LOCUS       NM_001403742            2968 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus membrane protein, palmitoylated 3 (MAGUK p55 subfamily
            member 3) (Mpp3), transcript variant 3, mRNA.
ACCESSION   NM_001403742 XM_006532138
VERSION     NM_001403742.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2968)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2968)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2968)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2968)
  AUTHORS   Chen,N., Koopmans,F., Gordon,A., Paliukhovich,I., Klaassen,R.V.,
            van der Schors,R.C., Peles,E., Verhage,M., Smit,A.B. and Li,K.W.
  TITLE     Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the
            presence of two Caspr2 isoforms with overlapping interactomes
  JOURNAL   Biochim Biophys Acta 1854 (7), 827-833 (2015)
   PUBMED   25707359
REFERENCE   5  (bases 1 to 2968)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2968)
  AUTHORS   Gavarini,S., Becamel,C., Altier,C., Lory,P., Poncet,J.,
            Wijnholds,J., Bockaert,J. and Marin,P.
  TITLE     Opposite effects of PSD-95 and MPP3 PDZ proteins on serotonin
            5-hydroxytryptamine2C receptor desensitization and membrane
            stability
  JOURNAL   Mol Biol Cell 17 (11), 4619-4631 (2006)
   PUBMED   16914526
  REMARK    GeneRIF: This indicates that, overall, interaction of 5-HT(2C)
            receptors with PDZ proteins inhibits receptor desensitization in
            cortical neurons.
REFERENCE   7  (bases 1 to 2968)
  AUTHORS   Kantardzhieva,A., Alexeeva,S., Versteeg,I. and Wijnholds,J.
  TITLE     MPP3 is recruited to the MPP5 protein scaffold at the retinal outer
            limiting membrane
  JOURNAL   FEBS J 273 (6), 1152-1165 (2006)
   PUBMED   16519681
REFERENCE   8  (bases 1 to 2968)
  AUTHORS   Becamel,C., Gavarini,S., Chanrion,B., Alonso,G., Galeotti,N.,
            Dumuis,A., Bockaert,J. and Marin,P.
  TITLE     The serotonin 5-HT2A and 5-HT2C receptors interact with specific
            sets of PDZ proteins
  JOURNAL   J Biol Chem 279 (19), 20257-20266 (2004)
   PUBMED   14988405
REFERENCE   9  (bases 1 to 2968)
  AUTHORS   Fukaya,M., Ueda,H., Yamauchi,K., Inoue,Y. and Watanabe,M.
  TITLE     Distinct spatiotemporal expression of mRNAs for the PSD-95/SAP90
            protein family in the mouse brain
  JOURNAL   Neurosci Res 33 (2), 111-118 (1999)
   PUBMED   10211776
REFERENCE   10 (bases 1 to 2968)
  AUTHORS   Lin,L., Peters,L.L., Ciciotte,S.L. and Chishti,A.H.
  TITLE     cDNA sequence and chromosomal localization of mouse Dlgh3 gene
            adjacent to the BRCA1 tumor suppressor locus
  JOURNAL   Biochim Biophys Acta 1443 (1-2), 211-216 (1998)
   PUBMED   9838122
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591145.25.
            
            On Apr 4, 2022 this sequence version replaced XM_006532138.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2326741.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               AL591145.25        73035-73255         c
            222-346             AL591145.25        72228-72352         c
            347-465             AL591145.25        71877-71995         c
            466-543             AL591145.25        71573-71650         c
            544-624             AL591145.25        70198-70278         c
            625-762             AL591145.25        69823-69960         c
            763-844             AL591145.25        66968-67049         c
            845-930             AL591145.25        65118-65203         c
            931-1005            AL591145.25        63123-63197         c
            1006-1202           AL591145.25        59811-60007         c
            1203-1267           AL591145.25        58216-58280         c
            1268-1288           AL591145.25        56703-56723         c
            1289-1330           AL591145.25        56139-56180         c
            1331-1495           AL591145.25        55016-55180         c
            1496-1576           AL591145.25        54852-54932         c
            1577-1670           AL591145.25        51843-51936         c
            1671-1779           AL591145.25        51486-51594         c
            1780-1902           AL591145.25        48520-48642         c
            1903-2968           AL591145.25        46160-47225         c
FEATURES             Location/Qualifiers
     source          1..2968
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 65.48 cM"
