LOCUS       NM_001356324            4081 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus membrane protein, palmitoylated 2 (MAGUK p55 subfamily
            member 2) (Mpp2), transcript variant 1, mRNA.
ACCESSION   NM_001356324 XM_006533683
VERSION     NM_001356324.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4081)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4081)
  AUTHORS   Peng,X., Chen,P., Zhang,Y., Wu,K., Ji,N., Gao,J., Wang,H.,
            Zhang,Y.M., Xu,T. and Hua,R.
  TITLE     MPP2 interacts with SK2 to rescue the excitability of glutamatergic
            neurons in the BLA and facilitate the extinction of conditioned
            fear in mice
  JOURNAL   CNS Neurosci Ther 30 (1), e14362 (2024)
   PUBMED   37469037
  REMARK    GeneRIF: MPP2 interacts with SK2 to rescue the excitability of
            glutamatergic neurons in the BLA and facilitate the extinction of
            conditioned fear in mice.
REFERENCE   3  (bases 1 to 4081)
  AUTHORS   Yamada,T., Saitoh,Y., Kametani,K., Kamijo,A., Sakamoto,T. and
            Terada,N.
  TITLE     Involvement of membrane palmitoylated protein 2 (MPP2) in the
            synaptic molecular complex at the mouse cerebellar glomerulus
  JOURNAL   Histochem Cell Biol 158 (5), 497-511 (2022)
   PUBMED   35854144
  REMARK    GeneRIF: Involvement of membrane palmitoylated protein 2 (MPP2) in
            the synaptic molecular complex at the mouse cerebellar glomerulus.
REFERENCE   4  (bases 1 to 4081)
  AUTHORS   Kim,G., Lujan,R., Schwenk,J., Kelley,M.H., Aguado,C., Watanabe,M.,
            Fakler,B., Maylie,J. and Adelman,J.P.
  TITLE     Membrane palmitoylated protein 2 is a synaptic scaffold protein
            required for synaptic SK2-containing channel function
  JOURNAL   Elife 5, e12637 (2016)
   PUBMED   26880549
  REMARK    GeneRIF: Thus, MPP2 is a novel synaptic scaffold that is required
            for proper synaptic localization and function of SK2-containing
            channels.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4081)
  AUTHORS   Chen,N., Koopmans,F., Gordon,A., Paliukhovich,I., Klaassen,R.V.,
            van der Schors,R.C., Peles,E., Verhage,M., Smit,A.B. and Li,K.W.
  TITLE     Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the
            presence of two Caspr2 isoforms with overlapping interactomes
  JOURNAL   Biochim Biophys Acta 1854 (7), 827-833 (2015)
   PUBMED   25707359
REFERENCE   6  (bases 1 to 4081)
  AUTHORS   Karnak,D., Lee,S. and Margolis,B.
  TITLE     Identification of multiple binding partners for the amino-terminal
            domain of synapse-associated protein 97
  JOURNAL   J Biol Chem 277 (48), 46730-46735 (2002)
   PUBMED   12351654
REFERENCE   7  (bases 1 to 4081)
  AUTHORS   Pershouse,M., Li,J., Yang,C., Su,H., Brundage,E., Di,W.,
            Biggs,P.J., Bradley,A. and Chinault,A.C.
  TITLE     BAC contig from a 3-cM region of mouse chromosome 11 surrounding
            Brca1
  JOURNAL   Genomics 69 (1), 139-142 (2000)
   PUBMED   11013085
REFERENCE   8  (bases 1 to 4081)
  AUTHORS   Kamberov,E., Makarova,O., Roh,M., Liu,A., Karnak,D., Straight,S.
            and Margolis,B.
  TITLE     Molecular cloning and characterization of Pals, proteins associated
            with mLin-7
  JOURNAL   J Biol Chem 275 (15), 11425-11431 (2000)
   PUBMED   10753959
REFERENCE   9  (bases 1 to 4081)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   10 (bases 1 to 4081)
  AUTHORS   Elder,B., Kuo,K., Gitschier,J., Kim,A., Chishti,A. and
            Metzenberg,A.
  TITLE     cDNA sequence and genomic structure of the murine p55 (Mpp1) gene
  JOURNAL   Genomics 38 (2), 231-234 (1996)
   PUBMED   8954807
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591145.25.
