LOCUS       NM_010824               2570 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus myeloperoxidase (Mpo), mRNA.
ACCESSION   NM_010824
VERSION     NM_010824.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2570)
  AUTHORS   Ko,K., Choi,S., Jo,M., Kim,C., Boonpraman,N., Youm,J. and Yi,S.S.
  TITLE     NOX4 and its association with myeloperoxidase and osteopontin in
            regulating endochondral ossification
  JOURNAL   J Vet Sci 25 (4), e49 (2024)
   PUBMED   38910308
  REMARK    GeneRIF: NOX4 and its association with myeloperoxidase and
            osteopontin in regulating endochondral ossification.
REFERENCE   2  (bases 1 to 2570)
  AUTHORS   Zhang,J., Han,Y., Jia,R., Zhu,Q., Wang,X., Liu,M. and Zhang,W.
  TITLE     Exploring the role of myeloperoxidase in the atherosclerotic
            process in hypoxic mice based on the MAPK signaling pathway
  JOURNAL   Biochem Pharmacol 225, 116275 (2024)
   PUBMED   38729447
  REMARK    GeneRIF: Exploring the role of myeloperoxidase in the
            atherosclerotic process in hypoxic mice based on the MAPK signaling
            pathway.
REFERENCE   3  (bases 1 to 2570)
  AUTHORS   Peters,V.B.M., Matheis,F., Erdmann,I., Nemade,H.N., Muders,D.,
            Toubartz,M., Torun,M., Mehrkens,D., Geissen,S., Nettersheim,F.S.,
            Picard,F., Guthoff,H., Hof,A., Arkenberg,P., Arand,B., Klinke,A.,
            Rudolph,V., Hansen,H.P., Bachurski,D., Adam,M., Hoyer,F.F.,
            Winkels,H., Baldus,S. and Mollenhauer,M.
  TITLE     Myeloperoxidase induces monocyte migration and activation after
            acute myocardial infarction
  JOURNAL   Front Immunol 15, 1360700 (2024)
   PUBMED   38736886
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2570)
  AUTHORS   Zhang,H., Wang,X., Liu,J., Zhang,Y., Ka,M., Ma,Y., Xu,J. and
            Zhang,W.
  TITLE     Role of neutrophil myeloperoxidase in the development and
            progression of high-altitude pulmonary edema
  JOURNAL   Biochem Biophys Res Commun 703, 149681 (2024)
   PUBMED   38382360
  REMARK    GeneRIF: Role of neutrophil myeloperoxidase in the development and
            progression of high-altitude pulmonary edema.
            Erratum:[Biochem Biophys Res Commun. 2024 Sep 24;726:150300. doi:
            10.1016/j.bbrc.2024.150300.. PMID: 38936247]
REFERENCE   5  (bases 1 to 2570)
  AUTHORS   Basnet,A., Landreth,K.M., Nohoesu,R., Santiago,S.P.,
            Geldenhuys,W.J., Boone,B.A. and Liu,T.W.
  TITLE     Targeting myeloperoxidase limits myeloid cell immunosuppression
            enhancing immune checkpoint therapy for pancreatic cancer
  JOURNAL   Cancer Immunol Immunother 73 (3), 57 (2024)
   PUBMED   38367056
  REMARK    GeneRIF: Targeting myeloperoxidase limits myeloid cell
            immunosuppression enhancing immune checkpoint therapy for
            pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2570)
  AUTHORS   Takahashi,Y., Shimizu,A., Sakai,T., Endo,Y., Osawa,N., Shisa,H. and
            Honjo,T.
  TITLE     Mapping of the nu gene using congenic nude strains and in situ
            hybridization
  JOURNAL   J Exp Med 175 (3), 873-876 (1992)
   PUBMED   1346798
REFERENCE   7  (bases 1 to 2570)
  AUTHORS   Todd,J.A., Aitman,T.J., Cornall,R.J., Ghosh,S., Hall,J.R.,
            Hearne,C.M., Knight,A.M., Love,J.M., McAleer,M.A., Prins,J.B. et
            al.
  TITLE     Genetic analysis of autoimmune type 1 diabetes mellitus in mice
  JOURNAL   Nature 351 (6327), 542-547 (1991)
   PUBMED   1675432
REFERENCE   8  (bases 1 to 2570)
  AUTHORS   Hearne,C.M., McAleer,M.A., Love,J.M., Aitman,T.J., Cornall,R.J.,
            Ghosh,S., Knight,A.M., Prins,J.B. and Todd,J.A.
  TITLE     Additional microsatellite markers for mouse genome mapping
  JOURNAL   Mamm Genome 1 (4), 273-282 (1991)
   PUBMED   1794058
REFERENCE   9  (bases 1 to 2570)
  AUTHORS   Robinson,T.J., Morris,D.J. and Ledbetter,D.H.
