LOCUS       NM_031260               4053 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus Mov10 like RISC complex RNA helicase 1 (Mov10l1),
            mRNA.
ACCESSION   NM_031260
VERSION     NM_031260.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4053)
  AUTHORS   Lannom,M.C., Nielsen,J., Nawaz,A., Shilikbay,T. and Ceman,S.
  TITLE     FMRP and MOV10 regulate Dicer1 expression and dendrite development
  JOURNAL   PLoS One 16 (11), e0260005 (2021)
   PUBMED   34847178
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4053)
  AUTHORS   Sun,Y.H., Wang,R.H., Du,K., Zhu,J., Zheng,J., Xie,L.H.,
            Pereira,A.A., Zhang,C., Ricci,E.P. and Li,X.Z.
  TITLE     Coupled protein synthesis and ribosome-guided piRNA processing on
            mRNAs
  JOURNAL   Nat Commun 12 (1), 5970 (2021)
   PUBMED   34645830
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4053)
  AUTHORS   Guan,Y., Keeney,S., Jain,D. and Wang,P.J.
  TITLE     yama, a mutant allele of Mov10l1, disrupts retrotransposon
            silencing and piRNA biogenesis
  JOURNAL   PLoS Genet 17 (2), e1009265 (2021)
   PUBMED   33635934
  REMARK    GeneRIF: yama, a mutant allele of Mov10l1, disrupts retrotransposon
            silencing and piRNA biogenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4053)
  AUTHORS   Hsieh,C.L., Xia,J. and Lin,H.
  TITLE     MIWI prevents aneuploidy during meiosis by cleaving excess
            satellite RNA
  JOURNAL   EMBO J 39 (16), e103614 (2020)
   PUBMED   32677148
REFERENCE   5  (bases 1 to 4053)
  AUTHORS   Sun,Y.H., Zhu,J., Xie,L.H., Li,Z., Meduri,R., Zhu,X., Song,C.,
            Chen,C., Ricci,E.P., Weng,Z. and Li,X.Z.
  TITLE     Ribosomes guide pachytene piRNA formation on long intergenic piRNA
            precursors
  JOURNAL   Nat Cell Biol 22 (2), 200-212 (2020)
   PUBMED   32015435
  REMARK    Erratum:[Nat Cell Biol. 2020 Mar;22(3):353. doi:
            10.1038/s41556-020-0482-3.. PMID: 32066908]
REFERENCE   6  (bases 1 to 4053)
  AUTHORS   Ueyama,T., Kasahara,H., Ishiwata,T., Yamasaki,N. and Izumo,S.
  TITLE     Csm, a cardiac-specific isoform of the RNA helicase Mov10l1, is
            regulated by Nkx2.5 in embryonic heart
  JOURNAL   J Biol Chem 278 (31), 28750-28757 (2003)
   PUBMED   12754203
  REMARK    GeneRIF: Nkx2.5 transactivates the Csm promoter, suggesting that
            Nkx2.5 is essential for embryonic Csm (cardiac-specific isoform of
            Mov10l1) expression
REFERENCE   7  (bases 1 to 4053)
  AUTHORS   Regan,C.P., Li,W., Boucher,D.M., Spatz,S., Su,M.S. and Kuida,K.
  TITLE     Erk5 null mice display multiple extraembryonic vascular and
            embryonic cardiovascular defects
  JOURNAL   Proc Natl Acad Sci U S A 99 (14), 9248-9253 (2002)
   PUBMED   12093914
REFERENCE   8  (bases 1 to 4053)
  AUTHORS   Liu,Z.P. and Olson,E.N.
  TITLE     Suppression of proliferation and cardiomyocyte hypertrophy by
            CHAMP, a cardiac-specific RNA helicase
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2043-2048 (2002)
   PUBMED   11854500
  REMARK    GeneRIF: CHAMP acts as an inhibitor of cell proliferation and
            cardiomyocyte hypertrophy.
REFERENCE   9  (bases 1 to 4053)
  AUTHORS   Liu,Z.P., Nakagawa,O., Nakagawa,M., Yanagisawa,H., Passier,R.,
            Richardson,J.A., Srivastava,D. and Olson,E.N.
  TITLE     CHAMP, a novel cardiac-specific helicase regulated by MEF2C
  JOURNAL   Dev Biol 234 (2), 497-509 (2001)
   PUBMED   11397016
REFERENCE   10 (bases 1 to 4053)
  AUTHORS   Wang,P.J., McCarrey,J.R., Yang,F. and Page,D.C.
