LOCUS       NM_008621               2525 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus membrane protein, palmitoylated (Mpp1), mRNA.
ACCESSION   NM_008621
VERSION     NM_008621.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2525)
  AUTHORS   Mburu,P., Romero,M.R., Hilton,H., Parker,A., Townsend,S.,
            Kikkawa,Y. and Brown,S.D.
  TITLE     Gelsolin plays a role in the actin polymerization complex of hair
            cell stereocilia
  JOURNAL   PLoS One 5 (7), e11627 (2010)
   PUBMED   20661277
  REMARK    GeneRIF: Gelsolin was identified as the additional interacting
            partners to p55 in the whirlin interactome of hair cell
            stereocilia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2525)
  AUTHORS   Quinn,B.J., Welch,E.J., Kim,A.C., Lokuta,M.A., Huttenlocher,A.,
            Khan,A.A., Kuchay,S.M. and Chishti,A.H.
  TITLE     Erythrocyte scaffolding protein p55/MPP1 functions as an essential
            regulator of neutrophil polarity
  JOURNAL   Proc Natl Acad Sci U S A 106 (47), 19842-19847 (2009)
   PUBMED   19897731
  REMARK    GeneRIF: Results show that p55 is required for neutrophil
            polarization by regulating Akt phosphorylation through a mechanism
            that is independent of PI3Kgamma activity.
REFERENCE   3  (bases 1 to 2525)
  AUTHORS   Seo,P.S., Quinn,B.J., Khan,A.A., Zeng,L., Takoudis,C.G., Hanada,T.,
            Bolis,A., Bolino,A. and Chishti,A.H.
  TITLE     Identification of erythrocyte p55/MPP1 as a binding partner of NF2
            tumor suppressor protein/Merlin
  JOURNAL   Exp Biol Med (Maywood) 234 (3), 255-262 (2009)
   PUBMED   19144871
REFERENCE   4  (bases 1 to 2525)
  AUTHORS   Robledo,R.F., Ciciotte,S.L., Gwynn,B., Sahr,K.E., Gilligan,D.M.,
            Mohandas,N. and Peters,L.L.
  TITLE     Targeted deletion of alpha-adducin results in absent beta- and
            gamma-adducin, compensated hemolytic anemia, and lethal
            hydrocephalus in mice
  JOURNAL   Blood 112 (10), 4298-4307 (2008)
   PUBMED   18723693
REFERENCE   5  (bases 1 to 2525)
  AUTHORS   Terada,N., Ohno,N., Saitoh,S., Seki,G., Komada,M., Suzuki,T.,
            Yamakawa,H., Soleimani,M. and Ohno,S.
  TITLE     Interaction of membrane skeletal protein, protein 4.1B and p55, and
            sodium bicarbonate cotransporter1 in mouse renal S1-S2 proximal
            tubules
  JOURNAL   J Histochem Cytochem 55 (12), 1199-1206 (2007)
   PUBMED   17712176
REFERENCE   6  (bases 1 to 2525)
  AUTHORS   Gosens,I., van Wijk,E., Kersten,F.F., Krieger,E., van der Zwaag,B.,
            Marker,T., Letteboer,S.J., Dusseljee,S., Peters,T.,
            Spierenburg,H.A., Punte,I.M., Wolfrum,U., Cremers,F.P., Kremer,H.
            and Roepman,R.
  TITLE     MPP1 links the Usher protein network and the Crumbs protein complex
            in the retina
  JOURNAL   Hum Mol Genet 16 (16), 1993-2003 (2007)
   PUBMED   17584769
REFERENCE   7  (bases 1 to 2525)
  AUTHORS   Mburu,P., Kikkawa,Y., Townsend,S., Romero,R., Yonekawa,H. and
            Brown,S.D.
  TITLE     Whirlin complexes with p55 at the stereocilia tip during hair cell
            development
  JOURNAL   Proc Natl Acad Sci U S A 103 (29), 10973-10978 (2006)
   PUBMED   16829577
REFERENCE   8  (bases 1 to 2525)
  AUTHORS   Elder,B., Kuo,K., Gitschier,J., Kim,A., Chishti,A. and
            Metzenberg,A.
  TITLE     cDNA sequence and genomic structure of the murine p55 (Mpp1) gene
  JOURNAL   Genomics 38 (2), 231-234 (1996)
   PUBMED   8954807
REFERENCE   9  (bases 1 to 2525)
  AUTHORS   Peters,L.L., Kirley,L.A., Kim,A.C. and Chishti,A.H.
  TITLE     Localization of the gene encoding the erythrocyte membrane protein
            p55 (Mpp1) on the mouse X Chromosome
  JOURNAL   Mamm Genome 7 (3), 245-246 (1996)
   PUBMED   8833260
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK048532.1 and AK081829.1.
