LOCUS       NM_018819                939 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus mitochondrial pyruvate carrier 1 (Mpc1), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_018819
VERSION     NM_018819.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 939)
  AUTHORS   Rauckhorst,A.J., Sheldon,R.D., Pape,D.J., Ahmed,A.,
            Falls-Hubert,K.C., Merrill,R.A., Brown,R.F., Deshmukh,K.,
            Vallim,T.A., Deja,S., Burgess,S.C. and Taylor,E.B.
  TITLE     A hierarchical hepatic de novo lipogenesis substrate supply network
            utilizing pyruvate, acetate, and ketones
  JOURNAL   Cell Metab 37 (1), 255-273 (2025)
   PUBMED   39471817
REFERENCE   2  (bases 1 to 939)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 939)
  AUTHORS   Shannon,C.E., Bakewell,T., Fourcaudot,M.J., Ayala,I., Smelter,A.A.,
            Hinostroza,E.A., Romero,G., Asmis,M., Freitas Lima,L.C., Wallace,M.
            and Norton,L.
  TITLE     The mitochondrial pyruvate carrier regulates adipose glucose
            partitioning in female mice
  JOURNAL   Mol Metab 88, 102005 (2024)
   PUBMED   39137831
REFERENCE   4  (bases 1 to 939)
  AUTHORS   Galvan,C., Flores,A.A., Cerrilos,V., Avila,I., Murphy,C., Zheng,W.,
            Christofk,H.R. and Lowry,W.E.
  TITLE     Defining metabolic flexibility in hair follicle stem cell induced
            squamous cell carcinoma
  JOURNAL   Sci Adv 10 (38), eadn2806 (2024)
   PUBMED   39303037
REFERENCE   5  (bases 1 to 939)
  AUTHORS   Song,C., Valeri,A., Song,F., Ji,X., Liao,X., Marmo,T., Seeley,R.,
            Rutter,J. and Long,F.
  TITLE     Sexual dimorphism of osteoclast reliance on mitochondrial oxidation
            of energy substrates in the mouse
  JOURNAL   JCI Insight 8 (24), e174293 (2023)
   PUBMED   37917194
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 939)
  AUTHORS   Vacanti,N.M., Divakaruni,A.S., Green,C.R., Parker,S.J., Henry,R.R.,
            Ciaraldi,T.P., Murphy,A.N. and Metallo,C.M.
  TITLE     Regulation of substrate utilization by the mitochondrial pyruvate
            carrier
  JOURNAL   Mol Cell 56 (3), 425-435 (2014)
   PUBMED   25458843
  REMARK    GeneRIF: Oxidative glutaminolysis supports the TCA cycle in mouse
            cells lacking MPC1/2.
REFERENCE   7  (bases 1 to 939)
  AUTHORS   Bricker,D.K., Taylor,E.B., Schell,J.C., Orsak,T., Boutron,A.,
            Chen,Y.C., Cox,J.E., Cardon,C.M., Van Vranken,J.G., Dephoure,N.,
            Redin,C., Boudina,S., Gygi,S.P., Brivet,M., Thummel,C.S. and
            Rutter,J.
  TITLE     A mitochondrial pyruvate carrier required for pyruvate uptake in
            yeast, Drosophila, and humans
  JOURNAL   Science 337 (6090), 96-100 (2012)
   PUBMED   22628558
REFERENCE   8  (bases 1 to 939)
  AUTHORS   Herzig,S., Raemy,E., Montessuit,S., Veuthey,J.L., Zamboni,N.,
            Westermann,B., Kunji,E.R. and Martinou,J.C.
  TITLE     Identification and functional expression of the mitochondrial
            pyruvate carrier
  JOURNAL   Science 337 (6090), 93-96 (2012)
   PUBMED   22628554
REFERENCE   9  (bases 1 to 939)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   10 (bases 1 to 939)
  AUTHORS   Trachtulec,Z. and Forejt,J.
  TITLE     Synteny of orthologous genes conserved in mammals, snake, fly,
            nematode, and fission yeast
  JOURNAL   Mamm Genome 12 (3), 227-231 (2001)
   PUBMED   11252172
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY160030.1, AK013391.1 and AC164431.2.