  TITLE     An abundance of X-linked genes expressed in spermatogonia
  JOURNAL   Nat Genet 27 (4), 422-426 (2001)
   PUBMED   11279525
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG086707.2, AF285587.1, AC119959.8, AK084786.1 and DV656742.1.
            
            On May 3, 2007 this sequence version replaced NM_031260.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF285587.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849384, SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-529               BG086707.2         1-529
            530-868             AF285587.1         419-757
            869-869             AC119959.8         56081-56081         c
            870-2588            AF285587.1         759-2477
            2589-3941           AK084786.1         159-1511
            3942-4053           DV656742.1         360-471
FEATURES             Location/Qualifiers
     source          1..4053
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 44.49 cM"
     gene            1..4053
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /note="Mov10 like RISC complex RNA helicase 1"
                     /db_xref="GeneID:83456"
                     /db_xref="MGI:MGI:1891384"
     exon            1..68
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /inference="alignment:Splign:2.1.0"
     exon            69..253
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..3691
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /EC_number="3.6.4.13"
                     /note="putative helicase Mov10l1; cardiac-specific RNA
                     helicase; cardiac helicase activated by MEF2 protein;
                     MOV10-like protein 1 homolog; moloney leukemia virus
                     10-like protein 1 homolog; Moloney leukemia virus 10-like
                     1 protein"
                     /codon_start=1
                     /product="RNA helicase Mov10l1"
                     /protein_id="NP_112550.2"
                     /db_xref="CCDS:CCDS27737.1"
                     /db_xref="GeneID:83456"
                     /db_xref="MGI:MGI:1891384"
                     /translation="MIDDLIYFSNDAVTSKVLLNVGQEVIAVVEENKVSNGLKAIRVE
                     AVSDKWEDDSKNSSKGLSDSSPRVLIGCVTSMLEGAGYISQTTYFSLESVCEGFHPCK
                     GDWVEAEYWIRPGTWSSEAISVKPLRYKRVDKVCISSLCGRNGVIEDSIFFSLDSLKL
                     PEGYIPRRHDIVNAVVVESSQSCYIWRALCMTPVKRDATLGEAPQEPYGALLLKNKGD
                     IEVTRMTSFGTLKEGESKSIVIWIENKGKVSRELVSCRLANWDKAHQFRFETQGRSKS
                     CPGAAAGSVPEGENVNSLNHHREDKTDEIPESRLANSTEISPDGCACKEESREKGNTP
                     EKQEPEPGGLIPPGEKTHIVVTCSAKNPGRCKELLLLCFSDFLIGRHLEVSVVSSEEA
                     LIAVREPFSWKKPKSSQTLVSAKTTVVVTTQKRNSRRQLPSFLPQYPIPDRLKKCVEQ
                     KIDILTFQPLLAELLNMSNYKEKFSTLLWLEEIHAEIELKEYNMSRVVLKRKGDLLVL
                     EVPGLAESRPSLYAGDKLILKSQEYNGHVIEYIGYVMEIHEEDVTLKLNPGFEQMYNF
                     EPMDVEFTYNRTTSRRCHYALEQVIHLGVKVLFPEEIILQSPQVTGNWSLAQDTKNDG
                     QSITNITRNDGQSMTKVTRNDSQSITNIIRNDGQSITNVTRNDGQPITKVTRNNSQSI
                     TNITRNDGQPITKNKKTVKDQTKHTTEERHVGTTDQPEKASSTAETMDEIQIPKARDK
                     EFFNPVLNENQKLAVRRILSGDCRPLPYILFGPPGTGKTVTIIEAVLQVHYALPDSRI
                     LVCAPSNSAADLVCLRLHESKVLKPAAMVRVNATCRFEETIIDAIKPYCRDGEDIWRA
                     SRFRIIITTCSSAGLFYQIGVRVGYFTHVFVDEAGQASEPECLIPLGLISDINGQIVL
                     AGDPMQLGPVIKSRLAMAYGLNVSMLERLMSRPAYLRDENAFGACGAYNPLLVTKLVK
                     NYRSHSALLALPSRLFYHRELEVCADPKVVTSLLGWEKLPRKGFPLIFHGVRGNEARE
                     GRSPSWFSPAEAVQVMRYCCLLARSVSSQVSSKDIGVITPYRKQVEKIKILLRNVDLT
                     DIKVGSVEEFQGQEYLVIVISTVRSNEDRFEDDRYFLGFLSNSKRFNVAITRPKALLI