            
            On May 9, 2015 this sequence version replaced NM_008621.2.
            
            Summary: This gene encodes a protein localized to the cell
            membrane. The protein serves as a scaffold for the assembly of the
            actin cytoskeleton, and plays a role in regulating apico-basal cell
            polarity. [provided by RefSeq, May 2015].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081829.1, BC138314.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AK048532.1         2-68
            68-2525             AK081829.1         1-2458
FEATURES             Location/Qualifiers
     source          1..2525
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 38.15 cM"
     gene            1..2525
                     /gene="Mpp1"
                     /gene_synonym="55kDa; C130070C03Rik; p55"
                     /note="membrane protein, palmitoylated"
                     /db_xref="GeneID:17524"
                     /db_xref="MGI:MGI:105941"
     exon            1..292
                     /gene="Mpp1"
                     /gene_synonym="55kDa; C130070C03Rik; p55"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1591
                     /gene="Mpp1"
                     /gene_synonym="55kDa; C130070C03Rik; p55"
                     /note="membrane protein, palmitoylated 1; erythrocyte
                     protein p55"
                     /codon_start=1
                     /product="55 kDa erythrocyte membrane protein"
                     /protein_id="NP_032647.1"
                     /db_xref="CCDS:CCDS30236.1"
                     /db_xref="GeneID:17524"
                     /db_xref="MGI:MGI:105941"
                     /translation="MTLKSSEGEGGNSMRTALSDLYLEHLLQKRNRPETSLNQSNVTT
                     EDMYTNGSPAPGSPAHAKGQEARRVRLIQFEKITEEPMGITLKLNEKQSCTVARILHG
                     GMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKVIANQQSRLPALQ
                     MFMRAQFDYDPQKDNLIPCKEAGLKFVTGDIIQIINKDDSNWWQGRVEGSSKESAGLI
                     PSPELQEWRVASVAHSAPSEAPSCSPFGKKKKCKDKYLAKHSSIFDQLDVVSYEEVVR
                     LPAFKRKTLVLIGASGVGRSHIKNGLLSHNPEKFAYPAPYTTRPPKKSEEDGKEYHFI
                     STEEMTKNISANEFLEFGSYQGNMFGTKFETVHQIHKQDKIAILDIEPQTLKTVRTAE
                     LSPFIVFIAPTDQGTQTEALQQLQKDSEAIRSQYAHYFDLSLVNNSVDETLKKLQEAF
                     DQACSSPQWVPVSWVY"
     exon            293..436
                     /gene="Mpp1"
                     /gene_synonym="55kDa; C130070C03Rik; p55"
                     /inference="alignment:Splign:2.1.0"
     exon            437..515
                     /gene="Mpp1"
                     /gene_synonym="55kDa; C130070C03Rik; p55"
                     /inference="alignment:Splign:2.1.0"
     exon            516..601
                     /gene="Mpp1"
                     /gene_synonym="55kDa; C130070C03Rik; p55"
                     /inference="alignment:Splign:2.1.0"
     exon            602..670
                     /gene="Mpp1"
                     /gene_synonym="55kDa; C130070C03Rik; p55"
                     /inference="alignment:Splign:2.1.0"
     exon            671..867
                     /gene="Mpp1"
                     /gene_synonym="55kDa; C130070C03Rik; p55"
                     /inference="alignment:Splign:2.1.0"
     exon            868..974
                     /gene="Mpp1"
                     /gene_synonym="55kDa; C130070C03Rik; p55"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1055
                     /gene="Mpp1"
                     /gene_synonym="55kDa; C130070C03Rik; p55"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1136
                     /gene="Mpp1"
                     /gene_synonym="55kDa; C130070C03Rik; p55"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1339
                     /gene="Mpp1"
                     /gene_synonym="55kDa; C130070C03Rik; p55"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1414
                     /gene="Mpp1"
                     /gene_synonym="55kDa; C130070C03Rik; p55"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..2525
