LOCUS       NM_010820               7526 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus multiple PDZ domain crumbs cell polarity complex
            component (Mpdz), transcript variant 2, mRNA.
ACCESSION   NM_010820
VERSION     NM_010820.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7526)
  AUTHORS   Baliova,M., Jahodova,I. and Jursky,F.
  TITLE     A Significant Difference in Core PDZ Interactivity of SARS-CoV,
            SARS-CoV2 and MERS-CoV Protein E Peptide PDZ Motifs In Vitro
  JOURNAL   Protein J 42 (4), 253-262 (2023)
   PUBMED   36932261
REFERENCE   2  (bases 1 to 7526)
  AUTHORS   Yu,M., Jiang,X., Cai,W., Yang,X., An,W., Zhang,M., Xu,Y., Zhang,B.
            and Tang,S.
  TITLE     PATJ and MPDZ are required for trophectoderm lineage specification
            in early mouse embryos
  JOURNAL   Reproduction 166 (2), 175-185 (2023)
   PUBMED   37318097
  REMARK    GeneRIF: PATJ and MPDZ are required for trophectoderm lineage
            specification in early mouse embryos.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7526)
  AUTHORS   Jarysta,A. and Tarchini,B.
  TITLE     Multiple PDZ domain protein maintains patterning of the apical
            cytoskeleton in sensory hair cells
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34228789
REFERENCE   4  (bases 1 to 7526)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7526)
  AUTHORS   Liu,W., Huang,Y., Wang,D., Han,F., Chen,H., Chen,J., Jiang,X.,
            Cao,J. and Liu,J.
  TITLE     MPDZ as a novel epigenetic silenced tumor suppressor inhibits
            growth and progression of lung cancer through the Hippo-YAP pathway
  JOURNAL   Oncogene 40 (26), 4468-4485 (2021)
   PUBMED   34108620
REFERENCE   6  (bases 1 to 7526)
  AUTHORS   Lee,S.S., Glaunsinger,B., Mantovani,F., Banks,L. and Javier,R.T.
  TITLE     Multi-PDZ domain protein MUPP1 is a cellular target for both
            adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6
            oncoproteins
  JOURNAL   J Virol 74 (20), 9680-9693 (2000)
   PUBMED   11000240
REFERENCE   7  (bases 1 to 7526)
  AUTHORS   Barritt,D.S., Pearn,M.T., Zisch,A.H., Lee,S.S., Javier,R.T.,
            Pasquale,E.B. and Stallcup,W.B.
  TITLE     The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the
            membrane-spanning proteoglycan NG2
  JOURNAL   J Cell Biochem 79 (2), 213-224 (2000)
   PUBMED   10967549
REFERENCE   8  (bases 1 to 7526)
  AUTHORS   Simpson,E.H., Suffolk,R., Bell,J.A., Jordan,S.A., Johnson,D.K.,
            Hunsicker,P.R., Weber,J.S., Justice,M.J. and Jackson,I.J.
  TITLE     A comparative transcript map and candidates for mutant phenotypes
            in the Tyrp1 (brown) deletion complex homologous to human 9p21-23
  JOURNAL   Mamm Genome 11 (1), 58-63 (2000)
   PUBMED   10602994
REFERENCE   9  (bases 1 to 7526)
  AUTHORS   Simpson,E.H., Suffolk,R. and Jackson,I.J.
  TITLE     Identification, sequence, and mapping of the mouse multiple PDZ
            domain protein gene, Mpdz
  JOURNAL   Genomics 59 (1), 102-104 (1999)
   PUBMED   10395806
REFERENCE   10 (bases 1 to 7526)
  AUTHORS   Lee,S.S., Weiss,R.S. and Javier,R.T.
  TITLE     Binding of human virus oncoproteins to hDlg/SAP97, a mammalian
            homolog of the Drosophila discs large tumor suppressor protein
  JOURNAL   Proc Natl Acad Sci U S A 94 (13), 6670-6675 (1997)
   PUBMED   9192623
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK160603.1, CR352325.4, AF326531.2, AK019164.1 and AL670939.6.