  TITLE     Chromosomal assignment and regional localization of myeloperoxidase
            in the mouse
  JOURNAL   Cytogenet Cell Genet 53 (2-3), 83-86 (1990)
   PUBMED   2164461
REFERENCE   10 (bases 1 to 2570)
  AUTHORS   Venturelli,D., Shirsat,N., Gemperlein,I., Bittenbender,S.,
            Hudson,S. and Rovera,G.
  TITLE     Nucleotide sequence of cDNA for murine myeloperoxidase
  JOURNAL   Nucleic Acids Res 17 (14), 5852 (1989)
   PUBMED   2548170
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY352425.1, CA547566.1, CN661559.1, BC053912.1 and AK220229.1.
            
            On Apr 15, 2009 this sequence version replaced NM_010824.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X15313.1, AK160229.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                BY352425.1         103-148
            47-492              CA547566.1         1-446
            493-1004            CN661559.1         175-686
            1005-2348           BC053912.1         725-2068
            2349-2545           AK220229.1         2122-2318
            2546-2570           BC053912.1         2266-2290
FEATURES             Location/Qualifiers
     source          1..2570
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6NCrl"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 52.22 cM"
     gene            1..2570
                     /gene="Mpo"
                     /gene_synonym="mKIAA4033"
                     /note="myeloperoxidase"
                     /db_xref="GeneID:17523"
                     /db_xref="MGI:MGI:97137"
     exon            1..292
                     /gene="Mpo"
                     /gene_synonym="mKIAA4033"
                     /inference="alignment:Splign:2.1.0"
     exon            293..370
                     /gene="Mpo"
                     /gene_synonym="mKIAA4033"
                     /inference="alignment:Splign:2.1.0"
     CDS             295..2451
                     /gene="Mpo"
                     /gene_synonym="mKIAA4033"
                     /EC_number="1.11.2.2"
                     /codon_start=1
                     /product="myeloperoxidase precursor"
                     /protein_id="NP_034954.2"
                     /db_xref="CCDS:CCDS25217.1"
                     /db_xref="GeneID:17523"
                     /db_xref="MGI:MGI:97137"
                     /translation="MKLLLALAGLLAPLAMLQTSNGATPALLGEVENSVVLSCMEEAK
                     QLVDRAYKERRESIKRSLQSGSASPTELLFYFKQPVAGTRTAVRAADYLHVALDLLKR
                     KLQPLWPRPFNVTDVLTPAQLNLLSVSSGCAYQDVRVTCPPNDKYRTITGHCNNRRSP
                     TLGASNRAFVRWLPAEYEDGVSMPFGWTPGVNRNGFKVPLARQVSNAIVRFPNDQLTK
                     DQERALMFMQWGQFLDHDITLTPEPATRFSFFTGLNCETSCLQQPPCFPLKIPPNDPR
                     IKNQKDCIPFFRSCPACTRNNITIRNQINALTSFVDASGVYGSEDPLARKLRNLTNQL
                     GLLAINTRFQDNGRALMPFDSLHDDPCLLTNRSARIPCFLAGDMRSSEMPELTSMHTL
                     FVREHNRLATQLKRLNPRWNGEKLYQEARKIVGAMVQIITYRDYLPLVLGPAAMKKYL
                     PQYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLNNQYRPTGPNPRVPLSKVFFAS
                     WRVVLEGGIDPILRGLMATPAKLNRQNQIVVDEIRERLFEQVMRIGLDLPALNMQRSR
                     DHGLPGYNAWRRFCGLPQPSTVGELGTVLKNLELARKLMAQYGTPNNIDIWMGGVSEP
                     LEPNGRVGQLLACLIGTQFRKLRDGDRFWWENPGVFSKQQRQALASISLPRIICDNTG
                     ITTVSKNNIFMSNTYPRDFVSCNTLPKLNLTSWKET"
     exon            371..464
                     /gene="Mpo"
                     /gene_synonym="mKIAA4033"
                     /inference="alignment:Splign:2.1.0"
     exon            465..640
                     /gene="Mpo"
                     /gene_synonym="mKIAA4033"
                     /inference="alignment:Splign:2.1.0"
     exon            641..764
                     /gene="Mpo"
                     /gene_synonym="mKIAA4033"
                     /inference="alignment:Splign:2.1.0"
     exon            765..894
                     /gene="Mpo"
                     /gene_synonym="mKIAA4033"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1101
                     /gene="Mpo"
                     /gene_synonym="mKIAA4033"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1420
                     /gene="Mpo"
                     /gene_synonym="mKIAA4033"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1581
                     /gene="Mpo"
