422)
  AUTHORS   Alves,C.H., Sanz,A.S., Park,B., Pellissier,L.P., Tanimoto,N.,
            Beck,S.C., Huber,G., Murtaza,M., Richard,F., Sridevi Gurubaran,I.,
            Garcia Garrido,M., Levelt,C.N., Rashbass,P., Le Bivic,A.,
            Seeliger,M.W. and Wijnholds,J.
  TITLE     Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa
            due to mutations in the CRB1 gene
  JOURNAL   Hum Mol Genet 22 (1), 35-50 (2013)
   PUBMED   23001562
REFERENCE   4  (bases 1 to 2422)
  AUTHORS   Aartsen,W.M., Arsanto,J.P., Chauvin,J.P., Vos,R.M., Versteeg,I.,
            Cardozo,B.N., Bivic,A.L. and Wijnholds,J.
  TITLE     PSD95beta regulates plasma membrane Ca2+ pump localization at the
            photoreceptor synapse
  JOURNAL   Mol Cell Neurosci 41 (2), 156-165 (2009)
   PUBMED   19233278
  REMARK    GeneRIF: Data suggest that both scaffold proteins PSD95beta and
            MPP4 are essential for the modulation of PMCA levels at the
            presynaptic plasma membrane and thereby influence the photoreceptor
            synaptic calcium handling.
REFERENCE   5  (bases 1 to 2422)
  AUTHORS   Yang,J., Pawlyk,B., Wen,X.H., Adamian,M., Soloviev,M., Michaud,N.,
            Zhao,Y., Sandberg,M.A., Makino,C.L. and Li,T.
  TITLE     Mpp4 is required for proper localization of plasma membrane calcium
            ATPases and maintenance of calcium homeostasis at the rod
            photoreceptor synaptic terminals
  JOURNAL   Hum Mol Genet 16 (9), 1017-1029 (2007)
   PUBMED   17341488
  REMARK    GeneRIF: Results show that Mpp4 organizes a presynaptic protein
            complex and has a role in modulating Ca(2+) homeostasis and
            synaptic transmission in rod photoreceptors.
REFERENCE   6  (bases 1 to 2422)
  AUTHORS   van de Pavert,S.A., Kantardzhieva,A., Malysheva,A., Meuleman,J.,
            Versteeg,I., Levelt,C., Klooster,J., Geiger,S., Seeliger,M.W.,
            Rashbass,P., Le Bivic,A. and Wijnholds,J.
  TITLE     Crumbs homologue 1 is required for maintenance of photoreceptor
            cell polarization and adhesion during light exposure
  JOURNAL   J Cell Sci 117 (Pt 18), 4169-4177 (2004)
   PUBMED   15316081
REFERENCE   7  (bases 1 to 2422)
  AUTHORS   Stohr,H., Stojic,J. and Weber,B.H.
  TITLE     Cellular localization of the MPP4 protein in the mammalian retina
  JOURNAL   Invest Ophthalmol Vis Sci 44 (12), 5067-5074 (2003)
   PUBMED   14638699
REFERENCE   8  (bases 1 to 2422)
  AUTHORS   Li,M., Zhang,S.S. and Barnstable,C.J.
  TITLE     Developmental and tissue expression patterns of mouse Mpp4 gene
  JOURNAL   Biochem Biophys Res Commun 307 (2), 229-235 (2003)
   PUBMED   12859944
  REMARK    GeneRIF: Results describe the temporal and spatial expression
            patterns of mouse membrane palmitoylated protein 4 (Mpp4) gene.
REFERENCE   9  (bases 1 to 2422)
  AUTHORS   Conte,I., Lestingi,M., den Hollander,A., Miano,M.G., Alfano,G.,
            Circolo,D., Pugliese,M., Testa,F., Simonelli,F., Rinaldi,E.,
            Baiget,M., Banfi,S. and Ciccodicola,A.
  TITLE     Characterization of MPP4, a gene highly expressed in photoreceptor
            cells, and mutation analysis in retinitis pigmentosa
  JOURNAL   Gene 297 (1-2), 33-38 (2002)
   PUBMED   12384283
REFERENCE   10 (bases 1 to 2422)
  AUTHORS   Inagaki,H., Tanaka,K., Takada,M., Maeda,S., Ichihara,S. and
            Saito,T.
  TITLE     Spatial distribution of mDLG6 mRNA in embryonic and adult mouse
            brain
  JOURNAL   Cell Biol Int 26 (7), 635-640 (2002)
   PUBMED   12127943
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI737565.1 and BC061694.1.