            
            [WARNING] On Apr 24, 2024 this sequence was replaced by
            NM_010820.4.
            
            On Mar 7, 2015 this sequence version replaced NM_010820.2.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. It encodes isoform 2, which is shorter
            than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ131869.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               AK160603.1         2-224
            224-234             CR352325.4         85351-85361         c
            235-6404            AF326531.2         1-6170
            6405-6607           AK019164.1         1636-1838
            6608-6608           AL670939.6         122208-122208       c
            6609-7525           AK019164.1         1840-2756
            7526-7526           AL670939.6         121290-121290       c
FEATURES             Location/Qualifiers
     source          1..7526
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 38.0 cM"
     gene            1..7526
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /note="multiple PDZ domain crumbs cell polarity complex
                     component"
                     /db_xref="GeneID:17475"
                     /db_xref="MGI:MGI:1343489"
     exon            1..180
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            181..250
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..6402
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     multi-PDZ domain protein 1; multiple PDZ domain protein"
                     /codon_start=1
                     /product="multiple PDZ domain protein isoform 2"
                     /protein_id="NP_034950.2"
                     /db_xref="CCDS:CCDS18292.1"
                     /db_xref="GeneID:17475"
                     /db_xref="MGI:MGI:1343489"
                     /translation="MLETIDKNRALQAAERLQSKLKERGDVANEDKLSLLKSVLQSPL
                     FSQILNLQTSLQQLKDQVNIATLATAAADHAHTPQFSSAVISNLQSESLLLSPNHGNL
                     EALPGPGAPAVMDGKPTCDELDQLIKNMAQGRHVEIFELLKPPCGGLGFSVVGLRSEN
                     RGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQVLDQTITHQQAISILQKAKDTVQ
                     LVIARGSLPPVSSPRISRSPSAASTISAHSNPMHWQHVETIELVNDGSGLGFGIIGGK
                     ATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMI
                     ARGAVEETPASSSLGITLSSSTSSTSEMRVDASTQKNDESETFDVELTKNVQGLGITI
                     AGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLR
                     HTGQTVRLTLMRKGASQEAELTSRGDTAKDVDLPAENCEKDEESLSLKRNTSILPIEE
                     EGFPLLSAELEEAEDVQQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATV
                     GHHFIRSVLPEGPVGHSGKLFSGDELLEVNGINLLGENHQDVVNILKELPIDVTMVCC
                     RRTVPPIALSEMDSLDINDLELTEKPHIDLGEFIGSSETEDPMLAMSDVDQNAEEIQT
                     PLAMWEAGGQSIELEKGSRGLGFSILDYQDPIDPANTVIVIRSLVPGGIAEKDGRLFP
                     GDRLMFVNDINLENSTLEEAVEALKGAPSGMVRIGVAKPLPLSPEEGYVSAKEDAFLC
                     SPHACKESGLSDKALFRADLALIDTPDAESIAESRFESQFSPDNDSVYSTQASIFSLH
                     DGTCSDGMNYGPSLPSSPPKDVTSSSEVVLGLHLSLEELYTQNLLQRQHAGSPPTDMR
                     PAPTSGFPISDYTTTNAVEQKYECANPVAWPHSQLPSSLSTSELAPALPAVAQKYLTD
                     QSSLASDAESVNLQSMSQEAFERTVTIAKGSSSLGMTVSANKDGLGVIVRSIIHGGAI
                     SRDGRIAVGDCILSINEESTISLTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFRVS
                     FGQQAGGIMALDIFSSYTGRDIPELPEREEGEGEESELQNAAYSSWSQPRRVELWREP