            
            On Jul 14, 2018 this sequence version replaced NM_018819.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC103767.1, AK170514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BY160030.1         1-26
            27-933              AK013391.1         2-908
            934-939             AC164431.2         99625-99630
FEATURES             Location/Qualifiers
     source          1..939
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 4.92 cM"
     gene            1..939
                     /gene="Mpc1"
                     /gene_synonym="0610006G08Rik; 3830411I18Rik; Brp44l"
                     /note="mitochondrial pyruvate carrier 1"
                     /db_xref="GeneID:55951"
                     /db_xref="MGI:MGI:1915240"
     exon            1..175
                     /gene="Mpc1"
                     /gene_synonym="0610006G08Rik; 3830411I18Rik; Brp44l"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..434
                     /gene="Mpc1"
                     /gene_synonym="0610006G08Rik; 3830411I18Rik; Brp44l"
                     /note="isoform 1 is encoded by transcript variant 1;
                     apoptosis-regulating basic protein; brain protein 44-like
                     protein"
                     /codon_start=1
                     /product="mitochondrial pyruvate carrier 1 isoform 1"
                     /protein_id="NP_061289.1"
                     /db_xref="CCDS:CCDS49944.1"
                     /db_xref="GeneID:55951"
                     /db_xref="MGI:MGI:1915240"
                     /translation="MAGALVRKAADYVRSKDFRDYLMSTHFWGPVANWGLPIAAINDM
                     KKSPEIISGRMTFALCCYSLTFMRFAYKVQPRNWLLFACHVTNEVAQLIQGGRLINYE
                     MSKRPSA"
     exon            176..179
                     /gene="Mpc1"
                     /gene_synonym="0610006G08Rik; 3830411I18Rik; Brp44l"
                     /inference="alignment:Splign:2.1.0"
     exon            180..276
                     /gene="Mpc1"
                     /gene_synonym="0610006G08Rik; 3830411I18Rik; Brp44l"
                     /inference="alignment:Splign:2.1.0"
     exon            277..409
                     /gene="Mpc1"
                     /gene_synonym="0610006G08Rik; 3830411I18Rik; Brp44l"
                     /inference="alignment:Splign:2.1.0"
     exon            410..939
                     /gene="Mpc1"
                     /gene_synonym="0610006G08Rik; 3830411I18Rik; Brp44l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      911..916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mpc1"
                     /gene_synonym="0610006G08Rik; 3830411I18Rik; Brp44l"
                     /note="hexamer: AATAAA"
     polyA_site      934
                     /gene="Mpc1"
                     /gene_synonym="0610006G08Rik; 3830411I18Rik; Brp44l"
                     /note="major polyA site"
ORIGIN      
        1 gagtgtcgtg aggcgggcgc tggggtgaga gcgccgaggg cctcagccga gtccacagcg
       61 gtgtcatctg tctaggtagc ggcttcaccg ccaacggcac ggccatggct ggagcgctgg
      121 tgcgcaaagc ggcggactat gtccggagca aggacttccg ggactatctc atgagtacgc
      181 acttctgggg cccagttgcc aactggggtc tccccattgc tgctatcaat gacatgaaga
      241 aatctccaga gattatcagt gggcggatga ctttcgccct ctgttgctat tctctgacat
      301 tcatgagatt tgcctacaag gtacaacctc gaaactggct tttgtttgca tgccatgtaa
      361 caaacgaagt agctcagctc attcagggag gacgacttat caactacgag atgagtaagc
      421 ggccatctgc atagcggtac aaggaccagc tcttgaaaga gacagtgctc cagccactgc
      481 tgcagccaca gatcatgtca gcatgagtag tcgtgctgaa gggaaaacac agaatgctat
      541 cttaatgacc atgccaacat tattgaatag ccgagagtcc ctaaacccac tctctgctgc
      601 cttatcaatg ctaaacctta tttgtcttca tcaagagtag ttcaaaatat gcaactaatt
      661 taataatttt gaatgatggt tttatctata gcaatctgta gtaatatgta tattatctat
      721 tgggatttgt gtaataaaaa atctaaggga acaaaatttt ataactacaa gcacttaagt
      781 actcaaaatt cttgactttt tctttaatga caatagtaaa ccctcagttg gtcacatgtc
      841 tacacataat ttccagtgat aacaagtatc ggtgttttcc atatgtaact cagatctgta
      901 acttaatggc aataaatggt ttaaatattt gctatttga
//