                     /gene_synonym="mKIAA4033"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1837
                     /gene="Mpo"
                     /gene_synonym="mKIAA4033"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..2008
                     /gene="Mpo"
                     /gene_synonym="mKIAA4033"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2246
                     /gene="Mpo"
                     /gene_synonym="mKIAA4033"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2458
                     /gene="Mpo"
                     /gene_synonym="mKIAA4033"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2546
                     /gene="Mpo"
                     /gene_synonym="mKIAA4033"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2525..2530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mpo"
                     /gene_synonym="mKIAA4033"
                     /note="hexamer: AATAAA"
     polyA_site      2546
                     /gene="Mpo"
                     /gene_synonym="mKIAA4033"
                     /note="major polyA site"
ORIGIN      
        1 ataacttctc agctttagct ccctgaattt tggttctttc aaaggatttg ggacactcag
       61 tttaaccaac actttgaggg gctggttgtt tgtgctctcc gggagaagct ctgatccatt
      121 cctttgtcca cccctccttc ttcatagacc cctttctgtg cacccctaac cccagtgggg
      181 gaggagagtc tagtcttggg ataggtccat ctctttttag gtcagcccgc ccccagcttt
      241 tacaccccag gcataaaaac ccgttgtcag tgagaggagt tgacagtgtc agagatgaag
      301 ctactcttgg ccttggcagg cctcctggcc cctctggcca tgcttcagac ctccaatggt
      361 gccaccccag ctctcctggg ggaagtggag aattcagttg tgctgagctg tatggaagag
      421 gccaagcagc tagtggacag agcctacaag gagcggagag aaagcatcaa gcggagcctc
      481 caaagcggct ctgccagccc cacggagctc ctgttttact tcaagcagcc ggtggcgggc
      541 accagaacag ctgtgagggc cgctgattat ctacatgtgg ccctagacct gctgaagagg
      601 aagctgcagc ccctgtggcc aaggcctttc aatgttacag atgtgttgac acctgctcag
      661 ctgaatctgt tgtccgtgtc aagtggctgt gcctatcagg acgtgagggt gacatgccca
      721 ccgaatgaca agtatcgcac catcactgga cactgcaaca acagacgaag ccccactctg
      781 ggggcctcca accgtgcctt tgtacgctgg ttgcctgcag agtatgaaga tggcgtctcc
      841 atgccctttg gctggacgcc tggagtcaat cgcaatggct tcaaggtgcc cctggctcgc
      901 caggtctcca atgccatcgt gcgcttcccc aacgatcagc tgaccaagga ccaggagcgt
      961 gcactcatgt tcatgcagtg gggacagttt ctggatcatg atatcacctt gactccagag
     1021 ccagctaccc ggttctcctt cttcactggc ctcaactgcg agaccagctg cctgcagcag
     1081 ccaccctgct tccccctcaa gatcccaccc aatgaccctc gaatcaagaa ccaaaaggac
     1141 tgcatcccct tcttccgctc ctgcccggca tgcaccagga acaacatcac cattcgcaac
     1201 cagatcaacg cgctcacttc cttcgtggac gccagcgggg tgtacggcag cgaggacccc
     1261 ctagccagaa agctgcgcaa cctcaccaac cagctggggc tgctggctat caatacacgc
     1321 ttccaagaca atggcagggc cctgatgccc tttgacagcc tgcacgatga cccctgcctc
     1381 ctcaccaacc gctccgcccg cattccttgt tttctggcag gggacatgcg ctccagcgag
     1441 atgccggagc tcacctccat gcacaccctc tttgttcgag agcataaccg gctggccaca
     1501 cagctcaagc gcctgaatcc tcgatggaat ggggagaagc tctaccagga ggcccggaag
     1561 attgtagggg ccatggtcca gatcatcaca taccgggact acctgccctt ggtgttgggg
     1621 ccagcagcca tgaagaagta cctaccccag taccgatctt acaacgactc agtagaccct
     1681 cgaatcgcca atgtcttcac caacgctttc cgttatggcc acaccctcat ccaacccttc
     1741 atgttccgcc tgaacaatca gtaccggccc acagggccca acccccgagt cccactcagc
     1801 aaggtctttt ttgccagctg gagagtcgtg ttggaaggtg gcattgaccc catcctccga
     1861 ggcctcatgg ccactccagc caaactgaat cgccagaatc aaattgtggt ggatgagatc
     1921 cgggagcgac tatttgagca agtcatgagg ataggactgg atttgcctgc tcttaacatg
     1981 cagcgcagcc gggatcacgg cctcccagga tacaatgcct ggagacgctt ttgtgggctt
     2041 ccacagccca gcacagtggg tgagctcggc acggtgctga agaacctgga gttggcacgg
     2101 aagctgatgg cacaatatgg cacgcccaac aacattgaca tctggatggg cggtgtgtcc
     2161 gagcccctgg agcccaatgg ccgtgtaggc cagctccttg cctgcctcat tggcactcag
     2221 tttaggaagc tacgtgatgg tgatcggttt tggtgggaga acccaggcgt gttcagtaaa
     2281 cagcagagac aggccttggc cagcatctcc ttgccccgta tcatctgtga caacactggc
     2341 atcaccaccg tgtcgaagaa caacatcttc atgtccaaca catacccccg agactttgtc
     2401 agctgtaaca cccttcctaa actgaacctg acttcctgga aggagaccta gaggttggga
     2461 gtctgccggg agaaggacgg aggccattgg ccttcctgtg ctatttgtac ctgaggttca
     2521 cactaataaa acatggtgga tggggaaaaa aaaaaaaaaa aaaaaaaaaa
//