                     SKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIIEVDGMDL
                     RDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLPHSLYPKYSFSSTNPFADSL
                     QLTTDQAPSQSESETEKPALCNVPPSSPSVFSEMGSDCAQPSATAVSEDEDKEDEFGY
                     SWKNIQERYGSLTGQLHVIELEKGQSGLGLSLAGNKDRTRMSVFIVGIDPTGAAGRDG
                     RLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNADAVNQMAVCPGIAAD
                     SPSSTSDSPQNKEVEPCSTTSASAADLSSLTDVYQLELPKDQGGLGIAICEEDTINGV
                     MIESLTEHGGAAKDGRLKPGDHILAVDDEVVAGCPVEKFISLLKTAKATVKLTVRAEN
                     PACPAVPSSAVTVSGERKDNSQTPAVPAPDLEPIPSTSRSSTPAVFASDPATCPIIPG
                     CETTIEISKGQTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGI
                     DLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEDVCDTFTIELQKRPGKGLGLSIV
                     GKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRHATQEAVAALLKCSLGAV
                     TLEVGRVKAAPFHSERRPSQSSQVSESSLSSFTPPLSGINTSESLESNSKKNALASEI
                     QGLRTVEIKKGPADSLGLSIAGGVGSPLGDVPIFIAMMHPNGVAAQTQKLRVGDRIVT
                     ICGTSTDGMTHTQAVNLMKNASGSIEVQVVAGGDVSVVTGHQQELANPCLAFTGLTSS
                     SIFPDDLGPPQSKTITLDRGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAAAEDGRL
                     KRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVLS"
     exon            251..417
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            418..630
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            631..770
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..984
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1113
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1323
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1438
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1527
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1690
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1762
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1869
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..2016
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2181
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2367
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2577
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2578..2694
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..2862
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..3138
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3139..3253
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3452
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3453..3557
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3558..3650
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3651..3828
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3829..3939
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3940..4038
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4039..4201
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4202..4398
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4399..4490
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4491..4581
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4582..4662
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4663..4755
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4756..4830
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4831..4996
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4997..5142
