LOCUS       NM_001122949            2958 bp    mRNA    linear   ROD 14-DEC-2022
DEFINITION  Mus musculus myeloproliferative leukemia virus oncogene (Mpl),
            transcript variant 1, mRNA.
ACCESSION   NM_001122949
VERSION     NM_001122949.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2958)
  AUTHORS   Roweth HG, Malloy MW, Goreczny GJ, Becker IC, Guo Q, Mittendorf EA,
            Italiano JE Jr, McAllister SS and Battinelli EM.
  TITLE     Pro-inflammatory megakaryocyte gene expression in murine models of
            breast cancer
  JOURNAL   Sci Adv 8 (41), eabo5224 (2022)
   PUBMED   36223471
REFERENCE   2  (bases 1 to 2958)
  AUTHORS   Valet C, Magnen M, Qiu L, Cleary SJ, Wang KM, Ranucci S, Grockowiak
            E, Boudra R, Conrad C, Seo Y, Calabrese DR, Greenland JR, Leavitt
            AD, Passegue E, Mendez-Ferrer S, Swirski FK and Looney MR.
  TITLE     Sepsis promotes splenic production of a protective platelet pool
            with high CD40 ligand expression
  JOURNAL   J Clin Invest 132 (7) (2022)
   PUBMED   35192546
REFERENCE   3  (bases 1 to 2958)
  AUTHORS   Marklin M, Tandler C, Kopp HG, Hoehn KL, Quintanilla-Martinez L,
            Borst O, Muller MR and Saur SJ.
  TITLE     C-Cbl regulates c-MPL receptor trafficking and its internalization
  JOURNAL   J Cell Mol Med 24 (21), 12491-12503 (2020)
   PUBMED   32954656
  REMARK    GeneRIF: C-Cbl regulates c-MPL receptor trafficking and its
            internalization.
REFERENCE   4  (bases 1 to 2958)
  AUTHORS   Xu L, Liu X, Peng F, Zhang W, Zheng L, Ding Y, Gu T, Lv K, Wang J,
            Ortinau L, Hu T, Shi X, Shi G, Shang G, Sun S, Iwawaki T, Ji Y, Li
            W, Rosen JM, Zhang XH, Park D, Adoro S, Catic A, Tong W, Qi L,
            Nakada D and Chen X.
  TITLE     Protein quality control through endoplasmic reticulum-associated
            degradation maintains haematopoietic stem cell identity and niche
            interactions
  JOURNAL   Nat Cell Biol 22 (10), 1162-1169 (2020)
   PUBMED   32958856
REFERENCE   5  (bases 1 to 2958)
  AUTHORS   Sabath DF, Lofton-Day C, Lin N, Lok S, Kaushansky K and Broudy VC.
  TITLE     Identification and characterization of an isoform of murine Mpl
  JOURNAL   Biochim Biophys Acta 1574 (3), 383-386 (2002)
   PUBMED   11997107
  REMARK    GeneRIF: mpl-II isoform cloning, base sequence, and amino acid
            sequence - lacks a 60 amino acid region required for surface
            expression of the protein
REFERENCE   6  (bases 1 to 2958)
  AUTHORS   Kaushansky K, Broudy VC, Lin N, Jorgensen MJ, McCarty J, Fox N,
            Zucker-Franklin D and Lofton-Day C.
  TITLE     Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte
            development
  JOURNAL   Proc Natl Acad Sci U S A 92 (8), 3234-3238 (1995)
   PUBMED   7536928
REFERENCE   7  (bases 1 to 2958)
  AUTHORS   Drachman JG, Griffin JD and Kaushansky K.
  TITLE     The c-Mpl ligand (thrombopoietin) stimulates tyrosine
            phosphorylation of Jak2, Shc, and c-Mpl
  JOURNAL   J Biol Chem 270 (10), 4979-4982 (1995)
   PUBMED   7534285
REFERENCE   8  (bases 1 to 2958)
  AUTHORS   Alexander WS and Dunn AR.
  TITLE     Structure and transcription of the genomic locus encoding murine
            c-Mpl, a receptor for thrombopoietin
  JOURNAL   Oncogene 10 (4), 795-803 (1995)
   PUBMED   7862460
REFERENCE   9  (bases 1 to 2958)
  AUTHORS   Kaushansky K.
  TITLE     The mpl ligand: molecular and cellular biology of the critical
            regulator of megakaryocyte development
  JOURNAL   Stem Cells 12 Suppl 1, 91-97 (1994)
   PUBMED   7696972
  REMARK    Review article
REFERENCE   10 (bases 1 to 2958)
  AUTHORS   Wendling F, Penciolelli JF, Charon M and Tambourin P.
  TITLE     Factor-independent erythropoietic progenitor cells in leukemia
            induced by the myeloproliferative leukemia virus
  JOURNAL   Blood 73 (5), 1161-1167 (1989)
   PUBMED   2539212
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627212.21 and AK041166.1.
            
            [WARNING] On Apr 19, 2023 this sequence was replaced by
            NM_001122949.3.