            
            On Dec 11, 2007 this sequence version replaced NM_145143.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream start codon, compared to variant 1. The encoded isoform
            (2) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061694.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                BI737565.1         1-83
            84-2422             BC061694.1         1-2339
FEATURES             Location/Qualifiers
     source          1..2422
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 29.2 cM"
     gene            1..2422
                     /gene="Mpp4"
                     /gene_synonym="Dlg6"
                     /note="membrane protein, palmitoylated 4 (MAGUK p55
                     subfamily member 4)"
                     /db_xref="GeneID:227157"
                     /db_xref="MGI:MGI:2386681"
     exon            1..105
                     /gene="Mpp4"
                     /gene_synonym="Dlg6"
                     /inference="alignment:Splign:2.1.0"
     exon            106..195
                     /gene="Mpp4"
                     /gene_synonym="Dlg6"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..2027
                     /gene="Mpp4"
                     /gene_synonym="Dlg6"
                     /note="isoform 2 is encoded by transcript variant 2; MAGUK
                     p55 subfamily member 4; discs large homolog 6; membrane
                     palmitoylated protein 4; mDLG6"
                     /codon_start=1
                     /product="MAGUK p55 subfamily member 4 isoform 2"
                     /protein_id="NP_660125.2"
                     /db_xref="CCDS:CCDS48271.1"
                     /db_xref="GeneID:227157"
                     /db_xref="MGI:MGI:2386681"
                     /translation="MRQSDRGAELTNEDRALPTPPDPENGLSGILRLLLQELSLFYSR
                     DVNGLCLLYDLLHSPWLQALLKVYDCLQRFKEKKLVPDTTHAQILACEVLELLPKASG
                     SPEIQELRQVLQAPHCKALLSAHDTVAQKDFEPLLPPLPDNIPDSEEAMRIVCLVKNQ
                     QPLGATIKRHEITGDILVARVIHGGLVERSGLLYAGDKLVEVNGVSVEGLDPEQVIHI
                     LAMSCGTIMFKVIPVSAPPVSSQKMVYVRAMIDYWPQEDPDIPCMDAGLPFLKGDILQ
                     IVDQNDALWWQARKISDLTICAGLIPSNHLLKRKQREFWWSQPYQPHTCLKSTRALSM
                     EEEDSMKIDEKCVEADEETFESEELAEAKDEFVGDGQKFFIAGFRRSMRLCRRKSHFS
                     QLHASLCCSCSCYSAVGAPYEEVVRYQRQPADKHRLIVLVGPSGVGVNELRRQLIGCN
                     PSCFQSAVPHTTRFPKSYEMDGREYHYVSRETFESLMYGHKMLEYGEYKGHLYGTSVN
                     AVHAVLDEGKICIMDLEPQDIQSARTRDLKPYVIFIKPPNTSSMRHSRKNAKITTDYY
                     VDMKFKDEDLQEMEELAQKMESQFGQFFDHVIVNDNLQDACGQLLSAIQKAQEELQWV
                     PEAWVSPDTES"
     exon            196..317
                     /gene="Mpp4"
                     /gene_synonym="Dlg6"
                     /inference="alignment:Splign:2.1.0"
     exon            318..395
                     /gene="Mpp4"
                     /gene_synonym="Dlg6"
                     /inference="alignment:Splign:2.1.0"
     exon            396..476
                     /gene="Mpp4"
                     /gene_synonym="Dlg6"
                     /inference="alignment:Splign:2.1.0"
     exon            477..608
                     /gene="Mpp4"
                     /gene_synonym="Dlg6"
                     /inference="alignment:Splign:2.1.0"
     exon            609..690
                     /gene="Mpp4"
                     /gene_synonym="Dlg6"
                     /inference="alignment:Splign:2.1.0"
     exon            691..776
                     /gene="Mpp4"
                     /gene_synonym="Dlg6"
                     /inference="alignment:Splign:2.1.0"
     exon            777..848
                     /gene="Mpp4"
                     /gene_synonym="Dlg6"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1045
                     /gene="Mpp4"
                     /gene_synonym="Dlg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1110
                     /gene="Mpp4"
                     /gene_synonym="Dlg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1128
                     /gene="Mpp4"
                     /gene_synonym="Dlg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1167
                     /gene="Mpp4"
                     /gene_synonym="Dlg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1188
                     /gene="Mpp4"
                     /gene_synonym="Dlg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1203
