LOCUS       NM_025837               1757 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus mannose phosphate isomerase (Mpi), transcript variant
            1, mRNA.
ACCESSION   NM_025837 XM_896700 XM_925002
VERSION     NM_025837.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1757)
  AUTHORS   Liang,R., Ye,Z.W., Qin,Z., Xie,Y., Yang,X., Sun,H., Du,Q., Luo,P.,
            Tang,K., Hu,B., Cao,J., Wong,X.H., Ling,G.S., Chu,H., Shen,J.,
            Yin,F., Jin,D.Y., Chan,J.F., Yuen,K.Y. and Yuan,S.
  TITLE     PMI-controlled mannose metabolism and glycosylation determines
            tissue tolerance and virus fitness
  JOURNAL   Nat Commun 15 (1), 2144 (2024)
   PUBMED   38459021
  REMARK    GeneRIF: PMI-controlled mannose metabolism and glycosylation
            determines tissue tolerance and virus fitness.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1757)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1757)
  AUTHORS   Sharma,V., Nayak,J., DeRossi,C., Charbono,A., Ichikawa,M., Ng,B.G.,
            Grajales-Esquivel,E., Srivastava,A., Wang,L., He,P., Scott,D.A.,
            Russell,J., Contreras,E., Guess,C.M., Krajewski,S., Del
            Rio-Tsonis,K. and Freeze,H.H.
  TITLE     Mannose supplements induce embryonic lethality and blindness in
            phosphomannose isomerase hypomorphic mice
  JOURNAL   FASEB J 28 (4), 1854-1869 (2014)
   PUBMED   24421398
  REMARK    GeneRIF: Data indicate that reduced phosphomannose isomerase (MPI)
            alters mannose flux in hypomorphic mice.
REFERENCE   4  (bases 1 to 1757)
  AUTHORS   Harada,Y., Nakajima,K., Masahara-Negishi,Y., Freeze,H.H.,
            Angata,T., Taniguchi,N. and Suzuki,T.
  TITLE     Metabolically programmed quality control system for dolichol-linked
            oligosaccharides
  JOURNAL   Proc Natl Acad Sci U S A 110 (48), 19366-19371 (2013)
   PUBMED   24218558
REFERENCE   5  (bases 1 to 1757)
  AUTHORS   Cano,M. and Ilundain,A.A.
  TITLE     Ontogeny of D-mannose transport and metabolism in rat small
            intestine
  JOURNAL   J Membr Biol 235 (2), 101-108 (2010)
   PUBMED   20523973
  REMARK    GeneRIF: Phosphomannose isomerase activity and mRNA levels
            increased at 1 month, and the values in the ileum were lower than
            in jejunum.
REFERENCE   6  (bases 1 to 1757)
  AUTHORS   Douglas,T.C. and Dawson,P.E.
  TITLE     Location of the gene for theta antigen in the mouse. III. The
            position of Thy-1 relative to Lap-1 and Mpi-1
  JOURNAL   J Hered 70 (4), 250-254 (1979)
   PUBMED   314952
REFERENCE   7  (bases 1 to 1757)
  AUTHORS   Lalley,P.A., Minna,J.D. and Francke,U.
  TITLE     Conservation of autosomal gene synteny groups in mouse and man
  JOURNAL   Nature 274 (5667), 160-163 (1978)
   PUBMED   662012
REFERENCE   8  (bases 1 to 1757)
  AUTHORS   Lalley,P.A., Francke,U. and Minna,J.D.
  TITLE     The genes coding for pyruvate kinase (M2) and mannosephosphate
            isomerase are linked in man and mouse
  JOURNAL   Cytogenet Cell Genet 22 (1-6), 581-584 (1978)
   PUBMED   752545
REFERENCE   9  (bases 1 to 1757)
  AUTHORS   Kozak,C.A. and Ruddle,F.H.