     gene            1..2968
                     /gene="Mpp3"
                     /gene_synonym="6430514B01; Dlgh3"
                     /note="membrane protein, palmitoylated 3 (MAGUK p55
                     subfamily member 3)"
                     /db_xref="GeneID:13384"
                     /db_xref="MGI:MGI:1328354"
     exon            1..221
                     /gene="Mpp3"
                     /gene_synonym="6430514B01; Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            222..346
                     /gene="Mpp3"
                     /gene_synonym="6430514B01; Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..2079
                     /gene="Mpp3"
                     /gene_synonym="6430514B01; Dlgh3"
                     /note="isoform 1 is encoded by transcript variant 3; MAGUK
                     p55 subfamily member 3; discs large homolog 3; Mpp3
                     membrane protein, palmitoylated 3"
                     /codon_start=1
                     /product="MAGUK p55 subfamily member 3 isoform 1"
                     /protein_id="NP_001390671.1"
                     /db_xref="GeneID:13384"
                     /db_xref="MGI:MGI:1328354"
                     /translation="MPVLSEDSGLHETLALLTSQLRPDSNHREEMGFLRDVFSEKSLS
                     YLMKIHEKLRYYERQSPTPVLHSAMALAEDVMEELQAASVHSDERELLQLLSTPHLRA
                     VLMVHDTVAQKNFDPVLPPLPDNIDEDFEEESVKIVRLVKNKEPLGATIRRDEHSGAV
                     VVARIMRGGAADRSGLVHVGDELREVNGIAVLHKRPDEISQILAQSQGSITLKIIPAT
                     QEEDRFKDSKVFMRALFHYDPREDRAIPCQEAGLPFQRRQVLEVVSQDDPTWWQAKRV
                     GDTNLRAGLIPSKQFQERRLSYRRTTGTLPSPQNFKKPPYDQPCDKETCDCDGYFKGH
                     YVAGLRRSFRLGCRERLGGSQEAKVPTGAESQVLLTYEEVARYQHQPGERPRLVVLIG
                     SLGAHLHELKQRVVAEDPQQFAVAVPHTTRPRKSHERDGVEYHFVSKQAFEADVHHNK
                     FLEHGEYKENLYGTSLEAIQAVMAKNKVCLVDVEPEALRHLRTPEFKPYVIFVKPAIQ
                     ERRKTPPVSPDSEDIASSLDEQQQEMAASAAFIDQHYGHLIDTVLVRQDLQEACSQLR
                     AVIETLSKDTSWVPISWVR"
     exon            347..465
                     /gene="Mpp3"
                     /gene_synonym="6430514B01; Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            466..543
                     /gene="Mpp3"
                     /gene_synonym="6430514B01; Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            544..624
                     /gene="Mpp3"
                     /gene_synonym="6430514B01; Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            625..762
                     /gene="Mpp3"
                     /gene_synonym="6430514B01; Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            763..844
                     /gene="Mpp3"
                     /gene_synonym="6430514B01; Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            845..930
                     /gene="Mpp3"
                     /gene_synonym="6430514B01; Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1005
                     /gene="Mpp3"
                     /gene_synonym="6430514B01; Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1202
                     /gene="Mpp3"
                     /gene_synonym="6430514B01; Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1267
                     /gene="Mpp3"
                     /gene_synonym="6430514B01; Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1288
                     /gene="Mpp3"
                     /gene_synonym="6430514B01; Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1330
                     /gene="Mpp3"
                     /gene_synonym="6430514B01; Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1495
                     /gene="Mpp3"
                     /gene_synonym="6430514B01; Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1576
                     /gene="Mpp3"
                     /gene_synonym="6430514B01; Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1670
                     /gene="Mpp3"
                     /gene_synonym="6430514B01; Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1779
                     /gene="Mpp3"
                     /gene_synonym="6430514B01; Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1902
                     /gene="Mpp3"
                     /gene_synonym="6430514B01; Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2968
                     /gene="Mpp3"