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5143..5226
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5227..5420
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5421..5568
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5569..5655
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5656..5746
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5747..5790
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5791..5913
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5914..6018
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            6019..6131
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            6132..6255
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            6256..7526
                     /gene="Mpdz"
                     /gene_synonym="B930003D11Rik; MUPP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagccccgc ggcctccggg aggctggtcc gcgcgcagca aggctggccg gccgcgggct
       61 ccggttctcc ggccacgcgt gagcgttcgc gccacacggc gctccgaggg ccgcgactac
      121 agcggagagg agccgagcgc tttgcccacc ccgggaatcc ccgccaggcc gccgagcccg
      181 aatgtccttt tagttggtgt ttggcatcat tatagagtac actgaacctt gaagatgttg
      241 gaaaccatag acaaaaatcg ggccctgcag gcagcagagc gcttgcaaag caagctgaaa
      301 gaacgcgggg atgttgcaaa tgaagacaaa ctgagtctcc tgaagtctgt cctgcagagt
      361 ccactcttca gtcagatctt gaaccttcag acttcactac agcagctaaa agaccaggta
      421 aacattgcta ctttggcaac tgcagctgct gaccatgccc acactcctca gttcagctct
      481 gctgtcattt ctaacctgca aagtgagtca cttctgctgt ctccaaatca tgggaacctg
      541 gaagcccttc ctggacctgg tgctccagct gtcatggatg ggaagcctac ctgtgacgaa
      601 cttgatcagc tcattaaaaa tatggcccag ggtcgccatg tggaaatatt tgagctcctt
      661 aaacctccgt gtggaggcct cggctttagt gttgttgggc tcagaagtga aaacaggggc
      721 gagctgggga tatttgtcca ggagattcag gagggcagtg tggctcacag agatggcaga
      781 cttaaggaaa ccgaccagat cctcgccatc aatggccagg tcctagacca gacgatcaca
      841 caccagcagg ccattagcat cctgcagaag gccaaagaca ccgtgcagct tgtgattgcc
      901 agaggatctt tgccgccggt ctccagccca cggatttccc gctctccatc agcagccagc
      961 accatttcag cccactcgaa tccaatgcac tggcagcatg tggagaccat agagctggta
     1021 aacgatgggt ccggcctggg gtttggcatc ataggaggaa aggcgactgg tgtcatagtg
     1081 aagacaatct tgcctggagg agtagccgac cagcatgggc gattatgcag tggagaccac
     1141 attctaaaga ttggtgacac tgacctagca ggaatgagca gtgagcaagt agcacaagtc
     1201 cttaggcagt gtggaaatag agttaagctg atgattgcca gaggtgctgt agaagaaacg
     1261 ccagcatcct cctctttggg catcaccctc tcctcttcca catcttctac ttcagagatg
     1321 cgagttgatg cttctactca gaaaaatgat gaaagtgaga cgtttgatgt ggaactcact
     1381 aaaaatgtcc aaggactagg aattaccatt gctggttata ttggagataa aaaattagag
     1441 ccttcaggaa tctttgtaaa gagcattaca aaaagcagtg ctgtggagca tgatggaaga
     1501 atccaaattg gagaccaaat tatagcagtc gatggcacca accttcaggg ttttaccaac
     1561 caacaagcag tagaggtgtt acgtcacaca ggacagacag tgcgtctgac actgatgagg
     1621 aagggagcaa gccaggaagc agaacttacg tcaagaggag acactgcaaa agatgtggac
     1681 ctcccagctg aaaattgtga aaaggatgaa gaatctttat cattgaagag aaataccagc
     1741 atattaccga ttgaagaaga agggtttcca ctgttgtcag ctgagctgga agaagctgaa
     1801 gatgtgcagc aagaggctgc cctgctgacc aagtggcaga ggattatggg aattaactat
     1861 gaaatagtgg tggctcatgt gagcaagttt agtgagaata gtgggctggg aataagtctg
     1921 gaggcaactg tgggccacca cttcatccgg tctgtgctac cagaaggccc tgtgggacac
     1981 agcgggaagc tcttcagtgg agatgagctc ttggaagtga atggtataaa tttgcttggg