                     ILGNPHVLVRDPCFGALLEYSVSNGVYTGCDLPPELQALQK"
     exon            254..416
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /inference="alignment:Splign:2.1.0"
     exon            417..529
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /inference="alignment:Splign:2.1.0"
     exon            530..714
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /inference="alignment:Splign:2.1.0"
     exon            715..855
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1082
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1206
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1401
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1516
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1694
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1765
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1857
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..1916
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2212
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2312
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2491
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2638
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2760
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..2860
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /inference="alignment:Splign:2.1.0"
     exon            2861..3025
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /inference="alignment:Splign:2.1.0"
     exon            3026..3199
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..3349
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /inference="alignment:Splign:2.1.0"
     exon            3350..3457
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /inference="alignment:Splign:2.1.0"
     exon            3458..3595
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /inference="alignment:Splign:2.1.0"
     exon            3596..3715
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /inference="alignment:Splign:2.1.0"
     exon            3716..4052
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4029..4034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /note="hexamer: AATAAA"
     polyA_site      4050
                     /gene="Mov10l1"
                     /gene_synonym="CHAMP; Csm"
                     /note="major polyA site"
ORIGIN      
        1 cttcttctgg aggaaggagg acatccctga ggaggaggtc gggcaaccag ggcgggagct
       61 gtcggaaggt gacaccaggt tgaaaacggt gcagggcgtt gtgacaaggt actgcagtga
      121 ctatggcatg attgacgact tgatctactt ttccaatgac gctgtgacga gtaaagtgct
      181 tctgaacgtg ggacaggaag tcattgctgt cgttgaagaa aacaaagtgt caaatggact
      241 gaaagcaatc agagtagaag ctgtctctga caaatgggaa gatgatagca aaaactctag
      301 caaagggttg tcagactcca gccccagagt gctgattggc tgtgtgactt ccatgttgga
      361 aggtgctggc tatatcagcc agaccacata cttctctttg gagagtgtgt gtgaaggttt
      421 ccacccatgc aagggtgact gggtagaggc tgagtattgg atcaggccag ggacatggag
      481 cagtgaggca atctctgtga agcctctgag gtacaagcgt gtggacaagg tttgcatttc
      541 cagcctgtgt gggaggaacg gggtgataga ggacagcatc ttcttcagcc tggactcctt
      601 gaagctgccg gaagggtaca taccgaggag acacgacatt gtcaatgctg tggttgtgga
      661 gagcagccag tcatgctaca tctggagagc actgtgcatg acccctgtga agagagatgc
      721 cactcttggt gaggcccctc aggagcccta tggagcactc ttactgaaaa acaaagggga
      781 cattgaagtt acaagaatga ccagttttgg aacattgaag gaaggagaaa gcaaatcaat
      841 cgtgatctgg atagagaata aagggaaggt ctctcgggag cttgtcagtt gcagactggc
      901 taactgggat aaagcacacc agtttagatt tgagacacag ggcagaagca agtcctgccc
      961 aggagcggct gctgggtctg ttcctgaagg tgaaaatgtt aattcattga atcatcacag
     1021 agaagacaaa actgatgaga ttccagagag ccgtctggcg aacagcacag aaatctctcc
