LOCUS       NM_026758               1107 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus M phase phosphoprotein 6 (Mphosph6), transcript
            variant 1, mRNA.
ACCESSION   NM_026758
VERSION     NM_026758.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1107)
  AUTHORS   Peng,R.R., Wang,L.L., Gao,W.Y., Zhu,F.Y., Hu,F., Zeng,W.T.,
            Shi,L.Y., Chen,X.C., Cai,J.Y., Zhang,D., Xia,Z.R. and Yang,Z.X.
  TITLE     The 5.8S pre-rRNA maturation factor, M-phase phosphoprotein 6, is a
            female fertility factor required for oocyte quality and meiosis
  JOURNAL   Cell Prolif 53 (3), e12769 (2020)
   PUBMED   32003502
  REMARK    GeneRIF: M-phase phosphoprotein 6 (MPP6) is important for 5.8S
            pre-rRNA maturation in somatic cells and was screened as a female
            fertility factor. MPP6 is required for 5.8S rRNA maturation,
            meiosis and quality control in mouse oocytes, and MPP6 level might
            be a marker for oocyte quality.
REFERENCE   2  (bases 1 to 1107)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122036.3, CJ084018.1, AK003245.1, DV660881.1 and AU022509.1.
            
            On Oct 24, 2017 this sequence version replaced NM_026758.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008161.1, AK003245.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC122036.3         92712-92719
            9-45                CJ084018.1         5-41
            46-560              AK003245.1         2-516
            561-617             DV660881.1         93-149
            618-1099            AK003245.1         577-1058
            1100-1107           AU022509.1         1-8                 c
FEATURES             Location/Qualifiers
     source          1..1107
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 65.09 cM"
     gene            1..1107
                     /gene="Mphosph6"
                     /gene_synonym="1110001M01Rik"
                     /note="M phase phosphoprotein 6"
                     /db_xref="GeneID:68533"
                     /db_xref="MGI:MGI:1915783"
     exon            1..123
                     /gene="Mphosph6"
                     /gene_synonym="1110001M01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..558
                     /gene="Mphosph6"
                     /gene_synonym="1110001M01Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="M-phase phosphoprotein 6 isoform 1"
                     /protein_id="NP_081034.1"
                     /db_xref="CCDS:CCDS22702.1"
                     /db_xref="GeneID:68533"
                     /db_xref="MGI:MGI:1915783"
                     /translation="MASERKTKLSKNLLRMKFMQRGLDSETKKQLEEEERKMISDEHW
                     YLDLPELKEKESFIVEEQSFSLCEDLLYGRMSFRGFNPEVEKLMLQMNSKNRAEAAEE
                     DETVEVDVSDEEMARRYETLVGTIGKKFVKKRDRANYEEDENGTIKAIKPKKMFLKPQ
                     D"
     exon            124..236
                     /gene="Mphosph6"
                     /gene_synonym="1110001M01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            237..327
                     /gene="Mphosph6"
                     /gene_synonym="1110001M01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            328..425
                     /gene="Mphosph6"
                     /gene_synonym="1110001M01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            426..1107
                     /gene="Mphosph6"
                     /gene_synonym="1110001M01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1073..1078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mphosph6"
                     /gene_synonym="1110001M01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1100
                     /gene="Mphosph6"
                     /gene_synonym="1110001M01Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtcttatcta gctccgctct tgaccgtgcg caagcgcagt gcggcgggaa agcctctgca
       61 agtgcgtcca acatggcgtc ggagcgcaag actaagttat ccaagaacct gctgcgcatg
      121 aagttcatgc aaagaggcct ggactcggaa accaagaaac agctagaaga ggaggagcgg
      181 aagatgatca gcgacgagca ctggtacctg gatttgccgg agttgaagga gaaggagagc
      241 ttcatcgtag aggagcagag cttctccctg tgtgaagatc ttctctacgg aaggatgtca
      301 ttcagggggt ttaatcctga ggttgagaag ttaatgcttc agatgaattc taagaaccga
      361 gcagaggcag cagaggaaga cgagacggta gaggtcgatg tgtctgatga ggaaatggca
      421 agaagatatg agactttggt gggaacaatt ggaaaaaagt ttgtcaagaa aagggaccga
      481 gccaattacg aagaagatga aaatggaact ataaaagcca taaaacctaa gaaaatgttc
      541 ttaaagcccc aagactaaaa tggatgcctc cgatacaggg gatggctgtg agcacagcat
      601 ggtcggaact catcctcctg tcgtcggtac tggttaaagc accgtttccc tctaaagaaa
      661 tgcataagtt tggagatgtg ctgttcttga gacagatgtg taatggatgt tatacatcct
      721 ttttatgaca ttctcagggg cttcagatat gtgggcacag gccgctccct agatttttga
      781 cctgattctg tgtgtatata cccacagaca ggccacatgc acaccgttct ccagttactg
      841 tccaggaatg acaattgtaa actaattatt gcctttgttt aactgccctt atatttatat
      901 ttatattttt ttggatcatg tctctccagt tcactttgga gtcacatctt tgagaacttt
      961 ccagaagtga tttgtcagga acagacatgg ctctcgggcc tttgtcgtgt tgagtagtgt
     1021 ggggtttgtg tattttaaac agtcatctgg gtcatttttc taatgttcta ttaataaact
     1081 tatacttttc tgttttctta cactttg
//