     2041 gaaaaccatc aagatgtggt caatatttta aaagagttgc ctatagatgt gacaatggta
     2101 tgctgccgtc ggactgtgcc acccattgcc ctatcagaaa tggatagcct ggacataaat
     2161 gatcttgaac tcacagaaaa gcctcatata gatctaggag agttcattgg gtcctcagag
     2221 acagaggatc ccatgctggc gatgtctgat gtggatcaga atgcagagga gattcaaaca
     2281 ccgctggcca tgtgggaggc aggcggtcag tccatagagc tggagaaagg gagcagaggc
     2341 cttggcttca gtattttaga ctatcaggac ccgatcgatc cagcaaacac agtaattgtc
     2401 attcgttccc tggtgcctgg tggcatagct gaaaaggatg gacggctttt tccaggagac
     2461 aggctcatgt ttgtcaatga cattaatctg gaaaacagca ctcttgaaga ggccgtggaa
     2521 gccctgaagg gagcgccctc agggatggtg cggataggag tggccaagcc tttgcctctg
     2581 tcaccagaag aagggtatgt ttcagccaag gaagacgcct ttctctgctc accgcacgcc
     2641 tgcaaggagt caggcctgtc cgacaaagcc ctcttcaggg ctgacttggc tctgatagat
     2701 acacctgatg ctgagtccat agctgaatca cgatttgaat ctcagttctc tcctgataac
     2761 gacagtgtct actctacaca agcctccatc ttctctcttc atgatggtac ttgcagtgat
     2821 ggcatgaact acggcccctc tcttccatca tctcctccca aggatgtgac cagcagttct
     2881 gaagtagtgc ttggtctgca tttgtccctg gaagaactct acacacagaa cctccttcag
     2941 agacagcatg ctggctctcc tcccacagac atgaggccag cacccacctc tggtttcccc
     3001 atcagtgact acacaactac aaatgctgtt gaacaaaaat acgaatgtgc aaacccagta
     3061 gcgtggcctc actcgcagtt accaagtagc ctaagcacct ccgagcttgc tcctgcactg
     3121 cctgctgtgg ctcagaagta tttaactgac cagagctctc tggcatctga tgctgagtct
     3181 gtcaacttgc agagtatgtc ccaggaagct tttgagagga ccgttactat agcaaaaggc
     3241 agctccagcc taggtatgac agtaagtgcc aataaagatg gcctgggagt gattgtgcgg
     3301 agcatcattc atgggggcgc cattagtcgt gatggccgga ttgctgtggg cgactgcatt
     3361 ttgtccatta atgaagaatc caccatcagt ctaaccaatg cccaggcacg ggccatgctc
     3421 agaagacatt ctctaattgg acctgatatc aaaattactt acgtgcctgc agaacatttg
     3481 gaagagttca gagtaagttt tggtcaacaa gctggaggaa taatggcact ggatattttt
     3541 tcttcataca ctggcagaga cattccagaa ctcccagagc gagaagaagg agaaggggaa
     3601 gaaagtgaac tgcagaatgc tgcctacagc agctggagcc agccacggag ggtggaactt
     3661 tggagagaac caagcaagtc cttgggcatc agcattgttg gtggtcgagg aatggggagc
     3721 cggctgagca atggtgaggt gatgaggggc attttcatca aacatgttct tgaagacagt
     3781 ccagctggca aaaatggaac tctgaagcca ggagacagaa taattgaggt ggatgggatg
     3841 gacctcagag atgcaagcca tgaacaagct gtggaagcca ttcggaaagc aggcaaccct
     3901 gtagtgttta tggtacagag cattataaac agaccaagga aatccccttt gccttccttg
     3961 ccgcacagcc tttaccctaa gtacagcttc agcagcacta acccatttgc agactctctc
     4021 cagctcacca ctgaccaggc acccagccag tcagaatctg agacagagaa gcctgcattg
     4081 tgcaatgttc ctccctcctc tccttcagtg ttctcagaaa tgggtagtga ttgtgcacag
     4141 ccatctgcaa ccgcagtctc agaagatgag gacaaagagg atgagtttgg ttacagctgg
     4201 aaaaatatcc aggagcgcta tggaagcctg acaggtcagc tccatgtgat tgagctggag
     4261 aaagggcaga gcgggttggg tctgagtctt gctgggaaca aagaccgcac cagaatgagt
     4321 gtgtttatag tggggattga tcccactgga gcagcgggga gagatggccg actacagatt
     4381 gccgacgagc ttttagagat caatggccaa atattgtatg gcagaagtca tcagaatgct
     4441 tcatcaatta ttaaatgtgc tccatctaaa gtaaaaataa tttttatcag aaatgcagat
     4501 gcagtgaacc agatggccgt atgtcctgga attgcagcag actctccgtc ttccacctca
     4561 gacagtcctc agaacaagga ggtggaacca tgcagtacta catctgcttc cgctgcggac
     4621 ctcagctcac ttacagatgt gtaccagctg gagcttccta aggatcaagg aggtttaggc
     4681 attgctatct gtgaggaaga cacaatcaac ggagtcatga tcgaaagcct aactgagcac
     4741 gggggagcag ccaaggatgg aaggctcaaa cctggagatc acatcttggc tgtagatgat