            
            On Oct 22, 2013 this sequence version replaced NM_001122949.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1, also known as
            c-mpl-I).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13861890.157918.1, BC103515.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849378 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AL627212.21        144772-144800       c
            30-708              AK041166.1         2-680
            709-732             AL627212.21        142932-142955       c
            733-920             AK041166.1         681-868
            921-921             AL627212.21        141847-141847       c
            922-2956            AK041166.1         870-2904
            2957-2958           AL627212.21        129702-129703       c
FEATURES             Location/Qualifiers
     source          1..2958
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 54.61 cM"
     gene            1..2958
                     /gene="Mpl"
                     /gene_synonym="c-mpl; CD110; hlb219; TPO-R"
                     /note="myeloproliferative leukemia virus oncogene"
                     /db_xref="GeneID:17480"
                     /db_xref="MGI:MGI:97076"
     exon            1..121
                     /gene="Mpl"
                     /gene_synonym="c-mpl; CD110; hlb219; TPO-R"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1944
                     /gene="Mpl"
                     /gene_synonym="c-mpl; CD110; hlb219; TPO-R"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; myeloproliferative leukemia protein;
                     proto-oncogene c-Mpl; thrombopoietin receptor"
                     /codon_start=1
                     /product="thrombopoietin receptor isoform 1 precursor"
                     /protein_id="NP_001116421.1"
                     /db_xref="CCDS:CCDS51284.1"
                     /db_xref="GeneID:17480"
                     /db_xref="MGI:MGI:97076"
                     /translation="MPSWALFMVTSCLLLALPNQAQVTSQDVFLLALGTEPLNCFSQT
                     FEDLTCFWDEEEAAPSGTYQLLYAYRGEKPRACPLYSQSVPTFGTRYVCQFPAQDEVR
                     LFFPLHLWVKNVSLNQTLIQRVLFVDSVGLPAPPRVIKARGGSQPGELQIHWEAPAPE
                     ISDFLRHELRYGPTDSSNATAPSVIQLLSTETCCPTLWMPNPVPVLDQPPCVHPTASQ
                     PHGPVRTSPAGEAPFLTVKGGSCLVSGLQAGKSYWLQLRSQPDGVSLRGSWGPWSFPV
                     TVDLPGDAVTIGLQCFTLDLKMVTCQWQQQDRTSSQGFFRHSRTRCCPTDRDPTWEKC
                     EEEEPRPGSQPALVSRCHFKSRNDSVIHILVEVTTAQGAVHSYLGSPFWIHQAVLLPT
                     PSLHWREVSSGRLELEWQHQSSWAAQETCYQLRYTGEGREDWKVLEPSLGARGGTLEL
                     RPRARYSLQLRARLNGPTYQGPWSAWSPPARVSTGSETAWITLVTALLLVLSLSALLG
                     LLLLKWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPSKATVTDSCEEVEPSL
                     LEILPKSSESTPLPLCPSQPQMDYRGLQPCLRTMPLSVCPPMAETGSCCTTHIANHSY
                     LPLSYWQQP"
     exon            122..254
                     /gene="Mpl"
                     /gene_synonym="c-mpl; CD110; hlb219; TPO-R"
                     /inference="alignment:Splign:2.1.0"
     exon            255..433
                     /gene="Mpl"
                     /gene_synonym="c-mpl; CD110; hlb219; TPO-R"
                     /inference="alignment:Splign:2.1.0"
     exon            434..732
                     /gene="Mpl"
                     /gene_synonym="c-mpl; CD110; hlb219; TPO-R"
                     /inference="alignment:Splign:2.1.0"
     exon            733..895
                     /gene="Mpl"
                     /gene_synonym="c-mpl; CD110; hlb219; TPO-R"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1022
                     /gene="Mpl"
                     /gene_synonym="c-mpl; CD110; hlb219; TPO-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1204
                     /gene="Mpl"
                     /gene_synonym="c-mpl; CD110; hlb219; TPO-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1347
                     /gene="Mpl"
                     /gene_synonym="c-mpl; CD110; hlb219; TPO-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1507
                     /gene="Mpl"
                     /gene_synonym="c-mpl; CD110; hlb219; TPO-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1604