            
            On Nov 16, 2022 this sequence version replaced NM_001356324.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141422.1, SRR17784643.281540.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               AL591145.25        128825-128975       c
            152-270             AL591145.25        127149-127267       c
            271-423             AL591145.25        111065-111217       c
            424-573             AL591145.25        110790-110939       c
            574-801             AL591145.25        109684-109911       c
            802-933             AL591145.25        108747-108878       c
            934-1039            AL591145.25        108551-108656       c
            1040-1108           AL591145.25        108397-108465       c
            1109-1270           AL591145.25        107992-108153       c
            1271-1473           AL591145.25        107263-107465       c
            1474-1602           AL591145.25        106917-107045       c
            1603-4081           AL591145.25        103511-105989       c
FEATURES             Location/Qualifiers
     source          1..4081
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 65.48 cM"
     gene            1..4081
                     /gene="Mpp2"
                     /gene_synonym="D11Bwg0652e; Dlg2; Dlgh2; Pals4"
                     /note="membrane protein, palmitoylated 2 (MAGUK p55
                     subfamily member 2)"
                     /db_xref="GeneID:50997"
                     /db_xref="MGI:MGI:1858257"
     exon            1..151
                     /gene="Mpp2"
                     /gene_synonym="D11Bwg0652e; Dlg2; Dlgh2; Pals4"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1779
                     /gene="Mpp2"
                     /gene_synonym="D11Bwg0652e; Dlg2; Dlgh2; Pals4"
                     /note="isoform 1 is encoded by transcript variant 1; p55
                     subfamily member of MAGUK family; MAGUK p55 subfamily
                     member 2; discs large homolog 2"
                     /codon_start=1
                     /product="MAGUK p55 subfamily member 2 isoform 1"
                     /protein_id="NP_001343253.1"
                     /db_xref="CCDS:CCDS88261.1"
                     /db_xref="GeneID:50997"
                     /db_xref="MGI:MGI:1858257"
                     /translation="MACSPGSEGSLEGISLGSSEEAELRREAMQQVLDNLGSLPNATG
                     AAELDLIFLRGIMESPIVRSLAKAHERLEETKLEAVRDNNLELVQEILRDLAELAEQS
                     STAAELARILQEPHFQSLLETHDSVASKTYETPPPSPGLDPTFSNQPVPPDAVRMVGI
                     RKTAGEHLGVTFRVEGGELVIARILHGGMVAQQGLLHVGDIIKEVNGQPVGSDPRALQ
                     ELLRSASGSVILKILPSYQEPHLPRQVFVKCHFDYDPARDSLSPCKEAGLRFNAGDLL
                     QIVNQDDANWWQACHVEGGSAGLIPSQLLEEKRKAFVKRDLELTPTSGTLCGSLSGKK
                     KKRMMYLTTKNAEFDRHELLIYEEVARMPPFRRKTLVLIGAQGVGRRSLKNKLILWDP
                     DRYGTTVPYTSRRPKDSEREGQGYSFVSRGEMEADIRAGRYLEHGEYEGNLYGTRIDS
                     IRGVVASGKVCVLDVNPQAVKVLRTAEFVPYVVFIEAPDYETLRAMNRAALESGVSTK
                     QLTEADLRRTVEESSRIQRGYGHYFDLSLVNSNLERTFRELQTAMEKLRTEPQWVPVS
                     WVY"
     exon            152..270
                     /gene="Mpp2"
                     /gene_synonym="D11Bwg0652e; Dlg2; Dlgh2; Pals4"
                     /inference="alignment:Splign:2.1.0"
     exon            271..423
                     /gene="Mpp2"
                     /gene_synonym="D11Bwg0652e; Dlg2; Dlgh2; Pals4"
                     /inference="alignment:Splign:2.1.0"