  TITLE     Assignment of the genes for thymidine kinase and galactokinase to
            Mus musculus chromosome 11 and the preferential segregation of this
            chromosome in Chinese hamster/mouse somatic cell hybrids
  JOURNAL   Somatic Cell Genet 3 (2), 121-133 (1977)
   PUBMED   204065
REFERENCE   10 (bases 1 to 1757)
  AUTHORS   Francke,U., Lalley,P.A., Moss,W., Ivy,J. and Minna,J.D.
  TITLE     Gene mapping in Mus musculus by interspecific cell hybridization:
            assignment of the genes for tripeptidase-1 to chromosome 10,
            dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome
            12, and adenylate kinase-1 to chromosome 2
  JOURNAL   Cytogenet Cell Genet 19 (2-3), 57-84 (1977)
   PUBMED   198184
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132777.1.
            
            On Apr 6, 2007 this sequence version replaced NM_025837.1.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132777.1, AF244360.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1757              AK132777.1         2-1758
FEATURES             Location/Qualifiers
     source          1..1757
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 31.05 cM"
     gene            1..1757
                     /gene="Mpi"
                     /gene_synonym="1110002E17Rik; Mpi-1; Mpi1"
                     /note="mannose phosphate isomerase"
                     /db_xref="GeneID:110119"
                     /db_xref="MGI:MGI:97075"
     exon            1..49
                     /gene="Mpi"
                     /gene_synonym="1110002E17Rik; Mpi-1; Mpi1"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1305
                     /gene="Mpi"
                     /gene_synonym="1110002E17Rik; Mpi-1; Mpi1"
                     /EC_number="5.3.1.8"
                     /note="phosphomannose isomerase; PMI; phosphohexomutase;
                     mannose phosphate isomerase 1"
                     /codon_start=1
                     /product="mannose-6-phosphate isomerase"
                     /protein_id="NP_080113.1"
                     /db_xref="CCDS:CCDS40650.1"
                     /db_xref="GeneID:110119"
                     /db_xref="MGI:MGI:97075"
                     /translation="MASPRVFPLSCVVQQYAWGKVGSKSEVACLLASSDPLAQISEDK
                     PYAELWMGTHPRGDAKILDNRISQKTLGQWIAENPDCLGSKVKNTFNGKLPFLFKVLS
                     VDTALSIQAHPNKELAEKLHLQAPEHYPDANHKPEMAIALTSFQGLCGFRPVEEIVTF
                     MKKVPEFQLLIGDDATAQLKESVGGDTEAMASALRNCFSHLMKSEKKVVVEQLNLLVK
                     RISQQVFDGNNMEDIYGKLLLQLHQQHPGDIGCFAIYFLNLLTLKPGEAMFLDANVPH
                     AYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLNYTPSPSNNRLFAPAQSQDDPY
                     LSIYDPPVPDFTVMKMEVPSSVTEYKVSTLDSASILLMVQGTVTAIIPSAHAEIPLYR
                     GGVLFIAANESVLLKITVPKDLLIFRACCLL"
     exon            50..177
                     /gene="Mpi"
                     /gene_synonym="1110002E17Rik; Mpi-1; Mpi1"
                     /inference="alignment:Splign:2.1.0"
     exon            178..378
                     /gene="Mpi"
                     /gene_synonym="1110002E17Rik; Mpi-1; Mpi1"
                     /inference="alignment:Splign:2.1.0"
     exon            379..520
                     /gene="Mpi"
                     /gene_synonym="1110002E17Rik; Mpi-1; Mpi1"