                     /gene_synonym="6430514B01; Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2311..2316
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mpp3"
                     /gene_synonym="6430514B01; Dlgh3"
                     /note="hexamer: ATTAAA"
     polyA_site      2354
                     /gene="Mpp3"
                     /gene_synonym="6430514B01; Dlgh3"
     regulatory      2945..2950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mpp3"
                     /gene_synonym="6430514B01; Dlgh3"
                     /note="hexamer: AATAAA"
     polyA_site      2968
                     /gene="Mpp3"
                     /gene_synonym="6430514B01; Dlgh3"
                     /note="major polyA site"
ORIGIN      
        1 cggcggggct ccgttcccag cccgcggtcc ccttcactgc tcggcgtccg cgcatcccgt
       61 gcgccccgct cattcccgcc gctctgcatc ccatctcccc ccacctcggg ggtttgctcc
      121 ccccccccca gctcctctgg gaaaccggct ggagccggga gtgtgtgttt gtgtggggaa
      181 gtcgggggca gtcgggggcc gcagctggaa gccgccgagg gaggtcataa gcagatcctg
      241 gtgatgtgtg ttcattactg agagattcct ctcccaccca cacaaactgt agggacagct
      301 ggggacctgc tgggcacagg catgccagta ctgtctgaag actcgggttt gcatgagacc
      361 ctggcactgc tcacctctca gctcaggcct gactccaacc acagggagga gatgggcttc
      421 ctgagagatg tcttcagtga gaagagcctc agttatttaa tgaagattca tgagaaactc
      481 cgctattatg agaggcagag tccaacccca gtcctccaca gcgccatggc ccttgctgag
      541 gatgtgatgg aggagctgca ggctgcctct gtgcacagtg atgagcggga gctgctgcag
      601 ctgctgtcca ccccccacct cagggctgtg ctcatggtcc acgacacggt tgcccagaag
      661 aacttcgatc ctgttctgcc ccctctgccc gataacatcg atgaggattt tgaagaggag
      721 tcggtgaaga ttgttcgctt ggtgaagaat aaggagcccc tgggtgccac catccgacgg
      781 gatgagcatt cgggggctgt tgtggtggcc aggatcatgc gagggggtgc ggcagaccgg
      841 agcggtctgg tccacgttgg cgatgagctc cgagaggtga atgggatcgc cgtcctgcac
      901 aagcgtccag acgagatcag ccaaattctg gcccaatccc agggatccat taccctgaag
      961 atcatccctg ccacccagga ggaagaccgc ttcaaagaca gcaaggtatt catgcgtgcc
     1021 ctcttccact atgaccctcg ggaggaccgt gccatcccct gccaggaggc tggcctgccc
     1081 ttccagcgga ggcaggtcct ggaggtggtg agccaagatg accccacctg gtggcaggcc
     1141 aagagagtag gcgacaccaa ccttcgagct ggcctcatcc catctaagca gttccaggag
     1201 aggcggctga gctaccggag aaccactggc accttaccaa gcccccagaa cttcaaaaag
     1261 cccccctatg atcagccttg tgacaaagag acctgtgact gtgatgggta ctttaaagga
     1321 cattatgtgg ctggtcttcg gagaagcttc cggctgggct gcagggagag gctgggtggc
     1381 tcgcaggaag caaaggtccc tacaggagct gagtctcagg tgctgctgac gtacgaggaa
     1441 gtggccaggt accaacacca gcctggggag cggccccgcc tggtggttct cattgggtcc
     1501 ctgggagccc acctccatga gctgaagcaa agggtggtgg ctgaggaccc ccagcagttt
     1561 gccgttgcag ttccacacac caccaggccc cggaagagcc acgagagaga cggggtggag
     1621 taccattttg tctccaagca agcgtttgag gccgacgtac atcacaacaa gttcctggag
     1681 catggagaat ataaagagaa tctctacggc accagcctag aggccattca ggctgttatg
     1741 gccaaaaaca aagtgtgttt ggtggatgta gaaccagaag cactaagaca cctgaggacc
     1801 cctgagttta agccctatgt tatatttgtg aagcctgcaa ttcaggagag aaggaagacg
     1861 ccgccggtgt ccccagactc tgaggacata gcatcttcac ttgatgaaca gcagcaagag
     1921 atggccgcct ctgctgcctt catagatcag cactatgggc acctgataga cactgtgctc
     1981 gtgaggcagg acctgcagga ggcctgcagc cagctcagag ctgtcataga gacgctgagc
     2041 aaggacactt cctgggtacc catcagctgg gtgaggtaac ttcaccccat agcatctggt
     2101 ctgaagggac cttgaagacc ctcgagtcca gcctccctca tgtaccatca aggaatctca
     2161 agtgcagaga ggaacaggac ttcccacgag ccatcgccac cgagcatcgg tgggaagcct
     2221 tgctcagtgt tggatttctg tctgctgttt gcactgcagc ccttcacgag cggagctgaa
     2281 aggggcagtc cacagaatag cgtgttgttc attaaagtct cgcaggcaag ttggccttga
     2341 ttctttgtac caaagctacg tagccactgt cttttggggg tggtggtggt gaatttgtat
     2401 agtgatttac catgatgttt cagctttata aatatgacac ttcactggtc cagctttttt
     2461 tggaaattgt tttacccaag agggtcttcc atgcaactga agaccttctt ctggcttgca
     2521 gcactgaaat gtttgggttg gttttggttt tttggttttg tttttttttt ttttttgggg
     2581 gggggggcgg ttagtgcttg cctggtggta gagaaattag ttccctgcct tttcacttgg
     2641 tgttgcgtac atgttttttt cctgcaagac agaggcatac ttaatggtcc acatggctca
     2701 ctagtccagt ctataatgca gcagtgcctt tggggactct tgaggaatgt caggctgcct
     2761 gtcccctttc tgaagacccc catgctgaaa gtgagtcctt gatgtgaatg gatctgtcct
     2821 ttgtgtgcag ctgtctcttt actgcctcgg ttccaagctg tctctatttt cagactgggg
     2881 cccctggtgt gctggattgt gggagtcaaa tgactgccat ctgtcaaagc tctgtctaag
     2941 ccacaataaa tcagtcctgt caaaagtg
//