     exon            424..573
                     /gene="Mpp2"
                     /gene_synonym="D11Bwg0652e; Dlg2; Dlgh2; Pals4"
                     /inference="alignment:Splign:2.1.0"
     exon            574..801
                     /gene="Mpp2"
                     /gene_synonym="D11Bwg0652e; Dlg2; Dlgh2; Pals4"
                     /inference="alignment:Splign:2.1.0"
     exon            802..933
                     /gene="Mpp2"
                     /gene_synonym="D11Bwg0652e; Dlg2; Dlgh2; Pals4"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1039
                     /gene="Mpp2"
                     /gene_synonym="D11Bwg0652e; Dlg2; Dlgh2; Pals4"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1108
                     /gene="Mpp2"
                     /gene_synonym="D11Bwg0652e; Dlg2; Dlgh2; Pals4"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1270
                     /gene="Mpp2"
                     /gene_synonym="D11Bwg0652e; Dlg2; Dlgh2; Pals4"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1473
                     /gene="Mpp2"
                     /gene_synonym="D11Bwg0652e; Dlg2; Dlgh2; Pals4"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1602
                     /gene="Mpp2"
                     /gene_synonym="D11Bwg0652e; Dlg2; Dlgh2; Pals4"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..4081
                     /gene="Mpp2"
                     /gene_synonym="D11Bwg0652e; Dlg2; Dlgh2; Pals4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4060..4065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mpp2"
                     /gene_synonym="D11Bwg0652e; Dlg2; Dlgh2; Pals4"
                     /note="hexamer: ATTAAA"
     polyA_site      4079
                     /gene="Mpp2"
                     /gene_synonym="D11Bwg0652e; Dlg2; Dlgh2; Pals4"
                     /note="major polyA site"
ORIGIN      
        1 agcccgcgtc tggctgggaa ggcgcggacc tcgcagggag cctgttctag gattgccaaa
       61 ggggtcgcca tggcctgcag cccaggcagt gagggttcct tggaggggat ttccctaggc
      121 tcctccgaag aagcagagct ccgcagggaa gctatgcagc aagtcttgga caacctggga
      181 tccctgccca atgccactgg ggccgcggaa ctggacctga tctttcttcg aggcataatg
      241 gaaagtccga tagtcagatc cctggccaag gcccacgagc ggctggagga gacgaagttg
      301 gaggccgtcc gggataacaa cctggagctg gtgcaggaaa tccttcggga cctggcagag
      361 ctggcagagc agagcagcac cgctgcagag ctggcacgca tcctccagga gccccacttc
      421 cagtccctcc tggagacaca tgactcagtg gcttcaaaga cctatgagac accaccccca
      481 agcccaggcc tggatcccac gtttagcaac cagccagtac ctcctgatgc ggtgcgcatg
      541 gtgggcattc ggaagactgc aggagaacac ctgggtgtga cattccgagt ggagggtggt
      601 gagctggtga ttgcccgcat tctgcatggg ggcatggtgg ctcagcaagg tctgctgcat
      661 gtcggtgaca tcatcaagga agtgaatgga cagccagtgg gcagcgatcc ccgggcactg
      721 caggagctcc tgcgcagtgc cagtggcagt gtcatcctca agatcttgcc cagctaccag
      781 gaaccccacc tgccccgaca ggtatttgtt aaatgccact tcgactatga ccctgcccgg
      841 gacagtctca gcccctgcaa ggaggcaggc ctgcgcttca acgcggggga cttgctccag
      901 attgtaaacc aagatgatgc caactggtgg caggcatgcc acgtagaagg cggcagtgcc
      961 ggcctcatcc ccagccagct gttggaggag aaacggaaag catttgtcaa gcgggacctg
     1021 gaactgaccc cgacctcagg gaccctatgc ggcagccttt caggaaagaa aaagaagcga
     1081 atgatgtatt tgaccaccaa gaatgcagag tttgaccgcc atgagctgct catttatgag
     1141 gaggtggccc gcatgccccc attccgcagg aaaaccctgg tactgattgg cgcgcagggt
     1201 gtgggccggc gcagcctgaa aaacaagctc attttgtggg atccagaccg ctacggcacc
     1261 acggtgccct acacatcacg gaggcccaag gactcagaac gggaggggca gggctacagc
