LOCUS       NM_025479               2679 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus M-phase specific PLK1 intereacting protein (Mplkip),
            mRNA.
ACCESSION   NM_025479
VERSION     NM_025479.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2679)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2679)
  AUTHORS   Townley,B.A., Buerer,L., Tsao,N., Bacolla,A., Mansoori,F.,
            Rusanov,T., Clark,N., Goodarzi,N., Schmidt,N., Srivatsan,S.N.,
            Sun,H., Sample,R.A., Brickner,J.R., McDonald,D., Tsai,M.S.,
            Walter,M.J., Wozniak,D.F., Holehouse,A.S., Pena,V., Tainer,J.A.,
            Fairbrother,W.G. and Mosammaparast,N.
  TITLE     A functional link between lariat debranching enzyme and the
            intron-binding complex is defective in non-photosensitive
            trichothiodystrophy
  JOURNAL   Mol Cell 83 (13), 2258-2275 (2023)
   PUBMED   37369199
REFERENCE   3  (bases 1 to 2679)
  AUTHORS   King,R., Struebing,F.L., Li,Y., Wang,J., Koch,A.A., Cooke
            Bailey,J.N., Gharahkhani,P., MacGregor,S., Allingham,R.R.,
            Hauser,M.A., Wiggs,J.L. and Geisert,E.E.
  CONSRTM   International Glaucoma Genetics Consortium; NEIGHBORHOOD Consortium
  TITLE     Genomic locus modulating corneal thickness in the mouse identifies
            POU6F2 as a potential risk of developing glaucoma
  JOURNAL   PLoS Genet 14 (1), e1007145 (2018)
   PUBMED   29370175
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2679)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 2679)
  AUTHORS   Nakabayashi,K., Amann,D., Ren,Y., Saarialho-Kere,U., Avidan,N.,
            Gentles,S., MacDonald,J.R., Puffenberger,E.G., Christiano,A.M.,
            Martinez-Mir,A., Salas-Alanis,J.C., Rizzo,R., Vamos,E., Raams,A.,
            Les,C., Seboun,E., Jaspers,N.G., Beckmann,J.S., Jackson,C.E. and
            Scherer,S.W.
  TITLE     Identification of C7orf11 (TTDN1) gene mutations and genetic
            heterogeneity in nonphotosensitive trichothiodystrophy
  JOURNAL   Am J Hum Genet 76 (3), 510-516 (2005)
   PUBMED   15645389
REFERENCE   6  (bases 1 to 2679)
  AUTHORS   Nakabayashi,K., Fernandez,B.A., Teshima,I., Shuman,C., Proud,V.K.,
            Curry,C.J., Chitayat,D., Grebe,T., Ming,J., Oshimura,M., Meguro,M.,
            Mitsuya,K., Deb-Rinker,P., Herbrick,J.A., Weksberg,R. and
            Scherer,S.W.
  TITLE     Molecular genetic studies of human chromosome 7 in Russell-Silver
            syndrome
  JOURNAL   Genomics 79 (2), 186-196 (2002)
   PUBMED   11829489
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154219.1.
            
            On Apr 13, 2018 this sequence version replaced NM_025479.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030630.1, BC139338.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-408               AC154219.1         148924-149331
            409-2679            AC154219.1         150353-152623
FEATURES             Location/Qualifiers
     source          1..2679
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 6.05 cM"
     gene            1..2679
                     /gene="Mplkip"
                     /gene_synonym="2810021B07Rik; C330007M08Rik; Ttdn1"
                     /note="M-phase specific PLK1 intereacting protein"
                     /db_xref="GeneID:66308"
                     /db_xref="MGI:MGI:1913558"
     exon            1..408
                     /gene="Mplkip"
                     /gene_synonym="2810021B07Rik; C330007M08Rik; Ttdn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..609
                     /gene="Mplkip"
                     /gene_synonym="2810021B07Rik; C330007M08Rik; Ttdn1"
                     /note="TTD non-photosensitive 1 protein homolog"
                     /codon_start=1
                     /product="M-phase-specific PLK1-interacting protein"
                     /protein_id="NP_079755.1"
                     /db_xref="CCDS:CCDS26253.1"
                     /db_xref="GeneID:66308"
                     /db_xref="MGI:MGI:1913558"
                     /translation="MHRPNFRPPTPPYPSPGIGGWGGGNNFRGALGGGPRPPSPRDGY
                     GSPHHTPPCGPRARPYGSSQSPRHGGNFSGARFGSPSPGGYPGSYSRSPAGSQHQFGY
                     SPGQQQTYPQGSPRTSTPFGSGRGREKRMSNELESYFKPSMLEDPWAGLEPVSVVDIS
                     QQYSNTQTFTGKKGRYFS"
     exon            409..2679
                     /gene="Mplkip"
                     /gene_synonym="2810021B07Rik; C330007M08Rik; Ttdn1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      879..884