     1081 agatggctgc gcttgtaaag aagaaagtag agaaaaagga aacacgccag agaaacagga
     1141 gccagagcct ggggggctca ttcctccggg ggagaagact cacattgtgg tcacatgcag
     1201 tgccaaaaac cctggccgtt gcaaggagct gcttctgctc tgtttctccg actttctcat
     1261 tgggcggcat cttgaagtga gtgtggtgag cagcgaggag gccctgatag ctgtgcgtga
     1321 gccgttttct tggaagaagc ctaaaagctc ccaaacatta gtgtctgcaa agactacagt
     1381 tgttgtaacc acacaaaaaa ggaactcgag gcgacaactt ccaagttttc ttccacagta
     1441 tccaatacca gatagactta aaaaatgtgt ggagcagaag attgacatcc tgactttcca
     1501 gccgcttctt gcagagctct tgaacatgtc aaactacaag gagaagttct ccaccctgct
     1561 gtggctagag gagatccatg cagaaatcga gctgaaggag tacaacatga gcagagttgt
     1621 cctcaagagg aagggggatc tgctggtcct ggaggtcccc gggctcgcag agagccggcc
     1681 ttccctctat gcaggtgaca aactgatttt aaaatctcaa gaatacaatg gacatgtcat
     1741 tgaatatatc ggctatgtca tggagattca tgaagaagat gtaactctta aacttaatcc
     1801 aggatttgaa caaatgtata attttgaacc tatggatgtg gagtttacat acaatcggac
     1861 cacaagcaga cggtgtcact atgcacttga gcaggtcatc catttgggtg taaaagtatt
     1921 atttccagaa gaaatcattt tacagtctcc tcaggtgaca gggaattgga gccttgcaca
     1981 ggacaccaaa aatgatgggc agtccatcac caacatcacc agaaatgatg gacagtccat
     2041 gaccaaggta accagaaatg acagccagtc catcaccaac atcatcagaa atgatggaca
     2101 gtccatcacc aacgtcacca gaaatgacgg gcagcccatc accaaggtaa ccagaaataa
     2161 cagccagtca atcaccaaca tcaccagaaa tgacgggcag cccatcacca agaacaagaa
     2221 aacagtgaag gaccaaacta aacacacaac agaggaaagg cacgtgggta ccacggacca
     2281 gccagagaag gcttcctcca ctgcagagac tatggatgaa atccagatcc caaaagcacg
     2341 agataaggag ttcttcaacc cagtgctcaa tgaaaaccaa aagctggccg tgaggaggat
     2401 cctgagtggc gactgccggc ctctcccata tatccttttt ggacctccgg gaactggaaa
     2461 gactgtgact ataatcgagg ctgttttgca ggtacattat gctttgccgg acagtcggat
     2521 tttggtctgc gctccttcca acagtgctgc tgaccttgtg tgtttgcgac ttcatgagag
     2581 caaggtgctg aagccagctg ccatggtccg ggtgaatgcc acctgcagat ttgaagagac
     2641 tattattgat gccatcaaac cgtattgcag agatggagaa gatatctgga gagcctcacg
     2701 cttcaggata ataatcacta catgtagcag tgcaggactg ttttaccaaa taggagtgag
     2761 agttggatac ttcacacatg tatttgtgga cgaggcagga caggcaagtg agccagaatg
     2821 ccttattcct ttgggactga tttcagacat caatggccag atcgtgcttg ctggagaccc
     2881 catgcagctc ggcccagtca tcaagtccag gctggccatg gcctatgggt tgaatgtgtc
     2941 catgttggag aggctgatgt ccagaccagc gtacctgaga gacgaaaatg cctttggcgc
     3001 ttgcggtgca tataacccat tgttggtcac aaagcttgtg aagaactaca ggtcccactc
     3061 ggctctgctg gcactgccct cacgcctgtt ctaccatagg gagcttgagg tctgtgctga
     3121 tcccaaagta gtgacttcac tgctgggctg ggagaagctg cccagaaaag gcttccctct
     3181 catcttccat ggagtgaggg ggaacgaggc tcgtgaaggg agaagcccat cgtggttcag
     3241 cccagccgag gctgtccagg tcatgcgcta ctgttgcctc ttggcccgga gtgtctccag
     3301 tcaagtgtct tccaaggata taggtgtcat cacaccctat cggaagcagg tggaaaaaat
     3361 aaaaatcctt ctgcgaaatg tggatttgac tgacataaag gttggctcgg tagaggagtt
     3421 ccagggacaa gagtacctgg tcatcgtcat ctccactgtg cggtcaaatg aagatagatt
     3481 tgaagatgac cgttattttt tgggtttctt gtccaattca aaaagattta atgttgcaat
     3541 cacaagaccc aaagcactgc tgatcattct gggaaaccct catgtgcttg tcagagatcc
     3601 ctgttttgga gcgctgctag aatacagtgt tagcaatggt gtctacacag ggtgtgatct
     3661 gcctcctgaa ctccaggctc tccaaaagtg agcactccag tccacttcct aaaaggtaaa
     3721 gcaccgtgga ggaaagagtg tggctccacg tgttcacctt aagcaggctg tggctagaca
     3781 gctgtgccag gacctgtgga catggtggag tctgctacaa cagggagcca ttgagcctca
     3841 ccctatgggc cattagtcca gccatgcttc agtcttctgt gactcctgcg gcttcctggt
     3901 ctcaagactg aatgttggta tgcatgggac cactgagtca gctgggctgc tcctgcttcc
     3961 ttggactgac cttggttcct aacagttagt ttctgcctgt gggcaatcac tgccactaca
     4021 ctcccccaaa taaacacttc cataacccca gaa
//