                     /gene="Mpp4"
                     /gene_synonym="Dlg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1245
                     /gene="Mpp4"
                     /gene_synonym="Dlg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1416
                     /gene="Mpp4"
                     /gene_synonym="Dlg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1497
                     /gene="Mpp4"
                     /gene_synonym="Dlg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1591
                     /gene="Mpp4"
                     /gene_synonym="Dlg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1700
                     /gene="Mpp4"
                     /gene_synonym="Dlg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1835
                     /gene="Mpp4"
                     /gene_synonym="Dlg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..2345
                     /gene="Mpp4"
                     /gene_synonym="Dlg6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2315..2320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mpp4"
                     /gene_synonym="Dlg6"
                     /note="hexamer: AATAAA"
     polyA_site      2345
                     /gene="Mpp4"
                     /gene_synonym="Dlg6"
                     /note="major polyA site"
ORIGIN      
        1 agagcttttc tctagagcat caggtgactg gcagctagca gcctcctggt gcttcctgct
       61 tgcttctctc ttgccaggag caacactgtg ttttcatcct tgcagctcca gcagggagga
      121 tgagacagtc tgacagagga gcagagctga ccaatgagga cagagctctt cccacgccac
      181 ctgatcctga gaatggtctc tctgggatcc tgaggctcct actgcaggaa ctgagccttt
      241 tctacagccg agatgtgaat ggtctgtgtc tcttatatga cctcctccat tcaccatggc
      301 tgcaggctct gctcaaggtc tacgactgcc tccagaggtt taaagagaag aagctagttc
      361 ctgatacaac tcatgcacag atcttagcct gtgaggtctt ggagctgtta cccaaagctt
      421 ccggttcccc cgagatccaa gagctaagac aagtccttca ggctcctcac tgcaaggcct
      481 tgctgagtgc ccatgacaca gtggctcaga aagactttga accccttctc cccccactgc
      541 cagacaatat ccccgacagt gaagaagcaa tgaggattgt ttgtctggtg aaaaaccaac
      601 agcccctggg agcaaccatc aagcgtcatg agataacagg ggatatcctg gtggccaggg
      661 tcatccatgg cgggctggtg gagaggagcg ggttgctgta tgctggagac aaactggtgg
      721 aagtgaatgg agtttcagta gagggcctgg accctgagca agtgatccat attttggcta
      781 tgtcttgtgg tacgatcatg ttcaaggtga ttccggtctc tgccccgcct gtgagcagcc
      841 agaagatggt ttatgttcgc gccatgattg attactggcc ccaagaggat cccgacatcc
      901 cctgcatgga tgctgggctg cctttcctga aaggggacat tctacagatt gtggaccaga
      961 atgatgccct ctggtggcag gcccggaaaa tctcagacct caccatctgt gctgggctaa
     1021 tcccttctaa ccaccttctg aagaggaagc agcgggagtt ctggtggtct cagccgtacc
     1081 aacctcacac ctgcctcaaa tccacccgag cactgtctat ggaggaagaa gacagcatga
     1141 agattgatga gaagtgtgtg gaagcagatg aagaaacttt tgaatctgag gaactcgcag
     1201 aagctaagga cgaatttgtc ggcgatgggc agaagttctt tatcgctggg ttccgccgca
     1261 gcatgcgcct ctgtcgcagg aagtctcact tcagccagct gcatgccagc ctgtgctgca
     1321 gctgcagctg ctacagtgcc gtgggcgctc cttacgagga ggtggtgagg taccagcggc
     1381 agccggcgga caaacaccgc ctcatagtgc ttgtgggacc ttctggcgtt ggagtcaatg
     1441 aactgagaag acagctcatt ggatgtaacc ccagctgttt tcaaagtgct gtgccacata
     1501 ccacccgttt cccaaagagt tatgaaatgg atggacgtga gtatcactac gtgtcaaggg
     1561 aaacatttga aagcctcatg tacggacaca agatgctgga gtatggtgag tacaagggcc
     1621 acctgtacgg aaccagtgtg aacgctgtac acgccgtcct tgatgaaggc aagatctgca
     1681 tcatggatct agagcctcag gatattcagt cggctcgaac ccgtgacttg aagccctacg
     1741 ttatatttat taagccacct aacacgagct ccatgagaca ctctcggaaa aacgctaaga
     1801 tcaccactga ctactatgtg gacatgaagt tcaaggatga agacctacaa gagatggagg
     1861 agttagccca gaaaatggag agtcagtttg gccagttttt tgatcacgtg attgtgaatg
     1921 acaacttgca agatgcatgt ggccagctgt tgtccgccat acagaaggct caggaagaac
     1981 tgcagtgggt gccagaggca tgggtttccc ctgacactga atcttaatct agtgtcctgc
     2041 ttaaagctgg aagcttcata gtgtgcccta aagatccgga ataacggctg ccattgaaaa
     2101 cagcagtgtt tgacccatta gaactgcgac tatgaagtcc ttattgtata gctataaata
     2161 gcatcctata catatacaga gctactcatt tggctctcag gcattttccc gatgtttccc
     2221 catatgagct aatggcaggt atgtgacaat gttgtcactg aatgtgagca ttttatagat
     2281 ttcatatggt gttttgtaag atgtaactct tctaaataaa ccagtctact taatgacaaa
     2341 ctgtaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2401 aaaaaaaaaa aaaaaaaaaa aa
//