     4801 gaagttgttg ctgggtgtcc tgttgaaaag ttcatcagcc ttctgaagac ggcaaaggca
     4861 actgtaaaac tgactgttcg agctgagaat ccagcttgtc cagctgttcc ttcttcagct
     4921 gtaacagtca gtggagaaag gaaagacaac tcccagactc ctgcagtccc agctccagac
     4981 ctggaaccca tcccaagtac aagcaggtcc tccacaccag cagtctttgc ttctgaccct
     5041 gccacctgcc ccatcatccc aggctgtgag acaacaattg agatttccaa aggccaaaca
     5101 ggcctgggac tgagtattgt tgggggctca gacacactgc tgggtgctat tattatccat
     5161 gaagtttatg aagagggagc agcgtgtaaa gatggaagac tatgggctgg agaccagatt
     5221 ttagaggtaa atgggattga cttgcgaaag gctacacatg atgaagcaat caatgtcctg
     5281 aggcagacgc ctcaaagagt acggctgacg ctctaccgag atgaggcccc atacaaagag
     5341 gaggatgtct gtgatacctt caccatcgag ctgcagaaga ggccaggcaa aggccttggg
     5401 ttgagtattg ttggcaaaag aaatgacact ggagtatttg tatcagacat tgtcaaggga
     5461 ggcattgcag acgccgatgg gagactgatg caaggggacc agattttaat ggtgaatgga
     5521 gaagatgtcc gtcatgccac ccaggaggca gtcgctgccc tgctaaagtg ttccctaggt
     5581 gcagtaaccc tggaggttgg aagagtcaaa gctgccccat tccactcaga acggaggcct
     5641 tctcaaagca gccaggtgag tgagagcagc ctgtcatctt tcactccccc actttctgga
     5701 ataaatacat cagagtcatt ggaaagtaac tcgaagaaaa atgcattagc atctgaaatt
     5761 cagggactaa gaacagtcga aataaaaaag gggcctgctg actcgctggg actcagcatt
     5821 gctggaggag tgggcagccc gctcggagat gtccctatat ttattgcgat gatgcaccca
     5881 aatggtgttg cagctcaaac acaaaaactc agagttgggg ataggattgt caccatctgt
     5941 ggcacatcca cggatgggat gactcacaca caggcggtta acttgatgaa aaatgcctca
     6001 ggctccattg aagtacaggt ggttgctgga ggagatgtga gtgtggtcac gggtcatcag
     6061 caagaacttg ccaatccttg tcttgctttc actgggctga catcaagcag tatatttccg
     6121 gatgatttag gccctccaca gtctaagacc attacgctag accgaggacc agatggctta
     6181 ggcttcagca ttgtaggcgg ctatggcagc cctcatggag acttaccaat ttatgtgaaa
     6241 acagtgtttg caaagggagc agcagcagaa gatgggcgtc taaaaagggg cgatcagatc
     6301 attgctgtca atgggcaaag tctagaagga gtgacccatg aagaagctgt tgccatcctc
     6361 aagaggacaa agggcaccgt caccctcatg gttctctctt gaagtgactg ccagagctga
     6421 agcagcccag ccactggctc ccctcctact gtaacagaga ggacctgttt gtatgctgtg
     6481 ttggtcggag aaaactacag tagggaggcg agaaacagag tgtttgttac tcacagccaa
     6541 gcatcatttt tcctttactc tgcatttcat gatcatatac tcaaaaagaa gagatatttg
     6601 catagataaa cctcagtttt atctcgacaa tatctaacaa tttaaggtca cgtggacaaa
     6661 attattatat gttcatcttg ttagtgtgga aacaaaatga tacaaagtta ggcaattagg
     6721 ttaaagatgg aaatttagaa aaaaagaaga cagttttgag ttttatagga cttcttcaat
     6781 ccagcagtcc aaaagaagaa aagaaagtgc ttgcaatact tttgaatagt ctactgtttt
     6841 aaaattgtga catattggtc ctacttacct ctaatgcata tttttctgct aaaattgttt
     6901 agcagtcctt gtaagcttta aaaagaaatt cctgtttagt gcatatctcg gtgtttgttt
     6961 tcagttttaa cctgctatat tttcatgttg ttataggtaa agtgctgatg ctaccctgtg
     7021 ttggctagag ttctaggaaa catccatgta gccatgggag acagagaagg agcccagagt
     7081 gttctaatgc tgatgtagca gactgatact acgtggaaaa catgttactg taccatgcta
     7141 ttgtttttcc attagtatta atcttaatga catagaaaaa gacagcgtgt tagtaattat
     7201 tttggttgta tgccattagt aaattgacag aaaaattaag ggggttaatg taacttcatc
     7261 tcactgctgt atattaacat cttacaatac aatagtctaa gactgaggga aacagatggg
     7321 gctgtttact gagacaactg gtgaggaatt atgtgttcaa tcccatttta gagcgtgaaa
     7381 ctcctacatt agaatagata aagtcacttt aaatactatc tatatttgta acagaagtcg
     7441 tatacatata ttttattata gcattcttgt gtaaatgcag aattaaagtg aataaataag
     7501 tttctgtggt gcacaacaaa caagca
//