                     /inference="alignment:Splign:2.1.0"
     exon            521..703
                     /gene="Mpi"
                     /gene_synonym="1110002E17Rik; Mpi-1; Mpi1"
                     /inference="alignment:Splign:2.1.0"
     exon            704..877
                     /gene="Mpi"
                     /gene_synonym="1110002E17Rik; Mpi-1; Mpi1"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1086
                     /gene="Mpi"
                     /gene_synonym="1110002E17Rik; Mpi-1; Mpi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1757
                     /gene="Mpi"
                     /gene_synonym="1110002E17Rik; Mpi-1; Mpi1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1421..1426
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mpi"
                     /gene_synonym="1110002E17Rik; Mpi-1; Mpi1"
                     /note="hexamer: AGTAAA"
     polyA_site      1445
                     /gene="Mpi"
                     /gene_synonym="1110002E17Rik; Mpi-1; Mpi1"
                     /note="major polyA site"
ORIGIN      
        1 aacgttcctg aagccgggtt tcaggcaact gggatggcga gtccgcgagt gttcccactt
       61 tcctgtgtgg tgcagcagta tgcctggggg aaggtgggct ccaaaagtga agtggcatgc
      121 ctgctggcta gcagtgatcc actggcccag atttcagagg acaagccata tgcagagctg
      181 tggatgggga cacacccccg gggagatgcc aagatccttg acaaccgtat ttcccagaag
      241 accttaggcc agtggattgc tgaaaacccg gactgcttgg gctcaaaggt caaaaacacc
      301 tttaatggaa agctgccctt cctcttcaaa gtactgtcag tggacacggc cctgtctatc
      361 caggcacacc ctaacaagga gctggcagag aagctgcatc tccaggctcc agagcactac
      421 cctgatgcca accacaagcc agaaatggcc attgccctta cctccttcca gggcttgtgt
      481 ggtttccggc cagtggagga gattgtgacc tttatgaaga aggtgcctga gttccagttg
      541 ctgattggag atgatgccac agcacagctg aaggagagcg tgggtgggga tactgaggcc
      601 atggcttctg ctctgaggaa ctgcttttcc cacctgatga agagtgagaa gaaggtggtg
      661 gtggagcagc ttaacctgtt ggtgaaacgg atctcccagc aagtatttga cggaaacaat
      721 atggaggaca tttatgggaa gctcttgctg cagctgcacc aacagcaccc aggtgatatc
      781 ggatgtttcg ccatctactt cctgaacctg ctcaccttga agcctgggga agccatgttt
      841 ctggatgcca acgtacccca tgcctacctg aagggagact gcgtggaatg catggcatgt
      901 tcggacaata ccgtgcgtgc tggcctgaca cccaaattca ttgatgtgcc aaccctgtgt
      961 gaaatgctca actacacacc tagccccagc aacaacaggc tgtttgcccc agcacagagt
     1021 caagatgacc cctatctctc tatctatgat cctcctgtgc cagacttcac tgttatgaag
     1081 atggaggtcc ctagctctgt cactgaatac aaagtctcaa cactagactc tgccagcatc
     1141 cttctgatgg tccaagggac agtgacagct atcatacctt cagcccatgc agaaatccct
     1201 ctgtaccgtg gtggagtgct cttcattgca gccaatgaga gtgtcttact gaagattact
     1261 gtgcccaagg atctgctgat attccgggcc tgctgtctgc tgtagagact agttcttagt
     1321 ctctctgcct accactgtat cctggccagc tccatatttc aggtgtagcc caatccctgt
     1381 ccctgttgtg cactctttga atgtatactg gattagaagc agtaaatttg gcattagtaa
     1441 ctccaggagc atgcccaggc tggaccatct tcaggacaag gtttctgtat gcatgaagcc
     1501 tgaggcctgc cactcttctg taccctctca acactgttac ctctgagcca gtgtgtccac
     1561 caaagaggca accactctgc cctagctgag gtgttaggct aacaaagcat gcatccccca
     1621 gcattagctc agcatgctct cagctgcaga gaagggaagg gaagggaagg gaaggaaggg
     1681 aaggggtagg ccagtggact aatgaagcgt attccctcta gctccgtcaa agtaattaaa
     1741 gatcacttgt gttgagg
//