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mplkip"
                     /gene_synonym="2810021B07Rik; C330007M08Rik; Ttdn1"
                     /note="hexamer: AATAAA"
     polyA_site      903
                     /gene="Mplkip"
                     /gene_synonym="2810021B07Rik; C330007M08Rik; Ttdn1"
                     /note="major polyA site"
     regulatory      1150..1155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mplkip"
                     /gene_synonym="2810021B07Rik; C330007M08Rik; Ttdn1"
                     /note="hexamer: AATAAA"
     polyA_site      1168
                     /gene="Mplkip"
                     /gene_synonym="2810021B07Rik; C330007M08Rik; Ttdn1"
     regulatory      2650..2655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mplkip"
                     /gene_synonym="2810021B07Rik; C330007M08Rik; Ttdn1"
                     /note="hexamer: AATAAA"
     polyA_site      2674
                     /gene="Mplkip"
                     /gene_synonym="2810021B07Rik; C330007M08Rik; Ttdn1"
ORIGIN      
        1 ccttctggcg gttgatcgca gaggttccgg tgaggcgttc ggcgtgtgag ctctgcggct
       61 tcgtttcctg atatgcaccg accgaatttt cgacccccaa ctcctccgta ccccagcccg
      121 gggataggag gttggggtgg cggaaataac ttccggggtg ccctgggcgg ggggccgcgg
      181 ccgccctccc cgcgggacgg gtacgggagt ccgcaccaca ctccgccctg cgggccccgg
      241 gctaggccgt acgggagcag ccagtctccg cggcacggcg gcaacttctc gggggcccgc
      301 ttcgggtctc cgtccccggg cggctaccca ggctcctact ccaggtcccc cgcggggtcc
      361 cagcatcagt tcggctactc cccagggcag cagcagacct acccccaggg ttctccaagg
      421 acatctacac catttggatc agggcgtggt agagaaaaaa gaatgtctaa tgagttggaa
      481 agttatttta agccttcaat gcttgaagac ccttgggctg gcctagaacc agtgtctgta
      541 gtggatataa gccaacagta cagcaatacg caaacattca caggcaaaaa aggaagatac
      601 ttttcttaat atttctgaaa ttcacctgga agcttcatgt gtcaggaaca tcctggacag
      661 aacttttact tgtgtaaaag agttgaaccc aaggatgatg actttgaata atgattagca
      721 gacctttggt atatctccaa ctttatcaag tgttgataac agcggaaatg ataggacaat
      781 ttacagtatt tagctatctg ggagtgtgta tcatagaaca cagttttcat atttgacatt
      841 tccaatataa cagacatttg tttttttcaa tgttttaaaa taaaacgttt tttgtcttcc
      901 taattgtgat ttttgtgaat atgtagaatt gctaaaacaa tgcttcagta atcacttaga
      961 ctttgagggt aaatgttttg caaactattt tttaatgaaa tgacaagcta tcttagacag
     1021 ttttctatat atttattaat agaaaatagt tctacatcca tttttttgta tttttgttaa
     1081 gatattgaaa cttaaaatca ctggaagtca cttaatatga tttatacttc tttattcaca
     1141 aaaggccaga ataaactata tatatgcagt tcagtgctct gcccaaattt ctctatattt
     1201 ggagcattgt aggcttactt tctcttgaag caaaagaagg tggtatgttg attttcattg
     1261 tgataaaatg ccaaaggaaa accaaggagg gactttggtt catagtttct aaagttccag
     1321 tggaagttca gctggatcta ttagttggtc ttgaggtgaa tcaaaatatg tctgcggata
     1381 tggcaaaagc tgttcacctt tggcaaccaa gctgcagaaa gacaggagga ggccagggat
     1441 aagaggagcc tttctagagc aactttgcct gtctctacct cccagtgata acatcatgtg
     1501 acccattaag gtattagtcc acttaggaag taaataccct gacaatctca tcacttccct
     1561 gtgaccagac aagccttcaa cacatgaccc atttgggcag acacttcata tccataccac
     1621 aacaaatgac taatagtaat ctcaaatgac ttccatgaca acgaaataaa tatatatttg
     1681 actccatcaa accaaagaag acaaatgata atgcaagttt actgtgtctg agacagtaag
     1741 gcctaattat cttgactcat agacacattt ttttaatatt ttttattaga tattttcttt
     1801 atatacattt caaatgctat cccgaaagtt ccctataccc tccccccagc cctgctcccc
     1861 tacaagaagc tcactccagc ttcttggccc tggtgttccc ctgtactgag gcatataaag
     1921 tttgcaagag caaggggcct ctcttcccag tgatggccga ctaggccatc ttctgctaca
     1981 tatgcagcta gagacacgag ctgtgggggt actggttagt tcatattgtt gtatggacac
     2041 atttctaatc tgaggaagag ttctatgaac tttagcttac tttgcctggc tggagtacaa
     2101 ggaaagggat gctatgtata tatacctgta ttaatagagc taaaacttgg aggagtattc
     2161 ctgagttatt taaagtcaag tcttgaacag tacagtatgt ttaaaaaaat tgtcgacatt
     2221 ctccaaaagg aaaatgaaat ggccattcca cctaggtaag ccataactat ttgttattgg
     2281 ggtggggacc cactggaagg attttatgca aataaaacct ccactggagc cagagctttg
     2341 aaacttttct actagttatt agctagatat cccagtttta tcatgtaaaa tgaggaaatt
     2401 catagtactt gtcttcattt aaccctatat tctgagtttt tagaatactg cctataaaat
     2461 aacgggcact aagtaaatgt ttaatcaata catgaattct ggttgtaact gttatattgc
     2521 tctgcctagt ctcatgtgta aaggggttaa tagagggatg ttatgtggct atttgaaaga
     2581 aaacgtccat actcaacatc ttgggttttt ttccatatat tttatatttg atacttattg
     2641 aaattcataa ataaaaaata acacttgaaa acaattact
//