                     /gene="Mpl"
                     /gene_synonym="c-mpl; CD110; hlb219; TPO-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1692
                     /gene="Mpl"
                     /gene_synonym="c-mpl; CD110; hlb219; TPO-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..2958
                     /gene="Mpl"
                     /gene_synonym="c-mpl; CD110; hlb219; TPO-R"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagggagga tgggctaagg caggcacaca gtgccggaga agatgccctc ttgggccctc
       61 ttcatggtca cctcctgcct cctcttggcc cttccaaacc aggcacaagt caccagccaa
      121 gatgtcttct tgctggcctt gggcacagag cccctgaact gcttctccca aacatttgag
      181 gacctcacct gcttctggga tgaggaagag gcagcaccca gtgggacata ccagctgctg
      241 tatgcctacc gaggagagaa gccccgtgca tgccccctgt attcccagag tgtgcccacc
      301 tttggaaccc ggtatgtgtg ccagtttcca gcccaggatg aagtgcgcct cttctttccg
      361 ctgcacctct gggtgaagaa tgtgtccctc aaccagactt tgatccagcg ggtgctgttt
      421 gtggatagtg tgggcctgcc agctcccccc agggtcatca aggccagggg tgggagccaa
      481 ccaggggaac ttcagatcca ctgggaggcc cctgctcctg aaatcagtga cttcctgagg
      541 catgaactcc gctatggccc cacggactcc agcaacgcca ctgccccctc cgtcattcag
      601 ctgctctcca cagaaacctg ctgccccact ttgtggatgc cgaacccagt ccctgttctt
      661 gaccagcctc cgtgtgttca tccgacagca tcccaaccgc atggaccagt gaggacctcc
      721 ccagctggag aagctccatt tctgacagtg aagggtggaa gctgtctcgt ctcaggcctc
      781 caggctggca aatcctactg gctccagcta cgcagccaac ccgacggggt ctcccttcgt
      841 ggctcctggg gaccctggtc cttccctgtg actgtggatc ttccaggaga tgcagtgaca
      901 attggacttc agtgctttac cttggatctg aagatggtca cctgccagtg gcagcaacaa
      961 gaccgcacta gctcccaagg cttcttccgc cacagcagga cgaggtgctg ccccacagac
     1021 agggacccca cctgggagaa atgtgaagag gaggaaccgc gtccaggatc acagcccgct
     1081 ctcgtctccc gctgccactt caagtcacga aatgacagtg ttattcacat ccttgtagag
     1141 gtgaccacag cgcaaggtgc cgttcacagc tacctgggct cccctttttg gatccaccag
     1201 gctgtgctcc ttcccacccc gagcctgcac tggagggagg tctcaagtgg aaggctggag
     1261 ttggagtggc agcaccagtc atcttgggca gctcaagaga cctgctacca gctccggtac
     1321 acgggagaag gccgtgagga ctggaaggtg ctggagccat ctctcggtgc ccggggaggg
     1381 accctagagc tgcgcccccg agctcgctac agcttgcagc tgcgtgccag gctcaacggc
     1441 cccacctacc aaggtccctg gagcgcctgg tctcccccag ctagggtgtc cacgggctcc
     1501 gagactgctt ggatcacctt ggtgactgct ctgctcctgg tgctgagcct cagtgccctt
     1561 ctgggcctac tgctgctaaa gtggcaattt cctgcgcact acaggagact gaggcatgct
     1621 ttgtggccct cgcttccaga cctacaccgg gtcctaggcc agtacctcag agacactgca
     1681 gccctaagtc cttctaaggc cacggttacc gatagctgtg aagaagtgga acccagcctc
     1741 ctggaaatcc tccctaagtc ctcagagagc actcctttac ctctgtgtcc ctcccaacct
     1801 cagatggact acagaggact gcaaccttgc ctgcggacca tgcccctgtc tgtgtgtcca
     1861 cccatggctg agacggggtc ctgctgcacc acacacattg ccaaccactc ctacctacca
     1921 ctaagctatt ggcagcagcc ctgaaggcag tccccatgct actgcagacc tatacattcc
     1981 tacacactac cttatccatc ctcaacacca tccattctgt tgccacccca ctccccctct
     2041 ggctttataa cactgatcac tccagatggc tgctcacaaa tccagagctc tgtctctgca
     2101 gctgcttggc tcctctggct gtttattttt atttttttaa ttttttagac actgtttatt
     2161 atataactct gatgacctat aacttgctat gtagaaacgg ctggcctcaa actcacagaa
     2221 atctgcctgc tgtgactaaa gttgccatgc cctgtagctc caaacccttg ggggtgggga
     2281 aagtctctgt ttccctatct cctacaggct ttaaagagtt cttcagtgag tcccctagct
     2341 tgctgttaag ggaactgtgc aagccttcta attatgagac ccagtggggt cttgctgtca
     2401 tctatttatt tgatctctct tggcatcctc ctccaccctg ggtgccacag tatcaccttc
     2461 cttcctggtt ctgttcctgc ctctctgagc atactagcag caaaagagcc aactctggag
     2521 ctagaaccag gttctggtcc tgtcgttcac acctgctagc tgtgcaaact taggcaaata
     2581 gcctttgagc cttttccctc tcatctacga agtgtggata ataacagaac cccatagagc
     2641 agtgtgaaca attgagaaca cactggctgg gacagtcaat gcttaaaatg ccccaattaa
     2701 tgtcctaagt atttcttctc ttcctattct ggcctttgtt acatgatgac catcagaaag
     2761 ttcttatctc cagcccagac ttctatagat agatcccaca gtgttttctg tggattttaa
     2821 catttgtttc ttgctcctgg atagtgagtt gaaaggcaag ggttaggatc tgtccttacc
     2881 ccccaccccc accccagcat cttcaatact atttcacgta tgataggtgg cagacctcca
     2941 ataaatatcg tctgaatg
//