                     /gene="Mpp1"
                     /gene_synonym="55kDa; C130070C03Rik; p55"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1959..1964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mpp1"
                     /gene_synonym="55kDa; C130070C03Rik; p55"
                     /note="hexamer: AATAAA"
     polyA_site      1984
                     /gene="Mpp1"
                     /gene_synonym="55kDa; C130070C03Rik; p55"
                     /note="major polyA site"
     regulatory      2504..2509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mpp1"
                     /gene_synonym="55kDa; C130070C03Rik; p55"
                     /note="hexamer: AATAAA"
     polyA_site      2521
                     /gene="Mpp1"
                     /gene_synonym="55kDa; C130070C03Rik; p55"
ORIGIN      
        1 agggtggaga gtaggcggag cgtgggtact gctctgcttg gccctcctgg ctctcagcgc
       61 agctcttgat ccctgcctcc tccgccgcct tagtctagct cgtctctgaa caggccgcag
      121 ttccccgatt tgcgattcct gggctcaaag ctctgcggct actgcgtctg gttgtctctg
      181 ctcctgagag atgacgctca agtcgagcga aggcgaggga gggaacagca tgcgcaccgc
      241 actttcggac ctctacctgg agcacttact acagaagcgt aaccgacctg agacttcatt
      301 gaaccagtca aatgttacta ctgaggacat gtacaccaat gggtcccctg ctccaggtag
      361 ccctgcccat gccaaaggtc aggaggctcg gagagttcgt ctcatacaat ttgagaagat
      421 cacagaagag cccatgggga tcactttgaa gctgaatgaa aaacagtcgt gtaccgtggc
      481 cagaattctc catggcggca tgattcatag acaaggctcc cttcatgttg gggatgagat
      541 cctagaaatc aatggcacaa atgtgactaa tcactcagta gatcagttgc agaaggcaat
      601 gaaggaaacc aaaggaatga tctcattaaa agtcattgct aatcagcaga gtcgccttcc
      661 tgcgctacag atgttcatga gagcacagtt tgactatgat ccccaaaagg acaaccttat
      721 tccttgcaag gaggcaggac tgaagtttgt tactggagac attatccaga taatcaacaa
      781 agatgacagc aattggtggc aggggcgggt ggagggctcc tccaaagagt ctgcaggatt
      841 aatcccttct cctgagctac aggaatggag agtggcaagc gtggctcact ctgctccaag
      901 tgaagcacca agttgcagtc cctttgggaa gaagaagaag tgtaaagaca agtacctggc
      961 taagcacagt tccatttttg accagttgga tgttgtttcc tatgaggaag ttgttcggct
     1021 ccctgcattc aagaggaaga ccttggtgtt gatcggagcc agtggggtgg gtcgtagcca
     1081 tattaagaat ggtctgctca gtcacaatcc agagaagttt gcgtaccctg ccccatatac
     1141 aacacggcca ccaaagaaga gtgaggaaga tgggaaggag tatcatttca tctcaacaga
     1201 ggagatgacg aagaacatct ctgccaatga gttcttggag tttggcagct atcagggcaa
     1261 catgtttggc accaaatttg aaacagtgca ccagattcat aagcaggaca agattgccat
     1321 ccttgacatt gagccccaga ccctaaagac tgttcggaca gctgagcttt cacctttcat
     1381 tgtgttcatc gcacctactg accagggcac tcagactgaa gccctgcagc agctgcagaa
     1441 ggactctgag gccatccgta gtcagtatgc tcattacttt gacctctctt tggtgaataa
     1501 tagtgttgat gaaactctta agaaattgca agaagccttt gaccaggctt gcagttctcc
     1561 acagtgggtg cctgtctcct gggtttacta agcttacaga attggcaaac atgtttcagc
     1621 cagcatttgg aatgccacct ccccgcaccc cctcccttgc ttaagccaaa agggttgctt
     1681 caacttttag ctctgctgtt ttcttactca ggctcctaaa ggggtgaagc tttcctacta
     1741 tctacatttc aaaatgatct ctggaaaatt gccataagaa taaccaaatg caatgctaca
     1801 tagataaacc aactgtcccc ctgaagcctg agctcctttg ctttcaacta tagaatgtct
     1861 ttttactctg gaataaatat cttctgaaaa ctttctaaaa tgccaaaatc aaacagctgt
     1921 gcaatagaat gtctgctgta gggaaaatct tccaaagcaa taaaaatgct gctgtgttaa
     1981 agtacccgtg accctgtaac tccattccca atcttaacct tccaagcaat gacattaaca
     2041 taagatctct gggaattacc tgtcactgcc tctataggtc tggtattcac aatgcacaaa
     2101 ggcgtcttct ctaggacttg ttaagtcgta agagaatggt ttaaaacatg ttacaaaagc
     2161 aggggctgtt tgggcattct atacctgcct atgctattaa caatttcccc taaaacttgt
     2221 gtttatattc ttggttttgg gcacatattt aagcaaagtt ccctgctccc tctgcagtca
     2281 acaccaaaac tggcagtttc ctacctggag tacctccaac ctcttcacaa gcccagtaca
     2341 atataaatgc atctacccct ttcctcttaa ccctggatta gtaatgatct cccttgagag
     2401 cagataggcc ccagtgccaa tgtaagaaag actcagaatt aggaaattta aaagtagcca
     2461 aaggaaaagc aaattcaaaa taggacataa acctcagact tttaataaaa atattctctc
     2521 acttt
//