     1321 tttgtgtccc gtggggagat ggaggctgac atccgagccg ggcgctacct agaacatggc
     1381 gagtatgagg gcaacctgta tggcacacgg atcgactcca tccggggcgt tgttgcctct
     1441 ggcaaggtgt gcgtgctgga tgtcaacccg caggcggtga aggtcctgag gacagctgag
     1501 tttgtccctt acgtggtgtt catagaggct cctgattatg agactctacg ggccatgaac
     1561 cgggctgcgc tggagagtgg cgtgtccact aagcagttga cggaggcaga tctgaggcgg
     1621 acagtggagg agagcagccg catccagagg ggctatgggc attacttcga cctcagcctg
     1681 gtcaacagca acctggagag gaccttccgt gagctccaga ctgccatgga gaaacttcgc
     1741 acggagcccc agtgggtgcc tgtgagctgg gtgtactgag gcttgctctg gaccttgtta
     1801 ctgcctggtt gggaatccaa cttccactcc acctgcgatg ctcccccatc ctgctaatgg
     1861 tcttcgtccc catctctggt tttccctgga ctgcagttcc cagcaagggc tggcttcagt
     1921 ataggggtgt gcactgccag ggaggtaggt gttcatgggg tacctctgta cccaggtgct
     1981 gcccactccc cgtgtctacc ggccaccaga cacccttttc taaggatcat gctgtgtcta
     2041 ggagtgtctc agatcactcc tgtaattccc agtccaggga agagcagagc tgcttgggac
     2101 cttgtggtca ggaggttcgt gacactgcca gccttttcct cctctggact ggccacaacc
     2161 aacctgttcc ctggcccctc ccacccctta ccatagtcct aggaacagcc ttgggctgtt
     2221 ctcatatggc caggtactca gaccactggt agctaggcag acccaggtaa tagtgccagc
     2281 ctgggccatg ttagaggctg gggtcacccc gtcatgagcc agttgctgca gctggcgatg
     2341 caggtctcag ctccgtgagg agcaaacata gtctgttccc tccctcactc caagcttctc
     2401 actgccaaag tctctccaca gactttctca atgtgtctct cttgtaagcc ctgctcctca
     2461 gacttgcggc tggtgggtag cagtaggact cagcccaggt tgacgatagg gcctagagag
     2521 ctgaaccctc tattgttggg acccaaagta cccccaggct ccacagcccg cagcaggttt
     2581 tattcacttc aggcttttct ctggatggat ctgggtgaac cgctggcatt agggcttatg
     2641 aggggcgggg agactgtgag tgggggcttg gaaacagatt agctttagtg gcacttgcca
     2701 cacagctcca gggggtacca ttggcactgc aggctgggca gtctgtggca ctgcctgctg
     2761 tggtgctggt ctgtgtttct ggccttggtg tgtgtgtgtg tgtgtgtgtg tcgcacatgc
     2821 acacatttgg ttgagtttga ggggggtcag aggattgcct tctcttggag gtggctcttt
     2881 gaggttccct tatgggttcc cctcaactcc accatttctt acaacccccc attccagact
     2941 ccagagcctg aatcttcctc tactctccca tcttcccttg tcctcagtac cagcctttag
     3001 cccttgggga gggtgatttt tgtaagatag gataatcctt ctaagaaccc catccatgac
     3061 atctggagac atttcattcc tcattcttga ggggccccat gtcctcacag gagacccccc
     3121 ttggcacctc catcctgtgc ctcccagttc tcccaagcgt caatctttgc tgcactgtca
     3181 gcccaagctt gtccctgaac cactgtgtgc ccatatccta gagaagggga gggagggaga
     3241 atagacagaa tatttattac aaatgctaga aatatattta ttatattagg aatctcattt
     3301 gcattggcat cggatgtgca gacgagacta aaggtgggac cccccgcccg ctgctcattt
     3361 gcatagctct gctagcacct acctgtggtt tatcctttag tcaatcaatg tcctttcctt
     3421 caatatcttg ctgtgacccc tgacccttac ttagccaaag gggactgccc tccttgccag
     3481 ttccttcctc ccctggagga tgagcgcagg ctcagaaaag catctgtgac agcccccgac
     3541 cccccttgat taaccgacag agttccccaa ccaaaagacc acggcctctg atagagatct
     3601 ggtgggcgcc atgctggaga gttggtacta gttcctccct ggatttatac tggaggtatt
     3661 tatccagtgt ggtatcaacc cccacatcct cctctctagt aatgtacaag ggcccctcct
     3721 ctctgaacag cctcctacct ctctctccca ctgagcctgg ctctacaacc cgtccatgca
     3781 ctggccaggg gggaacagag gctgtgagcc tcctcagctc accttgcacg tgttagaaca
     3841 tgttcgtgcc caccaagcta gctcactctg tgactctgtc gtctctctct ccctcccacc
     3901 gtggcctctt gtatttgggg acctcaggag gaggaggagg aggaggaccc tgccgcccct
     3961 gccatggtcc acactcaatc ccagcccgtt gctgtccctc tgtctccccc actccccacc
     4021 cccagccatc tagtttttaa gttttcttct tttcctttga ttaaacgtga cagcaagtgt
     4081 t
//
